|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
51-487 |
1.53e-166 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 477.84 E-value: 1.53e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 51 ESKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMG 130
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 131 IICQRAMVLHLAAAVFLTFLYWYSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLG 210
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 211 VFLLHTLLTWLVTNVLDFGLLGAALILSFSWWLLVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVMLCLE 290
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 291 IWYNQGLVIISGLLSnPTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLC 370
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 371 VIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVLGFKT 450
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*..
gi 15231620 451 SLGVAGIWWGMIAGVILQTLTLIVLTLKTNWTSEVEN 487
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
63-402 |
5.35e-47 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 166.65 E-value: 5.35e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 63 IVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATvGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHLA 142
Cdd:TIGR00797 3 ILANILQPLLGLVDTAFVGHLGPVDLAAVSLGS-SVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 143 AAVFLTFLYWYSG-PILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTWL 221
Cdd:TIGR00797 82 LGLPVLLVGYFFIdPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNYI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 222 VTNVL--DFGLLGAALILSFSWWLLVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVMLCLEIWYNQGLVI 299
Cdd:TIGR00797 162 LIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALLAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 300 ISGLLSnpTISLDAISICMYYlnWDMQFML--GLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLCVIVLVFR 377
Cdd:TIGR00797 242 LVARLG--SIALAAHQIALNV--ESLLFMPafGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*
gi 15231620 378 VGLSKAFTSDAEVIAAVSDLFPLLA 402
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
53-475 |
1.32e-45 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 164.93 E-value: 1.32e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 53 KLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVgIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGII 132
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFP-IFFLLIALGIGLGVGGTALVAQALGAGDREEARRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 133 CQRAMVLHLAAAVFLTFL-YWYSGPILKTMGQSVAIAHEGQIFAR----GMIPQIYAFALACpmqrFLQAQNIVNPLAYM 207
Cdd:COG0534 87 LGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRiillGLPFLLLFNVLNG----ILRGLGDTKTPMII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 208 SLGVFLLHTLLTWLVTNVLDFGLLGAALILSFSWWLLVAVnGMYILMSPNCKETWTGFSTRA-FRGIWPYFKLTVASAVM 286
Cdd:COG0534 163 MLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALL-LLYYLFRKRSLLRLRLRDLRPdRKILKRILRIGLPAGLQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 287 LCLEIWYNQGLVIISGLLSnpTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLIS 366
Cdd:COG0534 242 QLAESLGFLVLNALVARLG--TAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 367 SVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVL 446
Cdd:COG0534 320 LLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLL 399
|
410 420
....*....|....*....|....*....
gi 15231620 447 GFkTSLGVAGIWWGMIAGVILQTLTLIVL 475
Cdd:COG0534 400 AF-LGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
62-221 |
8.83e-22 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 91.86 E-value: 8.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 62 SIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATvGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHL 141
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHLGAVALAAVSIAN-SIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 142 AAAVFLTFLYW-YSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTW 220
Cdd:pfam01554 81 LLSLPIALLVLlFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 15231620 221 L 221
Cdd:pfam01554 161 L 161
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
51-464 |
8.07e-18 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 85.63 E-value: 8.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 51 ESKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATvGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMG 130
Cdd:PRK01766 10 EARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGT-SIWLPVILFGHGLLLALTPIVAQLNGAGRRERIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 131 IICQRAMVLHLAAAVFLTFLYWYSG-PILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSL 209
Cdd:PRK01766 89 HQVRQGLWLALFLSVLIMLVLYNAVpPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 210 GVFLLHTLLTWlvtnVLDFGLL--------GAALILSFSWWLLVAVNGMYILMSPNCKE--TWTGFSTRAFRGIWPYFKL 279
Cdd:PRK01766 169 LGLLINIPLNY----IFIYGKFgfpelggvGCGVATAIVYWVMFLAMLIYIKRARRFRDfrLFKGLYKPDWAVIKRLLKL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 280 TVASAVMLCLEIwynqGLVIISGLLSNP---------TISLDAISICmyylnwdmqFM--LGLSAAISVRVSNELGAGNP 348
Cdd:PRK01766 245 GLPIGLAIFFEV----SLFAVVTLLVSPlgtvtvaahQIALNFSSLL---------FMlpLSLAMALTIRVGFELGAGRT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 349 RVAMlSVVVVNITTVLISSVLCVIVLV-FRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVV 427
Cdd:PRK01766 312 LDAR-QYAYIGLAVGLGMALLTAIFLVlFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVI 390
|
410 420 430
....*....|....*....|....*....|....*..
gi 15231620 428 AYVNLVTYYVIGLPIGCVLGFKTSLGVAGIWWGMIAG 464
Cdd:PRK01766 391 FFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIG 427
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
51-487 |
1.53e-166 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 477.84 E-value: 1.53e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 51 ESKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMG 130
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 131 IICQRAMVLHLAAAVFLTFLYWYSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLG 210
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 211 VFLLHTLLTWLVTNVLDFGLLGAALILSFSWWLLVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVMLCLE 290
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 291 IWYNQGLVIISGLLSnPTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLC 370
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 371 VIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVLGFKT 450
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*..
gi 15231620 451 SLGVAGIWWGMIAGVILQTLTLIVLTLKTNWTSEVEN 487
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
63-402 |
5.35e-47 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 166.65 E-value: 5.35e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 63 IVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATvGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHLA 142
Cdd:TIGR00797 3 ILANILQPLLGLVDTAFVGHLGPVDLAAVSLGS-SVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 143 AAVFLTFLYWYSG-PILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTWL 221
Cdd:TIGR00797 82 LGLPVLLVGYFFIdPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNYI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 222 VTNVL--DFGLLGAALILSFSWWLLVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVMLCLEIWYNQGLVI 299
Cdd:TIGR00797 162 LIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALLAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 300 ISGLLSnpTISLDAISICMYYlnWDMQFML--GLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLCVIVLVFR 377
Cdd:TIGR00797 242 LVARLG--SIALAAHQIALNV--ESLLFMPafGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*
gi 15231620 378 VGLSKAFTSDAEVIAAVSDLFPLLA 402
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
53-475 |
1.32e-45 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 164.93 E-value: 1.32e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 53 KLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVgIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGII 132
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFP-IFFLLIALGIGLGVGGTALVAQALGAGDREEARRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 133 CQRAMVLHLAAAVFLTFL-YWYSGPILKTMGQSVAIAHEGQIFAR----GMIPQIYAFALACpmqrFLQAQNIVNPLAYM 207
Cdd:COG0534 87 LGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRiillGLPFLLLFNVLNG----ILRGLGDTKTPMII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 208 SLGVFLLHTLLTWLVTNVLDFGLLGAALILSFSWWLLVAVnGMYILMSPNCKETWTGFSTRA-FRGIWPYFKLTVASAVM 286
Cdd:COG0534 163 MLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALL-LLYYLFRKRSLLRLRLRDLRPdRKILKRILRIGLPAGLQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 287 LCLEIWYNQGLVIISGLLSnpTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLIS 366
Cdd:COG0534 242 QLAESLGFLVLNALVARLG--TAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 367 SVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVL 446
Cdd:COG0534 320 LLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLL 399
|
410 420
....*....|....*....|....*....
gi 15231620 447 GFkTSLGVAGIWWGMIAGVILQTLTLIVL 475
Cdd:COG0534 400 AF-LGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
51-467 |
5.46e-40 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 149.96 E-value: 5.46e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 51 ESKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATvGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMG 130
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGS-SLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 131 IICQRAMVLHLAAAVFLTFLYWYSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLG 210
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 211 VFLLHTLLTWLVT----NVLDFGLLGAALILSFSWWLLVAVNGMYILMSPNCKE--TWTGFSTRAFRGIWPYFKLTVASA 284
Cdd:cd13131 160 ALVLNIPLNYVLIfgkfGLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRyrLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 285 VMLCLEIWYNQGLVIISGLLSNPTISLDAISicmyyLNW-DMQFM--LGLSAAISVRVSNELGAGNPRVAMLSVVVVNIT 361
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIA-----LNFaSLLFMvpLGISMAATVRVGFALGAGDPADARRAGLVGLGL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 362 TVLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLP 441
Cdd:cd13131 315 GVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLP 394
|
410 420
....*....|....*....|....*.
gi 15231620 442 IGCVLGFKTSLGVAGIWWGMIAGVIL 467
Cdd:cd13131 395 LGYLLAFTTGLGAFGVWIGLIIGLAL 420
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
53-482 |
1.97e-29 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 119.92 E-value: 1.97e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 53 KLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATvGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGII 132
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLAT-QVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 133 CQRAMVLHLAAAVFLTFLYW-YSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQ-NIVNPLaYMSLG 210
Cdd:cd13137 80 LGQSLLLALLLSLPLALLGLlFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAgDTKTPM-YIMII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 211 VFLLHTLLTWLVTNVL----DFGLLGAALILSFSWwLLVAVNGMYILMSpncKETWTGFSTRAFRGIWPYFK--LTVASA 284
Cdd:cd13137 159 VNVLNIVLDYVLIFGLwgfpGLGVAGAALATVISR-VVGALLLLFLLLR---GRLPIKISFKGFRLDRKIIKklLRIGLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 285 VMLCLEIWYNQGLVIISGLLSNPTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVL 364
Cdd:cd13137 235 AGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 365 ISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGC 444
Cdd:cd13137 315 FMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAY 394
|
410 420 430
....*....|....*....|....*....|....*...
gi 15231620 445 VLGFKTSLGVAGIWWGMIAGVILQTLTLIVLTLKTNWT 482
Cdd:cd13137 395 LLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
59-477 |
2.24e-25 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 108.18 E-value: 2.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 59 SGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVgIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMV 138
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFP-LIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 139 LHLAAAVFLTFLYWYSGP-ILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTL 217
Cdd:cd12082 80 LAILLGLLLAALLLFFSPlILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 218 LTWLVTN---VLDFGLLGAALILSFSWWLLVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVMLCLEIWYN 294
Cdd:cd12082 160 LDPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 295 QGLVIISGLLSNPTiSLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLCVIVL 374
Cdd:cd12082 240 LIIVAIVAAFGGAA-ALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 375 VFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVLGFkTSLGV 454
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAY-LGLGL 397
|
410 420
....*....|....*....|...
gi 15231620 455 AGIWWGMIAGVILQTLTLIVLTL 477
Cdd:cd12082 398 YGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
53-475 |
1.21e-22 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 100.28 E-value: 1.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 53 KLLWTLSGASIVVSVLNYMLSFVTVMFTGHL-GSLQLAGASIATVGIQGL-AYGIMLGMASAvqTVCGQAYGARQYSSMG 130
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLLmALGLMIGVGGA--SLISRRLGAGDREKAN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 131 IICQRAMVLHLAAAVFLTFLYW-YSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSL 209
Cdd:cd13143 82 RIFSTALLLSLILGLLLTILGLlFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGML 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 210 GVFLLHTLLTWLVTNVLDFGLLGAAL--ILSFswwLLVAVNGMYILMSPNCKETWT-GFSTRAFRGIWPYFKLTVASAVM 286
Cdd:cd13143 162 IGAVLNIILDPLFIFVLGLGIAGAALatVIAQ---LISLLLLLLYFFRGKSLLKLSlLRFKLSLKIIKEILALGFPSFLM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 287 ----LCLEIWYNQGLVIISGllsnpTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITT 362
Cdd:cd13143 239 qlssSVVTIVLNLTLLGYGG-----DIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 363 VLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSG--VAIGSGWQAVVayVNLVTYYVigL 440
Cdd:cd13143 314 LIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGyfQAIGKAKRAAL--LSLLRQGL--F 389
|
410 420 430
....*....|....*....|....*....|....*.
gi 15231620 441 PIGCVLGFKTSLGVAGIWWGM-IAGVILQTLTLIVL 475
Cdd:cd13143 390 LIPLLLILPRLFGLDGIWLAFpLAEILTLLLALILL 425
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
53-481 |
1.23e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 100.34 E-value: 1.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 53 KLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVGIqGLAYGIMLGMASAVQTVCGQAYGARQYSSMGII 132
Cdd:cd13142 11 RTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANKV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 133 CQRAMVLHLAAAVFLTFLYWY-SGPIL-KTMGQSVAIAHE----GQIFARGMIPQIYAFALACPMQrflQAQNIVNPLAY 206
Cdd:cd13142 90 AGQTFSFVIILSLILAVLGYIlSRPLLlLLIGAPEEVYPLalayLRIIFLGLPFMFIFFVFNSLLR---GIGDTKTPMKI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 207 MSLGVFL---LHTLLTWLVTNVLDFGLLGAALILSFSWwLLVAVNGMYILMSpncKETWTGFSTRAFRGIWPYFKLTVAS 283
Cdd:cd13142 167 MFGSVLLnviLDPLLIFGIGPFPGLGVAGAALATVISR-GIAAVIGLYLLFK---GRVGLKISLRDLKPDWEWLKKIFRI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 284 AVMLCLEIWYNQ-GLVIISGLLSN-PTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNIT 361
Cdd:cd13142 243 GLPSSIEQSARAlGFTVMTALVAGfGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 362 TVLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLP 441
Cdd:cd13142 323 IFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIP 402
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 15231620 442 IGCVLGFKTSLGVAGIWWGMIAGVILQTLTLIVLTLKTNW 481
Cdd:cd13142 403 LAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTW 442
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
63-481 |
1.55e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 99.91 E-value: 1.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 63 IVVSVL-NYMLSFVTVMFTGHLGSLQLAGASIATVgIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHL 141
Cdd:cd13133 14 LVLSMLsQTVMGFTDRAFLGRLSEVALAASGPAGV-LYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQGLYFSL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 142 AAAVFLTFLYWYSGP-ILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTW 220
Cdd:cd13133 93 LLAPLLALLSALAAPlLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVVNIVLDY 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 221 -LVTNVLDF---GLLGAALILSFSWWLLVAVNGMYILMSPNCKETWTGFSTRA-FRGIWPYFKLTVASAVMLCLEIWYNQ 295
Cdd:cd13133 173 aLIFGKLGFpamGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAWRFdRELLRRILRLGLPSGLQFFLDVGAFT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 296 GLVIISGLLSnpTISLDAISICMyylNWDMQF---MLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLCVI 372
Cdd:cd13133 253 VFFLLIGRLG--TTELAATNIVF---SINSLAflpMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLLGIL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 373 VLVFRVGLSKAFTSD---AEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIgCVLGFK 449
Cdd:cd13133 328 FLLFPELLLSIFTPGadfALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPP-AYLLVV 406
|
410 420 430
....*....|....*....|....*....|..
gi 15231620 450 TSLGVAGIWWGMIAGVILQTLTLIVLTLKTNW 481
Cdd:cd13133 407 LGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
62-221 |
8.83e-22 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 91.86 E-value: 8.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 62 SIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATvGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHL 141
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHLGAVALAAVSIAN-SIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 142 AAAVFLTFLYW-YSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTW 220
Cdd:pfam01554 81 LLSLPIALLVLlFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 15231620 221 L 221
Cdd:pfam01554 161 L 161
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
63-481 |
5.88e-20 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 92.14 E-value: 5.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 63 IVVSVLNYMLSFVTVMFTGH-LGSLQLAGASIATvGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHL 141
Cdd:cd13138 13 LLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGS-PIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 142 AAAVFLTFLYWY-SGPILKTMGQSVAIAHEGQIFAR----GMIPQIYAFALACpmqrFLQAQ-NIVNPLaYMSLGVFLLH 215
Cdd:cd13138 92 ILGIVLTILGLLfAPPILRLMNTPAEILELAVSYLRicflGIPFIFGYNAYSA----ILRGLgDSKTPL-YFVIIACVLN 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 216 TLLTWLVTNVLDFGLLGAAL--ILSFSWWLLVAVNGMYILMSPncketwTGFSTRAFR----GIWPYFKLTVASAVMLCL 289
Cdd:cd13138 167 IILDLLFIAVFHMGVAGAALatVIAQAISVLLALYYLRKKKLP------FKLSLKDFRfdkeILKEILKIGLPSALQQSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 290 EiwyNQGLVIISGLLsNP--TISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISS 367
Cdd:cd13138 241 V---SISFLIINSIV-NSygVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 368 VLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVLG 447
Cdd:cd13138 317 IIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLS 396
|
410 420 430
....*....|....*....|....*....|....
gi 15231620 448 FKTSLGVAGIWWGMIAGVILQTLTLIVLTLKTNW 481
Cdd:cd13138 397 RLTGLGLFGIWLAMPISNILSAIICIIYYRKGRW 430
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
283-443 |
1.86e-18 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 82.61 E-value: 1.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 283 SAVMLCLEIWYNQGLVIISGLLSnpTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITT 362
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHLG--AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 363 VLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTyYVIGLPI 442
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPL 158
|
.
gi 15231620 443 G 443
Cdd:pfam01554 159 N 159
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
55-463 |
3.78e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 86.79 E-value: 3.78e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 55 LWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATvGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQ 134
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVAN-QILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 135 RAMVLHLAAAVFLTFLYW-YSGPILKTMGQSVAIAHEG----QIFARGMIPQIYAFALACpmqrFLQAQNIVNPLAYMSL 209
Cdd:cd13134 84 VALLFNLLLGLVFSLLLLfFGAELLRLMGLPPELLALGstylRIVGGSLFLQALSLTLSA----ILRSHGRTKIPMYVSL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 210 GVFLLHTLLTWLVTNVL----DFGLLGAALILSFSWWLLVAVNGMYILmspncKETWTGFSTRAFRGI-WPYFKLTVASA 284
Cdd:cd13134 160 IMNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLF-----RKLKIRFRLKDLRPFpKKLLKKILKIG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 285 VMLCLE-IWYNQGLVIISGLLSNP-TISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITT 362
Cdd:cd13134 235 LPSAGEeLSYNLSQTVITAFIARLgTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 363 VLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSdlfPLLAVSIFL---NGIQPILSGVAIGSGWQAVVAYVNLVTYYVIG 439
Cdd:cd13134 315 LLVSLAVALLLALFREPILGLFTDDPEIIALGK---TLLLISILLepgRAFNIVLIGSLRAAGDARFPVLIGIISMWGIS 391
|
410 420
....*....|....*....|....
gi 15231620 440 LPIGCVLGFKTSLGVAGIWWGMIA 463
Cdd:cd13134 392 VPLAYLLGIVLGLGLLGVWIAFAA 415
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
51-464 |
8.07e-18 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 85.63 E-value: 8.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 51 ESKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATvGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMG 130
Cdd:PRK01766 10 EARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGT-SIWLPVILFGHGLLLALTPIVAQLNGAGRRERIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 131 IICQRAMVLHLAAAVFLTFLYWYSG-PILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSL 209
Cdd:PRK01766 89 HQVRQGLWLALFLSVLIMLVLYNAVpPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 210 GVFLLHTLLTWlvtnVLDFGLL--------GAALILSFSWWLLVAVNGMYILMSPNCKE--TWTGFSTRAFRGIWPYFKL 279
Cdd:PRK01766 169 LGLLINIPLNY----IFIYGKFgfpelggvGCGVATAIVYWVMFLAMLIYIKRARRFRDfrLFKGLYKPDWAVIKRLLKL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 280 TVASAVMLCLEIwynqGLVIISGLLSNP---------TISLDAISICmyylnwdmqFM--LGLSAAISVRVSNELGAGNP 348
Cdd:PRK01766 245 GLPIGLAIFFEV----SLFAVVTLLVSPlgtvtvaahQIALNFSSLL---------FMlpLSLAMALTIRVGFELGAGRT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 349 RVAMlSVVVVNITTVLISSVLCVIVLV-FRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVV 427
Cdd:PRK01766 312 LDAR-QYAYIGLAVGLGMALLTAIFLVlFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVI 390
|
410 420 430
....*....|....*....|....*....|....*..
gi 15231620 428 AYVNLVTYYVIGLPIGCVLGFKTSLGVAGIWWGMIAG 464
Cdd:PRK01766 391 FFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIG 427
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
71-478 |
1.53e-12 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 69.13 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 71 MLSFVTVMFTGHLGSL-QLAGASIATVgIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHLAA-AVFLT 148
Cdd:cd13136 21 LLGLVDTAVVGHLGSAaYLGAVALGTT-IFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIALLVRALLLALAIgLLLIL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 149 FLYWYSGPILKTMGQSVAIAHEGQIFARGMIPQIYA-FALACPMQRFLQAQNIVNPLaYMSLGVFLLHTLLTWLVTNVLD 227
Cdd:cd13136 100 LQSPLLALALLLLGASAAVAALARQYLRIRILGAPAvLLNYVATGWFRGLQDTRTPL-ILQIVGNVVNIVLDPLFVFGLG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 228 FGLLGAAL--------ILSFSWWLLVAVNGMYILMSPNCKETWTGFsTRAFRGIWPYFKLTVA--SAVMLCLEIWYNQGL 297
Cdd:cd13136 179 WGVAGAALatviaqylGALLGLWLLRRRVRLLGKSLSRRLPSKAAL-KRLFKLNRDIFIRTLAllAAFLFFTALAARLGD 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 298 VIISGllsnPTISLDAISICMYylnwdmqFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLCVIVLVFR 377
Cdd:cd13136 258 VILAA----NQILLQFWLLSSY-------FLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFFLGG 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 378 VGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTyYVIGLPigCVLGFKTSLGVAGI 457
Cdd:cd13136 327 EPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVS-LAVFLP--LLFLLVPLWGNHGL 403
|
410 420
....*....|....*....|.
gi 15231620 458 WWGMIAGVILQTLTLIVLTLK 478
Cdd:cd13136 404 WLALILFMLLRGLTLALRLPR 424
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
75-481 |
1.22e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 66.48 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 75 VTVMFTGHLGSLqlagaSIATVG----IQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHLAAAVFLTFL 150
Cdd:cd13139 36 VDLYFVSRLGAL-----AIATVGltesVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAILLGVALSLILSIL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 151 -YWYSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFAL-------------ACPMQRFLQAQNIVNplaymslgvFLLHT 216
Cdd:cd13139 111 gYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLlflingifrgagdAAIAMRSLWLANGLN---------IILDP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 217 LLTWLVTNVLDFGLLGAALI--------LSFSWWLLVAVNGMYILMSPNCKETWtgfstrafRGIWPYFKLTVASAVMLC 288
Cdd:cd13139 182 LFIFGLGPIPAMGVTGAAIAttigrsigVLYQLYHLFKGKGRIQIRRRHLKLDW--------AIIKKIIKIAVGGILQFL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 289 LEIWYNQGLVIISGLLSnpTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSV 368
Cdd:cd13139 254 IASSSWIFLVRIIAEFG--STALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGI 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 369 LCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVLGF 448
Cdd:cd13139 332 VSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLAR 411
|
410 420 430
....*....|....*....|....*....|...
gi 15231620 449 KTSLGVAGIWWGMIAGVILQTLTLIVLTLKTNW 481
Cdd:cd13139 412 HLNLGPKGVFIAIPIAETVLAIAAIILFRRGKW 444
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
31-251 |
1.60e-09 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 59.77 E-value: 1.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 31 FLRRRGSTVTPRWWLKLAVWESKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVgIQGLAYGIMLGMA 110
Cdd:COG0534 207 LFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALR-IESLAFMPALGLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 111 SAVQTVCGQAYGARQYSSMGIICQRAMVLHLAAAVFLTFLYW-YSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALAC 189
Cdd:COG0534 286 QAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFlFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQF 365
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15231620 190 PMQRFLQAQNIVNPLAYMSLGVFLLHTLLTWLVTNVLDFGLLGAALILSFSWWLLVAVNGMY 251
Cdd:COG0534 366 VLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
51-481 |
6.17e-08 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 55.14 E-value: 6.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 51 ESKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVGIQGLAYgIMLGMASAVQTVCGQAYGARQYSSMG 130
Cdd:PRK00187 8 ELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSI-FCVGVIAAVGTLVAIRHGAGDIEGAT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 131 IICQRAMVLHLAAAVFLTFLYWYSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLG 210
Cdd:PRK00187 87 RLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 211 VFLLHTLLTWLVTNVL----DFGLLGAALILSfswwllVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVM 286
Cdd:PRK00187 167 GAVANLLLNYALIEGWfglpKLGLMGIGLVTA------LVSNGMALALALYIRRHPAYAAYPLRKGLSRPSRAALRELWR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 287 LCLEI----WYNQGLVIISGL---------LSNPTISLDAISicmyylnwdMQFML--GLSAAISVRVSNELGAGNPRVA 351
Cdd:PRK00187 241 LGLPIggtyAVEVGLFTFAALcmgalgstqLAAHQIALQIVS---------VAFMVpvGLSYAVTMRVGQHYGAGRLLEA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 352 MLSVVVVNITTVLISSVLCVIVLVFRVGLSKAFT-----SDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAV 426
Cdd:PRK00187 312 RRAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFLdrndpAFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDART 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 15231620 427 VAYVNLVTYYVIGLPIGCVLGFKTSLGVAGIWWGMIAGVILQTltlIVLTLKTNW 481
Cdd:PRK00187 392 TFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAA---VALTLAFEW 443
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-475 |
7.48e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 51.46 E-value: 7.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 52 SKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIAtVGIQGLAYGIMLGMASAVQTVCGQAYGA-RQYSSMG 130
Cdd:cd13144 7 LRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLA-FPIQNLMIAVAVGTGVGVNALLSRSLGEkDQKEANK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 131 IICQRAMVLHLAAAVFLTFLYWYSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQ-NIVNPLAYMSL 209
Cdd:cd13144 86 AANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTgNTITPMIAQLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 210 GV---FLLHTLLTWLVTNVLDFGLLGAAlILSFSWWLLVAVNGMYILMSpncKETWTGFSTRAFRGIWPY----FKLTVA 282
Cdd:cd13144 166 GAiinIILDPILIFGLFGFPAMGIAGAA-IATVIGQILAMFLAFFFLLR---KNKDVQPDLRLFRPSLRIikeiYAVGLP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 283 SAVMLCLEIWYNQGLVIISGLLSNPTISLDAISICMYylnwDMQFML--GLSAAISVRVSNELGAGNPRVAMLSVVVVNI 360
Cdd:cd13144 242 SIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQ----SFVFMPvfGLNNGLIPIVAYNYGAGNKDRIREAIKYAIL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 361 TTVLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGL 440
Cdd:cd13144 318 IAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLL 397
|
410 420 430
....*....|....*....|....*....|....*.
gi 15231620 441 PIGCVLGfkTSLGVAGIWWGM-IAGVILQTLTLIVL 475
Cdd:cd13144 398 PLAWLLA--KMFGLNGVWWSFpIAEIVSFLLSLLFL 431
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
295-481 |
2.71e-04 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 43.47 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 295 QGLVIISGLLSNPTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLCVIVL 374
Cdd:cd12082 14 YNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLLAALLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 375 VFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYY--VIGLPIGCVLGFKTSL 452
Cdd:cd12082 94 FFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLlnILLDPLLIFGLGPPEL 173
|
170 180
....*....|....*....|....*....
gi 15231620 453 GVAGIWWGMIAGVILQTLTLIVLTLKTNW 481
Cdd:cd12082 174 GIAGAALATVISYVIGALLLLIYLRKGKK 202
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
63-474 |
2.90e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 43.43 E-value: 2.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 63 IVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVGIQGLAyGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHLA 142
Cdd:cd13135 11 ILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTIT-GFLGSISIGFTILGSQSVGAKDIKRINDYAISSIVYNSI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 143 AAVFLTFLYWYSGPILKT-MGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTW- 220
Cdd:cd13135 90 IGVILFLLWLFGARIIFVlFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNVILDYv 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 221 LVTNVLDF---GLLGAALILSFSwwlLVAVNGMYILMSPNCKETWTGFSTRA-FRGIWPYFKLTVASAVMLCLE--IWYN 294
Cdd:cd13135 170 LIFGNFGFprlGIIGAAIATTIA---NVLNLIILVYLCRKIKKLTFKLSNTKvLKANIRPYKFTIKLGLPLGGEefLWNI 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 295 QGLVIISGLLSNPTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLCVIVL 374
Cdd:cd13135 247 GNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAAAIVFL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 375 VFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLV-TYYVIGLPIGCVLGFKtsLG 453
Cdd:cd13135 327 AFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIgTIIVVSVALLLIFVFK--LG 404
|
410 420
....*....|....*....|.
gi 15231620 454 VAGIWWGMIAGVILQTLTLIV 474
Cdd:cd13135 405 LAGVYITLFIDEIIRAIINFL 425
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
101-471 |
8.25e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 42.00 E-value: 8.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 101 LAYGIMLGMASAVqtvcGQAYGARQYSSMGIICQRAMVLHL-AAAVFLTFLYWYSGPILKTMGQSVAIAHEGQIFARGMI 179
Cdd:cd13146 62 LGNGIQVGVSSLL----ARAIGAQRAKELDQAADSGLALALlAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 180 PQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTWLVTNVLDFGLLGAALILSFSWWLLVAVNGMYILMSPNCK 259
Cdd:cd13146 138 PGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNV 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 260 ETWTGFSTRAFRGIWPYFKLTVASAVMLCLE----IWYNQGLVIISgllsnpTISLDAISICMYYLNWDMQFMLGLSAAI 335
Cdd:cd13146 218 TIHIKLSNISSSVIVEILRVGLPQMLLQLISsisfLIYNRIIIDID------PVAMTAFTLVGRLDQFILIPIFAISSAL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 336 SVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILS 415
Cdd:cd13146 292 LTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVT 371
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15231620 416 GV--AIGSGWQAVVayVNLVTYYVIGLPIGCVLGFKTSLGVAGIWWGMIAGVILQTLT 471
Cdd:cd13146 372 EFfqAIGKAWPSLL--LTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTALL 427
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
52-478 |
1.68e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 40.66 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 52 SKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIAtVGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGI 131
Cdd:cd13145 8 PKLIRKLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLS-FPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 132 ICQRAMVLHLAAAVFLTFL-YWYSGPILKTMG-----QSVAIAHEGQIFArGMIPQIYAFALAC---------PMQRFLQ 196
Cdd:cd13145 87 YAAQGLSFGIILAILLTVIgLFAAPPLFRLLGaegdyLDLALEYMDVIFA-GSIFFLLNFGLNGilnaqgdtkSYRNFLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 197 AQNIVNplaymslgvFLLHTLLTWLVTNVLDFGLLGAAlilsfswWLLVAVNGM---YILMSPNCKETWTGFSTRAFRGI 273
Cdd:cd13145 166 IGFFLN---------IILDPLFIFGGGGIPAMGVSGIA-------LATIISQFIgmfYLLYKVRKSGIISGCRLRDFIPR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 274 W-PYFKLTV----ASAVMLCLEIwynqGLVIISGLLS-NPTISLDAISICMYYlnwdMQFML----GLSAAISVRVSNEL 343
Cdd:cd13145 230 LdVYKEILKqgfpASLNMMTIGL----GIFVITYFVGqFGDEAVAAYGIALRI----EQILLlptiGLNTAVLSIAGQNF 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 344 GAGNP-RVAmlSVVVVNITT-VLISSVLCVIVLVFRVGLSKAFTSDAEVIAA----------VSDLFPLLAVSI-FLNGI 410
Cdd:cd13145 302 GAKKYdRVR--ETYKKALKYgFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIgagylridalIFYAYVVLFISVsVLQGL 379
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15231620 411 QPILSGVAIGSGWQAVVAYvnLVTYYVIGlpigcVLGFktslGVAGIWWGMIAGVILQTLTLIVLTLK 478
Cdd:cd13145 380 KRPIFALWIGLYRQLVGPA--LVFWLLVN-----VLGL----GVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
77-254 |
3.18e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 39.97 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 77 VMFTGHLGSLQLAGASIaTVGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHLA--AAVFLTFLYwYS 154
Cdd:cd13135 252 IRILNRIGELALGIYTL-VFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLiyIAAAIVFLA-FP 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231620 155 GPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTWLVTNVLDFGLLGAA 234
Cdd:cd13135 330 YKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGTIIVVSVALLLIFVFKLGLAGVY 409
|
170 180
....*....|....*....|
gi 15231620 235 LILSFSWWLLVAVNGMYILM 254
Cdd:cd13135 410 ITLFIDEIIRAIINFLKYRK 429
|
|
| |
