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Conserved domains on  [gi|15235711|ref|NP_193989|]
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Exostosin family protein [Arabidopsis thaliana]

Protein Classification

glycosyltransferase family 47 protein( domain architecture ID 10503356)

glycosyltransferase family 47 protein, also called exostosin (EXT) family protein

CAZY:  GT47
Gene Ontology:  GO:0006486|GO:0016757
PubMed:  36960794

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
37-373 1.14e-65

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


:

Pssm-ID: 397245  Cd Length: 290  Bit Score: 211.90  E-value: 1.14e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711    37 CTNRWIHIRTLPSRFNLDLLSTCNRYpitddlcpylanhglgpkthtrtRSWYRTDPLLLELIFHRRILeypCLTPDPNL 116
Cdd:pfam03016   2 CKGLKVYVYDLPPRFNEDLLQPCRSL-----------------------TGWYSAEQFLLESILHSRIE---CRTSDPDE 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711   117 ASAIYLPYYAGIDSLRYLYGPDLnssADHGSDLLEFLTRDQPEiWSRRSGHDHFLVMARPAWDFSqpLTVDPPIWGTSFL 196
Cdd:pfam03016  56 ADCFFVPFYASLDASRHLLNSAL---TDLFRELLDWLKSQYPY-WNRSGGRDHFIVSGHPAWSFR--RTAPDVDWGRAML 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711   197 ErreffNLTALTLESRYWPWQEQAVPYPTSFHPHslpfLESWIRRVRRSRRTSLMLFAGGGGTSSSPNIRRSIRLECTSI 276
Cdd:pfam03016 130 L-----NLTVLFSEDQFRPGKDVALPYPTPFHPD----IGQWQDISPSNRRKTLLFFAGNRRRGYSGKIRPLLLEECKGN 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711   277 NATQsdnkICDFVDCSNGICehdpiRFMRPMLQSSFCLQPPGDTPTRKATFDGIIAGCIPVFFedqtakmQYKWHLPESE 356
Cdd:pfam03016 201 PDAD----ICGGLQCTPGRD-----KYMELLRSSRFCLQPPGDTPTSPRLFDALLAGCIPVII-------SDGWELPFAD 264
                         330       340
                  ....*....|....*....|
gi 15235711   357 F---AEFSVTIPKEDVVFRG 373
Cdd:pfam03016 265 VidwRKFSVFVPENDIPELK 284
 
Name Accession Description Interval E-value
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
37-373 1.14e-65

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


Pssm-ID: 397245  Cd Length: 290  Bit Score: 211.90  E-value: 1.14e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711    37 CTNRWIHIRTLPSRFNLDLLSTCNRYpitddlcpylanhglgpkthtrtRSWYRTDPLLLELIFHRRILeypCLTPDPNL 116
Cdd:pfam03016   2 CKGLKVYVYDLPPRFNEDLLQPCRSL-----------------------TGWYSAEQFLLESILHSRIE---CRTSDPDE 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711   117 ASAIYLPYYAGIDSLRYLYGPDLnssADHGSDLLEFLTRDQPEiWSRRSGHDHFLVMARPAWDFSqpLTVDPPIWGTSFL 196
Cdd:pfam03016  56 ADCFFVPFYASLDASRHLLNSAL---TDLFRELLDWLKSQYPY-WNRSGGRDHFIVSGHPAWSFR--RTAPDVDWGRAML 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711   197 ErreffNLTALTLESRYWPWQEQAVPYPTSFHPHslpfLESWIRRVRRSRRTSLMLFAGGGGTSSSPNIRRSIRLECTSI 276
Cdd:pfam03016 130 L-----NLTVLFSEDQFRPGKDVALPYPTPFHPD----IGQWQDISPSNRRKTLLFFAGNRRRGYSGKIRPLLLEECKGN 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711   277 NATQsdnkICDFVDCSNGICehdpiRFMRPMLQSSFCLQPPGDTPTRKATFDGIIAGCIPVFFedqtakmQYKWHLPESE 356
Cdd:pfam03016 201 PDAD----ICGGLQCTPGRD-----KYMELLRSSRFCLQPPGDTPTSPRLFDALLAGCIPVII-------SDGWELPFAD 264
                         330       340
                  ....*....|....*....|
gi 15235711   357 F---AEFSVTIPKEDVVFRG 373
Cdd:pfam03016 265 VidwRKFSVFVPENDIPELK 284
 
Name Accession Description Interval E-value
Exostosin pfam03016
Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on ...
37-373 1.14e-65

Exostosin family; The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.


Pssm-ID: 397245  Cd Length: 290  Bit Score: 211.90  E-value: 1.14e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711    37 CTNRWIHIRTLPSRFNLDLLSTCNRYpitddlcpylanhglgpkthtrtRSWYRTDPLLLELIFHRRILeypCLTPDPNL 116
Cdd:pfam03016   2 CKGLKVYVYDLPPRFNEDLLQPCRSL-----------------------TGWYSAEQFLLESILHSRIE---CRTSDPDE 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711   117 ASAIYLPYYAGIDSLRYLYGPDLnssADHGSDLLEFLTRDQPEiWSRRSGHDHFLVMARPAWDFSqpLTVDPPIWGTSFL 196
Cdd:pfam03016  56 ADCFFVPFYASLDASRHLLNSAL---TDLFRELLDWLKSQYPY-WNRSGGRDHFIVSGHPAWSFR--RTAPDVDWGRAML 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711   197 ErreffNLTALTLESRYWPWQEQAVPYPTSFHPHslpfLESWIRRVRRSRRTSLMLFAGGGGTSSSPNIRRSIRLECTSI 276
Cdd:pfam03016 130 L-----NLTVLFSEDQFRPGKDVALPYPTPFHPD----IGQWQDISPSNRRKTLLFFAGNRRRGYSGKIRPLLLEECKGN 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235711   277 NATQsdnkICDFVDCSNGICehdpiRFMRPMLQSSFCLQPPGDTPTRKATFDGIIAGCIPVFFedqtakmQYKWHLPESE 356
Cdd:pfam03016 201 PDAD----ICGGLQCTPGRD-----KYMELLRSSRFCLQPPGDTPTSPRLFDALLAGCIPVII-------SDGWELPFAD 264
                         330       340
                  ....*....|....*....|
gi 15235711   357 F---AEFSVTIPKEDVVFRG 373
Cdd:pfam03016 265 VidwRKFSVFVPENDIPELK 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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