BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868   105 FKEQLHADILLKPGDDgpPIPAHRALLASKSEIFKNILDSDGCKtAPEYAITLQELNSEQLQALLEFLYTGTLASdklEK 184
Cdd:pfam00651   5 REQGELCDVTLVVGDK--EFRAHKAVLAACSPYFKALFSGQESE-SSVSEITLDDVSPEDFEALLEFMYTGKLIS---EE 78

                          90       100
                  ....*....|....*....|....*....
gi 15228868   185 NVYALFIAADKYMIHYLQELCEQYMLSSL 213
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868   105 FKEQLHADILLKPGDDgpPIPAHRALLASKSEIFKNILDSDGCKtAPEYAITLQELNSEQLQALLEFLYTGTLASdklEK 184
Cdd:pfam00651   5 REQGELCDVTLVVGDK--EFRAHKAVLAACSPYFKALFSGQESE-SSVSEITLDDVSPEDFEALLEFMYTGKLIS---EE 78

                          90       100
                  ....*....|....*....|....*....
gi 15228868   185 NVYALFIAADKYMIHYLQELCEQYMLSSL 213
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868    124 IPAHRALLASKSEIFKNILDSDGCKtAPEYAITLQELNSEQLQALLEFLYTGTLASDklEKNVYALFIAADKYMIHYLQE 203
Cdd:smart00225  11 FHAHKAVLAAHSPYFKALFSSDFKE-SDKSEIYLDDVSPEDFRALLNFLYTGKLDLP--EENVEELLELADYLQIPGLVE 87

                           90
                   ....*....|
gi 15228868    204 LCEQYMLSSL 213
Cdd:smart00225  88 LCEEFLLKLL 97

BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins. BPM protein, also termed protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15228868 212 SLDISSVLNVLDVSDLGSSKTLKEACVGFVVRNMDDVVFSDKYEPFSQKNQHLCVEI 268
Cdd:cd14736   3 GVDVNTVATTLALAEQHHASQLKAVCLKFVARNLAAVMQTDGFEYLKESCPSLQSEL 59

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868   105 FKEQLHADILLKPGDDgpPIPAHRALLASKSEIFKNILDSDGCKtAPEYAITLQELNSEQLQALLEFLYTGTLASdklEK 184
Cdd:pfam00651   5 REQGELCDVTLVVGDK--EFRAHKAVLAACSPYFKALFSGQESE-SSVSEITLDDVSPEDFEALLEFMYTGKLIS---EE 78

                          90       100
                  ....*....|....*....|....*....
gi 15228868   185 NVYALFIAADKYMIHYLQELCEQYMLSSL 213
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868  97 FLSSFVSGFKEQLHADILLKPGDDGPPIPAHRALLASKSEIFKNILDSDGCKTAPEYAITLQELNSEQLQALLEFLYTGT 176
Cdd:cd18294   1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNC 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 15228868 177 LasdKLE-KNVYALFIAADKYMIHYLQELCEQYM 209
Cdd:cd18294  81 V---TLSnHTVIEVLAAAVEYGLDELRKLCERFI 111

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 105 FKEQLHADILLKPgdDGPPIPAHRALLASKSEIFKNILdSDGCKTAPEYAITLQELNSEQLQALLEFLYTGTlASDKLEK 184
Cdd:cd18300   4 LNKGLFSDVTFIV--EDGTIPAHKALLVARCDVMAAMF-GGNFRESSAKEVELPGVSKETFLALLEYLYTDQ-APILEDG 79

                        90       100
                ....*....|....*....|....*....
gi 15228868 185 NVYALFIAADKYMIHYLQELCEQYMLSSL 213
Cdd:cd18300  80 DCVGLIVLANRLCLPRLVALCEQYIVKEL 108

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 126 AHRALLASKSEIFKNILdSDGCKTAPEYAITLQELNSEQLQALLEFLYTGTLasDKLEKNVYALFIAADKYMIHYLQELC 205
Cdd:cd18314  20 AHRIVLCARSPVFRSML-TGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQV--TLSEENVLDLLMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 110 HADILLKpgDDGPPIPAHRALLASKSEIFKNILDSDGcKTAPEYAITLQELNSEQLQALLEFLYTGTLASDKleKNVYAL 189
Cdd:cd18306  18 FCDVILQ--VGGHEIPAHRAVLACASPYLFELFSSDS-DGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPA--DLVKSV 92

                        90       100
                ....*....|....*....|....*
gi 15228868 190 FIAADKYMIHYLQELCEQYMLSSLD 214
Cdd:cd18306  93 YSAAKKLKMDRVKKACGDFLLEKLT 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 106 KEQLHADILLKPGddGPPIPAHRALLASKSEIFKNILdSDGCKTAPEYAITLQELNSEQLQALLEFLYTGTLASdkLEKN 185
Cdd:cd18250  17 AERKFFDVTLCAG--GREFPCHRTVLAAASSYFRAMF-AGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTV--TQDN 91

                        90       100       110
                ....*....|....*....|....*....|...
gi 15228868 186 VYALFIAADKYMIHYLQELCEQYMLSSLDISSV 218
Cdd:cd18250  92 VEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 112 DILLKPGDDgpPIPAHRALLASKSEIFKNILDSDGCKTAPEyAITLQELNSEQLQALLEFLYTGTLASDklEKNVYALFI 191
Cdd:cd18257  20 DVVLRVGDV--KIHAHKVVLASCSPYFKAMFTGNLSEKENS-EVEFQCIDETALQAIVEYAYTGTVFIS--QATVESLLP 94

                        90       100
                ....*....|....*....|...
gi 15228868 192 AADKYMIHYLQELCEQYMLSSLD 214
Cdd:cd18257  95 AANLLQIKLVLKECCDFLESQLD 117

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 120 DGPPIPAHRALLASKSEIFKNILDSDGCKTAPEYAITLQeLNSEQLQALLEFLYTGTLASDKLEKNVYAL---FIAADKY 196
Cdd:cd18302  14 DGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMP-IPSDILEIILDYLYTDEASAVKESQNVEFLcnvLVIADQL 92

                        90
                ....*....|
gi 15228868 197 MIHYLQELCE 206
Cdd:cd18302  93 LITRLKEICE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 105 FKEQLHADILLKPGddGPPIPAHRALLASKSEIFKNILDSDgCKTAPEYAITLQELNSEQLQALLEFLYTGTLASdkLEK 184
Cdd:cd18345  13 FERSAFSDVTLCVG--GREFQAHKAILAARSPVFNAMFEHE-MEERKQNRVEITDVDHEVMREMLRFIYTGKAPN--LDK 87

                        90       100       110
                ....*....|....*....|....*....|....
gi 15228868 185 NVYALFIAADKYMIHYLQELCEQYMLSSLDISSV 218
Cdd:cd18345  88 MADDLLAAADKYALERLKVMCEEALCSNLSVENV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 124 IPAHRALLASKSEIFKNILDSDgCKTAPEYAITLQELNSEQLQALLEFLYTGTLasDKLEKNVYALFIAADKYMIHYLQE 203
Cdd:cd18234  13 IPAHRLVLSAVSDYFAAMFTND-VREATEEEIKLKDVDPDALWTLVQYCYTGRL--ELKEDNVESLLATACLLQLSEVVE 89

                        90
                ....*....|....*.
gi 15228868 204 LCEQYMLSSLDISSVL 219
Cdd:cd18234  90 ACCGFLMKQLHPSNCL 105

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 105 FKEQLHADILLKpGDDGPPIPAHRALLASKSEIFKNILdsdgcktAPEYAITLQEL-NSEQLQALLEFLYTGTLASDklE 183
Cdd:cd18299   7 LHSPSCADVVFI-LQGGVRIFAHRIVLAAASSVFADLF-------LMMTVVTLDSDiTPEAFRRVLEFLYTGVLDEN--E 76

                        90       100
                ....*....|....*....|....*.
gi 15228868 184 KNVYALFIAADKYMIHYLQELCEQYM 209
Cdd:cd18299  77 DDLKELKDAAELLELFDLVMMCTNVL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 121 GPPIPAHRALLASKSEIFKNILDSDgCKTAPEYAITLQELNSEQLQALLEFLYTGtlASDKLEKNVYALFIAADKYMIHY 200
Cdd:cd18343  30 GQEFKAHKSILAARSPVFNAMFEHE-MEESKKNRVEINDVDPEVFKEMMRFIYTG--KAPNLDKMADNLLAAADKYALER 106

                        90
                ....*....|....*
gi 15228868 201 LQELCEQYMLSSLDI 215
Cdd:cd18343 107 LKVMCEEALCNNLSV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 120 DGPPIPAHRALLASKSEIFKNILDSDGCKTAPE-YAITLQELNSEQLQALLEFLYTGTLASDklEKNVYALFIAADKYMI 198
Cdd:cd18245  22 GGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGStYKIELEGISVEVMEEILDYIYTGQIKLS--EDNIQDIVQAADLLLM 99

                        90
                ....*....|.
gi 15228868 199 HYLQELCEQYM 209
Cdd:cd18245 100 TDLKDLCCEFL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 120 DGPPIPAHRALLASKSEIFKNIL--DSDGCKTAPEYAITLQELNSEQLQALLEFLYTGTLASDklEKNVYALFIAADKYM 197
Cdd:cd18258  25 EGKEFEVHQNVLASCSLYFKDLIkrSSRDSGGGEKLELTMSNINADVLELLLEFVYTGSLIID--SANAKTLLEAANKFQ 102

                        90       100
                ....*....|....*....|..
gi 15228868 198 IHYLQELCEQYMLSSLDISSVL 219
Cdd:cd18258 103 FHTFCKVCVSFLEKQLTASNCL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 112 DILLKPGddGPPIPAHRALLASKSEIFKNILDSdGCKTAPEYAITLQELNSEQLQALLEFLYTGTLASDklEKNVYALFI 191
Cdd:cd18238  17 DVTLKVG--EKSIHCHRLVLACVSPYFRAMFTS-EMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLT--VDNVQSLLY 91

                        90       100
                ....*....|....*....|....*...
gi 15228868 192 AADKYMIHYLQELCEQYMLSSLDISSVL 219
Cdd:cd18238  92 AASLLQVEEVAKACCEFMKDHLHPSNCL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 105 FKEQLHADILLKPGDDGPP--IPAHRALLASKSEIFKNILDSDGCKTAPEYAITlqELNSEQLQALLEFLYTG--TLASD 180
Cdd:cd18282   2 FNNELMADVHFIVGPPGGTqrIPAHKYVLATGSSVFYAMFYGGLAENKNEIEIP--DVEPAAFLNLLRYLYCDeiDLEPD 79

                        90       100       110
                ....*....|....*....|....*....|...
gi 15228868 181 klekNVYALFIAADKYMIHYLQELCEQYMLSSL 213
Cdd:cd18282  80 ----TVLATLYAAKKYLVPHLARACVQFLETSL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 126 AHRALLASKSEIFKNILDSDgCKTAPEYAITLQELNSEQLQALLEFLYTGTlaSDKLEKNVYALFIAADKYMIHYLQELC 205
Cdd:cd18279  32 AHKAILAARSPVFSAMFEHE-MEESKKNRVEINDVDPEVFKEMMRFIYTGK--APNLDKMADDLLAAADKYALERLKVMC 108

                        90
                ....*....|..
gi 15228868 206 EQYMLSSLDISS 217
Cdd:cd18279 109 EDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 106 KEQLHADILLKPgdDGPPIPAHRALLASKSEIFKNILDSdGCKTAPEYAITLQELNSEQLQALLEFLYTGTLasDKLEKN 185
Cdd:cd18240  13 LEGKLCDVVIRV--NGVEFPAHRNILCACSPYFRALFTN-GWNETEKKVYKIPGVSPEMMELIIEYAYTRTV--PITAEN 87

                        90       100
                ....*....|....*....|....*...
gi 15228868 186 VYALFIAADKYMIHYLQELCEQYMLSSL 213
Cdd:cd18240  88 VEELLPAADQFNIMGIVKACCDFLEDQL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868  83 NMKETEEEQKKRIVFLssfvsgFKEQLHADI--LLKPGDDGPPIPAHRALLASKSEIFKNILDSDGCKTAPEyaITLQEL 160
Cdd:cd18281   1 NWQASKTTVKERFAFL------FNNETLSDVhfIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAE--IELPDV 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15228868 161 NSEQLQALLEFLYtgtlaSDKLE---KNVYALFIAADKYMIHYLQELCEQYMLSSL 213
Cdd:cd18281  73 EPAAFLALLRFLY-----SDEVQigpETVMTTLYTAKKYAVPALESACVEFLKKNL 123

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15228868 120 DGPPIPAHRALLASKSEIFKNILDSDGCKTAPEyaITLQELNSEQLQALLEFLYTGT 176
Cdd:cd18315   9 EGGSLKAHKLVLAAASPYFAALLKETPPDEHPV--IILPDVPYSELKALLDFIYTGE 63

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868  124 IPAHRALLASKSEIFKNILdsdgCKTAPEYAITLQeLNSEQLQALLEFLYTG--TLASDKLEKnvyaLFIAADKYMIHYL 201
Cdd:PHA03098  23 IKVHKIILSSSSEYFKKMF----KNNFKENEINLN-IDYDSFNEVIKYIYTGkiNITSNNVKD----ILSIANYLIIDFL 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 15228868  202 QELCEQYMLSSLDISSVLNVLDVSDLGSSKTLKEACVGFVVRN 244
Cdd:PHA03098  94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNN 136

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 106 KEQLHADILLKPgdDGPPIPAHRALLASKSEIFKNILDSDGCKTAPEYaITLQELNSEQLQALLEFLYTGTLasDKLEKN 185
Cdd:cd18242  17 KSNTLCDVTLRV--EGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSE-VELQGLTASTMEILLDFVYTETV--HVTVEN 91

                        90       100       110
                ....*....|....*....|....*....|...
gi 15228868 186 VYALFIAADKYMIHYLQELCEQYMLSSLDISSV 218
Cdd:cd18242  92 VQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 105 FKEQLHADILLKPgdDGPPIPAHRALLASKSEIFKNILDSDGCKTAPEYaITLQELNSEQLQALLEFLYTGTLASDKlEK 184
Cdd:cd18286  12 FLNGEDSDITIKV--DGKTFKAHRCILCARSSYFAAMLSGSWAESNSSE-ITLTGVSHAAVSFVLLFIYGGVLDLPD-DV 87

                        90       100
                ....*....|....*....|....
gi 15228868 185 NVYALFIAADKYMIHYLQELCEQY 208
Cdd:cd18286  88 NLGELLSLADMYGLDGLKDVVAYT 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 111 ADILLKPGddGPPIPAHRALLASKSEIFKNILDSDGCKTAPEyAITLQELNSEQLQALLEFLYTGTLASDKleKNVYALF 190
Cdd:cd18259  33 SDVTLLVG--GREFPCHRSVLALCSHYFNAMFTGDFVESISA-RVEIKDVDPAVMESLIDFAYTGKLTINQ--GNVEALI 107

                        90       100
                ....*....|....*....|....*....
gi 15228868 191 IAADKYMIHYLQELCEQYMLSSLDISSVL 219
Cdd:cd18259 108 RTSNRLQFPTVRKVCSRYLQQQIDATNCL 136

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 125 PAHRALLASKSEIFKNILDSDGCKTAPEY----AITLQELNSEQLQALLEFLYTGtlASDKLEKNVYALFIAADKYMIHY 200
Cdd:cd18296  30 PCHKAFFCGRSDYFKALLRDHFAESEENNgsipVVTLHDVSPEVFAIVLYYIYTD--DTDLPPENAYDVLYVADMYLLPG 107

                        90
                ....*....|....
gi 15228868 201 LQELCEQYMLSSLD 214
Cdd:cd18296 108 LKRLCGTVLAQSLD 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 119 DDGPPIPAHRALLASKSEIFKNILDSDGCKTAPEYaITLQELNSEQLQALLEFLYTGTLASDKLEKNVYALFIAADKYMI 198
Cdd:cd18313   9 DNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKV-IKILGVPCDAVRVFIRFLYSSCYEEEEMEKFGIHLLVLSHVYVV 87

                        90
                ....*....|....*
gi 15228868 199 HYLQELCEQYMLSSL 213
Cdd:cd18313  88 PQLKRVCEKGLEQGL 102

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228868 120 DGPPIPAHR-ALLASkSEIFKNILDSdGCKTAPEYAITLQELNSEQLQALLEFLYTGTLasDKLEKNVYALFIAADKYMI 198
Cdd:cd18352  21 EGRRFYAHRiALLAS-SDAFRAMFDG-GYREKEARDIEIPNIRWEVFELMMRFIYTGSV--DITNDIAKDLLRAADQYLL 96