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Conserved domains on  [gi|15229055|ref|NP_190461|]
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myb domain protein 45 [Arabidopsis thaliana]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 999994)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03091 super family cl33633
hypothetical protein; Provisional
 15-126 3.81e-57

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 189.03  E-value: 3.81e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229055   15 KEKQRKGLWSPEEDEKLRSHVLKYGHGCWSTIPLQAGLQRNGKSCRLRWVNYLRPGLKKSLFTKQEETILLSLHSMLGNK 94
Cdd:PLN03091   9 KQKLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNR 88

                         90       100       110
                 ....*....|....*....|....*....|..
gi 15229055   95 WSQISKFLPGRTDNEIKNYWHSNLKKgvTLKQ 126
Cdd:PLN03091  89 WSQIAAQLPGRTDNEIKNLWNSCLKK--KLRQ 118
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 15-126 3.81e-57

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 189.03  E-value: 3.81e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229055   15 KEKQRKGLWSPEEDEKLRSHVLKYGHGCWSTIPLQAGLQRNGKSCRLRWVNYLRPGLKKSLFTKQEETILLSLHSMLGNK 94
Cdd:PLN03091   9 KQKLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNR 88

                         90       100       110
                 ....*....|....*....|....*....|..
gi 15229055   95 WSQISKFLPGRTDNEIKNYWHSNLKKgvTLKQ 126
Cdd:PLN03091  89 WSQIAAQLPGRTDNEIKNLWNSCLKK--KLRQ 118
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 11-137 8.53e-14

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 70.59  E-value: 8.53e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229055  11 EMKSKEKQRK-GLWSPEEDEKLRSHVLKYGHGCWSTIPLQAGLqRNGKSCRLRWVNYLRPGLKKSLFTKQEETILLSLHS 89
Cdd:COG5147  10 QIKLMQTKRKgGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDK 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15229055  90 MLGNKWSQISKFLPGRTDNEIKNYWHSNLKkgVTLKQHETtkKHQTPL 137
Cdd:COG5147  89 ELGTQWSTIADYKDRRTAQQCVERYVNTLE--DLSSTHDS--KLQRRN 132
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 73-118 2.36e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.91  E-value: 2.36e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15229055    73 KSLFTKQEETILLSLHSMLGNKWSQISKFLPGRTDNEIKNYWHSNL 118
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 76-118 8.73e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 52.96  E-value: 8.73e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15229055  76 FTKQEETILLSLHSMLG-NKWSQISKFLPGRTDNEIKNYWHSNL 118
Cdd:cd00167   2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
73-120 1.09e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.00  E-value: 1.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 15229055     73 KSLFTKQEETILLSLHSMLG-NKWSQISKFLPGRTDNEIKNYWHSNLKK 120
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 15-126 3.81e-57

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 189.03  E-value: 3.81e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229055   15 KEKQRKGLWSPEEDEKLRSHVLKYGHGCWSTIPLQAGLQRNGKSCRLRWVNYLRPGLKKSLFTKQEETILLSLHSMLGNK 94
Cdd:PLN03091   9 KQKLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNR 88

                         90       100       110
                 ....*....|....*....|....*....|..
gi 15229055   95 WSQISKFLPGRTDNEIKNYWHSNLKKgvTLKQ 126
Cdd:PLN03091  89 WSQIAAQLPGRTDNEIKNLWNSCLKK--KLRQ 118
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 14-142 2.83e-38

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 134.43  E-value: 2.83e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229055   14 SKEKQRKGLWSPEEDEKLRSHVLKYGHGCWSTIPLQAGLQRNGKSCRLRWVNYLRPGLKKSLFTKQEETILLSLHSMLGN 93
Cdd:PLN03212  19 TKMGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGN 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 15229055   94 KWSQISKFLPGRTDNEIKNYWHSNLKKGVtLKQHETTKKHQtPLITNSL 142
Cdd:PLN03212  99 RWSLIAGRIPGRTDNEIKNYWNTHLRKKL-LRQGIDPQTHK-PLDANNI 145
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 11-137 8.53e-14

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 70.59  E-value: 8.53e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229055  11 EMKSKEKQRK-GLWSPEEDEKLRSHVLKYGHGCWSTIPLQAGLqRNGKSCRLRWVNYLRPGLKKSLFTKQEETILLSLHS 89
Cdd:COG5147  10 QIKLMQTKRKgGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDK 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15229055  90 MLGNKWSQISKFLPGRTDNEIKNYWHSNLKkgVTLKQHETtkKHQTPL 137
Cdd:COG5147  89 ELGTQWSTIADYKDRRTAQQCVERYVNTLE--DLSSTHDS--KLQRRN 132
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 73-118 2.36e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.91  E-value: 2.36e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15229055    73 KSLFTKQEETILLSLHSMLGNKWSQISKFLPGRTDNEIKNYWHSNL 118
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 20-67 1.55e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 55.20  E-value: 1.55e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 15229055    20 KGLWSPEEDEKLRSHVLKYGhGCWSTIPLQAGLqRNGKSCRLRWVNYL 67
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPG-RTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 23-81 6.30e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 53.85  E-value: 6.30e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15229055    23 WSPEEDEKLRSHVLKYGHGcWSTIPLQAGlQRNGKSCRLRWVNYLRPGLKKSLFTKQEE 81
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELG-RRTPKQCFDRWRRKLNPKISRGPWSKEED 57
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 76-118 8.73e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 52.96  E-value: 8.73e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15229055  76 FTKQEETILLSLHSMLG-NKWSQISKFLPGRTDNEIKNYWHSNL 118
Cdd:cd00167   2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
73-120 1.09e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.00  E-value: 1.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 15229055     73 KSLFTKQEETILLSLHSMLG-NKWSQISKFLPGRTDNEIKNYWHSNLKK 120
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 23-67 1.92e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 52.19  E-value: 1.92e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15229055  23 WSPEEDEKLRSHVLKYGHGCWSTIPLQAGLqRNGKSCRLRWVNYL 67
Cdd:cd00167   2 WTEEEDELLLEAVKKYGKNNWEKIAKELPG-RTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
20-69 4.00e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 51.46  E-value: 4.00e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 15229055     20 KGLWSPEEDEKLRSHVLKYGHGCWSTIPLQAGLqRNGKSCRLRWVNYLRP 69
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPG-RTAEQCRERWRNLLKP 49
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 76-119 1.60e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 47.30  E-value: 1.60e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15229055    76 FTKQEETILLSLHSMLGNKWSQISKFLPGRTDNEIKNYWHSNLK 119
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLN 44
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 4-106 1.77e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 42.47  E-value: 1.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229055   4 KSEKSNREMKSKEKQRKGLWSPEEDEKLRSHVLKYGhGCWSTIPLQAGLQRNgkSCRLRWVNYLRPG--LKKSLFTKQEE 81
Cdd:COG5147 275 KSIYKHLRRKYNIFEQRGKWTKEEEQELAKLVVEHG-GSWTEIGKLLGRMPN--DCRDRWRDYVKCGdtLKRNRWSIEEE 351

                        90       100       110
                ....*....|....*....|....*....|...
gi 15229055  82 TILLSLHSMLGN--------KWSQISKFLPGRT 106
Cdd:COG5147 352 ELLDKVVNEMRLeaqqssriLWLLIAQNIRNRL 384
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 69-108 6.51e-04

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 36.90  E-value: 6.51e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15229055  69 PGLKKSLFTKQEETILLSLHSMLGNKWSQISKFLpGRTDN 108
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQ 39
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 23-46 2.05e-03

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 35.24  E-value: 2.05e-03
                        10        20
                ....*....|....*....|....
gi 15229055  23 WSPEEDEKLRSHVLKYGHGCWSTI 46
Cdd:cd11660   3 WTDEEDEALVEGVEKYGVGNWAKI 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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