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Conserved domains on  [gi|15235691|ref|NP_193986|]
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Phosphatidic acid phosphatase (PAP2) family protein [Arabidopsis thaliana]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130259)

phosphatase PAP2 family protein may be a histidine phosphatase that catalyzes the dephosphorylation of phospholipids such as phospholipid phosphatase 6 (PLPP6), or may be an inactive member such as PLPP7

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0016791|GO:0016311|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 19-201 7.86e-46

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


:

Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 149.01  E-value: 7.86e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  19 AVSHAIHTAAKPFLPPFVLLLLEISADFRFSFPVSLSFLL-SPPLRSFLVPFLLGLLFDLIFVGIVKLIFRRARPAYNHP 97
Cdd:cd03391   1 GVCARETSSWGPVRPLVKLLELSGHGIPWLAGTISCLWISsSPAGQEVLVNLLLGLLLDIITVAILKALVRRRRPAYNSP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  98 SMSAAVSADHYSFPSGHASRVFFVAASVHFFSAAAeasmtgpsysfldgwirdhndgdvkVEVVVVVWIWATVTAISRIL 177
Cdd:cd03391  81 DMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLA-------------------------VPLRVLLVLWATVVGISRVL 135

                       170       180
                ....*....|....*....|....
gi 15235691 178 LGRHYVLDVAAGAFLGIVEALFAL 201
Cdd:cd03391 136 LGRHHVLDVLAGAFLGYLEALLVE 159
 
Name Accession Description Interval E-value
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 19-201 7.86e-46

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 149.01  E-value: 7.86e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  19 AVSHAIHTAAKPFLPPFVLLLLEISADFRFSFPVSLSFLL-SPPLRSFLVPFLLGLLFDLIFVGIVKLIFRRARPAYNHP 97
Cdd:cd03391   1 GVCARETSSWGPVRPLVKLLELSGHGIPWLAGTISCLWISsSPAGQEVLVNLLLGLLLDIITVAILKALVRRRRPAYNSP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  98 SMSAAVSADHYSFPSGHASRVFFVAASVHFFSAAAeasmtgpsysfldgwirdhndgdvkVEVVVVVWIWATVTAISRIL 177
Cdd:cd03391  81 DMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLA-------------------------VPLRVLLVLWATVVGISRVL 135

                       170       180
                ....*....|....*....|....
gi 15235691 178 LGRHYVLDVAAGAFLGIVEALFAL 201
Cdd:cd03391 136 LGRHHVLDVLAGAFLGYLEALLVE 159
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 65-205 4.69e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 56.59  E-value: 4.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  65 FLVPFLLGLLFDLIFVGIVKLIFRRARPAYNHPSMSAAVSADHYSFPSGHASRVFFVAASVHFFsaaaeasmtgpsysFL 144
Cdd:COG0671  74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGYSFPSGHAAAAFALALVLALL--------------LP 139

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15235691 145 DGWIRdhndgdvkvevvVVVWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALFALRFLR 205
Cdd:COG0671 140 RRWLA------------ALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALLR 188
acidPPc smart00014
Acid phosphatase homologues;
70-201 5.64e-10

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 55.04  E-value: 5.64e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691     70 LLGLLFDLIFVGIVKLIFRRARP----AYNHPSMSAA--VSADHYSFPSGHASRVFFVAASVHFFSAAAEASmtgpsysf 143
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPfflsIGDACCTPNFllTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGR-------- 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 15235691    144 ldgwirdhndgdvkVEVVVVVWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALFAL 201
Cdd:smart00014  73 --------------KLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 69-204 3.42e-09

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 52.81  E-value: 3.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691    69 FLLGLLFDLIFVGIVKLIFRRARPAYNHP-----SMSAAVSADHYSFPSGHASRVFFVAASVHFFSAAAEASMTGPSYSF 143
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLegglvPAPSTLPGLGYSFPSGHSATAFALALLLALLLRRLRKIVRVLLALL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15235691   144 LdgwirdhndgdvkvevvvvvWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALFALRFL 204
Cdd:pfam01569  82 L--------------------LVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
 
Name Accession Description Interval E-value
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 19-201 7.86e-46

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 149.01  E-value: 7.86e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  19 AVSHAIHTAAKPFLPPFVLLLLEISADFRFSFPVSLSFLL-SPPLRSFLVPFLLGLLFDLIFVGIVKLIFRRARPAYNHP 97
Cdd:cd03391   1 GVCARETSSWGPVRPLVKLLELSGHGIPWLAGTISCLWISsSPAGQEVLVNLLLGLLLDIITVAILKALVRRRRPAYNSP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  98 SMSAAVSADHYSFPSGHASRVFFVAASVHFFSAAAeasmtgpsysfldgwirdhndgdvkVEVVVVVWIWATVTAISRIL 177
Cdd:cd03391  81 DMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLA-------------------------VPLRVLLVLWATVVGISRVL 135

                       170       180
                ....*....|....*....|....
gi 15235691 178 LGRHYVLDVAAGAFLGIVEALFAL 201
Cdd:cd03391 136 LGRHHVLDVLAGAFLGYLEALLVE 159
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 62-201 4.63e-13

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 63.25  E-value: 4.63e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  62 LRSFLVPFLLGLLFDLIFVGIVKLIFRRARPAYNHPSM----SAAVSADHYSFPSGHASRVFFVAASVHFFSAAAEAsmt 137
Cdd:cd01610   1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGpdgdPLLLTEGGYSFPSGHAAFAFALALFLALLLPRRLL--- 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15235691 138 gpsysfldgwirdhndgdvKVEVVVVVWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALFAL 201
Cdd:cd01610  78 -------------------RLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 65-205 4.69e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 56.59  E-value: 4.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  65 FLVPFLLGLLFDLIFVGIVKLIFRRARPAYNHPSMSAAVSADHYSFPSGHASRVFFVAASVHFFsaaaeasmtgpsysFL 144
Cdd:COG0671  74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGYSFPSGHAAAAFALALVLALL--------------LP 139

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15235691 145 DGWIRdhndgdvkvevvVVVWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALFALRFLR 205
Cdd:COG0671 140 RRWLA------------ALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALLR 188
acidPPc smart00014
Acid phosphatase homologues;
70-201 5.64e-10

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 55.04  E-value: 5.64e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691     70 LLGLLFDLIFVGIVKLIFRRARP----AYNHPSMSAA--VSADHYSFPSGHASRVFFVAASVHFFSAAAEASmtgpsysf 143
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPfflsIGDACCTPNFllTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGR-------- 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 15235691    144 ldgwirdhndgdvkVEVVVVVWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALFAL 201
Cdd:smart00014  73 --------------KLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 69-204 3.42e-09

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 52.81  E-value: 3.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691    69 FLLGLLFDLIFVGIVKLIFRRARPAYNHP-----SMSAAVSADHYSFPSGHASRVFFVAASVHFFSAAAEASMTGPSYSF 143
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLegglvPAPSTLPGLGYSFPSGHSATAFALALLLALLLRRLRKIVRVLLALL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15235691   144 LdgwirdhndgdvkvevvvvvWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALFALRFL 204
Cdd:pfam01569  82 L--------------------LVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 62-206 1.24e-08

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 52.65  E-value: 1.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  62 LRSFLVPFLLGLLFDLIFVGIVKLIFRRARPAYNHPSMSAAVSADH---YSFPSGHASRVFFVAASVHFFsaaaeasmtg 138
Cdd:cd03395  55 LLILLLVLLAVGFADQLASGFLKPLVARLRPCNALDGVRLVVLGDQggsYSFASSHAANSFALALFIWLF---------- 124

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15235691 139 psysFLDGWIRdhndgdvkvevvVVVWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALFALRFLRF 206
Cdd:cd03395 125 ----FRRGLFS------------PVLLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYLLFSW 176
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 11-205 2.62e-07

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 48.76  E-value: 2.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  11 GPILAVDAAVSHAIHTAAKPFLPPFVLLLLEIsADFRFSFPVSLSFLLSPPLRSFLVP---FLLGLLFDLIFVGIVKLIF 87
Cdd:cd03392   7 GWLTAFDQSVLSLLRSLRTPLLTAFMTAITFL-GSPAVLLIIVLLLALLLLLKRRRRAalfLLLALLGGGALNTLLKLLV 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  88 RRARPAYNHpsmsaAVSADHYSFPSGHASRVFFVAASVHFFsAAAEASMTGPSYSFLDGWIrdhndgdvkvevvvvvwIW 167
Cdd:cd03392  86 QRPRPPLHL-----LVPEGGYSFPSGHAMGATVLYGFLAYL-LARRLPRRRVRILLLILAA-----------------IL 142

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 15235691 168 ATVTAISRILLGRHYVLDVAAGAFLGIVEALFALRFLR 205
Cdd:cd03392 143 ILLVGLSRLYLGVHYPSDVLAGWLLGLAWLALLILLYR 180
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 66-195 2.59e-06

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 44.63  E-value: 2.59e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  66 LVPFLLGLLFDLIFVGIVKLIFRRARPAYNhpsmsaavSADHYSFPSGHASRVFFVAASVHFFSaaaeasmtgpsysfld 145
Cdd:cd03394   5 LLILAEAAALTAAVTEGLKFAVGRARPDGS--------NNGYRSFPSGHTASAFAAATFLQYRY---------------- 60

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15235691 146 GWIRDhndgdvkvevvvvvWIW----ATVTAISRILLGRHYVLDVAAGAFLGIV 195
Cdd:cd03394  61 GWRWY--------------GIPayalASLVGASRVVANRHWLSDVLAGAAIGIL 100
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 62-202 1.73e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 43.75  E-value: 1.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  62 LRSFLVPFLLGLLFDLIFVGIVKLIFRRARPAYNHPSMSAAVSADHY--------------------SFPSGHASRVF-- 119
Cdd:cd03390  44 LHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARCFPDGGTPSDTlvgidicctgdpgvlkegrkSFPSGHSSFAFag 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691 120 ------FVAASVHFFSAAaeasmtGPSYSFLdgwirdhndgdvkveVVVVVWIWATVTAISRILLGRHYVLDVAAGAFLG 193
Cdd:cd03390 124 lgflslYLAGKLHIFDPR------GSSWRLL---------------LALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIG 182


                ....*....
gi 15235691 194 IVEALFALR 202
Cdd:cd03390 183 LIIAYLSYR 191
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 69-200 1.51e-04

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 40.69  E-value: 1.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  69 FLLGLLFDLIFVGIVKLIFRRARPAY------NHPSMSAAVSADHY------------------SFPSGHASRVFFVAAs 124
Cdd:cd03384   9 FLFGLFATQLLTDLGKYVTGRLRPHFldvckpNYTDLTCSLDHQYIadctcctgdpdlirearlSFPSGHASLSMYAAV- 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15235691 125 vhFFSAAAEASMTGPSYSFLdgwirdhndgdvKVEVVVVVWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALFA 200
Cdd:cd03384  88 --FLALYLQARLKLRGSRLL------------RPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFL 149
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 109-202 1.96e-04

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 39.93  E-value: 1.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691 109 SFPSGHASRVFFVAASVHFFSAaaeasmtgpsysFLDGWIrdhndgdvkvevvvvVWIWATVTAISRILLGRHYVLDVAA 188
Cdd:cd03385  78 SFPSDHTTLFFSIAFSLLLRRR------------KWAGWI---------------LLILALLVAWSRIYLGVHYPLDMLG 130

                        90
                ....*....|....
gi 15235691 189 GAFLGIVEALFALR 202
Cdd:cd03385 131 AALVAVLSALLVFQ 144
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 78-199 2.82e-04

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 40.38  E-value: 2.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  78 IFVGIVKLIFRRARPAYNHPSMS---AAVSADH--YSFPSGHASRVFfvaasvhffSAAAEASMTGPSYSFLdgwirdhn 152
Cdd:cd03389  83 ILVNLLKFIIGRARPKLLFDDGLygfDPFHADYafTSFPSGHSATAG---------AAAAALALLFPRYRWA-------- 145

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15235691 153 dgdvkvevvvvVWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALF 199
Cdd:cd03389 146 -----------FILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALA 181
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 69-199 4.10e-04

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 39.56  E-value: 4.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235691  69 FLLGLLFDLIFVGIVKLIFRRARPAYNHPSMSAAvsadhYSFPSGHASRVFFVAAsvhFFSAAAEASMtGPSYSFLDGWI 148
Cdd:cd03382  47 LFIGLLANEALNYVLKRIIKEPRPCSGAYFVRSG-----YGMPSSHSQFMGFFAV---YLLLFIYLRL-GRLNSLVSRFL 117

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15235691 149 rdhndgdvkveVVVVVWIWATVTAISRILLGRHYVLDVAAGAFLGIVEALF 199
Cdd:cd03382 118 -----------LSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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