IQ-domain 22 [Arabidopsis thaliana]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| DUF4005 super family | cl16148 | Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing ... |
367-425 | 1.22e-04 | ||
Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins. The actual alignment was detected with superfamily member pfam13178: Pssm-ID: 404128 Cd Length: 97 Bit Score: 41.07 E-value: 1.22e-04
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| IQCD | cd23767 | IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
169-192 | 1.63e-03 | ||
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor. : Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 35.98 E-value: 1.63e-03
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| CBD_MYO6-like super family | cl41207 | calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, ... |
169-219 | 3.30e-03 | ||
calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, which are actin-based motor molecules with ATPase activity, include unconventional myosins that serve in intracellular movements. Myosin-VI, also called unconventional myosin-6 (MYO6), is a reverse-direction motor protein that moves towards the minus-end of actin filaments. It is required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Myosin-VI appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. It modulates RNA polymerase II-dependent transcription. As part of the DISP (DOCK7-Induced Septin disPlacement) complex, Myosin-VI may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Myosin-VI is encoded by gene MYO6, the human homolog of the gene responsible for deafness in Snell's waltzer mice. It is mutated in autosomal dominant non-syndromic hearing loss. This family also includes Drosophila melanogaster unconventional myosin VI Jaguar (Jar; also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. Jar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. It contributes to synaptic transmission and development at the Drosophila neuromuscular junction. Together with CLIP-190 (CAP-Gly domain-containing/cytoplasmic linker protein 190), Jar may coordinate the interaction between the actin and microtubule cytoskeleton. Jar may link endocytic vesicles to microtubules and possibly be involved in transport in the early embryo and in the dynamic process of dorsal closure; its function is believed to change during the life cycle. This model corresponds to the calmodulin (CaM) binding domain (CBD), which consists of three subdomains: a unique insert (Insert 2 or Ins2), an IQ motif, and a proximal tail domain (PTD, also known as lever arm extension or LAE). The actual alignment was detected with superfamily member cd21759: Pssm-ID: 409646 [Multi-domain] Cd Length: 149 Bit Score: 37.87 E-value: 3.30e-03
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| Name | Accession | Description | Interval | E-value | ||
| DUF4005 | pfam13178 | Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing ... |
367-425 | 1.22e-04 | ||
Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins. Pssm-ID: 404128 Cd Length: 97 Bit Score: 41.07 E-value: 1.22e-04
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| IQCD | cd23767 | IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
169-192 | 1.63e-03 | ||
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor. Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 35.98 E-value: 1.63e-03
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| CBD_MYO6-like | cd21759 | calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, ... |
169-219 | 3.30e-03 | ||
calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, which are actin-based motor molecules with ATPase activity, include unconventional myosins that serve in intracellular movements. Myosin-VI, also called unconventional myosin-6 (MYO6), is a reverse-direction motor protein that moves towards the minus-end of actin filaments. It is required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Myosin-VI appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. It modulates RNA polymerase II-dependent transcription. As part of the DISP (DOCK7-Induced Septin disPlacement) complex, Myosin-VI may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Myosin-VI is encoded by gene MYO6, the human homolog of the gene responsible for deafness in Snell's waltzer mice. It is mutated in autosomal dominant non-syndromic hearing loss. This family also includes Drosophila melanogaster unconventional myosin VI Jaguar (Jar; also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. Jar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. It contributes to synaptic transmission and development at the Drosophila neuromuscular junction. Together with CLIP-190 (CAP-Gly domain-containing/cytoplasmic linker protein 190), Jar may coordinate the interaction between the actin and microtubule cytoskeleton. Jar may link endocytic vesicles to microtubules and possibly be involved in transport in the early embryo and in the dynamic process of dorsal closure; its function is believed to change during the life cycle. This model corresponds to the calmodulin (CaM) binding domain (CBD), which consists of three subdomains: a unique insert (Insert 2 or Ins2), an IQ motif, and a proximal tail domain (PTD, also known as lever arm extension or LAE). Pssm-ID: 409646 [Multi-domain] Cd Length: 149 Bit Score: 37.87 E-value: 3.30e-03
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| IQ | pfam00612 | IQ calmodulin-binding motif; Calmodulin-binding motif. |
169-187 | 3.75e-03 | ||
IQ calmodulin-binding motif; Calmodulin-binding motif. Pssm-ID: 459869 Cd Length: 21 Bit Score: 34.60 E-value: 3.75e-03
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| Name | Accession | Description | Interval | E-value | ||
| DUF4005 | pfam13178 | Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing ... |
367-425 | 1.22e-04 | ||
Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins. Pssm-ID: 404128 Cd Length: 97 Bit Score: 41.07 E-value: 1.22e-04
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| IQCD | cd23767 | IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
169-192 | 1.63e-03 | ||
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor. Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 35.98 E-value: 1.63e-03
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| CBD_MYO6-like | cd21759 | calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, ... |
169-219 | 3.30e-03 | ||
calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, which are actin-based motor molecules with ATPase activity, include unconventional myosins that serve in intracellular movements. Myosin-VI, also called unconventional myosin-6 (MYO6), is a reverse-direction motor protein that moves towards the minus-end of actin filaments. It is required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Myosin-VI appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. It modulates RNA polymerase II-dependent transcription. As part of the DISP (DOCK7-Induced Septin disPlacement) complex, Myosin-VI may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Myosin-VI is encoded by gene MYO6, the human homolog of the gene responsible for deafness in Snell's waltzer mice. It is mutated in autosomal dominant non-syndromic hearing loss. This family also includes Drosophila melanogaster unconventional myosin VI Jaguar (Jar; also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. Jar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. It contributes to synaptic transmission and development at the Drosophila neuromuscular junction. Together with CLIP-190 (CAP-Gly domain-containing/cytoplasmic linker protein 190), Jar may coordinate the interaction between the actin and microtubule cytoskeleton. Jar may link endocytic vesicles to microtubules and possibly be involved in transport in the early embryo and in the dynamic process of dorsal closure; its function is believed to change during the life cycle. This model corresponds to the calmodulin (CaM) binding domain (CBD), which consists of three subdomains: a unique insert (Insert 2 or Ins2), an IQ motif, and a proximal tail domain (PTD, also known as lever arm extension or LAE). Pssm-ID: 409646 [Multi-domain] Cd Length: 149 Bit Score: 37.87 E-value: 3.30e-03
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| IQ | pfam00612 | IQ calmodulin-binding motif; Calmodulin-binding motif. |
169-187 | 3.75e-03 | ||
IQ calmodulin-binding motif; Calmodulin-binding motif. Pssm-ID: 459869 Cd Length: 21 Bit Score: 34.60 E-value: 3.75e-03
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| Blast search parameters | ||||
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