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Conserved domains on  [gi|15236274|ref|NP_192236|]
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Cyclin D6;1 [Arabidopsis thaliana]

Protein Classification

cyclin-D( domain architecture ID 15334368)

cyclin-D such the G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 57-151 1.87e-41

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410246  Cd Length: 99  Bit Score: 138.99  E-value: 1.87e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  57 NRNQAISSITQYSRKF-DDPSLTYLAVNYLDRFLSSEDMPQSKPWILKLISLSCVSLSAKMRKPD-MSVSDLPVEGEF-- 132
Cdd:cd20543   1 VRNEAIDWILKVRSRYgFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDvPLLVDLQVEEPKyv 80

                        90
                ....*....|....*....
gi 15236274 133 FDAQMIERMENVILGALKW 151
Cdd:cd20543  81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 156-250 5.33e-25

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410247  Cd Length: 90  Bit Score: 95.84  E-value: 5.33e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274 156 VTPFSFLAFFISLFELKEEdplllKHSLKSQTSDLTFSLQHDISFLEFKPSVIAGAALLFASFELCPLQFPCFSNRINQC 235
Cdd:cd20544   1 VTPFSFLDYFISKIGLSDS-----REELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLL 75

                        90
                ....*....|....*
gi 15236274 236 TYVNKDELMECYKAI 250
Cdd:cd20544  76 LSPNKEKVKKCYELM 90
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 57-151 1.87e-41

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 138.99  E-value: 1.87e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  57 NRNQAISSITQYSRKF-DDPSLTYLAVNYLDRFLSSEDMPQSKPWILKLISLSCVSLSAKMRKPD-MSVSDLPVEGEF-- 132
Cdd:cd20543   1 VRNEAIDWILKVRSRYgFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDvPLLVDLQVEEPKyv 80

                        90
                ....*....|....*....
gi 15236274 133 FDAQMIERMENVILGALKW 151
Cdd:cd20543  81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 156-250 5.33e-25

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 95.84  E-value: 5.33e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274 156 VTPFSFLAFFISLFELKEEdplllKHSLKSQTSDLTFSLQHDISFLEFKPSVIAGAALLFASFELCPLQFPCFSNRINQC 235
Cdd:cd20544   1 VTPFSFLDYFISKIGLSDS-----REELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLL 75

                        90
                ....*....|....*
gi 15236274 236 TYVNKDELMECYKAI 250
Cdd:cd20544  76 LSPNKEKVKKCYELM 90
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 29-154 1.43e-24

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 95.66  E-value: 1.43e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274    29 HSLFLVEFQHMPSSHYFHslKSSAFLLSNRNQAISSITQYSRKFD-DPSLTYLAVNYLDRFLSSEDMPQSKpwiLKLISL 107
Cdd:pfam00134   4 QYLRELELKYLPKPDYMD--QQPDINPKMRAILIDWLVEVHEKFKlLPETLYLAVNYLDRFLSKKSVPKNK---LQLVGV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 15236274   108 SCVSLSAKMRKPD-MSVSDLPVE-GEFFDAQMIERMENVILGALKWRMR 154
Cdd:pfam00134  79 TCLFIAAKYEEIYpPTVEDLVYItDNAYTREEILRMERLILETLNFDLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 156-252 2.27e-10

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 57.25  E-value: 2.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274   156 VTPFSFLAFFISLFElkeEDPLLLKHSLKSQTSDLTFslqHDISFLEFKPSVIAGAALLFASFElcpLQFPCFSNRINQC 235
Cdd:pfam02984   1 PTPLSFLRRFSKAAD---YLHDLELRTLAKYLLELTL---LDYDFLKYPPSLIAAAAVYLARKT---LNSPEWTETLEHY 71

                          90
                  ....*....|....*..
gi 15236274   236 TYVNKDELMECYKAIQE 252
Cdd:pfam02984  72 TGYSEEDLKPCVKLLLE 88
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 65-146 2.81e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 52.98  E-value: 2.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274     65 ITQYSRKFD-DPSLTYLAVNYLDRFLSSEDMPQSKPwilKLISLSCVSLSAKMRKPDMSVSDLPVEGEFFDAQMIERMEN 143
Cdd:smart00385   3 LRRVCKALNlDPETLNLAVNLLDRFLSDYKFLKYSP---SLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMER 79


                   ...
gi 15236274    144 VIL 146
Cdd:smart00385  80 LLL 82
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
28-212 6.63e-04

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 40.91  E-value: 6.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  28 PHSLFLVEFQHMPSSHYfhSLKSSAFLLSNRNQAISSITQYSRKFDDPSLT-YLAVNYLDRFLSSEDMPQSKpwiLKLIS 106
Cdd:COG5024 185 FEYLLKLELIDLPNPNY--LIKQSLYEWSMRSILVDWLVEVHGKFGLLPETlFLAINIIDRFLSSRVVSLEK---YQLVG 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274 107 LSCVSLSAKMRKpdmsvSDLPVEGEF-------FDAQMIERMENVILGALKWRMRSVTPFSFLAFFISLFELKEEDPLLL 179
Cdd:COG5024 260 ISALFIASKYEE-----VNCPSIKDLvyatdgaFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPA 334

                       170       180       190
                ....*....|....*....|....*....|...
gi 15236274 180 KHSLKsqtsdltFSLqHDISFLEFKPSVIAGAA 212
Cdd:COG5024 335 KFSSE-------ISP-VDYKFIQISPSWCAAAA 359
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 57-151 1.87e-41

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 138.99  E-value: 1.87e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  57 NRNQAISSITQYSRKF-DDPSLTYLAVNYLDRFLSSEDMPQSKPWILKLISLSCVSLSAKMRKPD-MSVSDLPVEGEF-- 132
Cdd:cd20543   1 VRNEAIDWILKVRSRYgFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDvPLLVDLQVEEPKyv 80

                        90
                ....*....|....*....
gi 15236274 133 FDAQMIERMENVILGALKW 151
Cdd:cd20543  81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 156-250 5.33e-25

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 95.84  E-value: 5.33e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274 156 VTPFSFLAFFISLFELKEEdplllKHSLKSQTSDLTFSLQHDISFLEFKPSVIAGAALLFASFELCPLQFPCFSNRINQC 235
Cdd:cd20544   1 VTPFSFLDYFISKIGLSDS-----REELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLL 75

                        90
                ....*....|....*
gi 15236274 236 TYVNKDELMECYKAI 250
Cdd:cd20544  76 LSPNKEKVKKCYELM 90
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 29-154 1.43e-24

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 95.66  E-value: 1.43e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274    29 HSLFLVEFQHMPSSHYFHslKSSAFLLSNRNQAISSITQYSRKFD-DPSLTYLAVNYLDRFLSSEDMPQSKpwiLKLISL 107
Cdd:pfam00134   4 QYLRELELKYLPKPDYMD--QQPDINPKMRAILIDWLVEVHEKFKlLPETLYLAVNYLDRFLSKKSVPKNK---LQLVGV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 15236274   108 SCVSLSAKMRKPD-MSVSDLPVE-GEFFDAQMIERMENVILGALKWRMR 154
Cdd:pfam00134  79 TCLFIAAKYEEIYpPTVEDLVYItDNAYTREEILRMERLILETLNFDLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 156-252 2.27e-10

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 57.25  E-value: 2.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274   156 VTPFSFLAFFISLFElkeEDPLLLKHSLKSQTSDLTFslqHDISFLEFKPSVIAGAALLFASFElcpLQFPCFSNRINQC 235
Cdd:pfam02984   1 PTPLSFLRRFSKAAD---YLHDLELRTLAKYLLELTL---LDYDFLKYPPSLIAAAAVYLARKT---LNSPEWTETLEHY 71

                          90
                  ....*....|....*..
gi 15236274   236 TYVNKDELMECYKAIQE 252
Cdd:pfam02984  72 TGYSEEDLKPCVKLLLE 88
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 65-146 2.81e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 52.98  E-value: 2.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274     65 ITQYSRKFD-DPSLTYLAVNYLDRFLSSEDMPQSKPwilKLISLSCVSLSAKMRKPDMSVSDLPVEGEFFDAQMIERMEN 143
Cdd:smart00385   3 LRRVCKALNlDPETLNLAVNLLDRFLSDYKFLKYSP---SLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMER 79


                   ...
gi 15236274    144 VIL 146
Cdd:smart00385  80 LLL 82
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 57-151 4.83e-08

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 50.00  E-value: 4.83e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  57 NRNQAISSITQYSRKFDDPSLTY-LAVNYLDRFLSSedmPQSKPWILKLISLSCVSLSAKMRKPDmsvSDLPVEGEF--- 132
Cdd:cd20526   1 QRDEAVRWLAELNSQFKFYPETFaLAVSILDRFLAS---VKARPKYLRCIAISCLFLAAKTNEED---EVIPSTKDLvrv 74

                        90       100
                ....*....|....*....|...
gi 15236274 133 ----FDAQMIERMENVILGALKW 151
Cdd:cd20526  75 skcgCSVAEVLRMERIILDKLHW 97
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 80-151 1.14e-06

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 47.29  E-value: 1.14e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15236274  80 LAVNYLDRFLSSEDMPQSKpwiLKLISLSCVSLSAKMRKP-DMSVSDLPVEGEF-FDAQMIERMENVILGALKW 151
Cdd:cd20515  79 LAVNYLDRFLSLVPIRKSQ---LQLLGAVCLFLASKLKETiPLTAEKLCIYTDNsITLQELLDWELLVLTKLKW 149
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 79-151 8.10e-06

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 44.61  E-value: 8.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  79 YLAVNYLDRFLS-SEDMPQSKpwiLKLISLSCVSLSAKM---RKPDMS----VSDlpveGEFFDAQmIERMENVILGALK 150
Cdd:cd20519  59 YLAVDFVDRYLStQTNVPKTQ---LQLIGITCLFIAAKLeeiYPPKLSefayVTD----GACTEDE-ILTMELIILKALN 130


                .
gi 15236274 151 W 151
Cdd:cd20519 131 W 131
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 79-150 1.08e-05

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 44.16  E-value: 1.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  79 YLAVNYLDRFLSSEDMPQSKpwiLKLISLSCVSLSAKMRK---PDMsvsdlpveGEF-------FDAQMIERMENVILGA 148
Cdd:cd20504  57 YLAVNYIDRFLSQMSVLRSK---LQLVGTACMFIAAKYEEiypPEV--------EEFvyitddtYTKKQVLRMEHLVLKV 125


                ..
gi 15236274 149 LK 150
Cdd:cd20504 126 LS 127
CYCLIN_CCND_rpt2 cd20516
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 157-253 2.03e-05

second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410220  Cd Length: 98  Bit Score: 42.60  E-value: 2.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274 157 TPFSFLAFFIS-LFELKEEDPLLLKHSlksQT-SDLTFSlqhDISFLEFKPSVIAGAALLfASFELCPLQFPCFS----N 230
Cdd:cd20516   1 TPLDFLEHILHrLPLDSEDVDKVRKHA---ETfIALCAT---DYKFSSYPPSMIAAASIL-AALRGLLLHSGNSKedllE 73

                        90       100
                ....*....|....*....|...
gi 15236274 231 RINQCTYVNKDELMECYKAIQER 253
Cdd:cd20516  74 KLQQLTRIDEDLLRACQEQIEDL 96
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 79-150 3.92e-05

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 42.52  E-value: 3.92e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15236274  79 YLAVNYLDRFLSSEDMPQSKpwiLKLISLSCVSLSAK---MRKPDM----SVSDlpvegEFFDAQMIERMENVILGALK 150
Cdd:cd20507  59 YLTVNIIDRYLSKKQVPRKK---LQLVGVTALLIASKyeeIYPPEIkdfvYITD-----NAYTREEILQMERDILKTLD 129
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 78-151 5.39e-05

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 41.43  E-value: 5.39e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15236274  78 TYLAVNYLDRFLSSEDMPQSKpwiLKLISLSCVSLSAKMRKPDMSV---SDLPVEGEFF--DAQMIERMENVILGALKW 151
Cdd:cd20528  28 LHLAVYLLDRFMDRYDISEDQ---LHLVALTCLLLAAKFEELDDNIpkiSDLNRYLCNSvySKQEYLQMELLILEFFQW 103
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 80-151 1.09e-04

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 41.50  E-value: 1.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  80 LAVNYLDRFLSSEdmPQSKPWiLKLISLSCVSLSAKMRKpdmsvsDLPVEGE----FFD----AQMIERMENVILGALKW 151
Cdd:cd20573  78 LAMNYLDRFLSVE--PTKKSR-LQLLGATCMFLASKMKE------TIPLTAEklciYTDnsirPEELLQMELLVLNKLKW 148
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 29-151 1.45e-04

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 41.52  E-value: 1.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  29 HSLFLVEFQHMPSSHYFHSLKSSAFLLSNRNQAISSITQYSRKFDDPSLTYLAVNYLDRFLSSEDMPQSKpwiLKLISLS 108
Cdd:cd20574  28 QNLLTIEERYLPQCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCH---LQLLGAV 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15236274 109 CVSLSAKMRKpdmsvsDLPVEGE----FFD----AQMIERMENVILGALKW 151
Cdd:cd20574 105 CMFLASKLKE------TIPLTAEklciYTDnsikPQELLEWELVVLGKLKW 149
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 156-252 1.75e-04

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 39.60  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274 156 VTPFSFLAFFISLFELKEEDPL----LLKHSLksqtsdltfslqHDISFLEFKPSVIAGAAlLFASFELCPLQFPCFSNR 231
Cdd:cd20537   1 PTPLSFLRRYLSLLGLDEKVRHlaryLLELSL------------LDYEFLKYRPSLIAAAA-LYLARKILGEPPPSPQLL 67

                        90       100
                ....*....|....*....|.
gi 15236274 232 INQCTYvNKDELMECYKAIQE 252
Cdd:cd20537  68 QLVTGY-SENDLQECAKELLE 87
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 79-151 2.91e-04

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 40.04  E-value: 2.91e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15236274  79 YLAVNYLDRFLSSEDMPQSKpwiLKLISLSCVSLSAKMRK--PDMSVSDLPVEGEFFDAQMIERMENVILGALKW 151
Cdd:cd20561  59 HLAVNYIDRFLSSMSVLRGK---LQLVGTAAMLLASKFEEiyPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTF 130
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
28-212 6.63e-04

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 40.91  E-value: 6.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  28 PHSLFLVEFQHMPSSHYfhSLKSSAFLLSNRNQAISSITQYSRKFDDPSLT-YLAVNYLDRFLSSEDMPQSKpwiLKLIS 106
Cdd:COG5024 185 FEYLLKLELIDLPNPNY--LIKQSLYEWSMRSILVDWLVEVHGKFGLLPETlFLAINIIDRFLSSRVVSLEK---YQLVG 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274 107 LSCVSLSAKMRKpdmsvSDLPVEGEF-------FDAQMIERMENVILGALKWRMRSVTPFSFLAFFISLFELKEEDPLLL 179
Cdd:COG5024 260 ISALFIASKYEE-----VNCPSIKDLvyatdgaFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPA 334

                       170       180       190
                ....*....|....*....|....*....|...
gi 15236274 180 KHSLKsqtsdltFSLqHDISFLEFKPSVIAGAA 212
Cdd:COG5024 335 KFSSE-------ISP-VDYKFIQISPSWCAAAA 359
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 58-149 1.14e-03

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 37.72  E-value: 1.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  58 RNQAISSITQYSRKFDDPSLTY-LAVNYLDRFLSsedMPQSKPWILKLISLSCVSLSAKMRKPD---MSVSDL-PVEGEF 132
Cdd:cd20523   1 RDAAVDRLRCLHRFYGFSPETFaLAVNLLDRFLS---KVKVKPKHLACITVSCFHIAIKSVEEDqniPSAEDLiRISQCG 77

                        90
                ....*....|....*..
gi 15236274 133 FDAQMIERMENVILGAL 149
Cdd:cd20523  78 CTAADLMRMEGIILEKL 94
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 80-151 1.29e-03

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 38.43  E-value: 1.29e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15236274  80 LAVNYLDRFLSSedMPQSKPWiLKLISLSCVSLSAKMRKP-DMSVSDLPVEGEF-FDAQMIERMENVILGALKW 151
Cdd:cd20575  79 LAMNYVDRYLSC--VPTRKAQ-LQLLGAVCMLLASKLRETtPLTIEKLCIYTDNsISPRQLLDWEILVLGKLKW 149
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 60-126 1.83e-03

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 36.62  E-value: 1.83e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15236274  60 QAISSITQYSRKFD-DPSLTYLAVNYLDRFLSSEDMPQSKPwilKLISLSCVSLSAKMRKPDMSVSDL 126
Cdd:cd00043   1 KAVDFIRRLCSKLGlPEEVLELAIELLDRFLSKGLLLGRSP---ELIAAACLYLACKLEELPRTLKEI 65
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 156-246 5.14e-03

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 36.11  E-value: 5.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274 156 VTPFSFLAFFISLFELKEEDPLLLKHSLKSQTSDLTFS--LQ------HDISFLEFKPSVIAGAALLFASfelcplqfpC 227
Cdd:cd20520   2 PTPNSWLNLYLQLAQLNPPPKENDSAFLLPQYSLDRFVraAQlldlciLDIGSLQFSYSVLAASALYLVS---------P 72

                        90
                ....*....|....*....
gi 15236274 228 FSNRINQCTYVNKDELMEC 246
Cdd:cd20520  73 DDEAIEQVTGYSWEQLAPC 91
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 70-151 6.15e-03

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 36.55  E-value: 6.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  70 RKFD-DPSLTYLAVNYLDRFLSSEDMPQSKpwiLKLISLSCVSLSAKMRkpDMSVsdlPVEGEF-------FDAQMIERM 141
Cdd:cd20567  66 LKFElMPETLYLTVNLIDRFLSVKQVPRKE---LQLVGVTAMLIASKYE--EIWA---PEVNDFvyisdnaYTRKQILVM 137

                        90
                ....*....|
gi 15236274 142 ENVILGALKW 151
Cdd:cd20567 138 EKTMLNTLEF 147
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 75-152 7.97e-03

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 35.85  E-value: 7.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236274  75 PSLTYLAVNYLDRFLSSEDMPQSKpwiLKLISLSCVSLSAKMRKpdmsVSDLPVEgEF-------FDAQMIERMENVILG 147
Cdd:cd20562  60 PDTLYLTVSYIDRFLSGNYVNRQR---LQLLGVSCMLIASKYEE----ICAPQVE-EFcyitdntYTKQEVLEMEIDVLN 131


                ....*
gi 15236274 148 ALKWR 152
Cdd:cd20562 132 ALQFE 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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