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Conserved domains on  [gi|15236915|ref|NP_192816|]
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LRR and NB-ARC domains-containing disease resistance protein [Arabidopsis thaliana]

Protein Classification

NB-LRR family disease resistance protein( domain architecture ID 12012142)

NB-LRR (nucleotide-binding-leucine rich repeat) family disease resistance protein guards the plant against pathogens via an indirect interaction with an avirulence protein contained in the plant, triggering a defense response that restricts the pathogen growth

CATH:  3.80.10.10
Gene Ontology:  GO:0006952|GO:0005515|GO:0000166
PubMed:  20483655|25825425|9545207|21459033|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NB-ARC pfam00931
NB-ARC domain;
157-399 2.63e-78

NB-ARC domain;


:

Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 254.23  E-value: 2.63e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   157 RETIFQRAWNRLMD-DGVGTMGLYGMGGVGKTTLLTQIHNTLHDTKNGVDIVIWVVVSSDLQIHKIQEDIGEKLGFIGKE 235
Cdd:pfam00931   1 REDMVEKVIGKLSEkDEPGIVGIHGMGGVGKTTLAAQIFNDFDEVEGHFDSVAWVVVSKTFTISTLQQTILQNLGLSEDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   236 WNKKQESQKAVDILNCLSKKRFVLLLDDIWKKVDLTKIGIPSQTRENKCKVVFTTRSLDVCARMGV-HDPMEVQCLSTND 314
Cdd:pfam00931  81 WDNKEEGELARKIRRALLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGGpSDPHEVELLEPDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   315 AWELFQEKVGQISLGSHPDILELAKKVAGKCRGLPLALNVIGETMAGKRAVQEWHHAVDVLTSYAAEFSGMDDHILLILK 394
Cdd:pfam00931 161 AWELFENKVFPKTLGECELLEDVAKEIVEKCRGLPLALKVLGGLLSCKKTVEEWKHVYDVLQSELKSNSYSLNSVRSILQ 240


                  ....*
gi 15236915   395 YSYDN 399
Cdd:pfam00931 241 LSYEN 245
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
504-643 3.15e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 3.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 504 LRKVPKVEDWGAVRRLSLMNNGIEEISGS-PECPELTTLFLQENKsLVHIsGEFFRHMRKLVVLDLSENhQLDGLPEQIS 582
Cdd:COG4886 103 LSGNEELSNLTNLESLDLSGNQLTDLPEElANLTNLKELDLSNNQ-LTDL-PEPLGNLTNLKSLDLSNN-QLTDLPEELG 179

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15236915 583 ELVALRYLDLSHTNIEGLPACLQDLKTLIHLNLECMrRLGSI-AGISKLSSLRTLGLRNSNI 643
Cdd:COG4886 180 NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-QLTDLpEPLANLTNLETLDLSNNQL 240
 
Name Accession Description Interval E-value
NB-ARC pfam00931
NB-ARC domain;
157-399 2.63e-78

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 254.23  E-value: 2.63e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   157 RETIFQRAWNRLMD-DGVGTMGLYGMGGVGKTTLLTQIHNTLHDTKNGVDIVIWVVVSSDLQIHKIQEDIGEKLGFIGKE 235
Cdd:pfam00931   1 REDMVEKVIGKLSEkDEPGIVGIHGMGGVGKTTLAAQIFNDFDEVEGHFDSVAWVVVSKTFTISTLQQTILQNLGLSEDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   236 WNKKQESQKAVDILNCLSKKRFVLLLDDIWKKVDLTKIGIPSQTRENKCKVVFTTRSLDVCARMGV-HDPMEVQCLSTND 314
Cdd:pfam00931  81 WDNKEEGELARKIRRALLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGGpSDPHEVELLEPDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   315 AWELFQEKVGQISLGSHPDILELAKKVAGKCRGLPLALNVIGETMAGKRAVQEWHHAVDVLTSYAAEFSGMDDHILLILK 394
Cdd:pfam00931 161 AWELFENKVFPKTLGECELLEDVAKEIVEKCRGLPLALKVLGGLLSCKKTVEEWKHVYDVLQSELKSNSYSLNSVRSILQ 240


                  ....*
gi 15236915   395 YSYDN 399
Cdd:pfam00931 241 LSYEN 245
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
504-643 3.15e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 3.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 504 LRKVPKVEDWGAVRRLSLMNNGIEEISGS-PECPELTTLFLQENKsLVHIsGEFFRHMRKLVVLDLSENhQLDGLPEQIS 582
Cdd:COG4886 103 LSGNEELSNLTNLESLDLSGNQLTDLPEElANLTNLKELDLSNNQ-LTDL-PEPLGNLTNLKSLDLSNN-QLTDLPEELG 179

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15236915 583 ELVALRYLDLSHTNIEGLPACLQDLKTLIHLNLECMrRLGSI-AGISKLSSLRTLGLRNSNI 643
Cdd:COG4886 180 NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-QLTDLpEPLANLTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
536-597 9.77e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 9.77e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15236915   536 PELTTLFLQENkSLVHISGEFFRHMRKLVVLDLSENhQLDGL-PEQISELVALRYLDLSHTNI 597
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNN-LLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 168-649 6.39e-08

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 56.81  E-value: 6.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   168 LMDDGVGTMGLYGMGGVGKTTLLTQIHNTLHDTKNGVDIVIWVVVSSDLQIHKIQ--EDIGEKL----GFIGKEWNKKQE 241
Cdd:PLN03210  202 LESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAFISKSMEIYSSAnpDDYNMKLhlqrAFLSEILDKKDI 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   242 SQKAVDILNCLSKKRFVLL-LDDIWKKVDLTKIGIPSQTRENKCKVVFTTRSLDVCARMGVHDPMEVqCLSTND-AWELF 319
Cdd:PLN03210  282 KIYHLGAMEERLKHRKVLIfIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMF 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   320 QEKVGQISlgSHPD-ILELAKKVAGKCRGLPLALNVIGETMAGkRAVQEWhhaVDVLTSYAaefSGMDDHILLILKYSYD 398
Cdd:PLN03210  361 CRSAFKKN--SPPDgFMELASEVALRAGNLPLGLNVLGSYLRG-RDKEDW---MDMLPRLR---NGLDGKIEKTLRVSYD 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   399 NLNDKHVRSCFQYCALYpedYSIKKYRLIDYWICEGFIDGNIGkeravnqgyeiLGTLVRACLLSEEgKNKLEvkMHDVV 478
Cdd:PLN03210  432 GLNNKKDKAIFRHIACL---FNGEKVNDIKLLLANSDLDVNIG-----------LKNLVDKSLIHVR-EDIVE--MHSLL 494

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   479 REMAlwtlsdlgknKErcIVQAGS---GLRKVpkVEDWGAVRRLSLMNNGIEEISGspecpelTTLFLQENKSLvHISGE 555
Cdd:PLN03210  495 QEMG----------KE--IVRAQSnepGEREF--LVDAKDICDVLEDNTGTKKVLG-------ITLDIDEIDEL-HIHEN 552

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   556 FFRHMRKLVVLD---------------LSENhqLDGLPEQISELVALRY----------------LDLSHTNIEGLPACL 604
Cdd:PLN03210  553 AFKGMRNLLFLKfytkkwdqkkevrwhLPEG--FDYLPPKLRLLRWDKYplrcmpsnfrpenlvkLQMQGSKLEKLWDGV 630

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 15236915   605 QDLKTLIHLNLECMRRLGSIAGISKLSSLRTLGLRNSNIMLDVMS 649
Cdd:PLN03210  631 HSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPS 675
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 519-643 9.47e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 9.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 519 LSLMNNGIEEISGSPECPELTTLFLQENKsLVHISGefFRHMRKLVVLDLSENH--QLDGLpeqiSELVALRYLDLSHTN 596
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNK-ITKIEN--LEFLTNLTHLYLQNNQieKIENL----ENLVNLKKLYLGGNR 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15236915 597 I---EGlpacLQDLKTLIHLNLECMRR---------LGSIAGISKlsSLRTLGLRNSNI 643
Cdd:cd21340  80 IsvvEG----LENLTNLEELHIENQRLppgekltfdPRSLAALSN--SLRVLNISGNNI 132
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 536-615 1.59e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915  536 PELTTLFLQENKslvhISGEFFRHM---RKLVVLDLSENhQLDG-LPEQISELVALRYLDLSHTNIEG-LPACLQDLKTL 610
Cdd:PLN00113 499 SELMQLKLSENK----LSGEIPDELsscKKLVSLDLSHN-QLSGqIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESL 573


                 ....*
gi 15236915  611 IHLNL 615
Cdd:PLN00113 574 VQVNI 578
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 178-290 3.15e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 42.13  E-value: 3.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 178 LYGMGGVGKTTLLTQIHNTLHdtKNGVDIVIwVVVSSDLQIHKIQEDIGEKLGFIGKEWNKKqesqkavdilnclsKKRF 257
Cdd:cd00009  24 LYGPPGTGKTTLARAIANELF--RPGAPFLY-LNASDLLEGLVVAELFGHFLVRLLFELAEK--------------AKPG 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15236915 258 VLLLDDI--------WKKVDLTKIGIPSQTRENKCKVVFTT 290
Cdd:cd00009  87 VLFIDEIdslsrgaqNALLRVLETLNDLRIDRENVRVIGAT 127
 
Name Accession Description Interval E-value
NB-ARC pfam00931
NB-ARC domain;
157-399 2.63e-78

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 254.23  E-value: 2.63e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   157 RETIFQRAWNRLMD-DGVGTMGLYGMGGVGKTTLLTQIHNTLHDTKNGVDIVIWVVVSSDLQIHKIQEDIGEKLGFIGKE 235
Cdd:pfam00931   1 REDMVEKVIGKLSEkDEPGIVGIHGMGGVGKTTLAAQIFNDFDEVEGHFDSVAWVVVSKTFTISTLQQTILQNLGLSEDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   236 WNKKQESQKAVDILNCLSKKRFVLLLDDIWKKVDLTKIGIPSQTRENKCKVVFTTRSLDVCARMGV-HDPMEVQCLSTND 314
Cdd:pfam00931  81 WDNKEEGELARKIRRALLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGGpSDPHEVELLEPDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   315 AWELFQEKVGQISLGSHPDILELAKKVAGKCRGLPLALNVIGETMAGKRAVQEWHHAVDVLTSYAAEFSGMDDHILLILK 394
Cdd:pfam00931 161 AWELFENKVFPKTLGECELLEDVAKEIVEKCRGLPLALKVLGGLLSCKKTVEEWKHVYDVLQSELKSNSYSLNSVRSILQ 240


                  ....*
gi 15236915   395 YSYDN 399
Cdd:pfam00931 241 LSYEN 245
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
504-643 3.15e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 3.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 504 LRKVPKVEDWGAVRRLSLMNNGIEEISGS-PECPELTTLFLQENKsLVHIsGEFFRHMRKLVVLDLSENhQLDGLPEQIS 582
Cdd:COG4886 103 LSGNEELSNLTNLESLDLSGNQLTDLPEElANLTNLKELDLSNNQ-LTDL-PEPLGNLTNLKSLDLSNN-QLTDLPEELG 179

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15236915 583 ELVALRYLDLSHTNIEGLPACLQDLKTLIHLNLECMrRLGSI-AGISKLSSLRTLGLRNSNI 643
Cdd:COG4886 180 NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN-QLTDLpEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
534-643 5.32e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.32e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 534 ECPELTTLFLQENKSLVHISgeffrhmrKLVVLDLSENhQLDGLPEQISELVALRYLDLSHTNIEGLPACLQDLKTLIHL 613
Cdd:COG4886  94 DLTNLTELDLSGNEELSNLT--------NLESLDLSGN-QLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSL 164

                        90       100       110
                ....*....|....*....|....*....|.
gi 15236915 614 NLEcMRRLGSI-AGISKLSSLRTLGLRNSNI 643
Cdd:COG4886 165 DLS-NNQLTDLpEELGNLTNLKELDLSNNQI 194
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
517-616 6.62e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 6.62e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 517 RRLSLMNNGIEEISGS-PECPELTTLFLQENKsLVHISGEFfRHMRKLVVLDLSENhQLDGLPEqISELVALRYLDLSHT 595
Cdd:COG4886 185 KELDLSNNQITDLPEPlGNLTNLEELDLSGNQ-LTDLPEPL-ANLTNLETLDLSNN-QLTDLPE-LGNLTNLEELDLSNN 260

                        90       100
                ....*....|....*....|.
gi 15236915 596 NIEGLPACLQdLKTLIHLNLE 616
Cdd:COG4886 261 QLTDLPPLAN-LTNLKTLDLS 280
LRR_8 pfam13855
Leucine rich repeat;
536-597 9.77e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 9.77e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15236915   536 PELTTLFLQENkSLVHISGEFFRHMRKLVVLDLSENhQLDGL-PEQISELVALRYLDLSHTNI 597
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNN-LLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 168-649 6.39e-08

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 56.81  E-value: 6.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   168 LMDDGVGTMGLYGMGGVGKTTLLTQIHNTLHDTKNGVDIVIWVVVSSDLQIHKIQ--EDIGEKL----GFIGKEWNKKQE 241
Cdd:PLN03210  202 LESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAFISKSMEIYSSAnpDDYNMKLhlqrAFLSEILDKKDI 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   242 SQKAVDILNCLSKKRFVLL-LDDIWKKVDLTKIGIPSQTRENKCKVVFTTRSLDVCARMGVHDPMEVqCLSTND-AWELF 319
Cdd:PLN03210  282 KIYHLGAMEERLKHRKVLIfIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMF 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   320 QEKVGQISlgSHPD-ILELAKKVAGKCRGLPLALNVIGETMAGkRAVQEWhhaVDVLTSYAaefSGMDDHILLILKYSYD 398
Cdd:PLN03210  361 CRSAFKKN--SPPDgFMELASEVALRAGNLPLGLNVLGSYLRG-RDKEDW---MDMLPRLR---NGLDGKIEKTLRVSYD 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   399 NLNDKHVRSCFQYCALYpedYSIKKYRLIDYWICEGFIDGNIGkeravnqgyeiLGTLVRACLLSEEgKNKLEvkMHDVV 478
Cdd:PLN03210  432 GLNNKKDKAIFRHIACL---FNGEKVNDIKLLLANSDLDVNIG-----------LKNLVDKSLIHVR-EDIVE--MHSLL 494

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   479 REMAlwtlsdlgknKErcIVQAGS---GLRKVpkVEDWGAVRRLSLMNNGIEEISGspecpelTTLFLQENKSLvHISGE 555
Cdd:PLN03210  495 QEMG----------KE--IVRAQSnepGEREF--LVDAKDICDVLEDNTGTKKVLG-------ITLDIDEIDEL-HIHEN 552

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915   556 FFRHMRKLVVLD---------------LSENhqLDGLPEQISELVALRY----------------LDLSHTNIEGLPACL 604
Cdd:PLN03210  553 AFKGMRNLLFLKfytkkwdqkkevrwhLPEG--FDYLPPKLRLLRWDKYplrcmpsnfrpenlvkLQMQGSKLEKLWDGV 630

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 15236915   605 QDLKTLIHLNLECMRRLGSIAGISKLSSLRTLGLRNSNIMLDVMS 649
Cdd:PLN03210  631 HSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPS 675
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 519-643 9.47e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 9.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 519 LSLMNNGIEEISGSPECPELTTLFLQENKsLVHISGefFRHMRKLVVLDLSENH--QLDGLpeqiSELVALRYLDLSHTN 596
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNK-ITKIEN--LEFLTNLTHLYLQNNQieKIENL----ENLVNLKKLYLGGNR 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15236915 597 I---EGlpacLQDLKTLIHLNLECMRR---------LGSIAGISKlsSLRTLGLRNSNI 643
Cdd:cd21340  80 IsvvEG----LENLTNLEELHIENQRLppgekltfdPRSLAALSN--SLRVLNISGNNI 132
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 536-615 1.59e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915  536 PELTTLFLQENKslvhISGEFFRHM---RKLVVLDLSENhQLDG-LPEQISELVALRYLDLSHTNIEG-LPACLQDLKTL 610
Cdd:PLN00113 499 SELMQLKLSENK----LSGEIPDELsscKKLVSLDLSHN-QLSGqIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESL 573


                 ....*
gi 15236915  611 IHLNL 615
Cdd:PLN00113 574 VQVNI 578
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 519-646 1.15e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 1.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 519 LSLMNNGIEE------ISGSPECPELTTLFLQENKSLVHIS----GEFFRHMRKLVVLDLSENHQLD-GLP---EQISEL 584
Cdd:cd00116 113 LKLNNNGLGDrglrllAKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDaGIRalaEGLKAN 192

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15236915 585 VALRYLDLS-----HTNIEGLPACLQDLKTLIHLNL-------ECMRRLGSiAGISKLSSLRTLGLRNSNIMLD 646
Cdd:cd00116 193 CNLEVLDLNnngltDEGASALAETLASLKSLEVLNLgdnnltdAGAAALAS-ALLSPNISLLTLSLSCNDITDD 265
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 178-290 3.15e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 42.13  E-value: 3.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 178 LYGMGGVGKTTLLTQIHNTLHdtKNGVDIVIwVVVSSDLQIHKIQEDIGEKLGFIGKEWNKKqesqkavdilnclsKKRF 257
Cdd:cd00009  24 LYGPPGTGKTTLARAIANELF--RPGAPFLY-LNASDLLEGLVVAELFGHFLVRLLFELAEK--------------AKPG 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15236915 258 VLLLDDI--------WKKVDLTKIGIPSQTRENKCKVVFTT 290
Cdd:cd00009  87 VLFIDEIdslsrgaqNALLRVLETLNDLRIDRENVRVIGAT 127
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 519-633 3.57e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 3.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915  519 LSLMNN----GIEEISGSPEcpeLTTLFLQENKslvhISGEF---FRHMRKLVVLDLSENHQLDGLPEQISELVALRYLD 591
Cdd:PLN00113 457 LSLARNkffgGLPDSFGSKR---LENLDLSRNQ----FSGAVprkLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLD 529

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 15236915  592 LSHTNIEG-LPACLQDLKTLIHLNLECMRRLGSI-AGISKLSSL 633
Cdd:PLN00113 530 LSHNQLSGqIPASFSEMPVLSQLDLSQNQLSGEIpKNLGNVESL 573
LRR_8 pfam13855
Leucine rich repeat;
561-616 5.88e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 5.88e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15236915   561 RKLVVLDLSENHqLDGL-PEQISELVALRYLDLSHTNIEGL-PACLQDLKTLIHLNLE 616
Cdd:pfam13855   1 PNLRSLDLSNNR-LTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLS 57
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 517-613 3.02e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 3.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 517 RRLSLMNNGIEEISGSPECPELTTLFLQ------------ENKSLVHISgeffrhmRKLVVLDLSENHqLDGLpEQISEL 584
Cdd:cd21340  71 KKLYLGGNRISVVEGLENLTNLEELHIEnqrlppgekltfDPRSLAALS-------NSLRVLNISGNN-IDSL-EPLAPL 141

                        90       100
                ....*....|....*....|....*....
gi 15236915 585 VALRYLDLSHTNIEGLPACLQDLKTLIHL 613
Cdd:cd21340 142 RNLEQLDASNNQISDLEELLDLLSSWPSL 170
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 156-204 5.31e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 38.64  E-value: 5.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15236915   156 GRETIFQR---AWNRLMDDGVGTMGLYGMGGVGKTTLLTQIHNTLHDTKNGV 204
Cdd:pfam13191   4 GREEELEQlldALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALERDGGYF 55
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 536-643 5.42e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 5.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915 536 PELTTLFLQEN---KSLVHISGEFFRHMRKLVVLDLSENHQLDGLPEQISELVA----LRYLDLSHTNI-----EGLPAC 603
Cdd:COG5238 208 TTVTTLWLKRNpigDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKnnttVETLYLSGNQIgaegaIALAKA 287

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15236915 604 LQDLKTL--IHLNLECMRRLGSIA---GISKLSSLRTLGLRNSNI 643
Cdd:COG5238 288 LQGNTTLtsLDLSVNRIGDEGAIAlaeGLQGNKTLHTLNLAYNGI 332
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 538-633 8.42e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 8.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236915  538 LTTLFLQENKSLVHISGEFFRhMRKLVVLDLSENHQLDGLPEQISELVALRYLDLSHTNIEG-LPACLQDLKTLIHLNLE 616
Cdd:PLN00113 190 LEFLTLASNQLVGQIPRELGQ-MKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGpIPSSLGNLKNLQYLFLY 268

                         90       100
                 ....*....|....*....|.
gi 15236915  617 CMRRLG----SIAGISKLSSL 633
Cdd:PLN00113 269 QNKLSGpippSIFSLQKLISL 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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