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Conserved domains on  [gi|15230488|ref|NP_190712|]
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Calcium-dependent phosphotriesterase superfamily protein [Arabidopsis thaliana]

Protein Classification

strictosidine synthase family protein( domain architecture ID 11465333)

strictosidine synthase family protein with similarity to strictosidine synthase that catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 161-247 1.75e-42

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


:

Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 142.96  E-value: 1.75e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488   161 DAVTVADN-GVLYFTDGSYKYNLHQFSFDILEGKPHGRLMSFDPTTKVTRVLLRDLYFANGVSLSPDQTHLVFCETPIRR 239
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*...
gi 15230488   240 CSKYYING 247
Cdd:pfam03088  81 ISRYWIKE 88
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 70-279 7.50e-28

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 109.98  E-value: 7.50e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488  70 PEDIAYHEDSGFIYTGCVDGWVKRVkvaeSVNDSLVEDLVNTGGRPLGIAFGIHGEVIVADAYKGLLNISGDGKKTELLT 149
Cdd:COG3386  10 GEGPVWDPDGRLYWVDIPGGRIHRY----DPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPADGEVTVLA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 150 EEAdGVRFKLPDAVTVADNGVLYFTDGSYKynlhqfsfdilegKPHGRLMSFDPTTKVtRVLLRDLYFANGVSLSPDQTH 229
Cdd:COG3386  86 DEY-GKPLNRPNDGVVDPDGRLYFTDMGEY-------------LPTGALYRVDPDGSL-RVLADGLTFPNGIAFSPDGRT 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15230488 230 LVFCETPIRRCSKYYING----GRVELFIQ--GLPGYPDNIRYDGDGHYWIAMPSG 279
Cdd:COG3386 151 LYVADTGAGRIYRFDLDAdgtlGNRRVFADlpDGPGGPDGLAVDADGNLWVALWGG 206
 
Name Accession Description Interval E-value
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 161-247 1.75e-42

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 142.96  E-value: 1.75e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488   161 DAVTVADN-GVLYFTDGSYKYNLHQFSFDILEGKPHGRLMSFDPTTKVTRVLLRDLYFANGVSLSPDQTHLVFCETPIRR 239
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*...
gi 15230488   240 CSKYYING 247
Cdd:pfam03088  81 ISRYWIKE 88
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 70-279 7.50e-28

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 109.98  E-value: 7.50e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488  70 PEDIAYHEDSGFIYTGCVDGWVKRVkvaeSVNDSLVEDLVNTGGRPLGIAFGIHGEVIVADAYKGLLNISGDGKKTELLT 149
Cdd:COG3386  10 GEGPVWDPDGRLYWVDIPGGRIHRY----DPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPADGEVTVLA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 150 EEAdGVRFKLPDAVTVADNGVLYFTDGSYKynlhqfsfdilegKPHGRLMSFDPTTKVtRVLLRDLYFANGVSLSPDQTH 229
Cdd:COG3386  86 DEY-GKPLNRPNDGVVDPDGRLYFTDMGEY-------------LPTGALYRVDPDGSL-RVLADGLTFPNGIAFSPDGRT 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15230488 230 LVFCETPIRRCSKYYING----GRVELFIQ--GLPGYPDNIRYDGDGHYWIAMPSG 279
Cdd:COG3386 151 LYVADTGAGRIYRFDLDAdgtlGNRRVFADlpDGPGGPDGLAVDADGNLWVALWGG 206
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 70-279 5.63e-16

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 76.53  E-value: 5.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488    70 PEDIAYHEDSGFIYtgCVD---GWVKRVKVAESVNDSLvedlvNTGGRPLGIAFGIHGEVIVADAY-KGLLNISgDGKKT 145
Cdd:pfam08450   2 GEGPVWDEEEGALY--WVDilgGRIHRLDPATGKETVW-----DTPGPVGAIAPRDDGGLIVALKDgVALLDLA-TGELT 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488   146 ELLTEEADGVRFKLPDAVTVADNGVLYFTDgsykynlhqFSFDILEGKPHGRLMSFDPTTKVTRVLlRDLYFANGVSLSP 225
Cdd:pfam08450  74 PLADPEDDDWPLNRFNDGKVDPDGRFWFGT---------MGDDEAPGGDPGALYRLDPDGKLTRVL-DGLTISNGLAWSP 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15230488   226 DQTHLVFCETPIRRCSKY-------YINGGRVELFIQGLPGYPDNIRYDGDGHYWIAMPSG 279
Cdd:pfam08450 144 DGRTLYFADSPARKIWAYdydldggLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGG 204
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 65-175 1.64e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.66  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488  65 GLLNSPEDIAYHEDsGFIYTgcVDGWVKRVKV-------AESVNDSLVED--LVNtggrPLGIAFGIHGEVIVADAYKGl 135
Cdd:cd14963 145 GELSYPNGIAVDED-GNIYV--ADSGNGRIQVfdkngkfIKELNGSPDGKsgFVN----PRGIAVDPDGNLYVVDNLSH- 216

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15230488 136 lNISG---DGKK-TELLTEEADGVRFKLPDAVTVADNGVLYFTD 175
Cdd:cd14963 217 -RVYVfdeQGKElFTFGGRGKDDGQFNLPNGLFIDDDGRLYVTD 259
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 110-275 3.26e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 38.80  E-value: 3.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 110 NTGGRPLGIAFGIHGEVIVADAYKGLL---NISGDGKKTELLTEEADGvRFKLPDAVTVADNGVLYFTDgSYKYNLHQFS 186
Cdd:cd14956  57 GQFGRPRGLAVDKDGWLYVADYWGDRIqvfTLTGELQTIGGSSGSGPG-QFNAPRGVAVDADGNLYVAD-FGNQRIQKFD 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 187 FD---ILE-GKPHGRLMSFDpttkvtrvllrdlyFANGVSLSPDQTHLV--FCETPIRRcskyYINGGRVeLFIQGLPG- 259
Cdd:cd14956 135 PDgsfLRQwGGTGIEPGSFN--------------YPRGVAVDPDGTLYVadTYNDRIQV----FDNDGAF-LRKWGGRGt 195

                       170       180
                ....*....|....*....|..
gi 15230488 260 ------YPDNIRYDGDGHYWIA 275
Cdd:cd14956 196 gpgqfnYPYGIAIDPDGNVFVA 217
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
160-279 7.91e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 37.69  E-value: 7.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 160 PDAVTVADNGVLYFTDGSykynlhqfsfdilegkpHGRLMSFDPTT-KVTRVLLRDLYFANGVSLSPDQThLVFCETPIR 238
Cdd:COG4257  19 PRDVAVDPDGAVWFTDQG-----------------GGRIGRLDPATgEFTEYPLGGGSGPHGIAVDPDGN-LWFTDNGNN 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15230488 239 RCSKYYINGGRVELFiqGLPG---YPDNIRYDGDGHYWIAMPSG 279
Cdd:COG4257  81 RIGRIDPKTGEITTF--ALPGggsNPHGIAFDPDGNLWFTDQGG 122
 
Name Accession Description Interval E-value
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 161-247 1.75e-42

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 142.96  E-value: 1.75e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488   161 DAVTVADN-GVLYFTDGSYKYNLHQFSFDILEGKPHGRLMSFDPTTKVTRVLLRDLYFANGVSLSPDQTHLVFCETPIRR 239
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*...
gi 15230488   240 CSKYYING 247
Cdd:pfam03088  81 ISRYWIKE 88
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 70-279 7.50e-28

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 109.98  E-value: 7.50e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488  70 PEDIAYHEDSGFIYTGCVDGWVKRVkvaeSVNDSLVEDLVNTGGRPLGIAFGIHGEVIVADAYKGLLNISGDGKKTELLT 149
Cdd:COG3386  10 GEGPVWDPDGRLYWVDIPGGRIHRY----DPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPADGEVTVLA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 150 EEAdGVRFKLPDAVTVADNGVLYFTDGSYKynlhqfsfdilegKPHGRLMSFDPTTKVtRVLLRDLYFANGVSLSPDQTH 229
Cdd:COG3386  86 DEY-GKPLNRPNDGVVDPDGRLYFTDMGEY-------------LPTGALYRVDPDGSL-RVLADGLTFPNGIAFSPDGRT 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15230488 230 LVFCETPIRRCSKYYING----GRVELFIQ--GLPGYPDNIRYDGDGHYWIAMPSG 279
Cdd:COG3386 151 LYVADTGAGRIYRFDLDAdgtlGNRRVFADlpDGPGGPDGLAVDADGNLWVALWGG 206
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 70-279 5.63e-16

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 76.53  E-value: 5.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488    70 PEDIAYHEDSGFIYtgCVD---GWVKRVKVAESVNDSLvedlvNTGGRPLGIAFGIHGEVIVADAY-KGLLNISgDGKKT 145
Cdd:pfam08450   2 GEGPVWDEEEGALY--WVDilgGRIHRLDPATGKETVW-----DTPGPVGAIAPRDDGGLIVALKDgVALLDLA-TGELT 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488   146 ELLTEEADGVRFKLPDAVTVADNGVLYFTDgsykynlhqFSFDILEGKPHGRLMSFDPTTKVTRVLlRDLYFANGVSLSP 225
Cdd:pfam08450  74 PLADPEDDDWPLNRFNDGKVDPDGRFWFGT---------MGDDEAPGGDPGALYRLDPDGKLTRVL-DGLTISNGLAWSP 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15230488   226 DQTHLVFCETPIRRCSKY-------YINGGRVELFIQGLPGYPDNIRYDGDGHYWIAMPSG 279
Cdd:pfam08450 144 DGRTLYFADSPARKIWAYdydldggLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGG 204
SSL_N pfam20067
Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of ...
 52-94 1.88e-05

Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of strictosidine synthase-like (SSL) proteins including Adipocyte plasma membrane- associated proteins (APMAPs) from animals, Protein STRICTOSIDINE SYNTHASE-LIKE (SSLs) from Arabidopsis and SGL proteins, being also present in bacterial sequences. It is about 50 amino acids in length. It contains residues involved in metal coordination in the active site. This domain is also found in Gluconolactonase and Sugar lactone lactonase. These proteins share a six-bladed beta-propeller fold structure and have similar structural and mechanistic features to SS (strictosidine synthase) that involve nucleophilic attack on an electrophilic substrate, although they do not catalyze the SS reaction as they lack the catalytic glutamate required for SS activity; they catalyze hydrolytic reactions instead. APMAPs shows similarity with paraoxonases (PON) and has a strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. They are involved in adipocyte differentiation.


Pssm-ID: 437899 [Multi-domain]  Cd Length: 46  Bit Score: 41.32  E-value: 1.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15230488    52 NERfLTGAEFIGVGLLNSPEDIAYHEDsGFIYTGCVDGWVKRV 94
Cdd:pfam20067   6 NDR-LAGAELIALGGEHGPEDIAVDPD-GRLYTGLHDGRIVRM 46
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 65-175 1.64e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.66  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488  65 GLLNSPEDIAYHEDsGFIYTgcVDGWVKRVKV-------AESVNDSLVED--LVNtggrPLGIAFGIHGEVIVADAYKGl 135
Cdd:cd14963 145 GELSYPNGIAVDED-GNIYV--ADSGNGRIQVfdkngkfIKELNGSPDGKsgFVN----PRGIAVDPDGNLYVVDNLSH- 216

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15230488 136 lNISG---DGKK-TELLTEEADGVRFKLPDAVTVADNGVLYFTD 175
Cdd:cd14963 217 -RVYVfdeQGKElFTFGGRGKDDGQFNLPNGLFIDDDGRLYVTD 259
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 63-275 1.80e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 42.69  E-value: 1.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488  63 GVGLLNSPEDIAyHEDSGFIYTgcVDGWVKRVKVAesvnDSLVEDLVNTGGR---------PLGIAFGIHGEVIVADAYK 133
Cdd:cd05819   3 GPGELNNPQGIA-VDSSGNIYV--ADTGNNRIQVF----DPDGNFITSFGSFgsgdgqfnePAGVAVDSDGNLYVADTGN 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 134 GLLN-ISGDGK-KTELLTEEADGVRFKLPDAVTVADNGVLYFTDGSykynlhqfsfdilegkpHGRLMSFDPTTKVTRVL 211
Cdd:cd05819  76 HRIQkFDPDGNfLASFGGSGDGDGEFNGPRGIAVDSSGNIYVADTG-----------------NHRIQKFDPDGEFLTTF 138

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15230488 212 ------LRDLYFANGVSLSPDQtHLVFCETPIRRCSKYYINGGRVELF-----IQGLPGYPDNIRYDGDGHYWIA 275
Cdd:cd05819 139 gsggsgPGQFNGPTGVAVDSDG-NIYVADTGNHRIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVDSDGNIYVA 212
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
107-212 5.07e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 5.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 107 DLVNTGGRPLGIAFGIHGEVIVADAYKGLLnisgdGK---KTELLTEEADGVRFKLPDAVTVADNGVLYFTDGSykynlh 183
Cdd:COG4257 182 ALPTPGAGPRGLAVDPDGNLWVADTGSGRI-----GRfdpKTGTVTEYPLPGGGARPYGVAVDGDGRVWFAESG------ 250

                        90       100
                ....*....|....*....|....*....
gi 15230488 184 qfsfdilegkpHGRLMSFDPTTKVTRVLL 212
Cdd:COG4257 251 -----------ANRIVRFDPDTELTEYVL 268
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 110-275 3.26e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 38.80  E-value: 3.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 110 NTGGRPLGIAFGIHGEVIVADAYKGLL---NISGDGKKTELLTEEADGvRFKLPDAVTVADNGVLYFTDgSYKYNLHQFS 186
Cdd:cd14956  57 GQFGRPRGLAVDKDGWLYVADYWGDRIqvfTLTGELQTIGGSSGSGPG-QFNAPRGVAVDADGNLYVAD-FGNQRIQKFD 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 187 FD---ILE-GKPHGRLMSFDpttkvtrvllrdlyFANGVSLSPDQTHLV--FCETPIRRcskyYINGGRVeLFIQGLPG- 259
Cdd:cd14956 135 PDgsfLRQwGGTGIEPGSFN--------------YPRGVAVDPDGTLYVadTYNDRIQV----FDNDGAF-LRKWGGRGt 195

                       170       180
                ....*....|....*....|..
gi 15230488 260 ------YPDNIRYDGDGHYWIA 275
Cdd:cd14956 196 gpgqfnYPYGIAIDPDGNVFVA 217
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-132 3.45e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 38.84  E-value: 3.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488  55 FLTGAEFIGVGLLNSPEDIAYHEDsGFIYTgcVDGWVKRVKV---AESVNDSLVEDLVNTGG--RPLGIAFGIHGEVIVA 129
Cdd:cd05819 183 TTFGSTGTGPGQFNYPTGIAVDSD-GNIYV--ADSGNNRVQVfdpDGAGFGGNGNFLGSDGQfnRPSGLAVDSDGNLYVA 259


                ...
gi 15230488 130 DAY 132
Cdd:cd05819 260 DTG 262
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 115-226 3.76e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 38.81  E-value: 3.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 115 PLGIAFGIHGEVIVADAYKGLLNI-SGDGKKTELLTEEADGVRFKLPDAVTVaDNGVLYFTDGSYkynlhqfsfdilegk 193
Cdd:cd14963  58 PYGIAVDSDGNIYVADLYNGRIQVfDPDGKFLKYFPEKKDRVKLISPAGLAI-DDGKLYVSDVKK--------------- 121

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15230488 194 phGRLMSFDPTTKVTRVLLR------DLYFANGVSLSPD 226
Cdd:cd14963 122 --HKVIVFDLEGKLLLEFGKpgsepgELSYPNGIAVDED 158
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
160-279 7.91e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 37.69  E-value: 7.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230488 160 PDAVTVADNGVLYFTDGSykynlhqfsfdilegkpHGRLMSFDPTT-KVTRVLLRDLYFANGVSLSPDQThLVFCETPIR 238
Cdd:COG4257  19 PRDVAVDPDGAVWFTDQG-----------------GGRIGRLDPATgEFTEYPLGGGSGPHGIAVDPDGN-LWFTDNGNN 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15230488 239 RCSKYYINGGRVELFiqGLPG---YPDNIRYDGDGHYWIAMPSG 279
Cdd:COG4257  81 RIGRIDPKTGEITTF--ALPGggsNPHGIAFDPDGNLWFTDQGG 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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