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Conserved domains on  [gi|22328224|ref|NP_192095|]
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Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-349 2.70e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 2.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224   38 YLLAGSG-SEILLYDLSSGELIRSFqvfegvRVHgtvcsKSFVHSAErytyklvifgekkvkiFS----LIVeLASSSGE 112
Cdd:COG2319  134 TLASGSAdGTVRLWDLATGKLLRTL------TGH-----SGAVTSVA----------------FSpdgkLLA-SGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  113 ISV-NLENFESLPRL---SNWVFDVCFLQDStgsleeedKLLAIGCSDNSLSIWDVKESRmafeiqspercLLYTMRLWG 188
Cdd:COG2319  186 VRLwDLATGKLLRTLtghTGAVRSVAFSPDG--------KLLASGSADGTVRLWDLATGK-----------LLRTLTGHS 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  189 DSISTL-------RIASGTIFNEIIVWravgldgdNVDHGhysaSHMLRLTGHEGSIFRIVWSLDGSKIVSVSDDRSARI 261
Cdd:COG2319  247 GSVRSVafspdgrLLASGSADGTVRLW--------DLATG----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  262 WEIDSQEVVGpVLFGHSVRVWDCCIS--DSLIVTAGEDCTCRVWGVD-GTQLEVIKEHIGrGIWRCLYDPNSSLLVTAGF 338
Cdd:COG2319  315 WDLATGKLLR-TLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLAtGELLRTLTGHTG-AVTSVAFSPDGRTLASGSA 392

                        330
                 ....*....|.
gi 22328224  339 DSAIKVHQLHN 349
Cdd:COG2319  393 DGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-349 2.70e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 2.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224   38 YLLAGSG-SEILLYDLSSGELIRSFqvfegvRVHgtvcsKSFVHSAErytyklvifgekkvkiFS----LIVeLASSSGE 112
Cdd:COG2319  134 TLASGSAdGTVRLWDLATGKLLRTL------TGH-----SGAVTSVA----------------FSpdgkLLA-SGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  113 ISV-NLENFESLPRL---SNWVFDVCFLQDStgsleeedKLLAIGCSDNSLSIWDVKESRmafeiqspercLLYTMRLWG 188
Cdd:COG2319  186 VRLwDLATGKLLRTLtghTGAVRSVAFSPDG--------KLLASGSADGTVRLWDLATGK-----------LLRTLTGHS 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  189 DSISTL-------RIASGTIFNEIIVWravgldgdNVDHGhysaSHMLRLTGHEGSIFRIVWSLDGSKIVSVSDDRSARI 261
Cdd:COG2319  247 GSVRSVafspdgrLLASGSADGTVRLW--------DLATG----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  262 WEIDSQEVVGpVLFGHSVRVWDCCIS--DSLIVTAGEDCTCRVWGVD-GTQLEVIKEHIGrGIWRCLYDPNSSLLVTAGF 338
Cdd:COG2319  315 WDLATGKLLR-TLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLAtGELLRTLTGHTG-AVTSVAFSPDGRTLASGSA 392

                        330
                 ....*....|.
gi 22328224  339 DSAIKVHQLHN 349
Cdd:COG2319  393 DGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-344 7.64e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.04  E-value: 7.64e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224    6 SRRKWNPHAGPylgeVSSLAFLNLPqhvssiPYLLAGSGSE-ILLYDLSSGELIRSFQVFEGVRVHGTVCSksfvhsaer 84
Cdd:cd00200    1 LRRTLKGHTGG----VTCVAFSPDG------KLLATGSGDGtIKVWDLETGELLRTLKGHTGPVRDVAASA--------- 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224   85 YTYKLVIFGE-KKVKIFSLivelasSSGEISVNLENFESlprlsnWVFDVCFLQDSTgsleeedklLAIGCS-DNSLSIW 162
Cdd:cd00200   62 DGTYLASGSSdKTIRLWDL------ETGECVRTLTGHTS------YVSSVAFSPDGR---------ILSSSSrDKTIKVW 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  163 DVKESRMAFEIQSPE---RCLLYtmrlwgdSISTLRIASGTIFNEIIVWRAVgldgdnvdhghySASHMLRLTGHEGSIF 239
Cdd:cd00200  121 DVETGKCLTTLRGHTdwvNSVAF-------SPDGTFVASSSQDGTIKLWDLR------------TGKCVATLTGHTGEVN 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  240 RIVWSLDGSKIVSVSDDRSARIWEIDSQEVVGpVLFGHSVRVWDCCISDS--LIVTAGEDCTCRVW-GVDGTQLEVIKEH 316
Cdd:cd00200  182 SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG-TLRGHENGVNSVAFSPDgyLLASGSEDGTIRVWdLRTGECVQTLSGH 260

                        330       340
                 ....*....|....*....|....*...
gi 22328224  317 IGRgIWRCLYDPNSSLLVTAGFDSAIKV 344
Cdd:cd00200  261 TNS-VTSLAWSPDGKRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 231-263 7.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 7.63e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 22328224     231 LTGHEGSIFRIVWSLDGSKIVSVSDDRSARIWE 263
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
231-263 6.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 6.54e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 22328224    231 LTGHEGSIFRIVWSLDGSKIVSVSDDRSARIWE 263
Cdd:pfam00400    7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-349 2.70e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 2.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224   38 YLLAGSG-SEILLYDLSSGELIRSFqvfegvRVHgtvcsKSFVHSAErytyklvifgekkvkiFS----LIVeLASSSGE 112
Cdd:COG2319  134 TLASGSAdGTVRLWDLATGKLLRTL------TGH-----SGAVTSVA----------------FSpdgkLLA-SGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  113 ISV-NLENFESLPRL---SNWVFDVCFLQDStgsleeedKLLAIGCSDNSLSIWDVKESRmafeiqspercLLYTMRLWG 188
Cdd:COG2319  186 VRLwDLATGKLLRTLtghTGAVRSVAFSPDG--------KLLASGSADGTVRLWDLATGK-----------LLRTLTGHS 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  189 DSISTL-------RIASGTIFNEIIVWravgldgdNVDHGhysaSHMLRLTGHEGSIFRIVWSLDGSKIVSVSDDRSARI 261
Cdd:COG2319  247 GSVRSVafspdgrLLASGSADGTVRLW--------DLATG----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  262 WEIDSQEVVGpVLFGHSVRVWDCCIS--DSLIVTAGEDCTCRVWGVD-GTQLEVIKEHIGrGIWRCLYDPNSSLLVTAGF 338
Cdd:COG2319  315 WDLATGKLLR-TLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLAtGELLRTLTGHTG-AVTSVAFSPDGRTLASGSA 392

                        330
                 ....*....|.
gi 22328224  339 DSAIKVHQLHN 349
Cdd:COG2319  393 DGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-344 7.64e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.04  E-value: 7.64e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224    6 SRRKWNPHAGPylgeVSSLAFLNLPqhvssiPYLLAGSGSE-ILLYDLSSGELIRSFQVFEGVRVHGTVCSksfvhsaer 84
Cdd:cd00200    1 LRRTLKGHTGG----VTCVAFSPDG------KLLATGSGDGtIKVWDLETGELLRTLKGHTGPVRDVAASA--------- 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224   85 YTYKLVIFGE-KKVKIFSLivelasSSGEISVNLENFESlprlsnWVFDVCFLQDSTgsleeedklLAIGCS-DNSLSIW 162
Cdd:cd00200   62 DGTYLASGSSdKTIRLWDL------ETGECVRTLTGHTS------YVSSVAFSPDGR---------ILSSSSrDKTIKVW 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  163 DVKESRMAFEIQSPE---RCLLYtmrlwgdSISTLRIASGTIFNEIIVWRAVgldgdnvdhghySASHMLRLTGHEGSIF 239
Cdd:cd00200  121 DVETGKCLTTLRGHTdwvNSVAF-------SPDGTFVASSSQDGTIKLWDLR------------TGKCVATLTGHTGEVN 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  240 RIVWSLDGSKIVSVSDDRSARIWEIDSQEVVGpVLFGHSVRVWDCCISDS--LIVTAGEDCTCRVW-GVDGTQLEVIKEH 316
Cdd:cd00200  182 SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG-TLRGHENGVNSVAFSPDgyLLASGSEDGTIRVWdLRTGECVQTLSGH 260

                        330       340
                 ....*....|....*....|....*...
gi 22328224  317 IGRgIWRCLYDPNSSLLVTAGFDSAIKV 344
Cdd:cd00200  261 TNS-VTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
106-344 3.03e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 3.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  106 LASSSGEISVNLENFES------LPRLSNWVFDVCFLQDStgsleeedKLLAIGCSDNSLSIWDVKESRmafeiqsperc 179
Cdd:COG2319   93 LASASADGTVRLWDLATglllrtLTGHTGAVRSVAFSPDG--------KTLASGSADGTVRLWDLATGK----------- 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  180 LLYTMRLWGDSISTL-------RIASGTIFNEIIVWravgldgdNVDHGHYSAShmlrLTGHEGSIFRIVWSLDGSKIVS 252
Cdd:COG2319  154 LLRTLTGHSGAVTSVafspdgkLLASGSDDGTVRLW--------DLATGKLLRT----LTGHTGAVRSVAFSPDGKLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  253 VSDDRSARIWEIDSQEVVGpVLFGHSVRVWDCCIS--DSLIVTAGEDCTCRVWGVDGTQLEVIKEHIGRGIWRCLYDPNS 330
Cdd:COG2319  222 GSADGTVRLWDLATGKLLR-TLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                        250
                 ....*....|....
gi 22328224  331 SLLVTAGFDSAIKV 344
Cdd:COG2319  301 KLLASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
106-356 1.79e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 1.79e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  106 LASSS--GEISV-NLENFESLPRL---SNWVFDVCFLQDStgsleeedKLLAIGCSDNSLSIWDVKESRmafeiqsperc 179
Cdd:COG2319  135 LASGSadGTVRLwDLATGKLLRTLtghSGAVTSVAFSPDG--------KLLASGSDDGTVRLWDLATGK----------- 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  180 LLYTMRLWGDSISTL-------RIASGTIFNEIIVWravgldgdNVDHGhysaSHMLRLTGHEGSIFRIVWSLDGSKIVS 252
Cdd:COG2319  196 LLRTLTGHTGAVRSVafspdgkLLASGSADGTVRLW--------DLATG----KLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  253 VSDDRSARIWEIDSQEVVGpVLFGHSVRVWDCCIS--DSLIVTAGEDCTCRVWGVD-GTQLEVIKEHIGRgIWRCLYDPN 329
Cdd:COG2319  264 GSADGTVRLWDLATGELLR-TLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGA-VRSVAFSPD 341

                        250       260
                 ....*....|....*....|....*..
gi 22328224  330 SSLLVTAGFDSAIKVHQLHNRGSETSL 356
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTL 368
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 107-350 1.41e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  107 ASSSGEISV-NLENFESLPRL---SNWVFDVCFLQDSTgsleeedkLLAIGCSDNSLSIWDVKESRMAFEI---QSPERC 179
Cdd:cd00200   27 GSGDGTIKVwDLETGELLRTLkghTGPVRDVAASADGT--------YLASGSSDKTIRLWDLETGECVRTLtghTSYVSS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  180 LLYTmrlwgdsiSTLRIASGTIF-NEIIVWravgldgdNVDHGHYSAShmlrLTGHEGSIFRIVWSLDGSKIVSVSDDRS 258
Cdd:cd00200   99 VAFS--------PDGRILSSSSRdKTIKVW--------DVETGKCLTT----LRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  259 ARIWEIDSQEVVGpVLFGHSVRVWDCCISD--SLIVTAGEDCTCRVWGVD-GTQLEVIKEHiGRGIWRCLYDPNSSLLVT 335
Cdd:cd00200  159 IKLWDLRTGKCVA-TLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLStGKCLGTLRGH-ENGVNSVAFSPDGYLLAS 236

                        250
                 ....*....|....*
gi 22328224  336 AGFDSAIKVHQLHNR 350
Cdd:cd00200  237 GSEDGTIRVWDLRTG 251
WD40 COG2319
WD40 repeat [General function prediction only];
190-357 4.70e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 4.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  190 SISTLRIASGTIFNEIIVWRAVGldgdnvdhghysASHMLRLTGHEGSIFRIVWSLDGSKIVSVSDDRSARIWEIDSQEV 269
Cdd:COG2319   87 SPDGRLLASASADGTVRLWDLAT------------GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  270 VGpVLFGHSVRVWDCCIS--DSLIVTAGEDCTCRVWGVD-GTQLEVIKEHiGRGIWRCLYDPNSSLLVTAGFDSAIKVHQ 346
Cdd:COG2319  155 LR-TLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLAtGKLLRTLTGH-TGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                        170
                 ....*....|.
gi 22328224  347 LHNRGSETSLD 357
Cdd:COG2319  233 LATGKLLRTLT 243
WD40 COG2319
WD40 repeat [General function prediction only];
185-366 5.54e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.88  E-value: 5.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  185 RLWGDSISTLRIASGTIFNEIIVWRAVGLDGDNVDHGHYSASHMLRLTGHEGSIFRIVWSLDGSKIVSVSDDRSARIWEI 264
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  265 DSQEVVGPvLFGHSVRVWDCCISD--SLIVTAGEDCTCRVWGV-DGTQLEVIKEHIGRgIWRCLYDPNSSLLVTAGFDSA 341
Cdd:COG2319  108 ATGLLLRT-LTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLaTGKLLRTLTGHSGA-VTSVAFSPDGKLLASGSDDGT 185

                        170       180       190
                 ....*....|....*....|....*....|..
gi 22328224  342 IKVHQLHN-------RGSETSLDAVGVlnSPD 366
Cdd:COG2319  186 VRLWDLATgkllrtlTGHTGAVRSVAF--SPD 215
WD40 COG2319
WD40 repeat [General function prediction only];
10-266 4.74e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 4.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224   10 WNPHAGPYL-------GEVSSLAFLnlP--QHVSSipyllAGSGSEILLYDLSSGELIRSFQVFEGVrvhgtvcsksfVH 80
Cdd:COG2319  189 WDLATGKLLrtltghtGAVRSVAFS--PdgKLLAS-----GSADGTVRLWDLATGKLLRTLTGHSGS-----------VR 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224   81 SAErytyklvifgekkvkiFS----LIVeLASSSGEISV-NLENFESLPRL---SNWVFDVCFLQDStgsleeedKLLAI 152
Cdd:COG2319  251 SVA----------------FSpdgrLLA-SGSADGTVRLwDLATGELLRTLtghSGGVNSVAFSPDG--------KLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  153 GCSDNSLSIWDVKESRmafeiqspercLLYTMRLWGDSISTL-------RIASGTIFNEIIVWRAVGldgdnvdhghysA 225
Cdd:COG2319  306 GSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVafspdgkTLASGSDDGTVRLWDLAT------------G 362

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 22328224  226 SHMLRLTGHEGSIFRIVWSLDGSKIVSVSDDRSARIWEIDS 266
Cdd:COG2319  363 ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 273-349 4.92e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 4.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  273 VLFGHSVRVWDCCISD--SLIVTAGEDCTCRVWGVDGTQLE-VIKEHIGrGIWRCLYDPNSSLLVTAGFDSAIKVHQLHN 349
Cdd:cd00200    4 TLKGHTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLrTLKGHTG-PVRDVAASADGTYLASGSSDKTIRLWDLET 82
WD40 COG2319
WD40 repeat [General function prediction only];
207-366 1.60e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  207 VWRAVGLDGDNVDHGHYSASHMLRLTGHEGSIFRIVWSLDGSKIVSVSDDRSARIWEIDSQEVVgPVLFGHSVRVWDCCI 286
Cdd:COG2319    8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTAAVLSVAF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328224  287 S--DSLIVTAGEDCTCRVWGVDGTQLEVIKEHIGRGIWRCLYDPNSSLLVTAGFDSAIKVHQLHN-------RGSETSLD 357
Cdd:COG2319   87 SpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgkllrtlTGHSGAVT 166


                 ....*....
gi 22328224  358 AVGVlnSPD 366
Cdd:COG2319  167 SVAF--SPD 173
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 231-263 7.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 7.63e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 22328224     231 LTGHEGSIFRIVWSLDGSKIVSVSDDRSARIWE 263
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
231-263 6.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 6.54e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 22328224    231 LTGHEGSIFRIVWSLDGSKIVSVSDDRSARIWE 263
Cdd:pfam00400    7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-303 8.52e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 8.52e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 22328224     273 VLFGHSVRVWDCCIS--DSLIVTAGEDCTCRVW 303
Cdd:smart00320    7 TLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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