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Conserved domains on  [gi|15235835|ref|NP_192524|]
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CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein [Arabidopsis thaliana]

Protein Classification

pathogenesis-related family 1 protein( domain architecture ID 10143537)

pathogenesis-related family 1 (PR-1) protein similar to Arabidopsis thaliana pathogenesis-related protein 1 that is partially responsible for acquired pathogen resistance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_PR-1 cd05381
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 29-160 8.41e-67

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.


:

Pssm-ID: 349400  Cd Length: 136  Bit Score: 199.40  E-value: 8.41e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835  29 PQDYFNAHNRARVSVGVSPLMWSQTLTAYAQAYAEKRR-DCGLFLSGGPYGETIKADIID-FSAEEFVSTFLNQKSDYDY 106
Cdd:cd05381   1 PQDFLDAHNQARAAVGVPPLVWDDTLAAYAQKYANQRRgDCSLVHSNGPYGENLFWGSGDnWSPADAVKSWVDEKPYYDY 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15235835 107 TTNTCRAGKSCDGYKQVLFRKSVFLGCAKVKCNN-GGFLAICSYDPSV-ILSERPF 160
Cdd:cd05381  81 ASNTCVGGKMCGHYTQVVWRNSTRLGCARVVCDNnGGTFVICNYDPPGnYIGERPY 136
 
Name Accession Description Interval E-value
CAP_PR-1 cd05381
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 29-160 8.41e-67

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.


Pssm-ID: 349400  Cd Length: 136  Bit Score: 199.40  E-value: 8.41e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835  29 PQDYFNAHNRARVSVGVSPLMWSQTLTAYAQAYAEKRR-DCGLFLSGGPYGETIKADIID-FSAEEFVSTFLNQKSDYDY 106
Cdd:cd05381   1 PQDFLDAHNQARAAVGVPPLVWDDTLAAYAQKYANQRRgDCSLVHSNGPYGENLFWGSGDnWSPADAVKSWVDEKPYYDY 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15235835 107 TTNTCRAGKSCDGYKQVLFRKSVFLGCAKVKCNN-GGFLAICSYDPSV-ILSERPF 160
Cdd:cd05381  81 ASNTCVGGKMCGHYTQVVWRNSTRLGCARVVCDNnGGTFVICNYDPPGnYIGERPY 136
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 27-151 8.49e-18

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 74.73  E-value: 8.49e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835     27 DQPQDYFNAHNRARVSVGVS-----------PLMWSQTLTAYAQAYAEKrrdC--GLFLSGGPYGETI-----KADIIDF 88
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAGGflaapaasnmlKLTWDCELASSAQNWANQ---CpfGHSTPRPGYGENLawwssSTALPDT 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15235835     89 SAEEFVSTFLNQKSDYDYTTNTCR-AGKSCDGYKQVLFRKSVFLGCAKVKCNNGGFLAI---CSYDP 151
Cdd:smart00198  78 YASAAVQLWYDEFQDYGYSSNTCKdTNGKIGHYTQVVWAKTYKVGCGVANCPDGTKKKTvvvCNYDP 144
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 33-149 3.76e-13

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 62.22  E-value: 3.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835    33 FNAHNRARVSVGVSPLMWSQTLTAYAQAYAEKRRDCGLFLSGGPYGETI----------KADIIDFSAEEFVSTFLNQKS 102
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNGSHNHRSPYGGNIyarvvaagyaLGDAGPDSAEDAVDGWYDSPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 15235835   103 DYDYTTntcragkscdgYKQVLFRKSVFLGCAKVKCNNGG-FLAICSY 149
Cdd:pfam00188  81 TYNCGH-----------RTNLLWPKSTKVGCAVAKCGDGGtYYFVCNY 117
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 20-63 3.28e-06

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


Pssm-ID: 441910  Cd Length: 144  Bit Score: 44.22  E-value: 3.28e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15235835  20 SVPLKAQDQPQDYFNAHNRARVSVGVSPLMWSQTLTAYAQAYAE 63
Cdd:COG2340  12 AAPAALSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQ 55
 
Name Accession Description Interval E-value
CAP_PR-1 cd05381
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 29-160 8.41e-67

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.


Pssm-ID: 349400  Cd Length: 136  Bit Score: 199.40  E-value: 8.41e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835  29 PQDYFNAHNRARVSVGVSPLMWSQTLTAYAQAYAEKRR-DCGLFLSGGPYGETIKADIID-FSAEEFVSTFLNQKSDYDY 106
Cdd:cd05381   1 PQDFLDAHNQARAAVGVPPLVWDDTLAAYAQKYANQRRgDCSLVHSNGPYGENLFWGSGDnWSPADAVKSWVDEKPYYDY 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15235835 107 TTNTCRAGKSCDGYKQVLFRKSVFLGCAKVKCNN-GGFLAICSYDPSV-ILSERPF 160
Cdd:cd05381  81 ASNTCVGGKMCGHYTQVVWRNSTRLGCARVVCDNnGGTFVICNYDPPGnYIGERPY 136
CAP_PRY1-like cd05384
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 29-151 3.80e-22

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349403  Cd Length: 129  Bit Score: 85.85  E-value: 3.80e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835  29 PQDYFNAHNRARVSVGVSPLMWSQTLTAYAQAYAEKRRDCG-LFLSGGPYGETIKADIIdfSAEEFVSTFLNQKSDYDYt 107
Cdd:cd05384   3 ASSILDAHNKKRALHGTQPLTWNDTLAEYAQDYADSYDCSGnLVHSGGPYGENLALGYS--SGAAAVDAWYDEISDYDY- 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15235835 108 tNTCRAGKSCDGYKQVLFRKSVFLGCAKVKC-NNGGFLAICSYDP 151
Cdd:cd05384  80 -SNPGFSESTGHFTQLVWKSTTQVGCAYKDCgGAWGLYIVCEYDP 123
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 27-151 8.49e-18

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 74.73  E-value: 8.49e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835     27 DQPQDYFNAHNRARVSVGVS-----------PLMWSQTLTAYAQAYAEKrrdC--GLFLSGGPYGETI-----KADIIDF 88
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAGGflaapaasnmlKLTWDCELASSAQNWANQ---CpfGHSTPRPGYGENLawwssSTALPDT 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15235835     89 SAEEFVSTFLNQKSDYDYTTNTCR-AGKSCDGYKQVLFRKSVFLGCAKVKCNNGGFLAI---CSYDP 151
Cdd:smart00198  78 YASAAVQLWYDEFQDYGYSSNTCKdTNGKIGHYTQVVWAKTYKVGCGVANCPDGTKKKTvvvCNYDP 144
CAP_PI16_HrTT-1 cd05559
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 34-149 1.79e-13

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349405  Cd Length: 134  Bit Score: 63.59  E-value: 1.79e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835  34 NAHNRARVSVGVSP-----LMWSQTLTAYAQAYAEK----------RRDCGLFLSGGPygetikadiiDFSAEEFVSTFL 98
Cdd:cd05559   6 DLHNQYRSQVSPSAanmlkMTWDTELEALAKAYARKciwehnpdrgRVGENLFASTGK----------PLDVELAVEDWH 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15235835  99 NQKSDYDYTTNTCRAGKSCDGYKQVLFRKSVFLGCAKVKCN--NG-----GFLAICSY 149
Cdd:cd05559  76 NEKEYYNFETKTCAPGKMCGHYTQVVWANTEKIGCGSYFCEtlEGvewenATLLVCNY 133
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 33-149 3.76e-13

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 62.22  E-value: 3.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835    33 FNAHNRARVSVGVSPLMWSQTLTAYAQAYAEKRRDCGLFLSGGPYGETI----------KADIIDFSAEEFVSTFLNQKS 102
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNGSHNHRSPYGGNIyarvvaagyaLGDAGPDSAEDAVDGWYDSPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 15235835   103 DYDYTTntcragkscdgYKQVLFRKSVFLGCAKVKCNNGG-FLAICSY 149
Cdd:pfam00188  81 TYNCGH-----------RTNLLWPKSTKVGCAVAKCGDGGtYYFVCNY 117
CAP cd00168
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 30-149 3.95e-12

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.


Pssm-ID: 349397  Cd Length: 128  Bit Score: 59.94  E-value: 3.95e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835  30 QDYFNAHN--RARVSVGVS---PLMWSQTLTAYAQAYAEKrrdcgLFLSGGPY------GETIKADIIDFSAEEFVSTFL 98
Cdd:cd00168   2 QEILDLHNsyRSSVSPPASnmpLMAWDQELADVAIGYAKD-----CIFSHSSPtsrqlaGENIAASSYDMDGVAALQAWH 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15235835  99 NQKSDYDYTTNTCRAGKSCDGYKQVLFRKSVFLGCAKVKCNNGGFLAICSY 149
Cdd:cd00168  77 NEIKNYNFGTAQPGFNSGTGHYTQMVWEKTTKLGCGVADCSDNSKFVVCNY 127
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 30-151 1.56e-10

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349401  Cd Length: 132  Bit Score: 55.68  E-value: 1.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835  30 QDYFNAHNRARVSVGVSPLMWSQTLTAYAQAYAEK--RRDCGLFLSGGPYGETI---KADIIDFSAEEFVSTFLNQKSDY 104
Cdd:cd05382   4 KECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKlaSSGTLQHSSPSSYGENLayfSGSGYDLTGEEAVDSWYNEIKNY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15235835 105 DYTTNtcRAGKSCDGYKQVLFRKSVFLGCAKVKCNNGGFLAICSYDP 151
Cdd:cd05382  84 NFNKP--GFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSP 128
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 34-150 5.83e-10

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 54.38  E-value: 5.83e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835  34 NAHNRARVSV------------GVSPLMWSQTLTAYAQAYAEKrrdCGL----FLSGGPYGETI-----KADIIDFSAEE 92
Cdd:cd05380   6 DAHNELRSKVakgklkglppaaNMPKLKWDCELAKLAQNWAKT---CVFahspCRNTGGVGQNLasvssSGKDLKELIED 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15235835  93 FVSTFLNQKSDYDYTTNT-CRAGKSCDGYKQVLFRKSVFLGCAKVKCNNGG---FLAICSYD 150
Cdd:cd05380  83 AVNAWFDELKDYGFGSNPnNNFNSGIGHFTQMVWAKTTKVGCAVARCPKGGgnkTYVVCNYS 144
CAP_GLIPR1-like cd05385
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 31-151 6.61e-10

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349404  Cd Length: 148  Bit Score: 54.33  E-value: 6.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835  31 DYFNAHNRARVSVgvSP-------LMWSQTLTAYAQAYAekrRDCglFLSGGPY--------------GETIKA-DIIDF 88
Cdd:cd05385   5 ECVRIHNELRSKV--SPpaanmryMSWDKALAKTARAWA---RKC--KFSHNIClkepgkchpnfttlGENIWLgSIFSF 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15235835  89 SAEEFVSTFLNQKSDYDYTTNTCRagKSCDGYKQVLFRKSVFLGCAKVKCNNGGF--------LAICSYDP 151
Cdd:cd05385  78 SVESAITSWYNEVKDYNFKTNSCS--RVCGHYTQVVWADSYKVGCAVHVCPNGGGffsgsssaIFVCNYGP 146
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 20-63 3.28e-06

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


Pssm-ID: 441910  Cd Length: 144  Bit Score: 44.22  E-value: 3.28e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15235835  20 SVPLKAQDQPQDYFNAHNRARVSVGVSPLMWSQTLTAYAQAYAE 63
Cdd:COG2340  12 AAPAALSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQ 55
CAP_bacterial cd05379
Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 30-63 1.61e-03

Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.


Pssm-ID: 349398  Cd Length: 120  Bit Score: 36.59  E-value: 1.61e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 15235835  30 QDYFNAHNRARVSVGVSPLMWSQTLTAYAQAYAE 63
Cdd:cd05379   2 QEVLELINEYRAKAGLPPLSWDPRLEKAAQDHAE 35
CAP_CRISP cd05383
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 34-152 8.33e-03

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.


Pssm-ID: 349402  Cd Length: 139  Bit Score: 34.64  E-value: 8.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235835  34 NAHNRARVSVGVSP-----LMWSQTLTAYAQAYAEK----------RRD----CG--LFLSGGPygetikadiidFSAEE 92
Cdd:cd05383   8 DLHNALRRSVNPPAsnmlkMSWNPEAAENAQRWANRcnfthsppngRTIpgirCGenIFMSSYP-----------ASWSE 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15235835  93 FVSTFLNQKSDYDYTTNTCRAGKSCDGYKQVLFRKSVFLGCAKVKCNNGG---FLAICSYDPS 152
Cdd:cd05383  77 VIQAWYDEYKDFKYGVGAKPPGSVTGHYTQVVWYSSYLVGCAVAYCPSQGslkYFYVCQYCPA 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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