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Conserved domains on  [gi|15229665|ref|NP_190576|]
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CYCLIN D3;3 [Arabidopsis thaliana]

Protein Classification

cyclin-D( domain architecture ID 15334368)

cyclin-D such the G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 85-183 3.98e-55

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410246  Cd Length: 99  Bit Score: 175.97  E-value: 3.98e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  85 CREKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKPWMSQLTALACLSLAAKVEEIRVPFLLDFQVEEARYV 164
Cdd:cd20543   1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                        90
                ....*....|....*....
gi 15229665 165 FEAKTIQRMELLVLSTLDW 183
Cdd:cd20543  81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 188-278 4.81e-24

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410247  Cd Length: 90  Bit Score: 94.30  E-value: 4.81e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665 188 VTPISFFDHIIRRYSfKSHHQLEFLSRCESLLLSIIPDSRFLSFSPSVLATAIMVSVIRDLKMCDEAVYQSQLMTLLKVD 267
Cdd:cd20544   1 VTPFSFLDYFISKIG-LSDSREELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLLLSPN 79

                        90
                ....*....|.
gi 15229665 268 SEKVNKCYELV 278
Cdd:cd20544  80 KEKVKKCYELM 90
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 85-183 3.98e-55

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 175.97  E-value: 3.98e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  85 CREKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKPWMSQLTALACLSLAAKVEEIRVPFLLDFQVEEARYV 164
Cdd:cd20543   1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                        90
                ....*....|....*....
gi 15229665 165 FEAKTIQRMELLVLSTLDW 183
Cdd:cd20543  81 FEAKTIQRMELLVLSTLEW 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 86-185 1.33e-26

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 102.21  E-value: 1.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665    86 REKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKPwmsQLTALACLSLAAKVEEIRVPFLLDFQVEEARyVF 165
Cdd:pfam00134  31 RAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKL---QLVGVTCLFIAAKYEEIYPPTVEDLVYITDN-AY 106

                          90       100
                  ....*....|....*....|
gi 15229665   166 EAKTIQRMELLVLSTLDWRM 185
Cdd:pfam00134 107 TREEILRMERLILETLNFDL 126
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 188-278 4.81e-24

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 94.30  E-value: 4.81e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665 188 VTPISFFDHIIRRYSfKSHHQLEFLSRCESLLLSIIPDSRFLSFSPSVLATAIMVSVIRDLKMCDEAVYQSQLMTLLKVD 267
Cdd:cd20544   1 VTPFSFLDYFISKIG-LSDSREELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLLLSPN 79

                        90
                ....*....|.
gi 15229665 268 SEKVNKCYELV 278
Cdd:cd20544  80 KEKVKKCYELM 90
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
86-243 9.61e-15

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 74.81  E-value: 9.61e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  86 REKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPFLLDFQveearYVF 165
Cdd:COG5024 213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK---YQLVGISALFIASKYEEVNCPSIKDLV-----YAT 284

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665 166 E----AKTIQRMELLVLSTLDWRMHPVTPISFfdhiIRRYSFKSHHQLeFLSRCESLLLSIIP-DSRFLSFSPSVLATAI 240
Cdd:COG5024 285 DgaftRDDIIRAERYMLEVLDFNISWPSPMSF----LRRISKASDYDI-FSRTPAKFSSEISPvDYKFIQISPSWCAAAA 359


                ...
gi 15229665 241 MVS 243
Cdd:COG5024 360 MYL 362
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 188-298 3.80e-14

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 68.03  E-value: 3.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665   188 VTPISFfdhiIRRYS--FKSHHQLEFLSRCESLLLSIIPDSRFLSFSPSVLATAIMVSVIRDLKMCDeavYQSQLMTLLK 265
Cdd:pfam02984   1 PTPLSF----LRRFSkaADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPE---WTETLEHYTG 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15229665   266 VDSEKVNKCYELVLDH--SPSKKRMMNWMQQPASP 298
Cdd:pfam02984  74 YSEEDLKPCVKLLLELllNAPSSKLQAVRRKYSSS 108
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 91-179 9.54e-14

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 66.08  E-value: 9.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665     91 DWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKPwmsQLTALACLSLAAKVEEIRVPFLLDFQVEEaryVFEAKTI 170
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSP---SLIAAAALYLASKTEETPPWTKELVHYTG---YFTEEEI 74


                   ....*....
gi 15229665    171 QRMELLVLS 179
Cdd:smart00385  75 LRMERLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 85-183 3.98e-55

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 175.97  E-value: 3.98e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  85 CREKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKPWMSQLTALACLSLAAKVEEIRVPFLLDFQVEEARYV 164
Cdd:cd20543   1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                        90
                ....*....|....*....
gi 15229665 165 FEAKTIQRMELLVLSTLDW 183
Cdd:cd20543  81 FEAKTIQRMELLVLSTLEW 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 86-185 1.33e-26

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 102.21  E-value: 1.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665    86 REKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKPwmsQLTALACLSLAAKVEEIRVPFLLDFQVEEARyVF 165
Cdd:pfam00134  31 RAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKL---QLVGVTCLFIAAKYEEIYPPTVEDLVYITDN-AY 106

                          90       100
                  ....*....|....*....|
gi 15229665   166 EAKTIQRMELLVLSTLDWRM 185
Cdd:pfam00134 107 TREEILRMERLILETLNFDL 126
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 188-278 4.81e-24

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 94.30  E-value: 4.81e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665 188 VTPISFFDHIIRRYSfKSHHQLEFLSRCESLLLSIIPDSRFLSFSPSVLATAIMVSVIRDLKMCDEAVYQSQLMTLLKVD 267
Cdd:cd20544   1 VTPFSFLDYFISKIG-LSDSREELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLLLSPN 79

                        90
                ....*....|.
gi 15229665 268 SEKVNKCYELV 278
Cdd:cd20544  80 KEKVKKCYELM 90
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
86-243 9.61e-15

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 74.81  E-value: 9.61e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  86 REKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPFLLDFQveearYVF 165
Cdd:COG5024 213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK---YQLVGISALFIASKYEEVNCPSIKDLV-----YAT 284

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665 166 E----AKTIQRMELLVLSTLDWRMHPVTPISFfdhiIRRYSFKSHHQLeFLSRCESLLLSIIP-DSRFLSFSPSVLATAI 240
Cdd:COG5024 285 DgaftRDDIIRAERYMLEVLDFNISWPSPMSF----LRRISKASDYDI-FSRTPAKFSSEISPvDYKFIQISPSWCAAAA 359


                ...
gi 15229665 241 MVS 243
Cdd:COG5024 360 MYL 362
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 188-298 3.80e-14

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 68.03  E-value: 3.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665   188 VTPISFfdhiIRRYS--FKSHHQLEFLSRCESLLLSIIPDSRFLSFSPSVLATAIMVSVIRDLKMCDeavYQSQLMTLLK 265
Cdd:pfam02984   1 PTPLSF----LRRFSkaADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPE---WTETLEHYTG 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15229665   266 VDSEKVNKCYELVLDH--SPSKKRMMNWMQQPASP 298
Cdd:pfam02984  74 YSEEDLKPCVKLLLELllNAPSSKLQAVRRKYSSS 108
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 91-179 9.54e-14

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 66.08  E-value: 9.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665     91 DWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKPwmsQLTALACLSLAAKVEEIRVPFLLDFQVEEaryVFEAKTI 170
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSP---SLIAAAALYLASKTEETPPWTKELVHYTG---YFTEEEI 74


                   ....*....
gi 15229665    171 QRMELLVLS 179
Cdd:smart00385  75 LRMERLLLE 83
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 86-183 2.49e-12

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 62.62  E-value: 2.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  86 REKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEI--RVPFLLDFQVEEARY 163
Cdd:cd20528   7 RRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQ---LHLVALTCLLLAAKFEELddNIPKISDLNRYLCNS 83

                        90       100
                ....*....|....*....|
gi 15229665 164 VFEAKTIQRMELLVLSTLDW 183
Cdd:cd20528  84 VYSKQEYLQMELLILEFFQW 103
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 90-183 7.55e-12

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 61.95  E-value: 7.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  90 LDWIFKVKSHYGFNSLTALLAVNYFDRFI-TSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPFLLDFQveearYV---- 164
Cdd:cd20519  41 LDWLMEVCEVYRLHRETFYLAVDFVDRYLsTQTNVPKTQ---LQLIGITCLFIAAKLEEIYPPKLSEFA-----YVtdga 112

                        90
                ....*....|....*....
gi 15229665 165 FEAKTIQRMELLVLSTLDW 183
Cdd:cd20519 113 CTEDEILTMELIILKALNW 131
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 86-183 3.94e-11

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 60.00  E-value: 3.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  86 REKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPFLLDFqVEEARYVF 165
Cdd:cd20568  41 RGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNK---LQLVGISALFIASKYEEVNSPSIKNF-AYMTDGAY 116

                        90
                ....*....|....*...
gi 15229665 166 EAKTIQRMELLVLSTLDW 183
Cdd:cd20568 117 TVEDILRAERYMLNTLEF 134
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 86-183 1.44e-09

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 55.45  E-value: 1.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  86 REKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPflldfQVEEARYV- 164
Cdd:cd20561  37 RAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGK---LQLVGTAAMLLASKFEEIYPP-----EVAEFVYIt 108

                        90       100
                ....*....|....*....|..
gi 15229665 165 ---FEAKTIQRMELLVLSTLDW 183
Cdd:cd20561 109 ddtYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 90-182 1.91e-09

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 54.95  E-value: 1.91e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  90 LDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPflldfQVEEARYV----F 165
Cdd:cd20504  39 VDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSK---LQLVGTACMFIAAKYEEIYPP-----EVEEFVYItddtY 110

                        90
                ....*....|....*..
gi 15229665 166 EAKTIQRMELLVLSTLD 182
Cdd:cd20504 111 TKKQVLRMEHLVLKVLS 127
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 90-182 2.41e-09

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 54.84  E-value: 2.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  90 LDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPFLLDFqVEEARYVFEAKT 169
Cdd:cd20507  41 VDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKK---LQLVGVTALLIASKYEEIYPPEIKDF-VYITDNAYTREE 116

                        90
                ....*....|...
gi 15229665 170 IQRMELLVLSTLD 182
Cdd:cd20507 117 ILQMERDILKTLD 129
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 86-185 5.99e-09

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 52.71  E-value: 5.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  86 REKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEiRVPFLLDFQVEEARYVF 165
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSL---LQLLGITCLFIACKFEE-RFPPEVATLCYLTDDSY 76

                        90       100
                ....*....|....*....|
gi 15229665 166 EAKTIQRMELLVLSTLDWRM 185
Cdd:cd20542  77 SKKQVLRMERRVLRRLRFDL 96
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 85-183 1.47e-08

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 51.93  E-value: 1.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  85 CREKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQtdkPWMSQLTALACLSLAAKV--EEIRVPFLLDFqVEEAR 162
Cdd:cd20526   1 QRDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKAR---PKYLRCIAISCLFLAAKTneEDEVIPSTKDL-VRVSK 76

                        90       100
                ....*....|....*....|.
gi 15229665 163 YVFEAKTIQRMELLVLSTLDW 183
Cdd:cd20526  77 CGCSVAEVLRMERIILDKLHW 97
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 43-183 1.64e-07

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 49.88  E-value: 1.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  43 PFLNLGLSDHDMLWDDdelstLISKQEPCLYDEILDDEFLVL---CREKALDWIFKVKSHYGFNSLTALLAVNYFDRFIT 119
Cdd:cd20579   2 PLPVLGWANRDEVWKN-----MLNKDKTYLRDKNFLQKHPLLqpkMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMA 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15229665 120 SRkfQTDKPWMSQLTALACLSLAAKVEEIRVPFLLDFQveearYVFEA----KTIQRMELLVLSTLDW 183
Cdd:cd20579  77 TQ--ENVVKTRLQLIGISSLFIAAKLEEIYPPKLHQFA-----YVTDGacteDEILSMELIIMKALKW 137
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 88-176 1.80e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 48.18  E-value: 1.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  88 KALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKPwmsQLTALACLSLAAKVEEIRVPFlldFQVEEARYVFEa 167
Cdd:cd00043   1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSP---ELIAAACLYLACKLEELPRTL---KEIAKVSGVSE- 73


                ....*....
gi 15229665 168 KTIQRMELL 176
Cdd:cd00043  74 KELRKAEKE 82
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 86-181 2.29e-07

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 48.09  E-value: 2.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  86 REKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPFLLDFQ-VEEARYV 164
Cdd:cd20536   2 RAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDC---FQLLGVTSLLIACKQEEIYPPEVKDLLaLCCGAYT 78

                        90
                ....*....|....*..
gi 15229665 165 FEAktIQRMELLVLSTL 181
Cdd:cd20536  79 REQ--ICNLECIILTKL 93
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 86-183 3.69e-07

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 48.69  E-value: 3.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  86 REKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKfQTDKPwMSQLTALACLSLAAKVEEIRVPFLLDFQveearYVF 165
Cdd:cd20580  43 RSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQK-NINKS-MLQLIGITSLFIASKLEEIYPPKLHEFA-----YVT 115

                        90       100
                ....*....|....*....|..
gi 15229665 166 EA----KTIQRMELLVLSTLDW 183
Cdd:cd20580 116 DGacseDDILDMELIILKALKW 137
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 90-181 1.74e-06

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 47.53  E-value: 1.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  90 LDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPflldfQVEEARYV----F 165
Cdd:cd20560  73 VDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGK---LQLVGTAAILLASKYEEIYPP-----EVDEFVYItddtY 144

                        90
                ....*....|....*.
gi 15229665 166 EAKTIQRMELLVLSTL 181
Cdd:cd20560 145 TKKQLLRMEHLLLKVL 160
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 90-184 2.00e-06

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 46.63  E-value: 2.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  90 LDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPflldfQVEEARYV----F 165
Cdd:cd20562  46 VDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQR---LQLLGVSCMLIASKYEEICAP-----QVEEFCYItdntY 117

                        90
                ....*....|....*....
gi 15229665 166 EAKTIQRMELLVLSTLDWR 184
Cdd:cd20562 118 TKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 90-183 8.26e-06

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 45.03  E-value: 8.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  90 LDWIFKVKSHYGFNSLTALLAVNYFDRF-----ITSRKFQtdkpwmsqLTALACLSLAAKVEEIRVPFLLDFqVEEARYV 164
Cdd:cd20567  58 IDWLIEVHLKFELMPETLYLTVNLIDRFlsvkqVPRKELQ--------LVGVTAMLIASKYEEIWAPEVNDF-VYISDNA 128

                        90
                ....*....|....*....
gi 15229665 165 FEAKTIQRMELLVLSTLDW 183
Cdd:cd20567 129 YTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 100-184 2.15e-05

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 42.89  E-value: 2.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665 100 YGFNSLTALLAVNYFDRFITSRKFQtdkPWMSQLTALACLSLAAKV--EEIRVPFLLDFqVEEARYVFEAKTIQRMELLV 177
Cdd:cd20583  16 FGFSTETFSLAVNLLDRFLAKMKVQ---PKHLGCVGLSCFYLAVKAieEERNVPLATDL-IRISQYRFTVSDMMRMEKII 91


                ....*..
gi 15229665 178 LSTLDWR 184
Cdd:cd20583  92 LEKLCWK 98
CYCLIN_CCND_rpt2 cd20516
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 189-280 3.13e-05

second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410220  Cd Length: 98  Bit Score: 42.21  E-value: 3.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665 189 TPISFFDHIIRRYSFKSH-------HQLEFLSRCESlllsiipDSRFLSFSPSVLATAIMVSVIRDLKMCDEAVYQ---S 258
Cdd:cd20516   1 TPLDFLEHILHRLPLDSEdvdkvrkHAETFIALCAT-------DYKFSSYPPSMIAAASILAALRGLLLHSGNSKEdllE 73

                        90       100
                ....*....|....*....|..
gi 15229665 259 QLMTLLKVDSEKVNKCYELVLD 280
Cdd:cd20516  74 KLQQLTRIDEDLLRACQEQIED 95
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 55-183 9.55e-05

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 42.29  E-value: 9.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  55 LWDDDELSTLISKQEPCL----YDEILDDEFLVLCREKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwm 130
Cdd:cd20515  21 LLDDRVLQNLLSLEERYLpsasYFKCVQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQ--- 97

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15229665 131 SQLTALACLSLAAKVEEiRVPFLLDFQVEEARYVFEAKTIQRMELLVLSTLDW 183
Cdd:cd20515  98 LQLLGAVCLFLASKLKE-TIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKW 149
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 55-183 1.25e-04

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 41.89  E-value: 1.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  55 LWDDDELSTLISKQEPCL----YDEILDDEFLVLCREKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKfqTDKPWM 130
Cdd:cd20573  20 LLNDRVLQTMLKAEETCLpsvsYFKCVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEP--TKKSRL 97

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15229665 131 sQLTALACLSLAAKVEEIrVPFLLDFQVEEARYVFEAKTIQRMELLVLSTLDW 183
Cdd:cd20573  98 -QLLGATCMFLASKMKET-IPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKW 148
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 90-184 3.25e-04

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 39.29  E-value: 3.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  90 LDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEE--IRVPFLLDFQvEEARYVFEA 167
Cdd:cd20559   3 LDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKH---YQLVGCTCLWIASKFWEskARVPLLSELS-KMCCNSYGE 78

                        90
                ....*....|....*..
gi 15229665 168 KTIQRMELLVLSTLDWR 184
Cdd:cd20559  79 ELFIQMEMHILNTLNWD 95
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 90-183 3.66e-04

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 40.23  E-value: 3.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  90 LDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKpwmSQLTALACLSLAAKVEEIRVPFLLDFqVEEARYVFEAKT 169
Cdd:cd20566  44 VDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKK---LQLVGVTALLLASKYEEMYSPEIGDF-VYITDNAYTKAQ 119

                        90
                ....*....|....
gi 15229665 170 IQRMELLVLSTLDW 183
Cdd:cd20566 120 IREMEMLILKELNF 133
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 49-183 4.59e-04

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 40.36  E-value: 4.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  49 LSDHDMLWDDDELSTLISKQE----PCLYDEILDDEFLVLCREKALDWIFKVKSHYGFNSLTALLAVNYFDRF---ITSR 121
Cdd:cd20574  15 LPDPNLLYDDRVLQNLLTIEErylpQCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFlavVPTR 94

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15229665 122 KFQTdkpwmsQLTALACLSLAAKVEEIrVPFLLDFQVEEARYVFEAKTIQRMELLVLSTLDW 183
Cdd:cd20574  95 KCHL------QLLGAVCMFLASKLKET-IPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_AtCycC_rpt1 cd20571
first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ...
 91-183 2.72e-03

first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; Plant CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410274 [Multi-domain]  Cd Length: 107  Bit Score: 37.14  E-value: 2.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  91 DWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFQTDKPwmsQLTALACLSLAAKVEEIRVPF-LLDFQVEEAR----YVF 165
Cdd:cd20571  12 NYIKKLAQHIKVRQRVVATAITYFRRVYTRKSFTEYDP---RLVAPTCLYLASKAEESTVQAkLLVFYMKRLYadeyHRY 88

                        90
                ....*....|....*...
gi 15229665 166 EAKTIQRMELLVLSTLDW 183
Cdd:cd20571  89 EIKDILEMEMKLLEALDY 106
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 60-240 6.83e-03

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 37.79  E-value: 6.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  60 ELSTLISKQEPCLYDEILDDeflvlCREKALDWIFKVKSHYGFNSLTALLAVNYFDRFItSRKFQTDKPWMSqlTALACL 139
Cdd:COG5333  24 AIELDLLVLEPELTLEKELN-----LVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFY-LKNSVEEISLYS--VVTTCV 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665 140 SLAAKVEEIRVPFLLDFQVEEARYVFEAKT----IQRMELLVLSTLDWRM---HPVTPISFFDHIIRRYSFKSHHQLEFL 212
Cdd:COG5333  96 YLACKVEDTPRDISIESFEARDLWSEEPKSsrerILEYEFELLEALDFDLhvhHPYKYLEGFLKDLQEKDKYKLLQIAWK 175

                       170       180
                ....*....|....*....|....*...
gi 15229665 213 SRCESLLLSIIpdsrfLSFSPSVLATAI 240
Cdd:COG5333 176 IINDALRTDLC-----LLYPPHIIALAA 198
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 188-281 7.38e-03

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 35.36  E-value: 7.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665 188 VTPISFFDHIIRRYSFKShhQLEFLSR--CESLLLsiipDSRFLSFSPSVLA-TAIMVSvirdLKMCDEA-VYQSQLMTL 263
Cdd:cd20537   1 PTPLSFLRRYLSLLGLDE--KVRHLARylLELSLL----DYEFLKYRPSLIAaAALYLA----RKILGEPpPSPQLLQLV 70

                        90
                ....*....|....*...
gi 15229665 264 LKVDSEKVNKCYELVLDH 281
Cdd:cd20537  71 TGYSENDLQECAKELLEL 88
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 85-181 7.91e-03

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 35.59  E-value: 7.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229665  85 CREKALDWIFKVKSHYGFNSLTALLAVNYFDRFITSRKFqtdKPWMSQLTALACLSLAAKV--EEIRVPFLLDFqVEEAR 162
Cdd:cd20584   1 LRDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKV---KPKHLSCIGICCFHLAARVveEECNIPSSHDL-IRISQ 76

                        90
                ....*....|....*....
gi 15229665 163 YVFEAKTIQRMELLVLSTL 181
Cdd:cd20584  77 CKCTVSDLKRMEKIISEKL 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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