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Conserved domains on  [gi|15231604|ref|NP_191454|]
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F-box/RNI-like superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/FBD/LRR-repeat protein( domain architecture ID 17779756)

F-box/FBD/LRR-repeat protein may be a component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FBD smart00579
domain in FBox and BRCT domain containing plant proteins;
326-405 1.06e-16

domain in FBox and BRCT domain containing plant proteins;


:

Pssm-ID: 214730  Cd Length: 72  Bit Score: 74.10  E-value: 1.06e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231604    326 RSLVSCpVKKLQIKGFRGTIRELEMIKHFLYSFRCLEKVEIYAEEKGRTRtdlevpgMFELIARMLRLYNEFYSCDVQFL 405
Cdd:smart00579   1 ECLLSS-LEVLEIKGYRGTEEEKELVKYFLENAPCLKKLTISVETSDDEE-------KLEILKELLSLPRASSSCQVQFL 72
F-box_AtFBL13-like cd22160
F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) ...
4-39 5.09e-11

F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438931  Cd Length: 36  Bit Score: 57.30  E-value: 5.09e-11
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15231604   4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWRNQFA 39
Cdd:cd22160   1 ISDLPDELLCHILSFLPTKDAVKTSVLSKRWRHLWR 36
 
Name Accession Description Interval E-value
FBD smart00579
domain in FBox and BRCT domain containing plant proteins;
326-405 1.06e-16

domain in FBox and BRCT domain containing plant proteins;


Pssm-ID: 214730  Cd Length: 72  Bit Score: 74.10  E-value: 1.06e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231604    326 RSLVSCpVKKLQIKGFRGTIRELEMIKHFLYSFRCLEKVEIYAEEKGRTRtdlevpgMFELIARMLRLYNEFYSCDVQFL 405
Cdd:smart00579   1 ECLLSS-LEVLEIKGYRGTEEEKELVKYFLENAPCLKKLTISVETSDDEE-------KLEILKELLSLPRASSSCQVQFL 72
F-box_AtFBL13-like cd22160
F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) ...
4-39 5.09e-11

F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438931  Cd Length: 36  Bit Score: 57.30  E-value: 5.09e-11
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15231604   4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWRNQFA 39
Cdd:cd22160   1 ISDLPDELLCHILSFLPTKDAVKTSVLSKRWRHLWR 36
F-box-like pfam12937
F-box-like; This is an F-box-like family.
4-35 9.69e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 45.17  E-value: 9.69e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15231604     4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWR 35
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWR 32
FBOX smart00256
A Receptor for Ubiquitination Targets;
7-36 3.20e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.88  E-value: 3.20e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 15231604      7 LPDEVLCHILSFLTTKEAALASVVSKRWRN 36
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRS 30
FBD pfam08387
FBD; This region is found in F-box (pfam00646) and other domain containing plant proteins; it ...
334-366 5.31e-03

FBD; This region is found in F-box (pfam00646) and other domain containing plant proteins; it is repeated in two family members. Its precise function is unknown, but it is thought to be associated with nuclear processes. In fact, several family members are annotated as being similar to transcription factors.


Pssm-ID: 462458  Cd Length: 45  Bit Score: 34.61  E-value: 5.31e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15231604   334 KKLQIKGFRGTIRELEMIKHFLYSFRCLEKVEI 366
Cdd:pfam08387  13 ETVEWRGYRGEEEEKEFAKYILENARVLKKATI 45
 
Name Accession Description Interval E-value
FBD smart00579
domain in FBox and BRCT domain containing plant proteins;
326-405 1.06e-16

domain in FBox and BRCT domain containing plant proteins;


Pssm-ID: 214730  Cd Length: 72  Bit Score: 74.10  E-value: 1.06e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231604    326 RSLVSCpVKKLQIKGFRGTIRELEMIKHFLYSFRCLEKVEIYAEEKGRTRtdlevpgMFELIARMLRLYNEFYSCDVQFL 405
Cdd:smart00579   1 ECLLSS-LEVLEIKGYRGTEEEKELVKYFLENAPCLKKLTISVETSDDEE-------KLEILKELLSLPRASSSCQVQFL 72
F-box_AtFBL13-like cd22160
F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) ...
4-39 5.09e-11

F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438931  Cd Length: 36  Bit Score: 57.30  E-value: 5.09e-11
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15231604   4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWRNQFA 39
Cdd:cd22160   1 ISDLPDELLCHILSFLPTKDAVKTSVLSKRWRHLWR 36
F-box-like pfam12937
F-box-like; This is an F-box-like family.
4-35 9.69e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 45.17  E-value: 9.69e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15231604     4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWR 35
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWR 32
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
4-36 4.00e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 43.30  E-value: 4.00e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15231604     4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWRN 36
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRS 33
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
5-36 1.56e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 41.66  E-value: 1.56e-05
                        10        20        30
                ....*....|....*....|....*....|..
gi 15231604   5 SSLPDEVLCHILSFLTTKEAALASVVSKRWRN 36
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRE 32
FBOX smart00256
A Receptor for Ubiquitination Targets;
7-36 3.20e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.88  E-value: 3.20e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 15231604      7 LPDEVLCHILSFLTTKEAALASVVSKRWRN 36
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRS 30
F-box_FBXL8 cd22121
F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also ...
5-35 7.88e-05

F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also called F-box and leucine-rich repeat protein 8, or F-box protein FBL8, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438893  Cd Length: 35  Bit Score: 39.65  E-value: 7.88e-05
                        10        20        30
                ....*....|....*....|....*....|.
gi 15231604   5 SSLPDEVLCHILSFLTTKEAALASVVSKRWR 35
Cdd:cd22121   1 NALPEEILVHIFRHLSLRDRYAAAQVCKHWR 31
F-box_AtARP8-like cd22156
F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar ...
4-35 2.22e-04

F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar proteins; AtARP8, also called F-box protein ARP8, is an F-box protein localized to the nucleolus in Arabidopsis. Unlike other plant nuclear actin-related proteins (ARPs), ARP8 is unique in having an F-box domain and an actin homology domain. It may play a role in nucleolar functions. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438927  Cd Length: 45  Bit Score: 38.51  E-value: 2.22e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 15231604   4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWR 35
Cdd:cd22156   2 FDQLPEDVLMQILRLLGPKDAAKLCLVCKSWR 33
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
4-36 5.75e-04

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 37.62  E-value: 5.75e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 15231604   4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWRN 36
Cdd:cd22104   1 WANLPSVVLVHIFSYLPPRDRLRASSTCRRWRE 33
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
4-36 8.98e-04

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 36.91  E-value: 8.98e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 15231604   4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWRN 36
Cdd:cd22147   2 LSALPVELSLKILSYLDAKSLCRAAQVSKKWRN 34
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
4-35 2.14e-03

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 35.79  E-value: 2.14e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 15231604   4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWR 35
Cdd:cd22123   1 LDQLPENVLLEILSYLPVRDLLRISRVCKRWR 32
F-box_4 pfam15966
F-box;
1-36 2.20e-03

F-box;


Pssm-ID: 464958  Cd Length: 116  Bit Score: 37.66  E-value: 2.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15231604     1 MDLFSSLPDEVLCHILSFLTTKEAALASVVSKRWRN 36
Cdd:pfam15966   2 LDSLSSLPFEVLQHIASFLDSFSLSQLSLVSRLMRE 37
FBD pfam08387
FBD; This region is found in F-box (pfam00646) and other domain containing plant proteins; it ...
334-366 5.31e-03

FBD; This region is found in F-box (pfam00646) and other domain containing plant proteins; it is repeated in two family members. Its precise function is unknown, but it is thought to be associated with nuclear processes. In fact, several family members are annotated as being similar to transcription factors.


Pssm-ID: 462458  Cd Length: 45  Bit Score: 34.61  E-value: 5.31e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15231604   334 KKLQIKGFRGTIRELEMIKHFLYSFRCLEKVEI 366
Cdd:pfam08387  13 ETVEWRGYRGEEEEKEFAKYILENARVLKKATI 45
F-box_AtSKIP3-like cd22162
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar ...
4-36 5.40e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar proteins; AtSKIP3, also called F-box protein SKIP3, F-box protein PP2-B9, or protein PHLOEM PROTEIN 2-LIKE B9, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. This subfamily also includes many other Arabidopsis thaliana protein PHLOEM PROTEIN 2-LIKE proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438933  Cd Length: 46  Bit Score: 34.87  E-value: 5.40e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 15231604   4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWRN 36
Cdd:cd22162   1 LEDLPEDCIALILSFTSPRDVCRLSAVSKTFRS 33
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
3-35 5.87e-03

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 34.56  E-value: 5.87e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 15231604   3 LFSSLPDEVLCHILSFLTTKEAALASVVSKRWR 35
Cdd:cd22148   1 FISLLPEHLALKILSYLSPKELLIASQVSKTWR 33
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
4-44 7.98e-03

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 34.24  E-value: 7.98e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15231604   4 FSSLPDEVLCHILSFLTTKEAALASVVSKRWrNQFALVPNL 44
Cdd:cd22118   1 ISSLPPEIMLKIFSYLNPQDLCRCAQVCTKW-SQLARDGSL 40
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
5-35 9.08e-03

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 33.83  E-value: 9.08e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 15231604   5 SSLPDEVLCHILSFLTTKEAALASVVSKRWR 35
Cdd:cd22151   1 RKLPDDLLQEIFKRLDPKSLARAACVCRRWR 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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