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Conserved domains on  [gi|15230522|ref|NP_190724|]
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Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Protein Classification

disease resistance family protein( domain architecture ID 1000118)

disease resistance family protein similar to Nicotiana glutinosa TMV resistance protein N; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein

Gene Ontology:  GO:0006952

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 6-858 5.90e-120

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 400.79  E-value: 5.90e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522     6 DVYISFdrSEDTVRYSFVSHLCAAFRRRGISSFIRENGSDSES---NGFSKLETSRASVVVFSEKYSSSKSCMEELVKVS 82
Cdd:PLN03210   14 DVFPSF--SGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSldpELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522    83 ERRRKNCLAVVPVFYPVTKSFMKKQIWNLG------------DVRSDWPSALLETVDLPGHELYDTQSDSDFVEEIVADV 150
Cdd:PLN03210   92 RCKEELGQLVIPVFYGLDPSHVRKQTGDFGeafektcqnkteDEKIQWKQALTDVANILGYHSQNWPNEAKMIEEIANDV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   151 REKLNMS------DNIGIYSKLGKIETLIYKQPWGVRSIGIWGMPGIGKTTLAKAAFDQLSGDYEASCFIkdfNKAFHEK 224
Cdd:PLN03210  172 LGKLNLTpsndfeDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI---DRAFISK 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   225 GLYGLLEAHF----------GKILREELGIKS-SITRPILLRNVLRHKRVLVVLDDVCKPLDAESFLGGFDWFCPGSLII 293
Cdd:PLN03210  249 SMEIYSSANPddynmklhlqRAFLSEILDKKDiKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGSRII 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   294 ITSRDKQVFSICRVDQIYEVPGLNEEEALQLFSRCAFGKEIIHESLQKLSKKVIDYANGNPLALIFFGCMSRKNPKPIEI 373
Cdd:PLN03210  329 VITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKEDWM 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   374 -AFPKVKKYLAHEIHDAVKSTYDSLSS-NEKNIFLDIACLFRGENVDCVIHLLEGCGFFPRVEINVLVEKCLVSMAEGRV 451
Cdd:PLN03210  409 dMLPRLRNGLDGKIEKTLRVSYDGLNNkKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHVREDIV 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   452 VMHNLIQSIGRKII----NGGKRRSRLWKPLIIKYFLEDRQvlGSEDIEAIFLDPSAL-SFDVNPMAFENMYNLRYLKIC 526
Cdd:PLN03210  489 EMHSLLQEMGKEIVraqsNEPGEREFLVDAKDICDVLEDNT--GTKKVLGITLDIDEIdELHIHENAFKGMRNLLFLKFY 566

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   527 SSNPG--NHYALHLPKGVKSLPEELRLLHWEHFPLLSLPQDFNTRNLVILNMCYSKLQRLWEGTKELGMLKRIMLCHSQQ 604
Cdd:PLN03210  567 TKKWDqkKEVRWHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKN 646

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   605 LVGIQELQIALNMEVIDLQGCARLQRF-----------------------LATG-HFQHLRVINLSGCIKIKSFPEVPPN 660
Cdd:PLN03210  647 LKEIPDLSMATNLETLKLSDCSSLVELpssiqylnkledldmsrcenleiLPTGiNLKSLYRLNLSGCSRLKSFPDISTN 726

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   661 IEELYLKQTGIRSIPT-VTFSPQDNSFIYDHKDHKFLNREvssdsQSLSIMVYLdnlkvldlsqclelediqgIPKNLRK 739
Cdd:PLN03210  727 ISWLDLDETAIEEFPSnLRLENLDELILCEMKSEKLWERV-----QPLTPLMTM-------------------LSPSLTR 782

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   740 LYLGGT-AIKELPSLMH-LSELVVLDLENCKRLHKLPMGIgNLSSLAVLNLSGCSELEDIQGIPRNLEELYLAGTAIQEV 817
Cdd:PLN03210  783 LFLSDIpSLVELPSSIQnLHKLEHLEIENCINLETLPTGI-NLESLESLDLSGCSRLRTFPDISTNISDLNLSRTGIEEV 861

                         890       900       910       920
                  ....*....|....*....|....*....|....*....|.
gi 15230522   818 TSLIKHLSELVVLDLQNCKRLQHLPMEISNLKSLVTLKLTD 858
Cdd:PLN03210  862 PWWIEKFSNLSFLDMNGCNNLQRVSLNISKLKHLETVDFSD 902
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 756-973 1.14e-04

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   756 LSELVVLDLENCKRLHKLPMGIGNLSSLAVLNLSGCselediqgiprnleelYLAGtaiqEVTSLIKHLSELVVLDLQNC 835
Cdd:PLN00113  139 IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN----------------VLVG----KIPNSLTNLTSLEFLTLASN 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   836 KRLQHLPMEISNLKSL--VTLKLTDPSGmsirEVSTSIIQngiseigISNLNYLLLTFNENAEQ---------RREYLpr 904
Cdd:PLN00113  199 QLVGQIPRELGQMKSLkwIYLGYNNLSG----EIPYEIGG-------LTSLNHLDLVYNNLTGPipsslgnlkNLQYL-- 265

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15230522   905 pRLPSSSLHGLVPR----FYALVSLSLFNASLM-HIPEEICSLPSVVLLDLGRNGFS-KIPESIKQLSKLHSLRL 973
Cdd:PLN00113  266 -FLYQNKLSGPIPPsifsLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQL 339
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 6-858 5.90e-120

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 400.79  E-value: 5.90e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522     6 DVYISFdrSEDTVRYSFVSHLCAAFRRRGISSFIRENGSDSES---NGFSKLETSRASVVVFSEKYSSSKSCMEELVKVS 82
Cdd:PLN03210   14 DVFPSF--SGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSldpELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522    83 ERRRKNCLAVVPVFYPVTKSFMKKQIWNLG------------DVRSDWPSALLETVDLPGHELYDTQSDSDFVEEIVADV 150
Cdd:PLN03210   92 RCKEELGQLVIPVFYGLDPSHVRKQTGDFGeafektcqnkteDEKIQWKQALTDVANILGYHSQNWPNEAKMIEEIANDV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   151 REKLNMS------DNIGIYSKLGKIETLIYKQPWGVRSIGIWGMPGIGKTTLAKAAFDQLSGDYEASCFIkdfNKAFHEK 224
Cdd:PLN03210  172 LGKLNLTpsndfeDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI---DRAFISK 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   225 GLYGLLEAHF----------GKILREELGIKS-SITRPILLRNVLRHKRVLVVLDDVCKPLDAESFLGGFDWFCPGSLII 293
Cdd:PLN03210  249 SMEIYSSANPddynmklhlqRAFLSEILDKKDiKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGSRII 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   294 ITSRDKQVFSICRVDQIYEVPGLNEEEALQLFSRCAFGKEIIHESLQKLSKKVIDYANGNPLALIFFGCMSRKNPKPIEI 373
Cdd:PLN03210  329 VITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKEDWM 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   374 -AFPKVKKYLAHEIHDAVKSTYDSLSS-NEKNIFLDIACLFRGENVDCVIHLLEGCGFFPRVEINVLVEKCLVSMAEGRV 451
Cdd:PLN03210  409 dMLPRLRNGLDGKIEKTLRVSYDGLNNkKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHVREDIV 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   452 VMHNLIQSIGRKII----NGGKRRSRLWKPLIIKYFLEDRQvlGSEDIEAIFLDPSAL-SFDVNPMAFENMYNLRYLKIC 526
Cdd:PLN03210  489 EMHSLLQEMGKEIVraqsNEPGEREFLVDAKDICDVLEDNT--GTKKVLGITLDIDEIdELHIHENAFKGMRNLLFLKFY 566

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   527 SSNPG--NHYALHLPKGVKSLPEELRLLHWEHFPLLSLPQDFNTRNLVILNMCYSKLQRLWEGTKELGMLKRIMLCHSQQ 604
Cdd:PLN03210  567 TKKWDqkKEVRWHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKN 646

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   605 LVGIQELQIALNMEVIDLQGCARLQRF-----------------------LATG-HFQHLRVINLSGCIKIKSFPEVPPN 660
Cdd:PLN03210  647 LKEIPDLSMATNLETLKLSDCSSLVELpssiqylnkledldmsrcenleiLPTGiNLKSLYRLNLSGCSRLKSFPDISTN 726

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   661 IEELYLKQTGIRSIPT-VTFSPQDNSFIYDHKDHKFLNREvssdsQSLSIMVYLdnlkvldlsqclelediqgIPKNLRK 739
Cdd:PLN03210  727 ISWLDLDETAIEEFPSnLRLENLDELILCEMKSEKLWERV-----QPLTPLMTM-------------------LSPSLTR 782

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   740 LYLGGT-AIKELPSLMH-LSELVVLDLENCKRLHKLPMGIgNLSSLAVLNLSGCSELEDIQGIPRNLEELYLAGTAIQEV 817
Cdd:PLN03210  783 LFLSDIpSLVELPSSIQnLHKLEHLEIENCINLETLPTGI-NLESLESLDLSGCSRLRTFPDISTNISDLNLSRTGIEEV 861

                         890       900       910       920
                  ....*....|....*....|....*....|....*....|.
gi 15230522   818 TSLIKHLSELVVLDLQNCKRLQHLPMEISNLKSLVTLKLTD 858
Cdd:PLN03210  862 PWWIEKFSNLSFLDMNGCNNLQRVSLNISKLKHLETVDFSD 902
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
692-993 4.56e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 4.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  692 DHKFLNREVSSDSQSLSIMVYLDNLKVLDLSQCLELEDIQGIPKNLRKLYLGGTaikelPSLMHLSELVVLDLENCKrLH 771
Cdd:COG4886   53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQ-LT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  772 KLPMGIGNLSSLAVLNLSGC--SEL-EDIQGIPrNLEELYLAGTAIQEVTSLIKHLSELVVLDLQNCKrLQHLPMEISNL 848
Cdd:COG4886  127 DLPEELANLTNLKELDLSNNqlTDLpEPLGNLT-NLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  849 KSLVTLKLTDpsgmsirevstsiiqNGISEIG--ISNLNyllltfnenaeqrreylprprlpssslhglvprfyALVSLS 926
Cdd:COG4886  205 TNLEELDLSG---------------NQLTDLPepLANLT-----------------------------------NLETLD 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15230522  927 LFNASLMHIPEeICSLPSVVLLDLGRNGFSKIPESiKQLSKLHSLRLRHCR----NLILLPALPQSLKLLN 993
Cdd:COG4886  235 LSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQltdlKLKELELLLGLNSLLL 303
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 6-155 1.32e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 90.12  E-value: 1.32e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522      6 DVYISFdRSEDTVRYsFVSHLCAAFRRRGISSFIREN----GSDSESNGFSKLETSRASVVVFSEKYSSSKSCMEELVKV 81
Cdd:pfam01582    2 DVFLSF-RGSDTREW-FVSHLLKELKQKGIKLFIDDRdlepGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522     82 SERRRKNCLAVVPVFYPVTKSFMKKQIWNLGDV------------RSDWPSALLETVDLPGHElyDTQSDSDFVEEIVAD 149
Cdd:pfam01582   80 LECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAfkkhkkvlteekVLKWRGALNEVANIWHSK--SVSDESKFWKKIAYD 157


                   ....*.
gi 15230522    150 VREKLN 155
Cdd:pfam01582  158 ISNKLN 163
TIR smart00255
Toll - interleukin 1 - resistance;
6-114 5.50e-18

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 81.60  E-value: 5.50e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522       6 DVYISFdRSEDTVRYSFVSHLCAAFRRRGISSFIREN--GSDSESNGFSKLETSRASVVVFSEKYSSSKSCMEELVK-VS 82
Cdd:smart00255    3 DVFISY-SGKEDVRNEFLSHLLEKLRGYGLCVFIDDFepGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAaLE 81

                            90       100       110
                    ....*....|....*....|....*....|..
gi 15230522      83 ERRRKNCLAVVPVFYPVTKSFMKKQIWNLGDV 114
Cdd:smart00255   82 NALEEGGLRVIPIFYEVIPSDVRKQPGKFRKV 113
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 713-835 6.36e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 6.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  713 LDNLKVLDLS--QCLELEDIQGIpKNLRKLYLGGTAIKELPSLMHLSELVVLDLENCK-----RLHKLPMGIGNLS-SLA 784
Cdd:cd21340   45 LTNLTHLYLQnnQIEKIENLENL-VNLKKLYLGGNRISVVEGLENLTNLEELHIENQRlppgeKLTFDPRSLAALSnSLR 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15230522  785 VLNLSGC--SELEDIQGIpRNLEELYLAG---TAIQEVTSLIKHLSELVVLDLQNC 835
Cdd:cd21340  124 VLNISGNniDSLEPLAPL-RNLEQLDASNnqiSDLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 756-973 1.14e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   756 LSELVVLDLENCKRLHKLPMGIGNLSSLAVLNLSGCselediqgiprnleelYLAGtaiqEVTSLIKHLSELVVLDLQNC 835
Cdd:PLN00113  139 IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN----------------VLVG----KIPNSLTNLTSLEFLTLASN 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   836 KRLQHLPMEISNLKSL--VTLKLTDPSGmsirEVSTSIIQngiseigISNLNYLLLTFNENAEQ---------RREYLpr 904
Cdd:PLN00113  199 QLVGQIPRELGQMKSLkwIYLGYNNLSG----EIPYEIGG-------LTSLNHLDLVYNNLTGPipsslgnlkNLQYL-- 265

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15230522   905 pRLPSSSLHGLVPR----FYALVSLSLFNASLM-HIPEEICSLPSVVLLDLGRNGFS-KIPESIKQLSKLHSLRL 973
Cdd:PLN00113  266 -FLYQNKLSGPIPPsifsLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQL 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
841-1012 2.31e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  841 LPMEISNLKSLVTLKLTDPSGMSIREVSTSIIQNGISEIGISNLNYLLLTFNENAEQRREYLPRPRLPSSSLHGLVPRFY 920
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  921 ALVSLSLFNASlmhIPEEICSLPSVVLLDLGRNGFSKIPESIKQLSKLHSLRLRHCRNLILLPALPQ--SLKLLNVHGCv 998
Cdd:COG4886   94 DLTNLTELDLS---GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNN- 169

                        170
                 ....*....|....
gi 15230522  999 SLESVSWGFEQFPS 1012
Cdd:COG4886  170 QLTDLPEELGNLTN 183
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 6-858 5.90e-120

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 400.79  E-value: 5.90e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522     6 DVYISFdrSEDTVRYSFVSHLCAAFRRRGISSFIRENGSDSES---NGFSKLETSRASVVVFSEKYSSSKSCMEELVKVS 82
Cdd:PLN03210   14 DVFPSF--SGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSldpELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522    83 ERRRKNCLAVVPVFYPVTKSFMKKQIWNLG------------DVRSDWPSALLETVDLPGHELYDTQSDSDFVEEIVADV 150
Cdd:PLN03210   92 RCKEELGQLVIPVFYGLDPSHVRKQTGDFGeafektcqnkteDEKIQWKQALTDVANILGYHSQNWPNEAKMIEEIANDV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   151 REKLNMS------DNIGIYSKLGKIETLIYKQPWGVRSIGIWGMPGIGKTTLAKAAFDQLSGDYEASCFIkdfNKAFHEK 224
Cdd:PLN03210  172 LGKLNLTpsndfeDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI---DRAFISK 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   225 GLYGLLEAHF----------GKILREELGIKS-SITRPILLRNVLRHKRVLVVLDDVCKPLDAESFLGGFDWFCPGSLII 293
Cdd:PLN03210  249 SMEIYSSANPddynmklhlqRAFLSEILDKKDiKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGSRII 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   294 ITSRDKQVFSICRVDQIYEVPGLNEEEALQLFSRCAFGKEIIHESLQKLSKKVIDYANGNPLALIFFGCMSRKNPKPIEI 373
Cdd:PLN03210  329 VITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKEDWM 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   374 -AFPKVKKYLAHEIHDAVKSTYDSLSS-NEKNIFLDIACLFRGENVDCVIHLLEGCGFFPRVEINVLVEKCLVSMAEGRV 451
Cdd:PLN03210  409 dMLPRLRNGLDGKIEKTLRVSYDGLNNkKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHVREDIV 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   452 VMHNLIQSIGRKII----NGGKRRSRLWKPLIIKYFLEDRQvlGSEDIEAIFLDPSAL-SFDVNPMAFENMYNLRYLKIC 526
Cdd:PLN03210  489 EMHSLLQEMGKEIVraqsNEPGEREFLVDAKDICDVLEDNT--GTKKVLGITLDIDEIdELHIHENAFKGMRNLLFLKFY 566

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   527 SSNPG--NHYALHLPKGVKSLPEELRLLHWEHFPLLSLPQDFNTRNLVILNMCYSKLQRLWEGTKELGMLKRIMLCHSQQ 604
Cdd:PLN03210  567 TKKWDqkKEVRWHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKN 646

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   605 LVGIQELQIALNMEVIDLQGCARLQRF-----------------------LATG-HFQHLRVINLSGCIKIKSFPEVPPN 660
Cdd:PLN03210  647 LKEIPDLSMATNLETLKLSDCSSLVELpssiqylnkledldmsrcenleiLPTGiNLKSLYRLNLSGCSRLKSFPDISTN 726

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   661 IEELYLKQTGIRSIPT-VTFSPQDNSFIYDHKDHKFLNREvssdsQSLSIMVYLdnlkvldlsqclelediqgIPKNLRK 739
Cdd:PLN03210  727 ISWLDLDETAIEEFPSnLRLENLDELILCEMKSEKLWERV-----QPLTPLMTM-------------------LSPSLTR 782

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   740 LYLGGT-AIKELPSLMH-LSELVVLDLENCKRLHKLPMGIgNLSSLAVLNLSGCSELEDIQGIPRNLEELYLAGTAIQEV 817
Cdd:PLN03210  783 LFLSDIpSLVELPSSIQnLHKLEHLEIENCINLETLPTGI-NLESLESLDLSGCSRLRTFPDISTNISDLNLSRTGIEEV 861

                         890       900       910       920
                  ....*....|....*....|....*....|....*....|.
gi 15230522   818 TSLIKHLSELVVLDLQNCKRLQHLPMEISNLKSLVTLKLTD 858
Cdd:PLN03210  862 PWWIEKFSNLSFLDMNGCNNLQRVSLNISKLKHLETVDFSD 902
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
692-993 4.56e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 4.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  692 DHKFLNREVSSDSQSLSIMVYLDNLKVLDLSQCLELEDIQGIPKNLRKLYLGGTaikelPSLMHLSELVVLDLENCKrLH 771
Cdd:COG4886   53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQ-LT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  772 KLPMGIGNLSSLAVLNLSGC--SEL-EDIQGIPrNLEELYLAGTAIQEVTSLIKHLSELVVLDLQNCKrLQHLPMEISNL 848
Cdd:COG4886  127 DLPEELANLTNLKELDLSNNqlTDLpEPLGNLT-NLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  849 KSLVTLKLTDpsgmsirevstsiiqNGISEIG--ISNLNyllltfnenaeqrreylprprlpssslhglvprfyALVSLS 926
Cdd:COG4886  205 TNLEELDLSG---------------NQLTDLPepLANLT-----------------------------------NLETLD 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15230522  927 LFNASLMHIPEeICSLPSVVLLDLGRNGFSKIPESiKQLSKLHSLRLRHCR----NLILLPALPQSLKLLN 993
Cdd:COG4886  235 LSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQltdlKLKELELLLGLNSLLL 303
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 6-155 1.32e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 90.12  E-value: 1.32e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522      6 DVYISFdRSEDTVRYsFVSHLCAAFRRRGISSFIREN----GSDSESNGFSKLETSRASVVVFSEKYSSSKSCMEELVKV 81
Cdd:pfam01582    2 DVFLSF-RGSDTREW-FVSHLLKELKQKGIKLFIDDRdlepGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522     82 SERRRKNCLAVVPVFYPVTKSFMKKQIWNLGDV------------RSDWPSALLETVDLPGHElyDTQSDSDFVEEIVAD 149
Cdd:pfam01582   80 LECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAfkkhkkvlteekVLKWRGALNEVANIWHSK--SVSDESKFWKKIAYD 157


                   ....*.
gi 15230522    150 VREKLN 155
Cdd:pfam01582  158 ISNKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
699-996 1.84e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.77  E-value: 1.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  699 EVSSDSQSLSIMVYLDNLKVLDLSQCLELEDIQGIPKNLRKLYLGGTAIKELPSLMHLSELVVLDLENCKRLHKLPMGIG 778
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  779 NLSSLAVLNLSGCSELEDIQgiprNLEELYLAGTAIQEVTSLIKHLSELVVLDLQNCKrLQHLPMEISNLKSLVTLKLTD 858
Cdd:COG4886   94 DLTNLTELDLSGNEELSNLT----NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ-LTDLPEPLGNLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  859 psgmsirevstsiiqNGISEIgisnlnyllltfnenaeqrreylprprlpSSSLHGLVprfyALVSLSLFNASLMHIPEE 938
Cdd:COG4886  169 ---------------NQLTDL-----------------------------PEELGNLT----NLKELDLSNNQITDLPEP 200

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  939 ICSLPSVVLLDLGRNGFSKIPESIKQLSKLHSLRLRHCRnLILLPALPQ--SLKLLNVHG 996
Cdd:COG4886  201 LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ-LTDLPELGNltNLEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
559-897 4.53e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 4.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  559 LLSLPQDFNTRNLVILNMCYSKLQRLWEGTKELGMLKRIMLCHSQQLVGIQELQIALNMEVIDLQGCARLQRFLATGHFQ 638
Cdd:COG4886   57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLT 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  639 HLRVINLSGCiKIKSFPEV---PPNIEELYLKQTGIRSIPTVtfspqdnsfiydhkdhkflnrevssdsqslsimvyLDN 715
Cdd:COG4886  137 NLKELDLSNN-QLTDLPEPlgnLTNLKSLDLSNNQLTDLPEE-----------------------------------LGN 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  716 LkvldlsqclelediqgipKNLRKLYLGGTAIKELP-SLMHLSELVVLDLENCKrLHKLPMGIGNLSSLAVLNLSGC--S 792
Cdd:COG4886  181 L------------------TNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNqlT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  793 ELEDIQGIPrNLEELYLAGTAIQEVTSLiKHLSELVVLDLQNCKrLQHLPMEISNLKSLVTLKLTDPSGMSIREVSTSII 872
Cdd:COG4886  242 DLPELGNLT-NLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQ-LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                        330       340
                 ....*....|....*....|....*
gi 15230522  873 QNGISEIGISNLNYLLLTFNENAEQ 897
Cdd:COG4886  319 LLTTLLLLLLLLKGLLVTLTTLALS 343
TIR smart00255
Toll - interleukin 1 - resistance;
6-114 5.50e-18

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 81.60  E-value: 5.50e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522       6 DVYISFdRSEDTVRYSFVSHLCAAFRRRGISSFIREN--GSDSESNGFSKLETSRASVVVFSEKYSSSKSCMEELVK-VS 82
Cdd:smart00255    3 DVFISY-SGKEDVRNEFLSHLLEKLRGYGLCVFIDDFepGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAaLE 81

                            90       100       110
                    ....*....|....*....|....*....|..
gi 15230522      83 ERRRKNCLAVVPVFYPVTKSFMKKQIWNLGDV 114
Cdd:smart00255   82 NALEEGGLRVIPIFYEVIPSDVRKQPGKFRKV 113
NB-ARC pfam00931
NB-ARC domain;
143-399 5.69e-18

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 84.74  E-value: 5.69e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522    143 VEEIVADVREKLNMSDNIGIysklgkietliykqpwgvrsIGIWGMPGIGKTTLAKAAF---DQLSGDYEASCFIKDfNK 219
Cdd:pfam00931    1 REDMVEKVIGKLSEKDEPGI--------------------VGIHGMGGVGKTTLAAQIFndfDEVEGHFDSVAWVVV-SK 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522    220 AFHEKGLYGLLEAHFGKILrEELGIKSSITRPILLRNVLRHKRVLVVLDDVCKPLDAESFLGGFDWFCPGSLIIITSRDK 299
Cdd:pfam00931   60 TFTISTLQQTILQNLGLSE-DDWDNKEEGELARKIRRALLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSE 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522    300 QVFSicRVDQIYEVP---GLNEEEALQLFSRCAFGKEI-IHESLQKLSKKVIDYANGNPLALIFFG-CMSRKNpkpieia 374
Cdd:pfam00931  139 EVAG--RVGGPSDPHeveLLEPDEAWELFENKVFPKTLgECELLEDVAKEIVEKCRGLPLALKVLGgLLSCKK------- 209

                          250       260
                   ....*....|....*....|....*
gi 15230522    375 FPKVKKYLAHEIHDAVKSTYDSLSS 399
Cdd:pfam00931  210 TVEEWKHVYDVLQSELKSNSYSLNS 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
550-899 3.32e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 3.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  550 RLLHWEHFPLLSLPQDFNTRNLVILNMCYSKLQRLWEGTKELGMLKRIMLCHSQqlvgIQELQIAL----NMEVIDLQGC 625
Cdd:COG4886   94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ----LTDLPEPLgnltNLKSLDLSNN 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  626 aRLQRF-LATGHFQHLRVINLSGCiKIKSFPEV---PPNIEELYLKQTGIRSIPtvtfspqdnsfiydhkdhkflnrevs 701
Cdd:COG4886  170 -QLTDLpEELGNLTNLKELDLSNN-QITDLPEPlgnLTNLEELDLSGNQLTDLP-------------------------- 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  702 sdsQSLSimvYLDNLKVLDLSQClELEDIQGIP--KNLRKLYLGGTAIKELPSLMHLSELVVLDLENCKRLHKLPMGIGN 779
Cdd:COG4886  222 ---EPLA---NLTNLETLDLSNN-QLTDLPELGnlTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  780 LSSLAVLNLSGCSELEDIQGIPRNLEELYLAGTAIQEVTSLIKHLSELVVLDLQNCKRLQHLPMEISNLKSLVTLKLTDP 859
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 15230522  860 SGMSIREVSTSIIQNGISEIGISNLNYLLLTFNENAEQRR 899
Cdd:COG4886  375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 713-835 6.36e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 6.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  713 LDNLKVLDLS--QCLELEDIQGIpKNLRKLYLGGTAIKELPSLMHLSELVVLDLENCK-----RLHKLPMGIGNLS-SLA 784
Cdd:cd21340   45 LTNLTHLYLQnnQIEKIENLENL-VNLKKLYLGGNRISVVEGLENLTNLEELHIENQRlppgeKLTFDPRSLAALSnSLR 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15230522  785 VLNLSGC--SELEDIQGIpRNLEELYLAG---TAIQEVTSLIKHLSELVVLDLQNC 835
Cdd:cd21340  124 VLNISGNniDSLEPLAPL-RNLEQLDASNnqiSDLEELLDLLSSWPSLRELDLTGN 178
COG3903 COG3903
Predicted ATPase [General function prediction only];
179-329 8.27e-08

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 56.95  E-value: 8.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  179 GVRSIGIWGMPGIGKTTLAKAAFDQLSGDY-EASCFIkDFNkAFHEKGLygLLEAhfgkILREeLGIKSSITRPIL--LR 255
Cdd:COG3903  175 AARLVTLTGPGGVGKTRLALEVAHRLADRFpDGVWFV-DLA-GVTDPAL--VLAA----VARA-LGVRDAPGRDPAarLR 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  256 NVLRHKRVLVVLD------DVCKPLdAESFLGGfdwfCPGSLIIITSRdkQVFsicRVD--QIYEVPGL---------NE 318
Cdd:COG3903  246 AALADRRLLLVLDncehvvDAAAAL-VRPLLPA----APGLRVLATSR--EPL---GLPgeRVLPLPPLavpppgaeaLA 315

                        170
                 ....*....|.
gi 15230522  319 EEALQLFSRCA 329
Cdd:COG3903  316 SEAVALFVERA 326
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
106-461 2.68e-07

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 55.20  E-value: 2.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  106 KQIWNLGDVRSDWPSALLETVDLPGHELYDTQSDSDFVEEIVADVREKLNMSDNIGIYSKLGKIEtliykqpWGVRSIGI 185
Cdd:COG5635  113 LLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELLE-------AKKKRLLI 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  186 WGMPGIGKTTLAKAAFDQLSGDYEASC-----FI--KDFNKAFHekgLYGLLEAHFGKILREELGikssitrpiLLRNVL 258
Cdd:COG5635  186 LGEPGSGKTTLLRYLALELAERYLDAEdpipiLIelRDLAEEAS---LEDLLAEALEKRGGEPED---------ALERLL 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  259 RHKRVLVVLD------------DVCKPLdaESFLGGFdwfcPGSLIIITSR----DKQVFSICRVdqiYEVPGLNEEEAL 322
Cdd:COG5635  254 RNGRLLLLLDgldevpdeadrdEVLNQL--RRFLERY----PKARVIITSRpegyDSSELEGFEV---LELAPLSDEQIE 324

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  323 QLFSRCAFGKEIIHESLQKL---SKKVIDYAnGNPLALIFFGCMSRKNPKpieiaFPK---------VKKYLAHEIHDAV 390
Cdd:COG5635  325 EFLKKWFEATERKAERLLEAleeNPELRELA-RNPLLLTLLALLLRERGE-----LPDtraelyeqfVELLLERWDEQRG 398

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15230522  391 KSTYDSLSSNEKNIFL-DIA-CLFRgenvdcvihllEGCGFFPRVEINVLVEKCLVSMAEGRVVMHNLIQSIG 461
Cdd:COG5635  399 LTIYRELSREELRELLsELAlAMQE-----------NGRTEFAREELEEILREYLGRRKDAEALLDELLLRTG 460
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 720-858 7.09e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 7.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  720 DLSQClelediqgipKNLRKLYLGGTAIKELPSLMHLSELVVLDLENcKRLHKLPmGIGNLSSLAVLNLSG--CSELEDI 797
Cdd:cd21340   19 NLSLC----------KNLKVLYLYDNKITKIENLEFLTNLTHLYLQN-NQIEKIE-NLENLVNLKKLYLGGnrISVVEGL 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15230522  798 QGiPRNLEELYLAGTAIQEVTSL------IKHLSE-LVVLDLQNCkRLQHLpMEISNLKSLVTLKLTD 858
Cdd:cd21340   87 EN-LTNLEELHIENQRLPPGEKLtfdprsLAALSNsLRVLNISGN-NIDSL-EPLAPLRNLEQLDASN 151
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 570-589 3.01e-06

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 44.64  E-value: 3.01e-06
                           10        20
                   ....*....|....*....|
gi 15230522    570 NLVILNMCYSKLQRLWEGTK 589
Cdd:pfam07725    1 NLVELNMPYSKLEKLWEGVK 20
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 756-973 1.14e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   756 LSELVVLDLENCKRLHKLPMGIGNLSSLAVLNLSGCselediqgiprnleelYLAGtaiqEVTSLIKHLSELVVLDLQNC 835
Cdd:PLN00113  139 IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN----------------VLVG----KIPNSLTNLTSLEFLTLASN 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   836 KRLQHLPMEISNLKSL--VTLKLTDPSGmsirEVSTSIIQngiseigISNLNYLLLTFNENAEQ---------RREYLpr 904
Cdd:PLN00113  199 QLVGQIPRELGQMKSLkwIYLGYNNLSG----EIPYEIGG-------LTSLNHLDLVYNNLTGPipsslgnlkNLQYL-- 265

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15230522   905 pRLPSSSLHGLVPR----FYALVSLSLFNASLM-HIPEEICSLPSVVLLDLGRNGFS-KIPESIKQLSKLHSLRL 973
Cdd:PLN00113  266 -FLYQNKLSGPIPPsifsLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQL 339
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 547-836 2.01e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  547 EELRLLHW-EHFPLLSLPQDFNTR-NLVILNMC---------YSKLQRLWEGTKELGMLKRIM---LCHSQQLVGIQELQ 612
Cdd:cd00116    8 ELLKTERAtELLPKLLCLQVLRLEgNTLGEEAAkalasalrpQPSLKELCLSLNETGRIPRGLqslLQGLTKGCGLQELD 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  613 IALNMEVIDlqGCARLQRFLATGHFQHLRVIN-----LSGCIKIKSFPEVPPNIEELYLKQTgirsiptvtfspqdnsfi 687
Cdd:cd00116   88 LSDNALGPD--GCGVLESLLRSSSLQELKLNNnglgdRGLRLLAKGLKDLPPALEKLVLGRN------------------ 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  688 ydhkdhkflNREVSSDSQSLSIMVYLDNLKVLDLSQclelediqgipkNlrklYLGGTAIKEL-PSLMHLSELVVLDLEN 766
Cdd:cd00116  148 ---------RLEGASCEALAKALRANRDLKELNLAN------------N----GIGDAGIRALaEGLKANCNLEVLDLNN 202

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15230522  767 CKRLHK----LPMGIGNLSSLAVLNLSGCSelediqgiprnleeLYLAGTAiQEVTSLIKHLSELVVLDLQNCK 836
Cdd:cd00116  203 NGLTDEgasaLAETLASLKSLEVLNLGDNN--------------LTDAGAA-ALASALLSPNISLLTLSLSCND 261
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
651-851 2.46e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.54  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   651 IKSFPEVPPNIEELYLKQTGIRSIPTVTFSPQDNSFIYDHKDH-----KFLNREVSSDSQSLSIMVYLDNLKVLDLSQCl 725
Cdd:PRK15387  234 LTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHlpalpSGLCKLWIFGNQLTSLPVLPPGLQELSVSDN- 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   726 ELEDIQGIPKNLRKLYLGGTAIKELPSLMH-LSELVVLDlencKRLHKLPMGIGNLSSLAVLNlsgcSELEDIQGIPRNL 804
Cdd:PRK15387  313 QLASLPALPSELCKLWAYNNQLTSLPTLPSgLQELSVSD----NQLASLPTLPSELYKLWAYN----NRLTSLPALPSGL 384

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 15230522   805 EELYLAGTAIQEVTSLIKHLSELVVldlqNCKRLQHLPMEISNLKSL 851
Cdd:PRK15387  385 KELIVSGNRLTSLPVLPSELKELMV----SGNRLTSLPMLPSGLLSL 427
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
727-957 3.99e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.77  E-value: 3.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   727 LEDIQGIPKNLRKLYLGGTAIKELPSLM-HLSELVVLDlencKRLHKLPMGIGNLSSLAVLNlsgcSELEDIQGIPRNLE 805
Cdd:PRK15387  274 LTHLPALPSGLCKLWIFGNQLTSLPVLPpGLQELSVSD----NQLASLPALPSELCKLWAYN----NQLTSLPTLPSGLQ 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522   806 ELYLAGTAIQEVTSLIKHLSELVVLDlqncKRLQHLPMEISNLKSLVTlkltdpSGMsiREVSTSIIQNGISEIGISNLN 885
Cdd:PRK15387  346 ELSVSDNQLASLPTLPSELYKLWAYN----NRLTSLPALPSGLKELIV------SGN--RLTSLPVLPSELKELMVSGNR 413

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15230522   886 YLLLtfnenaeqrreylprPRLPSsslhglvprfyALVSLSLFNASLMHIPEEICSLPSVVLLDLGRNGFSK 957
Cdd:PRK15387  414 LTSL---------------PMLPS-----------GLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 735-774 4.14e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 4.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15230522    735 KNLRKLYLGGTAIKELPSLMHLSELVVLDLENCKRLHKLP 774
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITDLS 40
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 7-97 4.21e-04

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 41.15  E-value: 4.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522      7 VYISFdRSEDTvrySFVSHLCAAFRRRGISSFIREN----GSDSESNGFSKLETSRASVVVFSEKYSSSKSCMEELVKVS 82
Cdd:pfam13676    1 VFISY-AGEDR---AWAEWLADALEAAGYRVWLDRWdirpGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAAL 76

                           90
                   ....*....|....*
gi 15230522     83 ERRRKNClAVVPVFY 97
Cdd:pfam13676   77 ADPEGRK-RLIPVRL 90
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
841-1012 2.31e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  841 LPMEISNLKSLVTLKLTDPSGMSIREVSTSIIQNGISEIGISNLNYLLLTFNENAEQRREYLPRPRLPSSSLHGLVPRFY 920
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230522  921 ALVSLSLFNASlmhIPEEICSLPSVVLLDLGRNGFSKIPESIKQLSKLHSLRLRHCRNLILLPALPQ--SLKLLNVHGCv 998
Cdd:COG4886   94 DLTNLTELDLS---GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNN- 169

                        170
                 ....*....|....
gi 15230522  999 SLESVSWGFEQFPS 1012
Cdd:COG4886  170 QLTDLPEELGNLTN 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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