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Conserved domains on  [gi|15237124|ref|NP_192866|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-675 4.98e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 4.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  514 DTDPLVYKQRLLGHTGSVLCLAAHRmfgdangcnSSHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptk 593
Cdd:cd00200  121 DVETGKCLTTLRGHTDWVNSVAFSP---------DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD--- 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  594 rpwSKCFLSVGDDSCVALSSLETLRVERMFPGHPNYPTKVVWDGTRGYIAClfrslsrkSDPIDVLYIWDVKTGARERVL 673
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS--------GSEDGTIRVWDLRTGECVQTL 257


                 ..
gi 15237124  674 HG 675
Cdd:cd00200  258 SG 259
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-675 4.98e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 4.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  514 DTDPLVYKQRLLGHTGSVLCLAAHRmfgdangcnSSHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptk 593
Cdd:cd00200  121 DVETGKCLTTLRGHTDWVNSVAFSP---------DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD--- 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  594 rpwSKCFLSVGDDSCVALSSLETLRVERMFPGHPNYPTKVVWDGTRGYIAClfrslsrkSDPIDVLYIWDVKTGARERVL 673
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS--------GSEDGTIRVWDLRTGECVQTL 257


                 ..
gi 15237124  674 HG 675
Cdd:cd00200  258 SG 259
WD40 COG2319
WD40 repeat [General function prediction only];
522-675 8.68e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 8.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  522 QRLLGHTGSVLCLAahrmFgDANGcnssHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptkrpwSKCFL 601
Cdd:COG2319  198 RTLTGHTGAVRSVA----F-SPDG----KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD------GRLLA 262

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15237124  602 SVGDDSCVALSSLETLRVERMFPGHPNYPTKVVW--DGTrgYIAclfrSLSRksDpiDVLYIWDVKTGARERVLHG 675
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGK--LLA----SGSD--D--GTVRLWDLATGKLLRTLTG 328
WD40 pfam00400
WD domain, G-beta repeat;
522-565 1.97e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.97e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 15237124    522 QRLLGHTGSVLCLAAHrmfgdangcNSSHVLISGSMDCTIRIWD 565
Cdd:pfam00400    5 KTLEGHTGSVTSLAFS---------PDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 522-565 2.13e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.13e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 15237124     522 QRLLGHTGSVLCLAAHrmfgdangcNSSHVLISGSMDCTIRIWD 565
Cdd:smart00320    6 KTLKGHTGPVTSVAFS---------PDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-675 4.98e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 4.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  514 DTDPLVYKQRLLGHTGSVLCLAAHRmfgdangcnSSHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptk 593
Cdd:cd00200  121 DVETGKCLTTLRGHTDWVNSVAFSP---------DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD--- 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  594 rpwSKCFLSVGDDSCVALSSLETLRVERMFPGHPNYPTKVVWDGTRGYIAClfrslsrkSDPIDVLYIWDVKTGARERVL 673
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS--------GSEDGTIRVWDLRTGECVQTL 257


                 ..
gi 15237124  674 HG 675
Cdd:cd00200  258 SG 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 521-675 1.34e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 1.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  521 KQRLLGHTGSVLCLAAHrmfgdangcNSSHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSpaptkrPWSKCF 600
Cdd:cd00200    2 RRTLKGHTGGVTCVAFS---------PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS------ADGTYL 66

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15237124  601 LSVGDDSCVALSSLETLRVERMFPGHPNYPTKVVWDGTRGYIACLFRSLSRKsdpidvlyIWDVKTGARERVLHG 675
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK--------VWDVETGKCLTTLRG 133
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-675 4.61e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 4.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  514 DTDPLVYKQRLLGHTGSVLCLAAhrmfgdangCNSSHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptk 593
Cdd:cd00200   37 DLETGELLRTLKGHTGPVRDVAA---------SADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPD--- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  594 rpwSKCFLSVGDDSCVALSSLETLRVERMFPGHPNYPTKVVWDGTRGYIAClfrslsrkSDPIDVLYIWDVKTGARERVL 673
Cdd:cd00200  105 ---GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS--------SSQDGTIKLWDLRTGKCVATL 173


                 ..
gi 15237124  674 HG 675
Cdd:cd00200  174 TG 175
WD40 COG2319
WD40 repeat [General function prediction only];
522-675 8.68e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 8.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  522 QRLLGHTGSVLCLAahrmFgDANGcnssHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptkrpwSKCFL 601
Cdd:COG2319  198 RTLTGHTGAVRSVA----F-SPDG----KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD------GRLLA 262

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15237124  602 SVGDDSCVALSSLETLRVERMFPGHPNYPTKVVW--DGTrgYIAclfrSLSRksDpiDVLYIWDVKTGARERVLHG 675
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGK--LLA----SGSD--D--GTVRLWDLATGKLLRTLTG 328
WD40 COG2319
WD40 repeat [General function prediction only];
522-675 5.83e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 5.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  522 QRLLGHTGSVLCLAahrmFgDANGcnssHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptkrpwSKCFL 601
Cdd:COG2319  156 RTLTGHSGAVTSVA----F-SPDG----KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD------GKLLA 220

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15237124  602 SVGDDSCVALSSLETLRVERMFPGHPNYPTKVVW--DGTRgyIAclfrSLSRKSdpidVLYIWDVKTGARERVLHG 675
Cdd:COG2319  221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRL--LA----SGSADG----TVRLWDLATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
522-675 9.57e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 9.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  522 QRLLGHTGSVLCLAAHrmfgdANGcnssHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptkrpwSKCFL 601
Cdd:COG2319  240 RTLTGHSGSVRSVAFS-----PDG----RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD------GKLLA 304

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15237124  602 SVGDDSCVALSSLETLRVERMFPGHPNYPTKVVWDGTRGYIAclfrslSRKSDpiDVLYIWDVKTGARERVLHG 675
Cdd:COG2319  305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLA------SGSDD--GTVRLWDLATGELLRTLTG 370
WD40 COG2319
WD40 repeat [General function prediction only];
514-675 1.40e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  514 DTDPLVYKQRLLGHTGSVLCLAAHrmfgdANGcnssHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptk 593
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAFS-----PDG----KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD--- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  594 rpwSKCFLSVGDDSCVALSSLETLRVERMFPGHPNYPTKVVW--DGTRgyIAclfrSLSRksDpiDVLYIWDVKTGARER 671
Cdd:COG2319  174 ---GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKL--LA----SGSA--D--GTVRLWDLATGKLLR 240


                 ....
gi 15237124  672 VLHG 675
Cdd:COG2319  241 TLTG 244
WD40 COG2319
WD40 repeat [General function prediction only];
522-639 6.62e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 6.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  522 QRLLGHTGSVLCLAAHrmfgdANGcnssHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptkrpwSKCFL 601
Cdd:COG2319  282 RTLTGHSGGVNSVAFS-----PDG----KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD------GKTLA 346

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 15237124  602 SVGDDSCVALSSLETLRVERMFPGHPNYPTKVVW--DGTR 639
Cdd:COG2319  347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFspDGRT 386
WD40 COG2319
WD40 repeat [General function prediction only];
512-675 6.70e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 6.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  512 RSDTDPLVYKQRLLGHTGSVLCLAAHRmfgdangcnSSHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAp 591
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSP---------DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD- 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  592 tkrpwSKCFLSVGDDSCVALSSLETLRVERMFPGHPNYPTKVVW--DGTRgyIAclfrSLSRksDpiDVLYIWDVKTGAR 669
Cdd:COG2319  132 -----GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKL--LA----SGSD--D--GTVRLWDLATGKL 196


                 ....*.
gi 15237124  670 ERVLHG 675
Cdd:COG2319  197 LRTLTG 202
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-643 2.29e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 2.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  514 DTDPLVYKQRLLGHTGSVLCLAAHrmfgdangcNSSHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSpaptk 593
Cdd:cd00200  163 DLRTGKCVATLTGHTGEVNSVAFS---------PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFS----- 228

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 15237124  594 rPWSKCFLSVGDDSCVALSSLETLRVERMFPGHPNYPTKVVWDGTRGYIA 643
Cdd:cd00200  229 -PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 522-609 6.02e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 6.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237124  522 QRLLGHTGSVLCLAAHrmfgdangcNSSHVLISGSMDCTIRIWDLESGNVIMIMHHHVAPVRQIILSPAptkrpwSKCFL 601
Cdd:cd00200  213 GTLRGHENGVNSVAFS---------PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD------GKRLA 277


                 ....*...
gi 15237124  602 SVGDDSCV 609
Cdd:cd00200  278 SGSADGTI 285
WD40 pfam00400
WD domain, G-beta repeat;
522-565 1.97e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.97e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 15237124    522 QRLLGHTGSVLCLAAHrmfgdangcNSSHVLISGSMDCTIRIWD 565
Cdd:pfam00400    5 KTLEGHTGSVTSLAFS---------PDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 522-565 2.13e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.13e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 15237124     522 QRLLGHTGSVLCLAAHrmfgdangcNSSHVLISGSMDCTIRIWD 565
Cdd:smart00320    6 KTLKGHTGPVTSVAFS---------PDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-565 3.88e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 3.88e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15237124  514 DTDPLVYKQRLLGHTGSVLCLAAHrmfgdangcNSSHVLISGSMDCTIRIWD 565
Cdd:cd00200  247 DLRTGECVQTLSGHTNSVTSLAWS---------PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
522-568 5.64e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 5.64e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 15237124  522 QRLLGHTGSVLCLAAHrmfgdANGcnssHVLISGSMDCTIRIWDLES 568
Cdd:COG2319  366 RTLTGHTGAVTSVAFS-----PDG----RTLASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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