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Conserved domains on  [gi|30680828|ref|NP_192607|]
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Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein [Arabidopsis thaliana]

Protein Classification

HPS-like domain-containing protein; protease inhibitor/seed storage/LTP family protein; alpha-amylase inhibitor/seed storage family protein; protease inhibitor/seed storage/LTP family protein; HPS-like domain-containing protein; protease inhibitor/seed storage/LTP family protein; nsLTP_like domain-containing protein; protease inhibitor/seed storage/LTP family protein; HPS-like domain-containing protein; protease inhibitor/seed storage/LTP family protein; protease inhibitor/seed storage/LTP family protein( domain architecture ID 12864497)

HPS (Hydrophobic Protein from Soybean) is a small hydrophobic protein with unknown function related to cereal-type alpha-amylase inhibitors and lipid transfer proteins; Protease inhibitor/seed storage/LTP family protein belongs to a protein family that is unique to higher plants and includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, among others; Protease inhibitor/seed storage/LTP family protein belongs to a protein family that is unique to higher plants and includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, among others; HPS (Hydrophobic Protein from Soybean) is a small hydrophobic protein with unknown function related to cereal-type alpha-amylase inhibitors and lipid transfer proteins; Protease inhibitor/seed storage/LTP family protein belongs to a protein family that is unique to higher plants and includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, among others; Protease inhibitor/seed storage/LTP family protein belongs to a protein family that is unique to higher plants and includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, among others; alpha-amylase inhibitors (AAIs) and seed storage (SS) proteins play an important role in the natural defenses of plants against insects and pathogens such as fungi, bacteria and viruses; AAIs impede the digestion of plant starch and proteins by inhibiting digestive alpha-amylases and proteinases.; HPS (Hydrophobic Protein from Soybean) is a small hydrophobic protein with unknown function related to cereal-type alpha-amylase inhibitors and lipid transfer proteins; Protease inhibitor/seed storage/LTP family protein belongs to a protein family that is unique to higher plants and includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, among others; Protease inhibitor/seed storage/LTP family protein belongs to a protein family that is unique to higher plants and includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, among others; nsLTP_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAI_LTSS cd00010
AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein ...
 55-118 4.96e-12

AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein family; a protein family unique to higher plants that includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, and similar proteins. Proteins in this family are known to play important roles, in defending plants from insects and pathogens, lipid transport between intracellular membranes, and nutrient storage. Many proteins of this family have been identified as allergens in humans. These proteins contain a common pattern of eight cysteines that form four disulfide bridges.


:

Pssm-ID: 237980  Cd Length: 63  Bit Score: 58.98  E-value: 4.96e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30680828  55 MMDCLGYLGVGSneTKPEKSCCTGIETVLQYNPQCICAGLVSAGEMGIEL-NSTRALATPKACKL 118
Cdd:cd00010   1 LAPCLSYLTGGA--TAPPSDCCSGLKSVVKSDPKCLCAALNGPGASLLGLkNATRALALPAACGL 63
rad23 super family cl36702
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 110-187 3.74e-04

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


The actual alignment was detected with superfamily member TIGR00601:

Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 3.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680828   110 LATPKACKLSIAPPhcGIITSGATTPGASPVSPSAGAPTTSPSAAKSPETSATSP---SSDETPSMTAPSPSSSGTNILS 186
Cdd:TIGR00601  74 VSKPKTGTGKVAPP--AATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESataTAPESPSTSVPSSGSDAASTLV 151


                  .
gi 30680828   187 V 187
Cdd:TIGR00601 152 V 152
 
Name Accession Description Interval E-value
AAI_LTSS cd00010
AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein ...
 55-118 4.96e-12

AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein family; a protein family unique to higher plants that includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, and similar proteins. Proteins in this family are known to play important roles, in defending plants from insects and pathogens, lipid transport between intracellular membranes, and nutrient storage. Many proteins of this family have been identified as allergens in humans. These proteins contain a common pattern of eight cysteines that form four disulfide bridges.


Pssm-ID: 237980  Cd Length: 63  Bit Score: 58.98  E-value: 4.96e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30680828  55 MMDCLGYLGVGSneTKPEKSCCTGIETVLQYNPQCICAGLVSAGEMGIEL-NSTRALATPKACKL 118
Cdd:cd00010   1 LAPCLSYLTGGA--TAPPSDCCSGLKSVVKSDPKCLCAALNGPGASLLGLkNATRALALPAACGL 63
AAI smart00499
Plant lipid transfer protein / seed storage protein / trypsin-alpha amylase inhibitor domain ...
 48-125 1.72e-09

Plant lipid transfer protein / seed storage protein / trypsin-alpha amylase inhibitor domain family;


Pssm-ID: 214698  Cd Length: 79  Bit Score: 52.77  E-value: 1.72e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680828     48 CSTVIYSMMDCLGYLGVGSNETKPEKSCCTGIETVlqYNPQCICAGLVSAGE---MGIELNSTRALATPKACKLSIAPPH 124
Cdd:smart00499   1 CGQVLLQLAPCLSYLVGGSRGAPPSQQCCSQLRGL--NSAQCRCLALRAAVLgilEIPGLNAQNAASLPSACGVPPPYTD 78


                   .
gi 30680828    125 C 125
Cdd:smart00499  79 C 79
LTP_2 pfam14368
Probable lipid transfer; The members of this family are probably involved in lipid transfer. ...
 34-124 1.30e-08

Probable lipid transfer; The members of this family are probably involved in lipid transfer. The family has several highly conserved cysteines, paired in various ways.


Pssm-ID: 433909  Cd Length: 100  Bit Score: 50.56  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680828    34 SPVGAPAPGPSSSDCSTVIYS-MMDCLGYLGVGSNETKPEKSCCTGIETVLQYNPQCICAGLVSAGEMGIELNSTRALAT 112
Cdd:pfam14368   7 AQAPAPPPAPAAASCTLSMLSgLSPCLPYLTGTPAATAPSPACCGALKSAVSTDVTCLCALVTAPLPIGFPINVTRALAL 86

                          90
                  ....*....|..
gi 30680828   113 PKACKLSIAPPH 124
Cdd:pfam14368  87 PRACGVKTPPSS 98
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 110-187 3.74e-04

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 3.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680828   110 LATPKACKLSIAPPhcGIITSGATTPGASPVSPSAGAPTTSPSAAKSPETSATSP---SSDETPSMTAPSPSSSGTNILS 186
Cdd:TIGR00601  74 VSKPKTGTGKVAPP--AATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESataTAPESPSTSVPSSGSDAASTLV 151


                  .
gi 30680828   187 V 187
Cdd:TIGR00601 152 V 152
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 129-198 4.62e-04

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 40.46  E-value: 4.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680828  129 TSGAT--TPGASPVSPSAGAPTTSPSAAKSPETS---------ATSPSSDETPSMTAPSPSSSGTNILSVPALTIVFVIV 197
Cdd:PLN02217 587 DSPSTvvAPSTSPPAGHLGSPPATPSKIVSPSTSppashlgspSTTPSSPESSIKVASTETASPESSIKVASTESSVSMV 666


                 .
gi 30680828  198 S 198
Cdd:PLN02217 667 S 667
 
Name Accession Description Interval E-value
AAI_LTSS cd00010
AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein ...
 55-118 4.96e-12

AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein family; a protein family unique to higher plants that includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, and similar proteins. Proteins in this family are known to play important roles, in defending plants from insects and pathogens, lipid transport between intracellular membranes, and nutrient storage. Many proteins of this family have been identified as allergens in humans. These proteins contain a common pattern of eight cysteines that form four disulfide bridges.


Pssm-ID: 237980  Cd Length: 63  Bit Score: 58.98  E-value: 4.96e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30680828  55 MMDCLGYLGVGSneTKPEKSCCTGIETVLQYNPQCICAGLVSAGEMGIEL-NSTRALATPKACKL 118
Cdd:cd00010   1 LAPCLSYLTGGA--TAPPSDCCSGLKSVVKSDPKCLCAALNGPGASLLGLkNATRALALPAACGL 63
AAI smart00499
Plant lipid transfer protein / seed storage protein / trypsin-alpha amylase inhibitor domain ...
 48-125 1.72e-09

Plant lipid transfer protein / seed storage protein / trypsin-alpha amylase inhibitor domain family;


Pssm-ID: 214698  Cd Length: 79  Bit Score: 52.77  E-value: 1.72e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680828     48 CSTVIYSMMDCLGYLGVGSNETKPEKSCCTGIETVlqYNPQCICAGLVSAGE---MGIELNSTRALATPKACKLSIAPPH 124
Cdd:smart00499   1 CGQVLLQLAPCLSYLVGGSRGAPPSQQCCSQLRGL--NSAQCRCLALRAAVLgilEIPGLNAQNAASLPSACGVPPPYTD 78


                   .
gi 30680828    125 C 125
Cdd:smart00499  79 C 79
LTP_2 pfam14368
Probable lipid transfer; The members of this family are probably involved in lipid transfer. ...
 34-124 1.30e-08

Probable lipid transfer; The members of this family are probably involved in lipid transfer. The family has several highly conserved cysteines, paired in various ways.


Pssm-ID: 433909  Cd Length: 100  Bit Score: 50.56  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680828    34 SPVGAPAPGPSSSDCSTVIYS-MMDCLGYLGVGSNETKPEKSCCTGIETVLQYNPQCICAGLVSAGEMGIELNSTRALAT 112
Cdd:pfam14368   7 AQAPAPPPAPAAASCTLSMLSgLSPCLPYLTGTPAATAPSPACCGALKSAVSTDVTCLCALVTAPLPIGFPINVTRALAL 86

                          90
                  ....*....|..
gi 30680828   113 PKACKLSIAPPH 124
Cdd:pfam14368  87 PRACGVKTPPSS 98
Tryp_alpha_amyl pfam00234
Protease inhibitor/seed storage/LTP family; This family is composed of trypsin-alpha amylase ...
 48-123 1.92e-07

Protease inhibitor/seed storage/LTP family; This family is composed of trypsin-alpha amylase inhibitors, seed storage proteins and lipid transfer proteins from plants.


Pssm-ID: 425543  Cd Length: 74  Bit Score: 46.79  E-value: 1.92e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30680828    48 CSTVIYSMMDCLGYLGVGSNetKPEKSCCTGIETVlqyNPQCICAGLVSAGEMGIELNSTRALATPKACKLSIAPP 123
Cdd:pfam00234   1 CGQVLLCLAPCLGYLQGGCQ--VPSQQCCSQLRQL---QAQCRCTAIRAIVLGIEGINPQAAASLPSMCGVNVPYG 71
nsLTP_like cd04660
nsLTP_like: Non-specific lipid-transfer protein (nsLTP)-like subfamily; composed of ...
 48-125 1.19e-05

nsLTP_like: Non-specific lipid-transfer protein (nsLTP)-like subfamily; composed of predominantly uncharacterized proteins with similarity to nsLTPs, including Medicago truncatula MtN5, the root-specific Phaseolus vulgaris PVR3, Antirrhinum majus FIL1, and Lilium longiflorum LIM3. Plant nsLTPs are small, soluble proteins that facilitate the transfer of fatty acids, phospholipids, glycolipids, and steroids between membranes. The MtN5 gene is induced during root nodule development. FIL1 is thought to be important in petal and stamen formation. The LIM3 gene is induced during the early prophase stage of meiosis in lily microsporocytes.


Pssm-ID: 240018  Cd Length: 73  Bit Score: 41.97  E-value: 1.19e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30680828  48 CSTVIYSMMDCLGYLGVGSNETKPEKSCCTGIETVlqyNPQCICAGLVSAGEMGIELNstRALATPKACKLSIAPPHC 125
Cdd:cd04660   1 CNMDLDLLAECQPYVTGPNPPPPPSRECCAALRRA---DLPCLCRYKTSLVLQIIDPD--KAVYLPAKCGLPLPPSSC 73
nsLTP1 cd01960
nsLTP1: Non-specific lipid-transfer protein type 1 (nsLTP1) subfamily; Plant nsLTPs are small, ...
 47-120 1.31e-05

nsLTP1: Non-specific lipid-transfer protein type 1 (nsLTP1) subfamily; Plant nsLTPs are small, soluble proteins that facilitate the transfer of fatty acids, phospholipids, glycolipids, and steroids between membranes. In addition to lipid transport and assembly, nsLTPs also play a key role in the defense of plants against pathogens. There are two closely-related types of nsLTPs, types 1 and 2, which differ in protein sequence, molecular weight, and biological properties. nsLTPs contain an internal hydrophobic cavity, which serves as the binding site for lipids. The hydrophobic cavity accommodates various fatty acid ligands containing from ten to 18 carbon atoms. In general, the cavity is larger in nsLTP1 than in nsLTP2. nsLTP1 proteins are located in extracellular layers and in vacuolar structures. They may be involved in the formation of cutin layers on plant surfaces by transporting cutin monomers. Many nsLTP1 proteins have been characterized as allergens in humans.


Pssm-ID: 238926  Cd Length: 89  Bit Score: 42.34  E-value: 1.31e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30680828  47 DCSTVIYSMMDCLGYLgvGSNETKPEKSCCTGIETVLQYNP-----QCICAGLVSAGEMGIELNSTRALATPKACKLSI 120
Cdd:cd01960   2 SCGQVTSLLAPCLGYL--TGGGPAPSPACCSGVKSLNGLAKttadrQAACNCLKSAAAGISGLNPGRAAGLPGKCGVSI 78
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 110-187 3.74e-04

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 3.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680828   110 LATPKACKLSIAPPhcGIITSGATTPGASPVSPSAGAPTTSPSAAKSPETSATSP---SSDETPSMTAPSPSSSGTNILS 186
Cdd:TIGR00601  74 VSKPKTGTGKVAPP--AATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESataTAPESPSTSVPSSGSDAASTLV 151


                  .
gi 30680828   187 V 187
Cdd:TIGR00601 152 V 152
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 129-198 4.62e-04

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 40.46  E-value: 4.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680828  129 TSGAT--TPGASPVSPSAGAPTTSPSAAKSPETS---------ATSPSSDETPSMTAPSPSSSGTNILSVPALTIVFVIV 197
Cdd:PLN02217 587 DSPSTvvAPSTSPPAGHLGSPPATPSKIVSPSTSppashlgspSTTPSSPESSIKVASTETASPESSIKVASTESSVSMV 666


                 .
gi 30680828  198 S 198
Cdd:PLN02217 667 S 667
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 111-180 2.13e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 38.53  E-value: 2.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680828  111 ATPKACKLSIAPPHCGIITSGATTPGASpvspSAGAPTTSPSAAKSPETSATSPSSDETPSMTAPSPSSS 180
Cdd:PLN02217 597 TSPPAGHLGSPPATPSKIVSPSTSPPAS----HLGSPSTTPSSPESSIKVASTETASPESSIKVASTESS 662
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 129-193 2.42e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 37.95  E-value: 2.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30680828   129 TSGATTPGASPVSPSAGAPTT--SPSAAKSPETSATSP---SSDETPSMTAP-SPSSSGTNILSVPALTIV 193
Cdd:TIGR00601  81 TGKVAPPAATPTSAPTPTPSPpaSPASGMSAAPASAVEeksPSEESATATAPeSPSTSVPSSGSDAASTLV 151
PRK10856 PRK10856
cytoskeleton protein RodZ;
129-191 4.32e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 37.31  E-value: 4.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680828  129 TSGATTPGASPVSPSAGAPTTSPSAAKSPETSATSPSSDETPSMTAPSPSSSGTNILSVPALT 191
Cdd:PRK10856 166 TSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAP 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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