NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15229648|ref|NP_190567|]
View 

F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 17779041)

F-box protein is the substrate-recognition component of an SCF (Skp1-cullin-F-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 101-340 7.16e-59

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


:

Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 190.65  E-value: 7.16e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   101 IFHCDGLFVCTilKDTRIVVWNPCTGQKKWIQTGEN--LDENGQDFVLGYYqdnkSSDKSYKILSYKG--YNYGDQEFKI 176
Cdd:TIGR01640   1 VVPCDGLICFS--YGKRLVVWNPSTGQSRWLPTPKSrrSNKESDTYFLGYD----PIEKQYKVLCFSDrsGNRNQSEHQV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   177 YDIKSNTWRNLDvtPIPGNYFTCSDyRVSLKGNTYWFAYDLK-DEQLGLISFDYTTERFERlWLPFQCDISDHDYSLS-V 254
Cdd:TIGR01640  75 YTLGSNSWRTIE--CSPPHHPLKSR-GVCINGVLYYLAYTLKtNPDYFIVSFDVSSERFKE-FIPLPCGNSDSVDYLSlI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   255 VGEEKLSVVLQLKDAPRREIWITNkmddETKEMSWRKLFEVEVGTRYYMWSGRPFL-VDEEKKIVVCCEKCQKKCqpvIT 333
Cdd:TIGR01640 151 NYKGKLAVLKQKKDTNNFDLWVLN----DAGKQEWSKLFTVPIPPLPDLVDDNFLSgFTDKGEIVLCCEDENPFY---IF 223


                  ....*..
gi 15229648   334 VSMVEAD 340
Cdd:TIGR01640 224 YYNVGEN 230
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 4-41 2.53e-13

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438928  Cd Length: 39  Bit Score: 63.63  E-value: 2.53e-13
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15229648   4 NLPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTF 41
Cdd:cd22157   2 SLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 101-340 7.16e-59

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 190.65  E-value: 7.16e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   101 IFHCDGLFVCTilKDTRIVVWNPCTGQKKWIQTGEN--LDENGQDFVLGYYqdnkSSDKSYKILSYKG--YNYGDQEFKI 176
Cdd:TIGR01640   1 VVPCDGLICFS--YGKRLVVWNPSTGQSRWLPTPKSrrSNKESDTYFLGYD----PIEKQYKVLCFSDrsGNRNQSEHQV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   177 YDIKSNTWRNLDvtPIPGNYFTCSDyRVSLKGNTYWFAYDLK-DEQLGLISFDYTTERFERlWLPFQCDISDHDYSLS-V 254
Cdd:TIGR01640  75 YTLGSNSWRTIE--CSPPHHPLKSR-GVCINGVLYYLAYTLKtNPDYFIVSFDVSSERFKE-FIPLPCGNSDSVDYLSlI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   255 VGEEKLSVVLQLKDAPRREIWITNkmddETKEMSWRKLFEVEVGTRYYMWSGRPFL-VDEEKKIVVCCEKCQKKCqpvIT 333
Cdd:TIGR01640 151 NYKGKLAVLKQKKDTNNFDLWVLN----DAGKQEWSKLFTVPIPPLPDLVDDNFLSgFTDKGEIVLCCEDENPFY---IF 223


                  ....*..
gi 15229648   334 VSMVEAD 340
Cdd:TIGR01640 224 YYNVGEN 230
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 204-366 1.15e-46

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 156.61  E-value: 1.15e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   204 VSLKGNTYWFAYDLKDEQLG-LISFDYTTERFE-RLWLPFQCDiSDHDYSLSVVGEEKLSVVLQLKDAPRREIWITNKMD 281
Cdd:pfam07734   2 VSLKGNTYWLAREKETNEEDfLLSFDFTTERFGpRLPLPFQSP-DLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   282 DEtkEMSWRKLFEVEVGTRYYMWS---GRPFLVDEEKKIVVCCEKCQKKCQpvITVSMVEADsnatRVYFPVVTmTSYWP 358
Cdd:pfam07734  81 PN--AVSWSKFLTVDMPPLPGLFFhffAGSFFIDEEKKVAVVCDKDKEKKT--NTIYIIGED----GYFKEVDS-SYCSP 151


                  ....*...
gi 15229648   359 HFVDYVPS 366
Cdd:pfam07734 152 LVCSYVPS 159
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 4-41 2.53e-13

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 63.63  E-value: 2.53e-13
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15229648   4 NLPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTF 41
Cdd:cd22157   2 SLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 3-44 3.41e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 46.38  E-value: 3.41e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15229648     3 LNLPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTFSRK 44
Cdd:pfam00646   2 LDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
5-45 1.50e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 44.35  E-value: 1.50e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15229648      5 LPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTFSRKH 45
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 101-340 7.16e-59

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 190.65  E-value: 7.16e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   101 IFHCDGLFVCTilKDTRIVVWNPCTGQKKWIQTGEN--LDENGQDFVLGYYqdnkSSDKSYKILSYKG--YNYGDQEFKI 176
Cdd:TIGR01640   1 VVPCDGLICFS--YGKRLVVWNPSTGQSRWLPTPKSrrSNKESDTYFLGYD----PIEKQYKVLCFSDrsGNRNQSEHQV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   177 YDIKSNTWRNLDvtPIPGNYFTCSDyRVSLKGNTYWFAYDLK-DEQLGLISFDYTTERFERlWLPFQCDISDHDYSLS-V 254
Cdd:TIGR01640  75 YTLGSNSWRTIE--CSPPHHPLKSR-GVCINGVLYYLAYTLKtNPDYFIVSFDVSSERFKE-FIPLPCGNSDSVDYLSlI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   255 VGEEKLSVVLQLKDAPRREIWITNkmddETKEMSWRKLFEVEVGTRYYMWSGRPFL-VDEEKKIVVCCEKCQKKCqpvIT 333
Cdd:TIGR01640 151 NYKGKLAVLKQKKDTNNFDLWVLN----DAGKQEWSKLFTVPIPPLPDLVDDNFLSgFTDKGEIVLCCEDENPFY---IF 223


                  ....*..
gi 15229648   334 VSMVEAD 340
Cdd:TIGR01640 224 YYNVGEN 230
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 204-366 1.15e-46

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 156.61  E-value: 1.15e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   204 VSLKGNTYWFAYDLKDEQLG-LISFDYTTERFE-RLWLPFQCDiSDHDYSLSVVGEEKLSVVLQLKDAPRREIWITNKMD 281
Cdd:pfam07734   2 VSLKGNTYWLAREKETNEEDfLLSFDFTTERFGpRLPLPFQSP-DLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229648   282 DEtkEMSWRKLFEVEVGTRYYMWS---GRPFLVDEEKKIVVCCEKCQKKCQpvITVSMVEADsnatRVYFPVVTmTSYWP 358
Cdd:pfam07734  81 PN--AVSWSKFLTVDMPPLPGLFFhffAGSFFIDEEKKVAVVCDKDKEKKT--NTIYIIGED----GYFKEVDS-SYCSP 151


                  ....*...
gi 15229648   359 HFVDYVPS 366
Cdd:pfam07734 152 LVCSYVPS 159
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 4-41 2.53e-13

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 63.63  E-value: 2.53e-13
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15229648   4 NLPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTF 41
Cdd:cd22157   2 SLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 3-44 3.41e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 46.38  E-value: 3.41e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15229648     3 LNLPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTFSRK 44
Cdd:pfam00646   2 LDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 3-37 5.64e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 45.51  E-value: 5.64e-07
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15229648   3 LNLPQELLEEILCRVPATSLKQLRLTCKEWNRLFN 37
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
5-45 1.50e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 44.35  E-value: 1.50e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15229648      5 LPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTFSRKH 45
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 2-46 6.01e-06

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 42.86  E-value: 6.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15229648     2 VLNLPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTFSRKHF 46
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 5-41 2.25e-04

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 38.41  E-value: 2.25e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15229648   5 LPQELLEEILCRVPATSLKQ-LRLTCKEWNRLFNDRTF 41
Cdd:cd22095   5 LPEELLRNIFAFLPAEDLYQnISLVCRHWRDIVSDPLF 42
F-box_FBA cd22083
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ...
 5-35 4.11e-04

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438855  Cd Length: 37  Bit Score: 37.37  E-value: 4.11e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 15229648   5 LPQELLEEILCRVPATSL-KQLRLTCKEWNRL 35
Cdd:cd22083   4 IPEELLLEILTHVPATSLiTNCRLVCTLWRDI 35
F-box_ScMFB1-like cd22146
F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and ...
 3-43 1.02e-03

F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and similar proteins; ScMFB1 is a novel mitochondria-associated F-box protein that functions to increase mitochondrial connectivity in yeast. ScMFB1 acts as a key component of a Skp1-Cdc53/Cullin-F-box protein (SCF) ubiquitin ligase complex machinery that regulates mitochondrial dynamics throughout the yeast's entire life cycle. It interacts with Skp1p in an F-box-dependent manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438917  Cd Length: 42  Bit Score: 36.46  E-value: 1.02e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15229648   3 LNLPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTFSR 43
Cdd:cd22146   2 LGLPLEILFEILIYLDIPDILNLSKTCRFLYVLLNDEILWR 42
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 3-44 1.30e-03

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 36.39  E-value: 1.30e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15229648   3 LNLPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTFSRK 44
Cdd:cd22152   3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRV 44
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 4-35 1.46e-03

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 36.16  E-value: 1.46e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 15229648   4 NLPQELLEEILCRV-PATSLKQLRLTCKEWNRL 35
Cdd:cd22110   3 DLPEEILEYILSYLsPYGDLKSAALVCKRWHRI 35
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
 2-44 2.78e-03

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 35.48  E-value: 2.78e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15229648   2 VLNLPQELLEEILCRVPATSLKQLRLTCKEWNRLFNDRTFSRK 44
Cdd:cd22102   1 ILDLPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTDTIWQR 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH