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Conserved domains on  [gi|15232798|ref|NP_190328|]
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tonoplast intrinsic protein 5;1 [Arabidopsis thaliana]

Protein Classification

aquaporin( domain architecture ID 10010685)

aquaporin is involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00167 PLN00167
aquaporin TIP5; Provisional
 1-256 8.67e-143

aquaporin TIP5; Provisional


:

Pssm-ID: 215085  Cd Length: 256  Bit Score: 400.43  E-value: 8.67e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798    1 MRRMIPTSFSSKFQGVLSMNALRCYVSEFISTFFFVLAAVGSVMSSRKLMAGDVSGPFGVLIPAIANALALSSSVYISWN 80
Cdd:PLN00167   1 MRKMAPTSLSARFQQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAAN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   81 VSGGHVNPAVTFAMAVAGRISVPTAMFYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTGFGASVLEGVLAFVLVYT 160
Cdd:PLN00167  81 ISGGHVNPAVTFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTTVGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  161 VFTASDPRRGLPLAVGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVYDNVVV 240
Cdd:PLN00167 161 VYAAGDPRRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVF 240

                        250
                 ....*....|....*.
gi 15232798  241 PVEDDRGSSTGDAIGV 256
Cdd:PLN00167 241 PTQDDRGSSTGDAVGV 256
 
Name Accession Description Interval E-value
PLN00167 PLN00167
aquaporin TIP5; Provisional
 1-256 8.67e-143

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 400.43  E-value: 8.67e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798    1 MRRMIPTSFSSKFQGVLSMNALRCYVSEFISTFFFVLAAVGSVMSSRKLMAGDVSGPFGVLIPAIANALALSSSVYISWN 80
Cdd:PLN00167   1 MRKMAPTSLSARFQQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAAN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   81 VSGGHVNPAVTFAMAVAGRISVPTAMFYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTGFGASVLEGVLAFVLVYT 160
Cdd:PLN00167  81 ISGGHVNPAVTFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTTVGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  161 VFTASDPRRGLPLAVGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVYDNVVV 240
Cdd:PLN00167 161 VYAAGDPRRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVF 240

                        250
                 ....*....|....*.
gi 15232798  241 PVEDDRGSSTGDAIGV 256
Cdd:PLN00167 241 PTQDDRGSSTGDAVGV 256
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 18-235 3.79e-49

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 161.33  E-value: 3.79e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798    18 SMNALRCYVSEFISTFFFVLAAVGSVMSSRKLMAGDvsGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVA 97
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSL--AVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798    98 GRISVPTAMFYWTSQMIASVMACLVLK-VTVMEQHVPIYKI--AGEMTGFGASVLEGVLAFVLVYTVFTASDPRRGLPLA 174
Cdd:pfam00230  82 RRFSLLRAIFYIVAQLLGAIAGAALLYgVTVGLQRAGLFANtlAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLG 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15232798   175 -VGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVY 235
Cdd:pfam00230 162 tVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 23-238 1.07e-41

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 142.39  E-value: 1.07e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  23 RCYVSEFISTFFFVLAAVGSVMSSRKLmagdVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRISV 102
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLA----GGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798 103 PTAMFYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTG------------FGASVLEGVLAFVLVYTVF-TASDPRR 169
Cdd:cd00333  77 IRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGifgtypspgvsnGNAFFVEFIGTFILVLVVFaTTDDPNG 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15232798 170 GLPLAVGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQA---VYWVGPLLGGATAALVYDNV 238
Cdd:cd00333 157 PPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHyfwVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 27-235 6.71e-37

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 129.73  E-value: 6.71e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798    27 SEFISTFFFVLAAVGSVMSSRKLMAGDVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRISVPTAM 106
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   107 FYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTG----FGASVLEGVLAFVLVYTVFTASDPRRGLPLA-VGPIFIG 181
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgvssGQAFFVEFIGTAILVLVIFATTDDRNRVPRGgFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15232798   182 FVAGANVLAAGPFSGGSMNPACAFGSAMVYGS--FKNQAVYWVGPLLGGATAALVY 235
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 25-236 2.67e-34

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 123.31  E-value: 2.67e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  25 YVSEFISTFFFVLAAVGSVMssrklMAGDVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRISVPT 104
Cdd:COG0580   6 LLAEFLGTFILVLLGCGVVA-----VLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798 105 AMFYWTSQMIASVMACLVLKVTVMeQHVPIYKIAGEMTG------------FGASVLEGVLAFVLVYTVFTASDPRRGLP 172
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYG-GHFDATEDGGAKLGvfatspaigyslGAAFLTEIIGTFVLVFVILGITDKRAAPG 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798 173 lAVGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQA------VYWVGPLLGGATAALVYD 236
Cdd:COG0580 160 -GLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKGGSdwgylwVPIVAPILGAALAALLYR 228
 
Name Accession Description Interval E-value
PLN00167 PLN00167
aquaporin TIP5; Provisional
 1-256 8.67e-143

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 400.43  E-value: 8.67e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798    1 MRRMIPTSFSSKFQGVLSMNALRCYVSEFISTFFFVLAAVGSVMSSRKLMAGDVSGPFGVLIPAIANALALSSSVYISWN 80
Cdd:PLN00167   1 MRKMAPTSLSARFQQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAAN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   81 VSGGHVNPAVTFAMAVAGRISVPTAMFYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTGFGASVLEGVLAFVLVYT 160
Cdd:PLN00167  81 ISGGHVNPAVTFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTTVGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  161 VFTASDPRRGLPLAVGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVYDNVVV 240
Cdd:PLN00167 161 VYAAGDPRRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVF 240

                        250
                 ....*....|....*.
gi 15232798  241 PVEDDRGSSTGDAIGV 256
Cdd:PLN00167 241 PTQDDRGSSTGDAVGV 256
PLN00166 PLN00166
aquaporin TIP2; Provisional
 17-240 3.86e-62

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 195.54  E-value: 3.86e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   17 LSMNALRCYVSEFISTFFFVLAAVGSVMSSRKLMAGDVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAV 96
Cdd:PLN00166  13 FSVASLKAYLSEFIATLLFVFAGVGSAIAFAKLTSDAALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   97 AGRISVPTAMFYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTGFGASVLEGVLAFVLVYTVF-TASDPRRGLPLAV 175
Cdd:PLN00166  93 GGNITIITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYaTAADPKKGSLGTI 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15232798  176 GPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVYDNVVV 240
Cdd:PLN00166 173 APIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVFI 237
PLN00027 PLN00027
aquaporin TIP; Provisional
 20-240 1.35e-57

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 183.83  E-value: 1.35e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   20 NALRCYVSEFISTFFFVLAAVGSVMSSRKLMAGDVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGR 99
Cdd:PLN00027  18 DALKAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  100 ISVPTAMFYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTGFGASVLEGVLAFVLVYTVF-TASDPRRGLPLAVGPI 178
Cdd:PLN00027  98 ITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYaTAVDPKKGDLGIIAPI 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15232798  179 FIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVYDNVVV 240
Cdd:PLN00027 178 AIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFI 239
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 18-235 3.79e-49

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 161.33  E-value: 3.79e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798    18 SMNALRCYVSEFISTFFFVLAAVGSVMSSRKLMAGDvsGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVA 97
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSL--AVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798    98 GRISVPTAMFYWTSQMIASVMACLVLK-VTVMEQHVPIYKI--AGEMTGFGASVLEGVLAFVLVYTVFTASDPRRGLPLA 174
Cdd:pfam00230  82 RRFSLLRAIFYIVAQLLGAIAGAALLYgVTVGLQRAGLFANtlAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLG 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15232798   175 -VGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVY 235
Cdd:pfam00230 162 tVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 23-238 1.07e-41

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 142.39  E-value: 1.07e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  23 RCYVSEFISTFFFVLAAVGSVMSSRKLmagdVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRISV 102
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLA----GGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798 103 PTAMFYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTG------------FGASVLEGVLAFVLVYTVF-TASDPRR 169
Cdd:cd00333  77 IRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGifgtypspgvsnGNAFFVEFIGTFILVLVVFaTTDDPNG 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15232798 170 GLPLAVGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQA---VYWVGPLLGGATAALVYDNV 238
Cdd:cd00333 157 PPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHyfwVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 27-235 6.71e-37

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 129.73  E-value: 6.71e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798    27 SEFISTFFFVLAAVGSVMSSRKLMAGDVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRISVPTAM 106
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   107 FYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTG----FGASVLEGVLAFVLVYTVFTASDPRRGLPLA-VGPIFIG 181
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgvssGQAFFVEFIGTAILVLVIFATTDDRNRVPRGgFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15232798   182 FVAGANVLAAGPFSGGSMNPACAFGSAMVYGS--FKNQAVYWVGPLLGGATAALVY 235
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 25-236 2.67e-34

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 123.31  E-value: 2.67e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  25 YVSEFISTFFFVLAAVGSVMssrklMAGDVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRISVPT 104
Cdd:COG0580   6 LLAEFLGTFILVLLGCGVVA-----VLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798 105 AMFYWTSQMIASVMACLVLKVTVMeQHVPIYKIAGEMTG------------FGASVLEGVLAFVLVYTVFTASDPRRGLP 172
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYG-GHFDATEDGGAKLGvfatspaigyslGAAFLTEIIGTFVLVFVILGITDKRAAPG 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798 173 lAVGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQA------VYWVGPLLGGATAALVYD 236
Cdd:COG0580 160 -GLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKGGSdwgylwVPIVAPILGAALAALLYR 228
PLN00184 PLN00184
aquaporin NIP1; Provisional
 17-238 6.26e-21

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 89.31  E-value: 6.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   17 LSMNALRCYVSEFISTFFFVLAAVGSVmssrklmAGDVSGPFGVLIPAIANALALSSSV--YISWNVSGGHVNPAVTFAM 94
Cdd:PLN00184  49 VSVPFLQKLIAEVLGTYFLVFTGCASV-------VVNMQNDNVVTLPGIAIVWGLTIMVliYSLGHISGAHINPAVTIAF 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   95 AVAGRISVPTAMFYWTSQMIASVMACLVLKVTVMEQH----------VPIYKIAGEMTGFgasVLEGVLAFVLVYTVFTA 164
Cdd:PLN00184 122 ASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGLDHdvcsgkhdvfIGSSPVGSDLQAF---VMEFIVTFYLMFIISGV 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15232798  165 SDPRRGLPLAVGpIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVYDNV 238
Cdd:PLN00184 199 ATDNRAIGELAG-LAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTV 271
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 17-235 5.58e-19

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 83.75  E-value: 5.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   17 LSMNALRCYVSEFISTFFFVLAAVGsVMSSRKLMAGDVsgpfGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAV 96
Cdd:PLN00183  40 MDLNPARMVLAEMVGTFILMFCVCG-IIASTQLSGGEV----GLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFAT 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   97 AGRISVPTAMFYWTSQMIASVMACLVlKVTVMEQHVPIYKIAGEMTGFGASVLEGVLAFVLVytvFTASDPRRGlPLAVG 176
Cdd:PLN00183 115 FGHFPWSKVPLYITAQTVGSVLATYV-GVSVYGVKADLMTTKPAQGCSSAFWVEFIATFIVM---FLAASLTSQ-PQSLG 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15232798  177 PI---FIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVY 235
Cdd:PLN00183 190 HLsgfVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMF 251
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 26-236 8.04e-19

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 83.42  E-value: 8.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   26 VSEFISTFFFVLAAVGSVMSSrKLMAGDVSGPfGVlipAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRISVPTA 105
Cdd:PLN00182  46 IAEMIGTYFIIFSGCGVVVVN-VLYGGTITFP-GI---CVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  106 MFYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTGFGASVLEGVLAFVLVYTVFTASDPRRGLPLAVGpIFIGFVAG 185
Cdd:PLN00182 121 PLYIGAQLTGSLLASLTLRLMFNVTPEAFFGTTPTDSSGQALVAEIIISFLLMFVISGVATDSRAVGELAG-IAVGMTII 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15232798  186 ANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVYD 236
Cdd:PLN00182 200 LNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYN 250
PLN00026 PLN00026
aquaporin NIP; Provisional
 27-244 1.60e-14

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 71.43  E-value: 1.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   27 SEFISTFFFVLAAVGSVMSSRKlmAGDVSGPFGVlipAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRISVPTAM 106
Cdd:PLN00026  76 AEFVGTFILIFAATAGPIVNQK--YDGAETLIGN---AACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVP 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  107 FYWTSQMIASVMACLVLKVT---VMEQHVPIYKIAgemTGfGASVLEGVLAFVLVYTVFT-ASDPRrglplAVGP---IF 179
Cdd:PLN00026 151 AYIAAQVSASICASFALKGVfhpFMSGGVTVPSVS---TG-QAFALEFIITFNLLFVVTAvATDTR-----AVGElagIA 221

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15232798  180 IGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVYDNVVVPVED 244
Cdd:PLN00026 222 VGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREED 286
PRK05420 PRK05420
aquaporin Z; Provisional
 22-238 1.71e-13

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 67.69  E-value: 1.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   22 LRCYVSEFISTFFFVLAAVGSVMssrkLMAGDVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRIS 101
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAV----LAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  102 VPTAMFYWTSQMIASVMACLVLkvtvmeqhvpiYKIAGEMTGFGAS-----------------------VLEGVLAFVLV 158
Cdd:PRK05420  78 AKELVPYIIAQVVGGIAAAAVL-----------YLIASGKAGFDLAgsgfasngygehspggysllaalVCEVVLTAFFL 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  159 YTVFTASDPRrgLPLAVGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQA--VYWVGPLLGGATAALVYD 236
Cdd:PRK05420 147 LVILGATDKR--APAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWALEQlwLFWVAPIVGAIIGGLIYR 224


                 ..
gi 15232798  237 NV 238
Cdd:PRK05420 225 LL 226
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 22-241 1.35e-10

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 60.14  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798   22 LRCYVSEFISTFFFVLAAVGSVMSSRKlmagdVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRIS 101
Cdd:PTZ00016  50 VREYVAEFLGTFVLLFFGEGVVATTHT-----VGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFP 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  102 VPTAMFYWTSQMI------ASVMAC-----------LVLKVTVMEQHVPIYKIAGEMTGFGASVLEGVLAFVLVYTVFTA 164
Cdd:PTZ00016 125 WKKLPGYFVAQLLgafvgaACVYGLyygffkdhgipELPWETMANGFAGVFATYPREGNFYAIFSELILTAILLLVILAI 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232798  165 SDPRRGLPLAVGPIFIGFVAGANVLAAGPFSGGSMNPACAFG----SAMVYGS--FKNQAVYW----VGPLLGGATAALV 234
Cdd:PTZ00016 205 TDPNNCPAFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGprlfSAILWGSevFTKDNYYFwvplVAPFVGAVLGMFL 284


                 ....*..
gi 15232798  235 YDNVVVP 241
Cdd:PTZ00016 285 YDKFIPP 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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