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Conserved domains on  [gi|15229104|ref|NP_190490|]
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O-acyltransferase (WSD1-like) family protein [Arabidopsis thaliana]

Protein Classification

WSD1 family O-acyltransferase( domain architecture ID 13158110)

WSD1 family O-acyltransferase similar to Arabidopsis thaliana wax ester synthase/acyl-coenzyme A: diacylglycerol acyltransferase WSD1 which is required for stem wax ester biosynthesis in Arabidopsis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WS_DGAT_C pfam06974
WS/DGAT C-terminal domain; This domain is found at the C-terminus of wax ester synthases (WS) ...
362-506 8.63e-69

WS/DGAT C-terminal domain; This domain is found at the C-terminus of wax ester synthases (WS)/diacylglycerol O-acyltransferases (DGAT). These enzymes are utilized for the in vivo production of biodiesel and other wax esters.


:

Pssm-ID: 462057  Cd Length: 144  Bit Score: 216.99  E-value: 8.63e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   362 WGNWIGYIVFPFSIGLrDDPLQHLRRAKRIIDRKKNSLEAALTFVAGKFiLKTFGVQVAAKIINRALSNTTMSFSNLIGP 441
Cdd:pfam06974   1 WGNRFGFVLLPLPTDL-DDPLERLRKAKASMDRKKRSLEAVLTYALLEL-LKLFGAKVAAALITRLLPNTTLVISNVPGP 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15229104   442 IEEISFYGHPITYMAPSVYGHP-HALTMHFQSYMNQMTISLTVDPTVISDPHRLLDDWEKSLQSIK 506
Cdd:pfam06974  79 REPLYFAGHPVKYIYPSVPGLPgQALNITIQSYAGKLRIGLAVDRDLIPDPHRLLDDFEEALEELK 144
acyl_WS_DGAT super family cl37191
acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, ...
116-509 8.68e-27

acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity]


The actual alignment was detected with superfamily member TIGR02946:

Pssm-ID: 274360 [Multi-domain]  Cd Length: 446  Bit Score: 112.78  E-value: 8.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   116 GNADAFLEtYVSNLTTVPLDISKPLWQLHLLDlKTSDAENVAVLKFHHSLGDGMSLMALVLACMrkTSNPDELP-SLPNQ 194
Cdd:TIGR02946  86 GTRRELLE-LVGRLMSTPLDRSRPLWEMHLIE-GLAGGRFAVLTKVHHALADGVAGLRLLARLL--DDDPDPPPlPAPPP 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   195 NRSSSRSSRLMAGSRGDSRFLW--LVMVIWSAIMLVLNTVCDALEFIATTMFLKDTETPIKGdfRFSKSKRMCLVhrTVS 272
Cdd:TIGR02946 162 PPQPSTRGLLSGALSGLPSALLrrVASTAPGVVRAAGRAVEGVARSARPALPFTAPPTPLNG--PISRKRRFAAQ--SLP 237
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   273 LDDIKLIKNTMKMTVNDVVLGVSQAGLSQYLDRRygekkkkvGEDQDSkrkatdmpkriRLRSALLVNLRPNTGIQDLad 352
Cdd:TIGR02946 238 LADVKAVAKAFGVTINDVVLAAVAGALRRYLEER--------GELPDD-----------PLVAMVPVSLRPMEDDSEG-- 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   353 mmakgstcrwGNWIGYIVFPFSIGLrDDPLQHLRRAKRIIDRKKNSLEAALTFVAGKFILKT-FGVQVAAKiinRALSNT 431
Cdd:TIGR02946 297 ----------GNQVSAVLVPLPTGI-ADPVERLSAIHASMTRAKESGQAMGANALLALSGLLpAPLLRLAL---RALARK 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   432 TMSFSNLI-----GPIEEISFYGHPITYMAP-SVYGHPHALTMHFQSYMNQMTISLTVDPTVISDPHRLLDDWEKSLQSI 505
Cdd:TIGR02946 363 AQRLFNLVisnvpGPREPLYLAGAKLDELYPlSPLLDGQGLNITVTSYNGQLDFGLLADRDAVPDPQELADALEAALEEL 442

                  ....
gi 15229104   506 KAAV 509
Cdd:TIGR02946 443 EAAA 446
COG4908 COG4908
Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...
28-194 1.64e-11

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];


:

Pssm-ID: 443936 [Multi-domain]  Cd Length: 243  Bit Score: 64.29  E-value: 1.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104  28 LSPAAR--VFHAPEFNCYVIS-VIGIKKKIDPDVIIEGLKQTLIRHPRFSSKMVStsVGNKKRQTqswvrtnVVVTDHVI 104
Cdd:COG4908   1 LSPAQKrfLFLEPGSNAYNIPaVLRLEGPLDVEALERALRELVRRHPALRTRFVE--EDGEPVQR-------IDPDADLP 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104 105 VSDIQTQNIENGNADAFLETYVSNLTTVPLDISK-PLWQLHLLdlKTSDAENVAVLKFHHSLGDGMSLMALVLACMR--- 180
Cdd:COG4908  72 LEVVDLSALPEPEREAELEELVAEEASRPFDLARgPLLRAALI--RLGEDEHVLLLTIHHIISDGWSLGILLRELAAlya 149
                       170
                ....*....|....*.
gi 15229104 181 --KTSNPDELPSLPNQ 194
Cdd:COG4908 150 alLEGEPPPLPELPIQ 165
 
Name Accession Description Interval E-value
WS_DGAT_C pfam06974
WS/DGAT C-terminal domain; This domain is found at the C-terminus of wax ester synthases (WS) ...
362-506 8.63e-69

WS/DGAT C-terminal domain; This domain is found at the C-terminus of wax ester synthases (WS)/diacylglycerol O-acyltransferases (DGAT). These enzymes are utilized for the in vivo production of biodiesel and other wax esters.


Pssm-ID: 462057  Cd Length: 144  Bit Score: 216.99  E-value: 8.63e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   362 WGNWIGYIVFPFSIGLrDDPLQHLRRAKRIIDRKKNSLEAALTFVAGKFiLKTFGVQVAAKIINRALSNTTMSFSNLIGP 441
Cdd:pfam06974   1 WGNRFGFVLLPLPTDL-DDPLERLRKAKASMDRKKRSLEAVLTYALLEL-LKLFGAKVAAALITRLLPNTTLVISNVPGP 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15229104   442 IEEISFYGHPITYMAPSVYGHP-HALTMHFQSYMNQMTISLTVDPTVISDPHRLLDDWEKSLQSIK 506
Cdd:pfam06974  79 REPLYFAGHPVKYIYPSVPGLPgQALNITIQSYAGKLRIGLAVDRDLIPDPHRLLDDFEEALEELK 144
acyl_WS_DGAT TIGR02946
acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, ...
116-509 8.68e-27

acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274360 [Multi-domain]  Cd Length: 446  Bit Score: 112.78  E-value: 8.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   116 GNADAFLEtYVSNLTTVPLDISKPLWQLHLLDlKTSDAENVAVLKFHHSLGDGMSLMALVLACMrkTSNPDELP-SLPNQ 194
Cdd:TIGR02946  86 GTRRELLE-LVGRLMSTPLDRSRPLWEMHLIE-GLAGGRFAVLTKVHHALADGVAGLRLLARLL--DDDPDPPPlPAPPP 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   195 NRSSSRSSRLMAGSRGDSRFLW--LVMVIWSAIMLVLNTVCDALEFIATTMFLKDTETPIKGdfRFSKSKRMCLVhrTVS 272
Cdd:TIGR02946 162 PPQPSTRGLLSGALSGLPSALLrrVASTAPGVVRAAGRAVEGVARSARPALPFTAPPTPLNG--PISRKRRFAAQ--SLP 237
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   273 LDDIKLIKNTMKMTVNDVVLGVSQAGLSQYLDRRygekkkkvGEDQDSkrkatdmpkriRLRSALLVNLRPNTGIQDLad 352
Cdd:TIGR02946 238 LADVKAVAKAFGVTINDVVLAAVAGALRRYLEER--------GELPDD-----------PLVAMVPVSLRPMEDDSEG-- 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   353 mmakgstcrwGNWIGYIVFPFSIGLrDDPLQHLRRAKRIIDRKKNSLEAALTFVAGKFILKT-FGVQVAAKiinRALSNT 431
Cdd:TIGR02946 297 ----------GNQVSAVLVPLPTGI-ADPVERLSAIHASMTRAKESGQAMGANALLALSGLLpAPLLRLAL---RALARK 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   432 TMSFSNLI-----GPIEEISFYGHPITYMAP-SVYGHPHALTMHFQSYMNQMTISLTVDPTVISDPHRLLDDWEKSLQSI 505
Cdd:TIGR02946 363 AQRLFNLVisnvpGPREPLYLAGAKLDELYPlSPLLDGQGLNITVTSYNGQLDFGLLADRDAVPDPQELADALEAALEEL 442

                  ....
gi 15229104   506 KAAV 509
Cdd:TIGR02946 443 EAAA 446
COG4908 COG4908
Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...
28-194 1.64e-11

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];


Pssm-ID: 443936 [Multi-domain]  Cd Length: 243  Bit Score: 64.29  E-value: 1.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104  28 LSPAAR--VFHAPEFNCYVIS-VIGIKKKIDPDVIIEGLKQTLIRHPRFSSKMVStsVGNKKRQTqswvrtnVVVTDHVI 104
Cdd:COG4908   1 LSPAQKrfLFLEPGSNAYNIPaVLRLEGPLDVEALERALRELVRRHPALRTRFVE--EDGEPVQR-------IDPDADLP 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104 105 VSDIQTQNIENGNADAFLETYVSNLTTVPLDISK-PLWQLHLLdlKTSDAENVAVLKFHHSLGDGMSLMALVLACMR--- 180
Cdd:COG4908  72 LEVVDLSALPEPEREAELEELVAEEASRPFDLARgPLLRAALI--RLGEDEHVLLLTIHHIISDGWSLGILLRELAAlya 149
                       170
                ....*....|....*.
gi 15229104 181 --KTSNPDELPSLPNQ 194
Cdd:COG4908 150 alLEGEPPPLPELPIQ 165
WES_acyltransf pfam03007
Wax ester synthase-like Acyl-CoA acyltransferase domain; This domain is found in wax ester ...
116-291 5.64e-09

Wax ester synthase-like Acyl-CoA acyltransferase domain; This domain is found in wax ester synthase genes. In these proteins this domain catalyzes the CoA dependent acyltransferase reaction with fatty alcohols to form wax esters.


Pssm-ID: 281060 [Multi-domain]  Cd Length: 261  Bit Score: 57.00  E-value: 5.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   116 GNADAFLETyVSNLTTVPLDISKPLWQLHLLDlkTSDAENVAVL-KFHHSLGDG---MSLMALVLACMRKTSNPDELPSL 191
Cdd:pfam03007  90 GGRRELHEL-VSRLHSRPLDRSRPLWEMHVIE--GLEGGRFAVLtKVHHALADGvggLNLLARLLDLDPDPPPRPTPPQT 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   192 PNQNrsssrSSRLMAGSRGDSRFLWLVMVIWSAIMLVLNTVCDALEFIATTMFLKDTETPIKGDF--RFSKSKRMCLVhr 269
Cdd:pfam03007 167 PPGD-----PRTQLRAGGALVGPAAGLGGVAGGVRGVVRSAGRLLERALEARSVALPFAAPHTPFnaPLSRARRFAAQ-- 239
                         170       180
                  ....*....|....*....|..
gi 15229104   270 TVSLDDIKLIKNTMKMTVNDVV 291
Cdd:pfam03007 240 SLPLADVKAVAKATGVTINDVV 261
Condensation pfam00668
Condensation domain; This domain is found in many multi-domain enzymes which synthesize ...
26-175 6.12e-03

Condensation domain; This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.


Pssm-ID: 395541 [Multi-domain]  Cd Length: 454  Bit Score: 39.24  E-value: 6.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104    26 QPLSPA--ARVFHA---PEFNCYVIS-VIGIKKKIDPDVIIEGLKQTLIRHPRFssKMVSTSVGNKK-RQtqswvrtnvV 98
Cdd:pfam00668   5 YPLSPAqkRMWFLEklePHSSAYNMPaVLKLTGELDPERLEKALQELINRHDAL--RTVFIRQENGEpVQ---------V 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104    99 VTDHVIVsDIQTQNIENGNADAF---LETYVSNLTTVPLDISK-PLWQLHLLdlKTSDAENVAVLKFHHSLGDGMSLMAL 174
Cdd:pfam00668  74 ILEERPF-ELEIIDISDLSESEEeeaIEAFIQRDLQSPFDLEKgPLFRAGLF--RIAENRHHLLLSMHHIIVDGVSLGIL 150

                  .
gi 15229104   175 V 175
Cdd:pfam00668 151 L 151
 
Name Accession Description Interval E-value
WS_DGAT_C pfam06974
WS/DGAT C-terminal domain; This domain is found at the C-terminus of wax ester synthases (WS) ...
362-506 8.63e-69

WS/DGAT C-terminal domain; This domain is found at the C-terminus of wax ester synthases (WS)/diacylglycerol O-acyltransferases (DGAT). These enzymes are utilized for the in vivo production of biodiesel and other wax esters.


Pssm-ID: 462057  Cd Length: 144  Bit Score: 216.99  E-value: 8.63e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   362 WGNWIGYIVFPFSIGLrDDPLQHLRRAKRIIDRKKNSLEAALTFVAGKFiLKTFGVQVAAKIINRALSNTTMSFSNLIGP 441
Cdd:pfam06974   1 WGNRFGFVLLPLPTDL-DDPLERLRKAKASMDRKKRSLEAVLTYALLEL-LKLFGAKVAAALITRLLPNTTLVISNVPGP 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15229104   442 IEEISFYGHPITYMAPSVYGHP-HALTMHFQSYMNQMTISLTVDPTVISDPHRLLDDWEKSLQSIK 506
Cdd:pfam06974  79 REPLYFAGHPVKYIYPSVPGLPgQALNITIQSYAGKLRIGLAVDRDLIPDPHRLLDDFEEALEELK 144
acyl_WS_DGAT TIGR02946
acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, ...
116-509 8.68e-27

acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274360 [Multi-domain]  Cd Length: 446  Bit Score: 112.78  E-value: 8.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   116 GNADAFLEtYVSNLTTVPLDISKPLWQLHLLDlKTSDAENVAVLKFHHSLGDGMSLMALVLACMrkTSNPDELP-SLPNQ 194
Cdd:TIGR02946  86 GTRRELLE-LVGRLMSTPLDRSRPLWEMHLIE-GLAGGRFAVLTKVHHALADGVAGLRLLARLL--DDDPDPPPlPAPPP 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   195 NRSSSRSSRLMAGSRGDSRFLW--LVMVIWSAIMLVLNTVCDALEFIATTMFLKDTETPIKGdfRFSKSKRMCLVhrTVS 272
Cdd:TIGR02946 162 PPQPSTRGLLSGALSGLPSALLrrVASTAPGVVRAAGRAVEGVARSARPALPFTAPPTPLNG--PISRKRRFAAQ--SLP 237
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   273 LDDIKLIKNTMKMTVNDVVLGVSQAGLSQYLDRRygekkkkvGEDQDSkrkatdmpkriRLRSALLVNLRPNTGIQDLad 352
Cdd:TIGR02946 238 LADVKAVAKAFGVTINDVVLAAVAGALRRYLEER--------GELPDD-----------PLVAMVPVSLRPMEDDSEG-- 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   353 mmakgstcrwGNWIGYIVFPFSIGLrDDPLQHLRRAKRIIDRKKNSLEAALTFVAGKFILKT-FGVQVAAKiinRALSNT 431
Cdd:TIGR02946 297 ----------GNQVSAVLVPLPTGI-ADPVERLSAIHASMTRAKESGQAMGANALLALSGLLpAPLLRLAL---RALARK 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   432 TMSFSNLI-----GPIEEISFYGHPITYMAP-SVYGHPHALTMHFQSYMNQMTISLTVDPTVISDPHRLLDDWEKSLQSI 505
Cdd:TIGR02946 363 AQRLFNLVisnvpGPREPLYLAGAKLDELYPlSPLLDGQGLNITVTSYNGQLDFGLLADRDAVPDPQELADALEAALEEL 442

                  ....
gi 15229104   506 KAAV 509
Cdd:TIGR02946 443 EAAA 446
COG4908 COG4908
Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...
28-194 1.64e-11

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];


Pssm-ID: 443936 [Multi-domain]  Cd Length: 243  Bit Score: 64.29  E-value: 1.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104  28 LSPAAR--VFHAPEFNCYVIS-VIGIKKKIDPDVIIEGLKQTLIRHPRFSSKMVStsVGNKKRQTqswvrtnVVVTDHVI 104
Cdd:COG4908   1 LSPAQKrfLFLEPGSNAYNIPaVLRLEGPLDVEALERALRELVRRHPALRTRFVE--EDGEPVQR-------IDPDADLP 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104 105 VSDIQTQNIENGNADAFLETYVSNLTTVPLDISK-PLWQLHLLdlKTSDAENVAVLKFHHSLGDGMSLMALVLACMR--- 180
Cdd:COG4908  72 LEVVDLSALPEPEREAELEELVAEEASRPFDLARgPLLRAALI--RLGEDEHVLLLTIHHIISDGWSLGILLRELAAlya 149
                       170
                ....*....|....*.
gi 15229104 181 --KTSNPDELPSLPNQ 194
Cdd:COG4908 150 alLEGEPPPLPELPIQ 165
WES_acyltransf pfam03007
Wax ester synthase-like Acyl-CoA acyltransferase domain; This domain is found in wax ester ...
116-291 5.64e-09

Wax ester synthase-like Acyl-CoA acyltransferase domain; This domain is found in wax ester synthase genes. In these proteins this domain catalyzes the CoA dependent acyltransferase reaction with fatty alcohols to form wax esters.


Pssm-ID: 281060 [Multi-domain]  Cd Length: 261  Bit Score: 57.00  E-value: 5.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   116 GNADAFLETyVSNLTTVPLDISKPLWQLHLLDlkTSDAENVAVL-KFHHSLGDG---MSLMALVLACMRKTSNPDELPSL 191
Cdd:pfam03007  90 GGRRELHEL-VSRLHSRPLDRSRPLWEMHVIE--GLEGGRFAVLtKVHHALADGvggLNLLARLLDLDPDPPPRPTPPQT 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104   192 PNQNrsssrSSRLMAGSRGDSRFLWLVMVIWSAIMLVLNTVCDALEFIATTMFLKDTETPIKGDF--RFSKSKRMCLVhr 269
Cdd:pfam03007 167 PPGD-----PRTQLRAGGALVGPAAGLGGVAGGVRGVVRSAGRLLERALEARSVALPFAAPHTPFnaPLSRARRFAAQ-- 239
                         170       180
                  ....*....|....*....|..
gi 15229104   270 TVSLDDIKLIKNTMKMTVNDVV 291
Cdd:pfam03007 240 SLPLADVKAVAKATGVTINDVV 261
Condensation pfam00668
Condensation domain; This domain is found in many multi-domain enzymes which synthesize ...
26-175 6.12e-03

Condensation domain; This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.


Pssm-ID: 395541 [Multi-domain]  Cd Length: 454  Bit Score: 39.24  E-value: 6.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104    26 QPLSPA--ARVFHA---PEFNCYVIS-VIGIKKKIDPDVIIEGLKQTLIRHPRFssKMVSTSVGNKK-RQtqswvrtnvV 98
Cdd:pfam00668   5 YPLSPAqkRMWFLEklePHSSAYNMPaVLKLTGELDPERLEKALQELINRHDAL--RTVFIRQENGEpVQ---------V 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229104    99 VTDHVIVsDIQTQNIENGNADAF---LETYVSNLTTVPLDISK-PLWQLHLLdlKTSDAENVAVLKFHHSLGDGMSLMAL 174
Cdd:pfam00668  74 ILEERPF-ELEIIDISDLSESEEeeaIEAFIQRDLQSPFDLEKgPLFRAGLF--RIAENRHHLLLSMHHIIVDGVSLGIL 150

                  .
gi 15229104   175 V 175
Cdd:pfam00668 151 L 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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