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Conserved domains on  [gi|15234593|ref|NP_192419|]
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myb domain protein 74 [Arabidopsis thaliana]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 999994)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03091 super family cl33633
hypothetical protein; Provisional
 1-129 7.55e-64

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 208.68  E-value: 7.55e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234593    1 MGRSPCCEKKNgLKKGPWTPEEDQKLIDYINIHGYGNWRTLPKNAGLQRCGKSCRLRWTNYLRPDIKRGRFSFEEEETII 80
Cdd:PLN03091   1 MGRHSCCYKQK-LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLII 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 15234593   81 QLHSIMGNKWSAIAARLPGRTDNEIKNYWNTHIRKRLLKMGIDPVTHTP 129
Cdd:PLN03091  80 ELHAVLGNRWSQIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTHKP 128
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 1-129 7.55e-64

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 208.68  E-value: 7.55e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234593    1 MGRSPCCEKKNgLKKGPWTPEEDQKLIDYINIHGYGNWRTLPKNAGLQRCGKSCRLRWTNYLRPDIKRGRFSFEEEETII 80
Cdd:PLN03091   1 MGRHSCCYKQK-LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLII 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 15234593   81 QLHSIMGNKWSAIAARLPGRTDNEIKNYWNTHIRKRLLKMGIDPVTHTP 129
Cdd:PLN03091  80 ELHAVLGNRWSQIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTHKP 128
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 68-113 3.09e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 71.38  E-value: 3.09e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15234593    68 RGRFSFEEEETIIQLHSIMGNKWSAIAARLPGRTDNEIKNYWNTHI 113
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 13-126 5.52e-14

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 72.51  E-value: 5.52e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234593  13 LKKGPWTPEEDQKLIDYINIHGYGNWrtlPKNAGL--QRCGKSCRLRWTNYLRPDIKRGRFSFEEEETIIQLHSIMGNKW 90
Cdd:COG5147  18 RKGGSWKRTEDEDLKALVKKLGPNNW---SKVASLliSSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQW 94

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15234593  91 SAIAARLPGRTDNEIKNYWNTHIRKRLLKMGIDPVT 126
Cdd:COG5147  95 STIADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQR 130
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
68-115 2.17e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 60.70  E-value: 2.17e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 15234593     68 RGRFSFEEEETIIQLHSIMG-NKWSAIAARLPGRTDNEIKNYWNTHIRK 115
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 17-62 5.24e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 59.51  E-value: 5.24e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15234593  17 PWTPEEDQKLIDYINIHGYGNWRTLPKNAGLqRCGKSCRLRWTNYL 62
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPG-RTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 1-129 7.55e-64

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 208.68  E-value: 7.55e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234593    1 MGRSPCCEKKNgLKKGPWTPEEDQKLIDYINIHGYGNWRTLPKNAGLQRCGKSCRLRWTNYLRPDIKRGRFSFEEEETII 80
Cdd:PLN03091   1 MGRHSCCYKQK-LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLII 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 15234593   81 QLHSIMGNKWSAIAARLPGRTDNEIKNYWNTHIRKRLLKMGIDPVTHTP 129
Cdd:PLN03091  80 ELHAVLGNRWSQIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTHKP 128
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 4-129 1.09e-60

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 194.14  E-value: 1.09e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234593    4 SPCCEKKnGLKKGPWTPEEDQKLIDYINIHGYGNWRTLPKNAGLQRCGKSCRLRWTNYLRPDIKRGRFSFEEEETIIQLH 83
Cdd:PLN03212  15 TPCCTKM-GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLH 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 15234593   84 SIMGNKWSAIAARLPGRTDNEIKNYWNTHIRKRLLKMGIDPVTHTP 129
Cdd:PLN03212  94 RLLGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKLLRQGIDPQTHKP 139
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 68-113 3.09e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 71.38  E-value: 3.09e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15234593    68 RGRFSFEEEETIIQLHSIMGNKWSAIAARLPGRTDNEIKNYWNTHI 113
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 15-62 4.45e-14

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 65.60  E-value: 4.45e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 15234593    15 KGPWTPEEDQKLIDYINIHGyGNWRTLPKNAGLqRCGKSCRLRWTNYL 62
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPG-RTDNQCKNRWQNYL 46
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 13-126 5.52e-14

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 72.51  E-value: 5.52e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234593  13 LKKGPWTPEEDQKLIDYINIHGYGNWrtlPKNAGL--QRCGKSCRLRWTNYLRPDIKRGRFSFEEEETIIQLHSIMGNKW 90
Cdd:COG5147  18 RKGGSWKRTEDEDLKALVKKLGPNNW---SKVASLliSSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQW 94

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15234593  91 SAIAARLPGRTDNEIKNYWNTHIRKRLLKMGIDPVT 126
Cdd:COG5147  95 STIADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQR 130
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
68-115 2.17e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 60.70  E-value: 2.17e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 15234593     68 RGRFSFEEEETIIQLHSIMG-NKWSAIAARLPGRTDNEIKNYWNTHIRK 115
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
15-64 2.24e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 60.70  E-value: 2.24e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 15234593     15 KGPWTPEEDQKLIDYINIHGYGNWRTLPKNAGLqRCGKSCRLRWTNYLRP 64
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPG-RTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 17-62 5.24e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 59.51  E-value: 5.24e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15234593  17 PWTPEEDQKLIDYINIHGYGNWRTLPKNAGLqRCGKSCRLRWTNYL 62
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPG-RTPKQCRERWRNLL 45
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 70-113 1.10e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.74  E-value: 1.10e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15234593  70 RFSFEEEETIIQLHSIMG-NKWSAIAARLPGRTDNEIKNYWNTHI 113
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 18-77 3.95e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.01  E-value: 3.95e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15234593    18 WTPEEDQKLIDYINIHGYgNWRTLPKNAGlQRCGKSCRLRWTNYLRPDIKRGRFSFEEEE 77
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGN-DWKQIAKELG-RRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 71-114 3.45e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 43.84  E-value: 3.45e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15234593    71 FSFEEEETIIQLHSIMGNKWSAIAARLPGRTDNEIKNYWNTHIR 114
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLN 44
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 17-39 2.66e-04

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 38.32  E-value: 2.66e-04
                        10        20
                ....*....|....*....|...
gi 15234593  17 PWTPEEDQKLIDYINIHGYGNWR 39
Cdd:cd11660   2 KWTDEEDEALVEGVEKYGVGNWA 24
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 64-103 4.49e-04

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 37.67  E-value: 4.49e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15234593  64 PDIKRGRFSFEEEETIIQLHSIMGNKWSAIaARLPGRTDN 103
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTI-APIVGRTAQ 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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