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Conserved domains on  [gi|15228867|ref|NP_191181|]
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transcription regulator [Arabidopsis thaliana]

Protein Classification

basic helix-loop-helix domain-containing protein( domain architecture ID 385)

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor

CATH:  4.10.280.10
Gene Ontology:  GO:0003677|GO:0046983
PubMed:  20219281|15186484|1755826|8018712
SCOP:  4000913

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bHLH_SF super family cl00081
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 5-65 1.66e-04

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


The actual alignment was detected with superfamily member cd18918:

Pssm-ID: 469605 [Multi-domain]  Cd Length: 70  Bit Score: 38.08  E-value: 1.66e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15228867   5 EHKRGSSLREKFHLLRS-ITDSHAESETSIIVDASKYIKKLKQKVEKINNATTSEQSFRESS 65
Cdd:cd18918   5 ERERREKLNEKFSDLRNlIPNPTKNDRASILSDAIKYINELQRTVEELKSLVEKKRCGERDR 66
 
Name Accession Description Interval E-value
bHLH_AtMYC1_like cd18918
basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; ...
 5-65 1.66e-04

basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; MYC1, also termed AtbHLH12, or EN 58, acts as a transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2.


Pssm-ID: 381488 [Multi-domain]  Cd Length: 70  Bit Score: 38.08  E-value: 1.66e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15228867   5 EHKRGSSLREKFHLLRS-ITDSHAESETSIIVDASKYIKKLKQKVEKINNATTSEQSFRESS 65
Cdd:cd18918   5 ERERREKLNEKFSDLRNlIPNPTKNDRASILSDAIKYINELQRTVEELKSLVEKKRCGERDR 66
HLH smart00353
helix loop helix domain;
4-50 6.29e-03

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 33.35  E-value: 6.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 15228867      4 REHKRGSSLREKFHLLRS-ITDSHAESETS---IIVDASKYIKKLKQKVEK 50
Cdd:smart00353   3 RERRRRRKINEAFDELRSlLPTLPKNKKLSkaeILRLAIEYIKSLQEELQK 53
 
Name Accession Description Interval E-value
bHLH_AtMYC1_like cd18918
basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; ...
 5-65 1.66e-04

basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; MYC1, also termed AtbHLH12, or EN 58, acts as a transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2.


Pssm-ID: 381488 [Multi-domain]  Cd Length: 70  Bit Score: 38.08  E-value: 1.66e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15228867   5 EHKRGSSLREKFHLLRS-ITDSHAESETSIIVDASKYIKKLKQKVEKINNATTSEQSFRESS 65
Cdd:cd18918   5 ERERREKLNEKFSDLRNlIPNPTKNDRASILSDAIKYINELQRTVEELKSLVEKKRCGERDR 66
HLH smart00353
helix loop helix domain;
4-50 6.29e-03

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 33.35  E-value: 6.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 15228867      4 REHKRGSSLREKFHLLRS-ITDSHAESETS---IIVDASKYIKKLKQKVEK 50
Cdd:smart00353   3 RERRRRRKINEAFDELRSlLPTLPKNKKLSkaeILRLAIEYIKSLQEELQK 53
bHLH_AtTT8_like cd11451
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 ...
 5-65 6.34e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 (TT8) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as TT8, EGL1, and GL3. TT8, also termed AtbHLH42, or EN 32, is involved in the control of flavonoid pigmentation and plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). EGL1, also termed AtbHLH2, or EN 30, or AtMYC146, or protein enhancer of GLABRA 3, is involved in epidermal cell fate specification and regulates negatively stomata formation but promotes trichome formation. GL3, also termed AtbHLH1, or AtMYC6, or protein shapeshifter, or EN 31, is involved in epidermal cell fate specification. It regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication.


Pssm-ID: 381457  Cd Length: 75  Bit Score: 33.93  E-value: 6.34e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15228867   5 EHKRGSSLREKFHLLRSITDSHAE-SETSIIVDASKYIKKLKQKVEKINNATTSEQSFRESS 65
Cdd:cd11451  10 ERRRREKLNERFITLRSMVPFVTKmDKVSILGDAIEYLKQLQRRVEELESRRKSSDTETRPT 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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