|
Name |
Accession |
Description |
Interval |
E-value |
| Glyco_transf_8 |
pfam01501 |
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ... |
67-321 |
4.98e-69 |
|
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.
Pssm-ID: 279798 [Multi-domain] Cd Length: 252 Bit Score: 216.42 E-value: 4.98e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 67 HVAITLDVEYLRGSIAAVNSILQHSVCPESVFFHFIAVSEETNL--LESLVRSVFPRLKfnIYDFAPETVRGLISSSVRQ 144
Cdd:pfam01501 1 CIALALDKNYLLGASVSIKSLLKNNSDFALNFHIFTDDIPVENLdiLNWLASSYKPVLP--LLESDIKIFEYFSKLKLRS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 145 -ALEQPLNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEychanfTKYFTGGFWSEERFSGTFR 223
Cdd:pfam01501 79 pKYWSLLNYLRLYLPDLF-PKLDKILYLDADIVVQGDLSPLWDIDLGGKVLAAVE------DNYFQRYPNFSEPIILENF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 224 GRKPCYFNTGVMVIDLKKWRRGGYTKRIEKWMEIQRRERIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGDNvRGSCRD 303
Cdd:pfam01501 152 GPPACYFNAGMLLFDLDAWRKENITERYIKWLNLNENRTLWKLGDQDPLNIVFYGKVKPLDPRWNVLGLGYYN-KKKSLN 230
|
250
....*....|....*...
gi 15235247 304 LHPGPVSLLHWSGSGKPW 321
Cdd:pfam01501 231 EITENAAVIHYNGPTKPW 248
|
|
| GT8_like_1 |
cd06429 |
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ... |
66-339 |
6.79e-40 |
|
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.
Pssm-ID: 133051 [Multi-domain] Cd Length: 257 Bit Score: 141.37 E-value: 6.79e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 66 VHVAITLDvEYLRGSIAAVNSIlQHSVCPESVFFHFIAVSEETNLLES-LVRSVFPRLKFNIYDFAPETVRG-------- 136
Cdd:cd06429 1 IHVVIFSD-NRLAAAVVINSSI-SNNKDPSNLVFHIVTDNQNYGAMRSwFDLNPLKIATVKVLNFDDFKLLGkvkvdslm 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 137 -LISSSVRQALEQ-------PLNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGApeychanftkyf 208
Cdd:cd06429 79 qLESEADTSNLKQrkpeyisLLNFARFYLPELF-PKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGA------------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 209 tggfwseerFSGTfrgrkpcyFNTGVMVIDLKKWRRGGYTKRIEKWMEIQRRE--RIYELGSLPPFLLVFSGHVAPISHR 286
Cdd:cd06429 146 ---------VETS--------WNPGVNVVNLTEWRRQNVTETYEKWMELNQEEevTLWKLITLPPGLIVFYGLTSPLDPS 208
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 15235247 287 WNQHGLGGDnvrGSCRDLHPGPVSLLHWSGSGKPWIRLdskRPCPLDALWTPY 339
Cdd:cd06429 209 WHVRGLGYN---YGIRPQDIKAAAVLHFNGNMKPWLRT---AIPSYKELWEKY 255
|
|
| RfaJ |
COG1442 |
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ... |
62-339 |
2.35e-36 |
|
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441051 [Multi-domain] Cd Length: 301 Bit Score: 133.18 E-value: 2.35e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 62 NPSLVHVAITLDVEYLRGSIAAVNSILQHSVCpESVFFHFIA--VSEET-NLLESLVRSvfPRLKFNIYDFAPETVRGL- 137
Cdd:COG1442 2 NKNTINIVFAIDDNYLPGLGVSIASLLENNPD-RPYDFHILTdgLSDENkERLEALAAK--YNVSIEFIDVDDELLKDLp 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 138 ISSSVRQAleqplNYARSYLADLLEPCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGA-PEYCHANFTKYftggfwSEE 216
Cdd:COG1442 79 VSKHISKA-----TYYRLLIPELLPDDYDKVLYLDADTLVLGDLSELWDIDLGGNLLAAvRDGTVTGSQKK------RAK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 217 RFSGTFRGRkpcYFNTGVMVIDLKKWRRGGYTKRIEKWMEiQRRERIyelgslpPFL------LVFSGHVAPISHRWN-Q 289
Cdd:COG1442 148 RLGLPDDDG---YFNSGVLLINLKKWREENITEKALEFLK-ENPDKL-------KYPdqdilnIVLGGKVKFLPPRYNyQ 216
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 15235247 290 HGLGGDNVRGSCRDLHPG----PVsLLHWSGSGKPWirlDSKRPCPLDALWTPY 339
Cdd:COG1442 217 YSLYYELKDKSNKKELLEarknPV-IIHYTGPTKPW---HKWCTHPYADLYWEY 266
|
|
| PLN02867 |
PLN02867 |
Probable galacturonosyltransferase |
62-339 |
1.66e-24 |
|
Probable galacturonosyltransferase
Pssm-ID: 178458 [Multi-domain] Cd Length: 535 Bit Score: 104.21 E-value: 1.66e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 62 NPSLVHVAITLDvEYLRGSIAaVNSILQHSVCPESVFFHFIAVSEE---------TNLLESLVRSVfprLKFNIYDFAPE 132
Cdd:PLN02867 208 DPSFHHVVLLTD-NVLAASVV-ISSTVQNAANPEKLVFHIVTDKKTytpmhawfaINSIKSAVVEV---KGLHQYDWSQE 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 133 T---------VRGLISSSVRQALEQP----------------------LNYARSYLADLLePCVNRVIYLDSDLVVVDDI 181
Cdd:PLN02867 283 VnvgvkemleIHRLIWSHYYQNLKESdfqfegthkrslealspsclslLNHLRIYIPELF-PDLNKIVFLDDDVVVQHDL 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 182 AKLWKTSLGSRIIGA--PEYCHAN------FTKYFTggfWSEERFSGTFRGRKpCYFNTGVMVIDLKKWRRGGYTKRIEK 253
Cdd:PLN02867 362 SSLWELDLNGKVVGAvvDSWCGDNccpgrkYKDYLN---FSHPLISSNLDQER-CAWLYGMNVFDLKAWRRTNITEAYHK 437
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 254 WMEIQRRE--RIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGDNVRGSCRDLhpGPVSLLHWSGSGKPWirLDSKRPcP 331
Cdd:PLN02867 438 WLKLSLNSglQLWQPGALPPALLAFKGHVHPIDPSWHVAGLGSRPPEVPREIL--ESAAVLHFSGPAKPW--LEIGFP-E 512
|
....*...
gi 15235247 332 LDALWTPY 339
Cdd:PLN02867 513 VRSLWYRH 520
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Glyco_transf_8 |
pfam01501 |
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ... |
67-321 |
4.98e-69 |
|
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.
Pssm-ID: 279798 [Multi-domain] Cd Length: 252 Bit Score: 216.42 E-value: 4.98e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 67 HVAITLDVEYLRGSIAAVNSILQHSVCPESVFFHFIAVSEETNL--LESLVRSVFPRLKfnIYDFAPETVRGLISSSVRQ 144
Cdd:pfam01501 1 CIALALDKNYLLGASVSIKSLLKNNSDFALNFHIFTDDIPVENLdiLNWLASSYKPVLP--LLESDIKIFEYFSKLKLRS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 145 -ALEQPLNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEychanfTKYFTGGFWSEERFSGTFR 223
Cdd:pfam01501 79 pKYWSLLNYLRLYLPDLF-PKLDKILYLDADIVVQGDLSPLWDIDLGGKVLAAVE------DNYFQRYPNFSEPIILENF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 224 GRKPCYFNTGVMVIDLKKWRRGGYTKRIEKWMEIQRRERIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGDNvRGSCRD 303
Cdd:pfam01501 152 GPPACYFNAGMLLFDLDAWRKENITERYIKWLNLNENRTLWKLGDQDPLNIVFYGKVKPLDPRWNVLGLGYYN-KKKSLN 230
|
250
....*....|....*...
gi 15235247 304 LHPGPVSLLHWSGSGKPW 321
Cdd:pfam01501 231 EITENAAVIHYNGPTKPW 248
|
|
| GT8_like_1 |
cd06429 |
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ... |
66-339 |
6.79e-40 |
|
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.
Pssm-ID: 133051 [Multi-domain] Cd Length: 257 Bit Score: 141.37 E-value: 6.79e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 66 VHVAITLDvEYLRGSIAAVNSIlQHSVCPESVFFHFIAVSEETNLLES-LVRSVFPRLKFNIYDFAPETVRG-------- 136
Cdd:cd06429 1 IHVVIFSD-NRLAAAVVINSSI-SNNKDPSNLVFHIVTDNQNYGAMRSwFDLNPLKIATVKVLNFDDFKLLGkvkvdslm 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 137 -LISSSVRQALEQ-------PLNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGApeychanftkyf 208
Cdd:cd06429 79 qLESEADTSNLKQrkpeyisLLNFARFYLPELF-PKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGA------------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 209 tggfwseerFSGTfrgrkpcyFNTGVMVIDLKKWRRGGYTKRIEKWMEIQRRE--RIYELGSLPPFLLVFSGHVAPISHR 286
Cdd:cd06429 146 ---------VETS--------WNPGVNVVNLTEWRRQNVTETYEKWMELNQEEevTLWKLITLPPGLIVFYGLTSPLDPS 208
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 15235247 287 WNQHGLGGDnvrGSCRDLHPGPVSLLHWSGSGKPWIRLdskRPCPLDALWTPY 339
Cdd:cd06429 209 WHVRGLGYN---YGIRPQDIKAAAVLHFNGNMKPWLRT---AIPSYKELWEKY 255
|
|
| RfaJ |
COG1442 |
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ... |
62-339 |
2.35e-36 |
|
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441051 [Multi-domain] Cd Length: 301 Bit Score: 133.18 E-value: 2.35e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 62 NPSLVHVAITLDVEYLRGSIAAVNSILQHSVCpESVFFHFIA--VSEET-NLLESLVRSvfPRLKFNIYDFAPETVRGL- 137
Cdd:COG1442 2 NKNTINIVFAIDDNYLPGLGVSIASLLENNPD-RPYDFHILTdgLSDENkERLEALAAK--YNVSIEFIDVDDELLKDLp 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 138 ISSSVRQAleqplNYARSYLADLLEPCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGA-PEYCHANFTKYftggfwSEE 216
Cdd:COG1442 79 VSKHISKA-----TYYRLLIPELLPDDYDKVLYLDADTLVLGDLSELWDIDLGGNLLAAvRDGTVTGSQKK------RAK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 217 RFSGTFRGRkpcYFNTGVMVIDLKKWRRGGYTKRIEKWMEiQRRERIyelgslpPFL------LVFSGHVAPISHRWN-Q 289
Cdd:COG1442 148 RLGLPDDDG---YFNSGVLLINLKKWREENITEKALEFLK-ENPDKL-------KYPdqdilnIVLGGKVKFLPPRYNyQ 216
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 15235247 290 HGLGGDNVRGSCRDLHPG----PVsLLHWSGSGKPWirlDSKRPCPLDALWTPY 339
Cdd:COG1442 217 YSLYYELKDKSNKKELLEarknPV-IIHYTGPTKPW---HKWCTHPYADLYWEY 266
|
|
| GT8_A4GalT_like |
cd04194 |
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ... |
66-321 |
2.84e-31 |
|
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.
Pssm-ID: 133037 [Multi-domain] Cd Length: 248 Bit Score: 118.09 E-value: 2.84e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 66 VHVAITLDVEYLRGSIAAVNSILQHsvCPESVF-FHFIA--VSEET-NLLESLVRSVFPRLKF-----NIYDFAPETVRG 136
Cdd:cd04194 1 MNIVFAIDDNYAPYLAVTIKSILAN--NSKRDYdFYILNddISEENkKKLKELLKKYNSSIEFikidnDDFKFFPATTDH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 137 lISSSVrqaleqplnYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGA-PEychanftkyfTGGFWSE 215
Cdd:cd04194 79 -ISYAT---------YYRLLIPDLL-PDYDKVLYLDADIIVLGDLSELFDIDLGDNLLAAvRD----------PFIEQEK 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 216 ERFSGTFRGRKPCYFNTGVMVIDLKKWRRGGYTKRIEKWMEIQRRERIY-ELGSLPpflLVFSGHVAPISHRWN-QHGLG 293
Cdd:cd04194 138 KRKRRLGGYDDGSYFNSGVLLINLKKWREENITEKLLELIKEYGGRLIYpDQDILN---AVLKDKILYLPPRYNfQTGFY 214
|
250 260 270
....*....|....*....|....*....|..
gi 15235247 294 GDN----VRGSCRDLHPGPVSLLHWSGSGKPW 321
Cdd:cd04194 215 YLLkkksKEEQELEEARKNPVIIHYTGSDKPW 246
|
|
| Glyco_transf_8 |
cd00505 |
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ... |
68-323 |
2.31e-26 |
|
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.
Pssm-ID: 132996 [Multi-domain] Cd Length: 246 Bit Score: 105.22 E-value: 2.31e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 68 VAITLDVEYLRGSIAAVNSILQHSvcPESVFFHFIAvseeTNLLESLVRSVFP--RLKFNIYDFAPETVRGLISSSVRQA 145
Cdd:cd00505 4 VIVATGDEYLRGAIVLMKSVLRHR--TKPLRFHVLT----NPLSDTFKAALDNlrKLYNFNYELIPVDILDSVDSEHLKR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 146 LEQPLNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYChanftkyftgGFWSEERFSGTFRGR 225
Cdd:cd00505 78 PIKIVTLTKLHLPNLV-PDYDKILYVDADILVLTDIDELWDTPLGGQELAAAPDP----------GDRREGKYYRQKRSH 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 226 K--PCYFNTGVMVIDLKKWRRGG-YTKRIEKWMEIQRRERIYELGSLPPFL--LVFSGHVAPisHRWNQHGLGGDnvRGS 300
Cdd:cd00505 147 LagPDYFNSGVFVVNLSKERRNQlLKVALEKWLQSLSSLSGGDQDLLNTFFkqVPFIVKSLP--CIWNVRLTGCY--RSL 222
|
250 260
....*....|....*....|....
gi 15235247 301 -CRDLHPGPVSLLHWSGSGKPWIR 323
Cdd:cd00505 223 nCFKAFVKNAKVIHFNGPTKPWNK 246
|
|
| PLN02867 |
PLN02867 |
Probable galacturonosyltransferase |
62-339 |
1.66e-24 |
|
Probable galacturonosyltransferase
Pssm-ID: 178458 [Multi-domain] Cd Length: 535 Bit Score: 104.21 E-value: 1.66e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 62 NPSLVHVAITLDvEYLRGSIAaVNSILQHSVCPESVFFHFIAVSEE---------TNLLESLVRSVfprLKFNIYDFAPE 132
Cdd:PLN02867 208 DPSFHHVVLLTD-NVLAASVV-ISSTVQNAANPEKLVFHIVTDKKTytpmhawfaINSIKSAVVEV---KGLHQYDWSQE 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 133 T---------VRGLISSSVRQALEQP----------------------LNYARSYLADLLePCVNRVIYLDSDLVVVDDI 181
Cdd:PLN02867 283 VnvgvkemleIHRLIWSHYYQNLKESdfqfegthkrslealspsclslLNHLRIYIPELF-PDLNKIVFLDDDVVVQHDL 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 182 AKLWKTSLGSRIIGA--PEYCHAN------FTKYFTggfWSEERFSGTFRGRKpCYFNTGVMVIDLKKWRRGGYTKRIEK 253
Cdd:PLN02867 362 SSLWELDLNGKVVGAvvDSWCGDNccpgrkYKDYLN---FSHPLISSNLDQER-CAWLYGMNVFDLKAWRRTNITEAYHK 437
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 254 WMEIQRRE--RIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGDNVRGSCRDLhpGPVSLLHWSGSGKPWirLDSKRPcP 331
Cdd:PLN02867 438 WLKLSLNSglQLWQPGALPPALLAFKGHVHPIDPSWHVAGLGSRPPEVPREIL--ESAAVLHFSGPAKPW--LEIGFP-E 512
|
....*...
gi 15235247 332 LDALWTPY 339
Cdd:PLN02867 513 VRSLWYRH 520
|
|
| PLN02870 |
PLN02870 |
Probable galacturonosyltransferase |
150-346 |
3.67e-23 |
|
Probable galacturonosyltransferase
Pssm-ID: 215468 [Multi-domain] Cd Length: 533 Bit Score: 100.01 E-value: 3.67e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 150 LNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCHAnftkyftGGFW-SEERFSGTFRGRKP- 227
Cdd:PLN02870 329 LNHLRIYLPELF-PNLDKVVFLDDDVVIQRDLSPLWDIDLGGKVNGAVETCRG-------EDEWvMSKRFRNYFNFSHPl 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 228 ---------CYFNTGVMVIDLKKWRRGGYTKRIEKWME--IQRRERIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGDN 296
Cdd:PLN02870 401 iaknldpeeCAWAYGMNIFDLRAWRKTNIRETYHSWLKenLKSNLTMWKLGTLPPALIAFKGHVHPIDPSWHMLGLGYQS 480
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 15235247 297 vRGSCRDLHPGPVslLHWSGSGKPWIRLDSKRpcpLDALWTPY-----DLYRHSH 346
Cdd:PLN02870 481 -KTNIESVKKAAV--IHYNGQSKPWLEIGFEH---LRPFWTKYvnysnDFIRNCH 529
|
|
| PLN02829 |
PLN02829 |
Probable galacturonosyltransferase |
150-324 |
5.09e-23 |
|
Probable galacturonosyltransferase
Pssm-ID: 215443 [Multi-domain] Cd Length: 639 Bit Score: 99.92 E-value: 5.09e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 150 LNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCHANFTKYFTGGFWSEERFSGTFRGRKpCY 229
Cdd:PLN02829 443 LNHLRFYLPEIF-PKLNKVLFLDDDIVVQKDLTGLWSIDLKGNVNGAVETCGESFHRFDRYLNFSNPLISKNFDPHA-CG 520
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 230 FNTGVMVIDLKKWRRGGYTKRIEKWMEIQRRERIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGdNVRGSCRDLHPGPV 309
Cdd:PLN02829 521 WAYGMNVFDLDEWKRQNITEVYHSWQKLNHDRQLWKLGTLPPGLITFWKRTYPLDRSWHVLGLGY-NPNVNQRDIERAAV 599
|
170
....*....|....*
gi 15235247 310 slLHWSGSGKPWIRL 324
Cdd:PLN02829 600 --IHYNGNMKPWLEI 612
|
|
| PLN02718 |
PLN02718 |
Probable galacturonosyltransferase |
62-322 |
2.34e-22 |
|
Probable galacturonosyltransferase
Pssm-ID: 178320 [Multi-domain] Cd Length: 603 Bit Score: 98.04 E-value: 2.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 62 NPSLVHVAITLDveYLRGSIAAVNSILQHSVCPESVFFHfiAVSEETN--------LLESLVRSVFPRLKFNIYDFAP-- 131
Cdd:PLN02718 310 DPDLYHYVVFSD--NVLACSVVVNSTISSSKEPEKIVFH--VVTDSLNypaismwfLLNPPGKATIQILNIDDMNVLPad 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 132 --ETVRGLISSSVRqaLEQPLNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCHANFTKY-- 207
Cdd:PLN02718 386 ynSLLMKQNSHDPR--YISALNHARFYLPDIF-PGLNKIVLFDHDVVVQRDLSRLWSLDMKGKVVGAVETCLEGEPSFrs 462
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 208 ------FTGGfWSEERFSGtfrgrKPCYFNTGVMVIDLKKWRRGGYTKRIEKWMEIQRRERIYELGSLPPFLLVFSGHVA 281
Cdd:PLN02718 463 mdtfinFSDP-WVAKKFDP-----KACTWAFGMNLFDLEEWRRQKLTSVYHKYLQLGVKRPLWKAGSLPIGWLTFYNQTV 536
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 15235247 282 PISHRWNQHGLGGDN-VRGScrDLHPGPVslLHWSGSGKPWI 322
Cdd:PLN02718 537 ALDKRWHVLGLGHESgVGAS--DIEQAAV--IHYDGVMKPWL 574
|
|
| PLN02659 |
PLN02659 |
Probable galacturonosyltransferase |
150-339 |
9.67e-22 |
|
Probable galacturonosyltransferase
Pssm-ID: 215356 [Multi-domain] Cd Length: 534 Bit Score: 95.87 E-value: 9.67e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 150 LNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCHANFTKYFTGGFWSEERFSGTFRGR--KP 227
Cdd:PLN02659 330 MNHIRIHLPELF-PSLNKVVFLDDDIVVQTDLSPLWDIDMNGKVNGAVETCRGEDKFVMSKKLKSYLNFSHPLIAKnfDP 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 228 --CYFNTGVMVIDLKKWRRGGYTKRIEKWME--IQRRERIYELGSLPPFLLVFSGHVAPISHRWNQHGLG-GDNVrgSCR 302
Cdd:PLN02659 409 neCAWAYGMNIFDLEAWRKTNISSTYHHWLEenLKSDLSLWQLGTLPPGLIAFHGHVHVIDPFWHMLGLGyQENT--SLA 486
|
170 180 190
....*....|....*....|....*....|....*..
gi 15235247 303 DLHPGPVslLHWSGSGKPWirLDSKRPcPLDALWTPY 339
Cdd:PLN02659 487 DAESAGV--VHFNGRAKPW--LDIAFP-QLRPLWAKY 518
|
|
| PLN02742 |
PLN02742 |
Probable galacturonosyltransferase |
150-344 |
2.52e-21 |
|
Probable galacturonosyltransferase
Pssm-ID: 215395 [Multi-domain] Cd Length: 534 Bit Score: 94.84 E-value: 2.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 150 LNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCHANFTKYFTGGFWSEERFSGTFrgrKP-- 227
Cdd:PLN02742 339 LNHLRFYIPEIY-PALEKVVFLDDDVVVQKDLTPLFSIDLHGNVNGAVETCLETFHRYHKYLNFSHPLISSHF---DPda 414
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 228 CYFNTGVMVIDLKKWRRGGYTKRIEKWMEIQRRERIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGD-NVrgSCRDLHP 306
Cdd:PLN02742 415 CGWAFGMNVFDLVAWRKANVTAIYHYWQEQNVDRTLWKLGTLPPGLLTFYGLTEPLDRRWHVLGLGYDtNI--DPRLIES 492
|
170 180 190
....*....|....*....|....*....|....*...
gi 15235247 307 GPVslLHWSGSGKPWIRLDSKRPCPldaLWTPYDLYRH 344
Cdd:PLN02742 493 AAV--LHFNGNMKPWLKLAIERYKP---LWERYVNYSH 525
|
|
| PLN02523 |
PLN02523 |
galacturonosyltransferase |
150-339 |
4.75e-21 |
|
galacturonosyltransferase
Pssm-ID: 215286 [Multi-domain] Cd Length: 559 Bit Score: 94.17 E-value: 4.75e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 150 LNYARSYLADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCHANFTKYFTGGFWSEERFSGTFrGRKPCY 229
Cdd:PLN02523 363 LNHLRFYLPEMY-PKLHRILFLDDDVVVQKDLTGLWKIDMDGKVNGAVETCFGSFHRYAQYLNFSHPLIKEKF-NPKACA 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 230 FNTGVMVIDLKKWRRGGYTKRIEKWMEIQRRERIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGdNVRGSCRDLHPGPV 309
Cdd:PLN02523 441 WAYGMNIFDLDAWRREKCTEQYHYWQNLNENRTLWKLGTLPPGLITFYSTTKPLDKSWHVLGLGY-NPSISMDEIRNAAV 519
|
170 180 190
....*....|....*....|....*....|..
gi 15235247 310 slLHWSGSGKPW--IRLDSKRPcpldaLWTPY 339
Cdd:PLN02523 520 --IHFNGNMKPWldIAMNQFKP-----LWTKY 544
|
|
| PLN02910 |
PLN02910 |
polygalacturonate 4-alpha-galacturonosyltransferase |
50-324 |
1.44e-20 |
|
polygalacturonate 4-alpha-galacturonosyltransferase
Pssm-ID: 215493 [Multi-domain] Cd Length: 657 Bit Score: 92.70 E-value: 1.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 50 NGDECLSSGGVCNPSLVHVAITLDvEYLRGSIAaVNSILQHSVCPESVFFHFiaVSEETNlleslvrsvFPRLK--FNIY 127
Cdd:PLN02910 330 QNKDYVNKKKLEDPSLYHYAIFSD-NVLATSVV-VNSTVLHAKEPQKHVFHI--VTDKLN---------FAAMKmwFIIN 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 128 DFAPETV--------RGLISS--SVRQALEQP--------------------------------LNYARSYLADLLePCV 165
Cdd:PLN02910 397 PPAKATIqveniddfKWLNSSycSVLRQLESArikeyyfkanhpsslsagadnlkyrnpkylsmLNHLRFYLPEVY-PKL 475
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 166 NRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCHANFTKYFTGGFWSEERFSGTFRGrKPCYFNTGVMVIDLKKWRRG 245
Cdd:PLN02910 476 EKILFLDDDIVVQKDLTPLWSIDMQGMVNGAVETCKESFHRFDKYLNFSNPKISENFDP-NACGWAFGMNMFDLKEWRKR 554
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15235247 246 GYTKRIEKWMEIQRRERIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGDNvrgSCRDLHPGPVSLLHWSGSGKPWIRL 324
Cdd:PLN02910 555 NITGIYHYWQDLNEDRTLWKLGSLPPGLITFYNLTYPLDRSWHVLGLGYDP---ALNQTEIENAAVVHYNGNYKPWLDL 630
|
|
| PLN02769 |
PLN02769 |
Probable galacturonosyltransferase |
157-324 |
3.47e-16 |
|
Probable galacturonosyltransferase
Pssm-ID: 215412 [Multi-domain] Cd Length: 629 Bit Score: 79.35 E-value: 3.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 157 LADLLePCVNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCHANF--TKYFTGgfwseerfSGTFrGRKPCYFNTGV 234
Cdd:PLN02769 445 LPEIF-KKLKKVVVLDDDVVVQRDLSFLWNLDMGGKVNGAVQFCGVRLgqLKNYLG--------DTNF-DTNSCAWMSGL 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 235 MVIDLKKWRRGGYTKRIEKWM-EIQ-RRERIYELGSLPPFLLVFSGHVAPISHRWNQHGLGGD------NVRGScrdlhp 306
Cdd:PLN02769 515 NVIDLDKWRELDVTETYLKLLqKFSkDGEESLRAAALPASLLTFQDLIYPLDDRWVLSGLGHDygideqAIKKA------ 588
|
170
....*....|....*...
gi 15235247 307 gpvSLLHWSGSGKPWIRL 324
Cdd:PLN02769 589 ---AVLHYNGNMKPWLEL 603
|
|
| GT8_LARGE_C |
cd06431 |
LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in ... |
66-261 |
7.17e-07 |
|
LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis; The catalytic domain of LARGE is a putative glycosyltransferase. Mutations of LARGE in mouse and human cause dystroglycanopathies, a disease associated with hypoglycosylation of the membrane protein alpha-dystroglycan (alpha-DG) and consequent loss of extracellular ligand binding. LARGE needs to both physically interact with alpha-dystroglycan and function as a glycosyltransferase in order to stimulate alpha-dystroglycan hyperglycosylation. LARGE localizes to the Golgi apparatus and contains three conserved DxD motifs. While two of the motifs are indispensible for glycosylation function, one is important for localization of th eenzyme. LARGE was originally named because it covers approximately large trunck of genomic DNA, more than 600bp long. The predicted protein structure contains an N-terminal cytoplasmic domain, a transmembrane region, a coiled-coil motif, and two putative catalytic domains. This catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis.
Pssm-ID: 133053 Cd Length: 280 Bit Score: 50.17 E-value: 7.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 66 VHVAI-------TLDVeylrgsIAAVNSILQHSVCPesVFFHFIAVSEETNLLESLVRS-VFPRLKFNIYD---FAPETv 134
Cdd:cd06431 1 IHVAIvcagynaSRDV------VTLVKSVLFYRRNP--LHFHLITDEIARRILATLFQTwMVPAVEVSFYNaeeLKSRV- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 135 rGLISSSvrqaleqplNYARSY------LADLLEPCVNRVIYLDSDLVVVDDIAKLWK---TSLGSRIIGAPEychaNFT 205
Cdd:cd06431 72 -SWIPNK---------HYSGIYglmklvLTEALPSDLEKVIVLDTDITFATDIAELWKifhKFTGQQVLGLVE----NQS 137
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 15235247 206 KYFTGGFWSEER-FSGTFRGrkpcyFNTGVMVIDLKKWRRGGYTkriEKWMEIQRRE 261
Cdd:cd06431 138 DWYLGNLWKNHRpWPALGRG-----FNTGVILLDLDKLRKMKWE---SMWRLTAERE 186
|
|
| GT8_HUGT1_C_like |
cd06432 |
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain ... |
159-244 |
5.83e-06 |
|
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
Pssm-ID: 133054 Cd Length: 248 Bit Score: 47.00 E-value: 5.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 159 DLLEPC-VNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCH-----ANFtKYFTGGFWSEErfsgtFRGRKpcYFNT 232
Cdd:cd06432 89 DVLFPLnVDKVIFVDADQIVRTDLKELMDMDLKGAPYGYTPFCDsrkemDGF-RFWKQGYWKSH-----LRGRP--YHIS 160
|
90
....*....|..
gi 15235247 233 GVMVIDLKKWRR 244
Cdd:cd06432 161 ALYVVDLKRFRR 172
|
|
| Glyco_transf_24 |
pfam18404 |
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein ... |
165-244 |
3.88e-04 |
|
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
Pssm-ID: 436473 Cd Length: 268 Bit Score: 41.45 E-value: 3.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235247 165 VNRVIYLDSDLVVVDDIAKLWKTSLGSRIIGAPEYCHAN-----FtKYFTGGFWSEErfsgtFRGRKpcYFNTGVMVIDL 239
Cdd:pfam18404 96 LDKVIFVDADQVVRTDLKELVDMDLEGAPYGYTPMCDSRkemegF-RFWKQGYWKDH-----LRGRP--YHISALYVVDL 167
|
....*
gi 15235247 240 KKWRR 244
Cdd:pfam18404 168 KRFRQ 172
|
|
| |
