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Conserved domains on  [gi|15231733|ref|NP_191528|]
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IQ-domain 13 [Arabidopsis thaliana]

Protein Classification

IQ and DUF4005 domain-containing protein( domain architecture ID 10635720)

IQ and DUF4005 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4005 super family cl16148
Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing ...
 388-492 5.07e-13

Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins.


The actual alignment was detected with superfamily member pfam13178:

Pssm-ID: 404128  Cd Length: 97  Bit Score: 64.96  E-value: 5.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231733   388 GGGRATQDSPFKDDDSltscppfSAPSYMAPTVSAKAKLRANSNPKERmdrtpVSTNEKRRSSFPlgsfkWNKGSLFMSN 467
Cdd:pfam13178  10 YSSSGTSNTPFTPSRS-------SLPNYMAATESAKAKLRSQSAPRQR-----PSTPERDRSGSA-----AKRLSLPAPS 72

                          90       100
                  ....*....|....*....|....*
gi 15231733   468 NSNNKGPGSSSSGAVVLEKHKTLKS 492
Cdd:pfam13178  73 PNGKGSSYGPRARQVQASYKHSLRS 97
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 168-194 6.80e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.22  E-value: 6.80e-05
                        10        20
                ....*....|....*....|....*..
gi 15231733 168 KNAYAIKIQAAFRGYMARRSFRALKGL 194
Cdd:cd23767   8 MNRAATLIQALWRGYKVRKELKKKKKK 34
 
Name Accession Description Interval E-value
DUF4005 pfam13178
Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing ...
 388-492 5.07e-13

Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins.


Pssm-ID: 404128  Cd Length: 97  Bit Score: 64.96  E-value: 5.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231733   388 GGGRATQDSPFKDDDSltscppfSAPSYMAPTVSAKAKLRANSNPKERmdrtpVSTNEKRRSSFPlgsfkWNKGSLFMSN 467
Cdd:pfam13178  10 YSSSGTSNTPFTPSRS-------SLPNYMAATESAKAKLRSQSAPRQR-----PSTPERDRSGSA-----AKRLSLPAPS 72

                          90       100
                  ....*....|....*....|....*
gi 15231733   468 NSNNKGPGSSSSGAVVLEKHKTLKS 492
Cdd:pfam13178  73 PNGKGSSYGPRARQVQASYKHSLRS 97
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 168-194 6.80e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.22  E-value: 6.80e-05
                        10        20
                ....*....|....*....|....*..
gi 15231733 168 KNAYAIKIQAAFRGYMARRSFRALKGL 194
Cdd:cd23767   8 MNRAATLIQALWRGYKVRKELKKKKKK 34
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 172-189 2.35e-04

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 38.08  E-value: 2.35e-04
                           10
                   ....*....|....*...
gi 15231733    172 AIKIQAAFRGYMARRSFR 189
Cdd:smart00015   6 AIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 172-189 4.23e-04

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 37.30  E-value: 4.23e-04
                          10
                  ....*....|....*...
gi 15231733   172 AIKIQAAFRGYMARRSFR 189
Cdd:pfam00612   4 AIKIQAAWRGYLARKRYK 21
 
Name Accession Description Interval E-value
DUF4005 pfam13178
Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing ...
 388-492 5.07e-13

Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins.


Pssm-ID: 404128  Cd Length: 97  Bit Score: 64.96  E-value: 5.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231733   388 GGGRATQDSPFKDDDSltscppfSAPSYMAPTVSAKAKLRANSNPKERmdrtpVSTNEKRRSSFPlgsfkWNKGSLFMSN 467
Cdd:pfam13178  10 YSSSGTSNTPFTPSRS-------SLPNYMAATESAKAKLRSQSAPRQR-----PSTPERDRSGSA-----AKRLSLPAPS 72

                          90       100
                  ....*....|....*....|....*
gi 15231733   468 NSNNKGPGSSSSGAVVLEKHKTLKS 492
Cdd:pfam13178  73 PNGKGSSYGPRARQVQASYKHSLRS 97
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 168-194 6.80e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.22  E-value: 6.80e-05
                        10        20
                ....*....|....*....|....*..
gi 15231733 168 KNAYAIKIQAAFRGYMARRSFRALKGL 194
Cdd:cd23767   8 MNRAATLIQALWRGYKVRKELKKKKKK 34
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 172-189 2.35e-04

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 38.08  E-value: 2.35e-04
                           10
                   ....*....|....*...
gi 15231733    172 AIKIQAAFRGYMARRSFR 189
Cdd:smart00015   6 AIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 172-189 4.23e-04

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 37.30  E-value: 4.23e-04
                          10
                  ....*....|....*...
gi 15231733   172 AIKIQAAFRGYMARRSFR 189
Cdd:pfam00612   4 AIKIQAAWRGYLARKRYK 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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