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Conserved domains on  [gi|15231221|ref|NP_190158|]
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Major facilitator superfamily protein [Arabidopsis thaliana]

Protein Classification

NRT1/PTR family MFS transporter( domain architecture ID 13024493)

NRT1/PTR (nitrate transporter/peptide transporter) family major facilitator superfamily (MFS) transporter is a proton-coupled transporter that facilitates the transport of one or more from a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
26-537 0e+00

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 597.71  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  26 FPFMIATLLGISVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGI 105
Cdd:cd17416   1 MPFIIGNETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 106 FLLTLISSFENLRPRPCETGSILCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYDKP-----RDKGSFFNWYF 180
Cdd:cd17416  81 VLLTLTAAIPSLRPPPCETASSLCQSPSKLQLAVLYSALALLSIGAGGIRPCSLAFGADQFDKKtesgkRGLESFFNWYY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 181 LTVNTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFYKhdkpmgspftslirvlvaailkikvvtsske 260
Cdd:cd17416 161 FTFTVAQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILFLAGSRLYV------------------------------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 261 edyhrevekesktcigmpsksfrflnraalksekdlnqedglchnpwrlcsveeVEDFKSVLRVLPLWLAILFVGTSIGV 340
Cdd:cd17416 210 ------------------------------------------------------VEDLKSLIRVIPIWSTGIILSLAMAQ 235
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 341 QASMTVLQALVTDRGLDSKFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKIT--HKQLTPLQQVGIGQVFNILSMAIS 418
Cdd:cd17416 236 QMSLTVLQALVMDRHLGPSFQIPAGSITVFLLITLTIFIPLYDRVLVPLLRKITgrGRGLTLLQRVGIGIVFSILSMAVA 315
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 419 AIVEAKRLKTVENE----HPMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVTSVAFGISFYLSTALIN 494
Cdd:cd17416 316 AIVERKRRKTALTQgngtSPMSVLWLVPQLVLMGIAEAFHFIGQIEFFYQEFPESMRSTATSLFSLGMGVASYLSSALIS 395
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*....
gi 15231221 495 LIQRTT------AWLPDDINHGRVDNVYWVLVIGGVLNLGYFFVCSWYF 537
Cdd:cd17416 396 AVHRTTgrggggSWLPDDINKGRLDYVYWLLAGLGALNLGYFLVCSWRY 444
 
Name Accession Description Interval E-value
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
26-537 0e+00

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 597.71  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  26 FPFMIATLLGISVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGI 105
Cdd:cd17416   1 MPFIIGNETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 106 FLLTLISSFENLRPRPCETGSILCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYDKP-----RDKGSFFNWYF 180
Cdd:cd17416  81 VLLTLTAAIPSLRPPPCETASSLCQSPSKLQLAVLYSALALLSIGAGGIRPCSLAFGADQFDKKtesgkRGLESFFNWYY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 181 LTVNTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFYKhdkpmgspftslirvlvaailkikvvtsske 260
Cdd:cd17416 161 FTFTVAQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILFLAGSRLYV------------------------------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 261 edyhrevekesktcigmpsksfrflnraalksekdlnqedglchnpwrlcsveeVEDFKSVLRVLPLWLAILFVGTSIGV 340
Cdd:cd17416 210 ------------------------------------------------------VEDLKSLIRVIPIWSTGIILSLAMAQ 235
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 341 QASMTVLQALVTDRGLDSKFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKIT--HKQLTPLQQVGIGQVFNILSMAIS 418
Cdd:cd17416 236 QMSLTVLQALVMDRHLGPSFQIPAGSITVFLLITLTIFIPLYDRVLVPLLRKITgrGRGLTLLQRVGIGIVFSILSMAVA 315
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 419 AIVEAKRLKTVENE----HPMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVTSVAFGISFYLSTALIN 494
Cdd:cd17416 316 AIVERKRRKTALTQgngtSPMSVLWLVPQLVLMGIAEAFHFIGQIEFFYQEFPESMRSTATSLFSLGMGVASYLSSALIS 395
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*....
gi 15231221 495 LIQRTT------AWLPDDINHGRVDNVYWVLVIGGVLNLGYFFVCSWYF 537
Cdd:cd17416 396 AVHRTTgrggggSWLPDDINKGRLDYVYWLLAGLGALNLGYFLVCSWRY 444
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
93-504 7.62e-59

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 200.62  E-value: 7.62e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221    93 VISASAFISLLGIFLLTLiSSFENLRPrpcetgsilcqspsKLHLGVLYAALALVTAGTSGTRVALASAGANQYDK--PR 170
Cdd:pfam00854   3 TIFLGSIIYAIGHILLAL-SAIPSLRP--------------PVHVALFFIGLALIALGTGGIKPNVSSFGGDQFEEtdPR 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   171 DKGSFFNWYFLTVNTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFYKHDKPMGSPFTSLIRVL-VAAI 249
Cdd:pfam00854  68 RRSRFFSIFYFSINAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLpVAAW 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   250 LKIKVVTSSK------EEDYHREVEKESKTCIGMPsksfrflnraalksekdlnqedGLCHNPWrlCSVEEVEDFKSVLR 323
Cdd:pfam00854 148 NKVKLNGSSAgikklhWLDWARELDALIILGIVVP----------------------GIFFNIW--CTKTKVEEVKRLLR 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   324 VLPLWLAILFVGTSIGVQASMTVLQALVTDRGLDSkFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKIThKQLTPLQQ 403
Cdd:pfam00854 204 VLPLFLPLIMFWALYDQMGTSWVLQARTMNRKIGS-FEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCT-GGLTPLQK 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   404 VGIGQVFNILSMAISAIVEAKRLKTV-----ENEHPMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVT 478
Cdd:pfam00854 282 MAVGLFLASLAFAIAAIVQLKRNDTGpefpiAQEVPISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLF 361
                         410       420
                  ....*....|....*....|....*.
gi 15231221   479 SVAFGISFYLSTALINLIQRTTAWLP 504
Cdd:pfam00854 362 LLTNALGNFLSGVIATLTAKPTNVLG 387
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
75-440 3.10e-13

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 72.49  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221    75 MLPVVTAILADSFFGNIPVISasaFISLLGIFLLTLISsfenlrprpceTGSIlCQSPSKLHLGVLYAALALVTAGTSGT 154
Cdd:TIGR00926  38 LTPLIGAIIADGWLGKFKTIL---YLSIVYVVGHALLS-----------FGAI-PSSGHPLHDLLDLLGLALIALGTGGI 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   155 RVALASAGANQY--DKPRDKGSFFNWYFLTVNTGAIISATAIVYTQENAS-------WRLGFGLCAAANLISFIVFISGK 225
Cdd:TIGR00926 103 KPCVSAFGGDQFeeRQLSLRSRFFSFFYFAINAGSLISTIITPILRGDVGcfgcqdcYPLAFGVPAILMILALIVFMAGS 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   226 RFYKHDKPMGSPFTSLIRVLVAAILKiKVVTSSKEEDYHrevekesktcigmpsksfrFLNRAALKSEKDLnqedglchn 305
Cdd:TIGR00926 183 KMYKKKPPKGNIVSKVIKCIVTALRK-RFSTRSEHWPLH-------------------WLDYAKDKHDIRM--------- 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   306 pwrlcsveeVEDFKSVLRVLPLWLAILFVGTSIGVQASMTVLQAlvtdRGLDSK---FKVPAGSLQVIVLIsscVFLVLN 382
Cdd:TIGR00926 234 ---------IRSTKRLLRVLVLFIPLPMFWALFDQQGSRWTLQA----TRMDGDvggFEIQPDQMQVVNPL---LILIFV 297
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   383 NWTIYPIYQKIT--HKQLTPLQQVGIGQVFNILSMAISAIVEAKRLKTVENEHPMSVLWL 440
Cdd:TIGR00926 298 PIFDYIVYPAIAkcGTRFTSLRKMAVGGLLAALSFFVAALVQLKVNPTLPEEPSANEIFL 357
PRK15462 PRK15462
dipeptide permease;
41-232 1.38e-08

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 57.27  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   41 YGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIFLLtlissfenlrpr 120
Cdd:PRK15462  26 YGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLMAIGHVVL------------ 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  121 pcetgsilcqSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQY---DKPRDKGsfFNWYFLTVNTGAIISATAIVYT 197
Cdd:PRK15462  94 ----------GASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYeptDPRRDGG--FSLMYAAGNVGSIIAPIACGYA 161
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 15231221  198 QENASWRLGFGLCAAANLISFIVFISGKRFYKHDK 232
Cdd:PRK15462 162 QEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFTHTR 196
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
24-222 1.23e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.64  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  24 ITFPFMIATLLGISVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFF-GNIPVISASAFISL 102
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrRRKLVLAIGLLLAA 259
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 103 LGIFLLTLISSfenlrprpcetgsilcqspsklhLGVLYAALALVTAGTSGTRVALASAGANQYDkPRDKGSFFNWYFLT 182
Cdd:COG2271 260 LALLLLALLPS-----------------------PALAIALLFLAGFGLGGAFGLLWALAAELFP-KKARGTASGLVNTF 315
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15231221 183 VNTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFI 222
Cdd:COG2271 316 GFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
 
Name Accession Description Interval E-value
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
26-537 0e+00

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 597.71  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  26 FPFMIATLLGISVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGI 105
Cdd:cd17416   1 MPFIIGNETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 106 FLLTLISSFENLRPRPCETGSILCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYDKP-----RDKGSFFNWYF 180
Cdd:cd17416  81 VLLTLTAAIPSLRPPPCETASSLCQSPSKLQLAVLYSALALLSIGAGGIRPCSLAFGADQFDKKtesgkRGLESFFNWYY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 181 LTVNTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFYKhdkpmgspftslirvlvaailkikvvtsske 260
Cdd:cd17416 161 FTFTVAQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILFLAGSRLYV------------------------------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 261 edyhrevekesktcigmpsksfrflnraalksekdlnqedglchnpwrlcsveeVEDFKSVLRVLPLWLAILFVGTSIGV 340
Cdd:cd17416 210 ------------------------------------------------------VEDLKSLIRVIPIWSTGIILSLAMAQ 235
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 341 QASMTVLQALVTDRGLDSKFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKIT--HKQLTPLQQVGIGQVFNILSMAIS 418
Cdd:cd17416 236 QMSLTVLQALVMDRHLGPSFQIPAGSITVFLLITLTIFIPLYDRVLVPLLRKITgrGRGLTLLQRVGIGIVFSILSMAVA 315
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 419 AIVEAKRLKTVENE----HPMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVTSVAFGISFYLSTALIN 494
Cdd:cd17416 316 AIVERKRRKTALTQgngtSPMSVLWLVPQLVLMGIAEAFHFIGQIEFFYQEFPESMRSTATSLFSLGMGVASYLSSALIS 395
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*....
gi 15231221 495 LIQRTT------AWLPDDINHGRVDNVYWVLVIGGVLNLGYFFVCSWYF 537
Cdd:cd17416 396 AVHRTTgrggggSWLPDDINKGRLDYVYWLLAGLGALNLGYFLVCSWRY 444
MFS_NPF cd17351
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ...
27-534 8.39e-99

Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340909 [Multi-domain]  Cd Length: 445  Bit Score: 306.86  E-value: 8.39e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  27 PFMIATLLGISVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIF 106
Cdd:cd17351   2 PFILGNEFAERLAFYGIAVNLVTYLTKVMHLSNAKAANTVTNFSGTSYLTPLLGAFLADAYLGRYWTIAIFSVIYLVGLI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 107 LLTLISSFENLRPRPCETGSiLCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYD-----KPRDKGSFFNWYFL 181
Cdd:cd17351  82 LLTLSASVPSLRPPPCNPDS-PCEPASSTQLTVLYVGLYLIALGTGGIKPCVSAFGADQFDetdpkEKKQKPSFFNWFYF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 182 TVNTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFYkhdkpmgspftslirvlvaailkikvvtsskee 261
Cdd:cd17351 161 SINLGSLLAVTLVVYIQDNVSWGWGFGIPAAAMALAVIVFVAGTPFY--------------------------------- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 262 dyhREVekesktcigmpsksfrflnraalksekdlnqedglchnpwrlcsveevedfKSVLRVLPLWLAILFVGTSIGVQ 341
Cdd:cd17351 208 ---REV---------------------------------------------------KCLLRLLPIWATTILLSTVYAQM 233
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 342 ASMTVLQALVTDRGLDSKFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKIT-HKQ-LTPLQQVGIGQVFNILSMAISA 419
Cdd:cd17351 234 QTFFVQQGLTMDRRLGGSFEIPAASLSVFSTLFVLLFIPLYDRVFVPFARRYTgNPRgITPLQRIGIGLVLSILAMAVAA 313
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 420 IVEAKRLKTVENEH---------PMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVTSVAFGISFYLST 490
Cdd:cd17351 314 LVEVKRLRVARAHGlldsptgvvPMSVFWLLPQYFLLGLAEVFTYIGQLEFFYDEAPDGMRSLGTALFLLTIALGNFLSS 393
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|
gi 15231221 491 ALINLIQRTTA------WLPDDINHGRVDNVYWVLVIGGVLNLGYFFVCS 534
Cdd:cd17351 394 ALVTIVNKITGkgggpgWLPNNLNKGRLDYFYWLLAVLSAVNFLVFLVCA 443
MFS_NPF3 cd17415
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ...
24-536 1.63e-87

NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340973 [Multi-domain]  Cd Length: 448  Bit Score: 277.41  E-value: 1.63e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  24 ITFPFMIATLLGISVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLL 103
Cdd:cd17415   2 KTMPFIFGNEICERLASVGFHTNLITYLTLQLHMPLVKAANILTNFNGTASLTPLLGAFIADSFAGRFWTITIGSIIYQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 104 GIFLLTLISSFENLRPRPCETGSILCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYD--KPRDKG---SFFNW 178
Cdd:cd17415  82 GMVLLTISAILPSLRPPPCNGHEVCACQASSAQLSILYLSLLLTALGSGGIRPCVVAFGADQFDesDPKQAKqtwNFFNW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 179 YFLTVNTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFYKhdkpmgspftslirvlvaailkikvvtss 258
Cdd:cd17415 162 YYFCMGIAILLAVTVIVYIQDNVGWGWGFGIPTIAMAISVIAFVVGSPLYR----------------------------- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 259 keedyhrevekesktcigmpsksfrflnraalksekdlnqedglchnpwrlcsveeveDFKSVLRVLPLWLAILFVGTSI 338
Cdd:cd17415 213 ----------------------------------------------------------ELKSIIRMLPIWAAGILLVTAS 234
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 339 GVQASMTVLQALVTDRGLDSKFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKITHKQ--LTPLQQVGIGQVFNILSMA 416
Cdd:cd17415 235 SQQHTFSIQQARTMNRHLTPSFQIPPASMSVFGILSLLTTVPLYDRVLMPVARKFTGNErgITFLQRMGIGLFISILATV 314
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 417 ISAIVEAKRlKTVENEH----------PMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVTSVAFGISF 486
Cdd:cd17415 315 VAAFVEVKR-KSVAANHglldrphatvPISVFWLVPQYILHGIAEAFMSIGHLEFFYDQSPESMRSTATALFWSTISLGS 393
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15231221 487 YLSTALINLIQRTTA-----WLPDDINHGRVDNVYWVLVIGGVLNLGYFFVCSWY 536
Cdd:cd17415 394 YLSTLLVTLVHKETSrggrwWLPNNLNRGRLDYFYWLVAVLQAVNLVYFLICARW 448
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
41-539 3.16e-87

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 276.84  E-value: 3.16e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  41 YGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIFLLTLISSFENLRPR 120
Cdd:cd17417  19 YGIASNLVTYLTTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYLLGLVLLTLSASLPSLKPP 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 121 PCetgSILCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYD-----KPRDKGSFFNWYFLTVNTGAIISATAIV 195
Cdd:cd17417  99 EC---NGTCSKASTLQVAFFFFSLYLVAIGQGGHKPCVQAFGADQFDeddpkEKKQKSSFFNWWYFSICAGSLTAVTVLV 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 196 YTQENASWRLGFGLCAAANLISFIVFISGKRFYKHdkpmgspftslirvlvaailkikvvtsskeedyhrevekesktci 275
Cdd:cd17417 176 YIQDNVGWALGFGIPTIVMALALFVFLLGTPLYRY--------------------------------------------- 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 276 gmpsksfrflnraalksekdlnqedglchnpwrlcSVEEVedfKSVLRVLPLWLAILFVGTSIGVQASMTVLQALVTDRG 355
Cdd:cd17417 211 -----------------------------------KVEEV---KLVLRLIPIWFTTLVFTVVFAQSPTFFTKQGVTMDRT 252
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 356 LDSKFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKITHKQ--LTPLQQVGIGQVFNILSMAISAIVEAKRLKTVENEH 433
Cdd:cd17417 253 IGPNFKIPPASLQSFITLSILISIPIYDRVFVPIARKITGNPrgITLLQRIGIGMFLSILAMVIAALVEMKRLKVAKEHG 332
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 434 --------PMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVTSVAFGISFYLSTALINLIQRTT----- 500
Cdd:cd17417 333 lispkatvPMSIFWLLPQYILLGIADVFTMVGMQEFFYDQVPDEMRSLGTALYLSVFGVGSFLSSFLISIVDKITsssgg 412
                       490       500       510       520
                ....*....|....*....|....*....|....*....|
gi 15231221 501 -AWLPDDINHGRVDNVYWVLVIGGVLNLGYFFVCSWYFTY 539
Cdd:cd17417 413 qSWFNNNLNRAHLDYFYWLLAVLSAVNFVLFLFVAKSYVY 452
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
37-534 9.42e-80

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 257.30  E-value: 9.42e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  37 SVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIFLLTLISSFEN 116
Cdd:cd17419  15 TLAYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFVIGLLLLTLSSALPS 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 117 LRPRPCETGSILCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYD-----KPRDKGSFFNWYFLTVNTGAIISA 191
Cdd:cd17419  95 LRPPQCGDGDLKCPPASAAQTTFLYFSLYLIALGYGGYQPCIATLGADQFDdedpiEKASKSAFFSYFYQALNLGSLFSN 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 192 TAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFYkhdkpmgspftslirvlvaailkikvvtsskeedyhREVekes 271
Cdd:cd17419 175 TILVYFEDNGSWGLGFGISAGAAFIGLVLFLAGTPFY------------------------------------REV---- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 272 ktcigmpsksfrflnraalksekdlnqedglchnpwrlcsveevedfKSVLRVLPLWLAILFVGTSIGVQASMTVLQALV 351
Cdd:cd17419 215 -----------------------------------------------KCILRLLPIWLSTIIYSVVYTQMATLFVEQGAA 247
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 352 TDRGLdSKFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKITH--KQLTPLQQVGIGQVFNILSMAISAIVEAKRLKTV 429
Cdd:cd17419 248 MDTSF-GNFKIPPASMSVFEILSVAVGTVLYRKFLVPLLRKVTGhpKGITELQRMGIGLVIGILAMVVAALVEIQRLKVA 326
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 430 ENEH--------PMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRN--TATSVTSVAFGisFYLSTALINLIQRT 499
Cdd:cd17419 327 RPSNlddptspsPLSIFWQIPQYVLVGASEVFTYVGQLEFFYDQAPDGLRSlgSALCMASVALG--NYLSSLLVTIVNKV 404
                       490       500       510       520
                ....*....|....*....|....*....|....*....|.
gi 15231221 500 T------AWLPDDINHGRVDNVYWVLVIGGVLNLGYFFVCS 534
Cdd:cd17419 405 TtkdgspGWIPDNLNKGHLDRFYWLLAALSGIDFVVFLICA 445
MFS_NPF6 cd17413
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ...
38-534 2.93e-76

NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340971 [Multi-domain]  Cd Length: 457  Bit Score: 248.52  E-value: 2.93e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  38 VTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIFLLTLISSFENL 117
Cdd:cd17413  16 LTTLGIGVNLVTYLTGTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQALGVLVLTLSTTLPSL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 118 RPRPC-ETGSILCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYDK--PRDKG---SFFNWYFLTVNTGAIISA 191
Cdd:cd17413  96 RPPPCnHTTSHHCEPASGIQLTVLYLALYLIALGTGGIKSSVSGFGSDQFDEndPKERKlmsYFFNRFFFCISVGSLLAV 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 192 TAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFYKHDKPMGSpftslirvlvaailkikvvtsskeedyhrevekes 271
Cdd:cd17413 176 TVLVYIQDNVGRGWGYGICAAAMVLAIVVFLAGTKRYRFKKSIGS----------------------------------- 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 272 ktcigmpsksfrflnraalksekdlnqedglchnpwrlcsvEEVEDFKSVLRVLPLWLAILFVGTSIGVQASMTVLQALV 351
Cdd:cd17413 221 -----------------------------------------TQVEEVKMVVRMLPIWATTILFWTVYAQMTTFSVEQAET 259
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 352 TDRGLDSkFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKIT-HKQ-LTPLQQVGIGQVFNILSMAISAIVEAKRLKTV 429
Cdd:cd17413 260 MDRNIGS-FEIPPASMAVFLVATILLTTAVYDRVIVPLCRKLTgHPQgLTTLQRIGVGLVFSCLAMAVAALVELKRLRIA 338
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 430 ENEH------PMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSV--TSVAFGisFYLSTALINLIQRTT- 500
Cdd:cd17413 339 HAHGkpvktvPMSVFWLVPQYFLVGAGEAFIYTGQLDFFIRESPKGMKSMSTGLflSTLSLG--FFVSSFLVSIVNRVTg 416
                       490       500       510
                ....*....|....*....|....*....|....*....
gi 15231221 501 -----AWLPDDINHGRVDNVYWVLVIGGVLNLGYFFVCS 534
Cdd:cd17413 417 kshphGWLADNLNKGRLDYFYWLLAVLSALNFVIFLVFA 455
MFS_NPF4 cd17414
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ...
44-535 4.13e-69

NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340972 [Multi-domain]  Cd Length: 456  Bit Score: 229.60  E-value: 4.13e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  44 VLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIFLLTLISSFENLRPRPCE 123
Cdd:cd17414  22 ANNLVTYLINNMHYSLAKSANIVTNFVGTAFLLALLGGFLSDSFLSSFKTIIIFGSIELLGLILLTVQAHIPSLQPPSCN 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 124 T-GSILCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYDK-----PRDKGSFFNWYFLTVNTGAIISATAIVYT 197
Cdd:cd17414 102 SlGDLTCKEPSGSQAAILFVGLYLVALGVGCIKPNLPSHGADQFDEndpkgRRQLSSFFNWYYFSFSLGALIAVTLVVWV 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 198 QENASWRLGFGLCAAANLISFIVFISGKRFYKHDkpmgspftslirvlvaailkikvvtsskeedyhrevekesktcigm 277
Cdd:cd17414 182 EENKGWDWGFGVSAAVIAVGILVFVAGTPFYRNK---------------------------------------------- 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 278 psksfrflnraalksekdlnqedglchnpwrlcsvEEVEDFKSVLRVLPLWLAILFVGTSIGVQASMTVLQALVTDRGLD 357
Cdd:cd17414 216 -----------------------------------TQVEEVKIVLKMLPIFACTIILNCILAQLQTFSVQQGSTMNRTKI 260
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 358 SKFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKITHKQ--LTPLQQVGIGQVFNILSMAISAIVEAKRLKT-VENEH- 433
Cdd:cd17414 261 GSFNIPPASLQAIPVIFMLILVPLYDHLLVPFARKITGHEsgITHLQRIGIGLVLSTLSMVVAALVETKRKKVaVENGLl 340
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 434 ------PMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVTSVAFGISFYLSTALINLIQRTTAW----- 502
Cdd:cd17414 341 nskenlPISIFWIALQFLILGISDMFTAVGLLEFFYTESPSSMRSLGTALTWCSYSFGFYLSSVLVSVVNKVTGSgghgg 420
                       490       500       510
                ....*....|....*....|....*....|....*.
gi 15231221 503 --LPDDINHGRVDNVYWVLVIGGVLN-LGYFFVCSW 535
Cdd:cd17414 421 wlLGENLNRDRLDLFYWLLCVLSTINfLNYLFWARR 456
MFS_NPF8 cd17418
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ...
27-536 9.42e-65

NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340976 [Multi-domain]  Cd Length: 447  Bit Score: 218.11  E-value: 9.42e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  27 PFMIATLLGISVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIF 106
Cdd:cd17418   5 PFILGNECCERLAYYGIATNLITYLTKELHQGNVSAANNVTNWSGTCYITPLIGAFIADAYWGRYWTIASFSAIYFIGMV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 107 LLTLISSFENLRPRPCetGSILCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYDK--PRD---KGSFFNWYFL 181
Cdd:cd17418  85 LLTLSASVPGLKPASC--IGSLCPPATSVQYAVFFLGLYLIALGTGGIKPCVSSFGADQFDDtdPKEkvrKSSFFNWFYF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 182 TVNTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFYkhdkpmgspftslirvlvaailkikvvtsskee 261
Cdd:cd17418 163 SINIGALISSSVLVWIQENVGWGWGFGIPTVFMGIAIVSFFFGTPLY--------------------------------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 262 dyhREVekesktcigmpsksfrflnraalksekdlnqedglchnpwrlcsveevedfKSVLRVLPLWLAILFVGTSIGVQ 341
Cdd:cd17418 210 ---REV---------------------------------------------------KILIRLLPIWASGIVFATVYSQM 235
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 342 ASMTVLQALVTDRgLDSKFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKIT--HKQLTPLQQVGIGQVFNILSMAISA 419
Cdd:cd17418 236 STMFVQQGRTMDR-MGGNFEIPPASLSLFDTLSVLIWVPIYDRFIVPLVRKFTghERGFTQLQRMGIGLFISVLSMVAAA 314
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 420 IVEAKRLKTVENEH--------PMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRN--TATSVTSVAFGisFYLS 489
Cdd:cd17418 315 IVEIVRLQLARTHNlvesgppvPMSIFWQIPQYFLIGAAEVFTFIGQLEFFYDQSPDAMRSlcSALSLLTTALG--NYLS 392
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....
gi 15231221 490 TALINLIQRTTA------WLPDDINHGRVDNVYWVLVIGGVLN-LGYFFVCSWY 536
Cdd:cd17418 393 SLIVTLVTYVTTkggkpgWIPDNLNNGHLDYFFWLLASLSFLNiLVYLWIAKRY 446
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
93-504 7.62e-59

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 200.62  E-value: 7.62e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221    93 VISASAFISLLGIFLLTLiSSFENLRPrpcetgsilcqspsKLHLGVLYAALALVTAGTSGTRVALASAGANQYDK--PR 170
Cdd:pfam00854   3 TIFLGSIIYAIGHILLAL-SAIPSLRP--------------PVHVALFFIGLALIALGTGGIKPNVSSFGGDQFEEtdPR 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   171 DKGSFFNWYFLTVNTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFYKHDKPMGSPFTSLIRVL-VAAI 249
Cdd:pfam00854  68 RRSRFFSIFYFSINAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLpVAAW 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   250 LKIKVVTSSK------EEDYHREVEKESKTCIGMPsksfrflnraalksekdlnqedGLCHNPWrlCSVEEVEDFKSVLR 323
Cdd:pfam00854 148 NKVKLNGSSAgikklhWLDWARELDALIILGIVVP----------------------GIFFNIW--CTKTKVEEVKRLLR 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   324 VLPLWLAILFVGTSIGVQASMTVLQALVTDRGLDSkFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKIThKQLTPLQQ 403
Cdd:pfam00854 204 VLPLFLPLIMFWALYDQMGTSWVLQARTMNRKIGS-FEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCT-GGLTPLQK 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   404 VGIGQVFNILSMAISAIVEAKRLKTV-----ENEHPMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVT 478
Cdd:pfam00854 282 MAVGLFLASLAFAIAAIVQLKRNDTGpefpiAQEVPISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLF 361
                         410       420
                  ....*....|....*....|....*.
gi 15231221   479 SVAFGISFYLSTALINLIQRTTAWLP 504
Cdd:pfam00854 362 LLTNALGNFLSGVIATLTAKPTNVLG 387
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
39-534 1.82e-45

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 165.69  E-value: 1.82e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  39 TSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIFLLTLISsfENLR 118
Cdd:cd06175  14 TFYGIGANLVPFLTGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGVAILTVST--IPPG 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 119 PRPCETGSILCQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYDK--PRDKGSFFNWYFLTVNTGAIISATAIVY 196
Cdd:cd06175  92 LRPLRCNPSHCEQASGIQLTGFYAALYLIALGTGGVKANVSPLGADQFDErgPSKTQSFFNWFYFCINVGSLLAMLGTPY 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 197 TQENASWRLGFGLCAAANLISFIVFisgkrfykhdkpmgspftslirvlvaailkikvvtsskeedyhrevekesktcig 276
Cdd:cd06175 172 IQDNVGWAAAYGIPFVAILLALVVF------------------------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 277 mpsksfrflnraalksekdlnqedglchnpwrlcsveeveDFKSVLRVLPLWLAILFVGTSIGVQASMTVLQALVTDRGL 356
Cdd:cd06175 197 ----------------------------------------EVKQLLRALPLFAFCILFWTVYAQMTTSYVLQALTLVRST 236
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 357 DSkFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKITHKqLTPLQQVGIGQVFNILSMAISAIVEAKRLKTVENEHP-- 434
Cdd:cd06175 237 GL-FTIPPASMQAFNPILLLLLIPVLDKVVYPLIRRYGVG-LSPLTKIGLGFFFGSLSMFVAGFLELKRLNTAHAHGPvv 314
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 435 ----MSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVTSVAFGISFYLSTALINLIQRTT--AWLPDDIN 508
Cdd:cd06175 315 ttspLSFWWQIPQYLLLGIGEILVSITGLEFAYREAPKSMKGFIMGLLLLTSGFGSFFGSVLVTLVSKPTdgAHIADDLN 394
                       490       500
                ....*....|....*....|....*.
gi 15231221 509 HGRVDNVYWVLVIGGVLNLGYFFVCS 534
Cdd:cd06175 395 KGVLTNFFFLLAVLAALNFLIFLLVS 420
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
27-541 6.84e-20

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 92.30  E-value: 6.84e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  27 PFMIATLLGISVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIF 106
Cdd:cd17347   5 PFIVGNEFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYCLGHI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 107 LLTLISSfenlrprpcetgsilcQSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQYDKPRDKGS--FFNWYFLTVN 184
Cdd:cd17347  85 VLAVTAI----------------PPLGPPHVWGLLIGLLLIAIGTGGIKPCVSAFGGDQFGADQQHLLarFFSWFYFAIN 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 185 TGAIISA--TAIVYTQ----ENASWRLGFGLCAAANLISFIVFISGKRFYKhdkpmgspftslirvlvaailkikvvtss 258
Cdd:cd17347 149 AGSLLSTflTPILRADvqfgGHDCYPLAFGVPGVLMAVATLVFWLGRKHYK----------------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 259 keedyhrevekesktcigmpsksfrflnraalksekdlnqedglchnpwrlcsveeveDFKSVLRVLPLWLAILFVGTSI 338
Cdd:cd17347 200 ----------------------------------------------------------DVKALLRVLVLFIPLPVFWALF 221
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 339 GVQASMTVLQALVTDRGLdSKFKVPAGSLQVI--VLIssCVFLVLNNWTIYPIYQKITHKqLTPLQQVGIGQVFNILSMA 416
Cdd:cd17347 222 DQQGSRWTLQAEQMDGLV-GGFTILPDQMQALnpILI--LILIPLFDYVIYPLLERCGIP-LTPLRKMGVGMILAALAFV 297
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 417 ISAIVEAK------------RLKTVENEHPMSV--LWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVtsvaf 482
Cdd:cd17347 298 IAGFLQLRidgglpgqpdpgEVTTFEDIEPNSVsiLWQLPQYVVLTAGEVLFSITGLEFAYTQAPKSMKSVVQAA----- 372
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15231221 483 gisFYLSTALINLIQRTTAWLpddINHGRVDNVYWVLVIGGVLNLGYFFVCSWYFTYRK 541
Cdd:cd17347 373 ---WLLTVALGNLIVVIVAEL---IQFSSQAAEYFFFAGLMLVVAVVFALLARFYKYVT 425
MFS_SLC15A3_4 cd17348
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ...
41-532 7.48e-16

Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340906 [Multi-domain]  Cd Length: 435  Bit Score: 79.83  E-value: 7.48e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  41 YGWVLNLIVFL-IEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIFLLTLISSfenlrp 119
Cdd:cd17348  19 YGITSNLVLFLnGSPFNWEGTQASQALLLFMGATYLLSPFGGWLADAYLGRFWTILLSLLLYLLGMLLFPATAA------ 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 120 rpcetgsilcqspsklhlGVLYAALALVTAGTSGTRVALASAGANQY-DKPRDKGS-FFNWYFLTVNTGAIISATAIVYT 197
Cdd:cd17348  93 ------------------PALYAGLLLVGLGVGSVKANITPFGADQVkDRGPEATRrFFNWFYWSINLGAILSLGGVAYI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 198 QENASWRLGFGLCAAANLISFIVFISGKRFYKhdkpmgspftslirvlvaailkikvvtsskeedyhrevekesktcigm 277
Cdd:cd17348 155 QQNVSFLIGYSIPAVCVGLAFLVFLCGQPVFI------------------------------------------------ 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 278 psksfrflnraalksekdlnqedglchnpwrlcsveeveDFKSVLRVLPLWLAILFVGTSIGVQASMTVLQAL------- 350
Cdd:cd17348 187 ---------------------------------------DVKALVKILPVFLALIPYWTVYFQMQTTYVLQSLhlkipni 227
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 351 ---VTDRGLDSKFKVPAGSLQVIVLISSCVFLVLNNWTIYPIYQKitHKQL-TPLQQVGIGQVFNILSMAISAIVEAKRL 426
Cdd:cd17348 228 fisNIAGITNSSHTFPAAWLTMFDAVLILILIPLKDKLVDPFLKR--RGLLpSSLKRIAVGMFFVMCSAIAAGILESKRL 305
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 427 KTVENEH--------------PMSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVTSVAFGISFYLSTAL 492
Cdd:cd17348 306 EIVKHNTtiqqqignvtyyaaDLPIWWQIPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGL 385
                       490       500       510       520
                ....*....|....*....|....*....|....*....|.
gi 15231221 493 INLIQ-RTTAWLPDDINHGRVDNVYwvlviggvLNLgYFFV 532
Cdd:cd17348 386 LALVSiKEIGWMSSHKDFGNINGCR--------LNY-YFFL 417
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
75-440 3.10e-13

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 72.49  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221    75 MLPVVTAILADSFFGNIPVISasaFISLLGIFLLTLISsfenlrprpceTGSIlCQSPSKLHLGVLYAALALVTAGTSGT 154
Cdd:TIGR00926  38 LTPLIGAIIADGWLGKFKTIL---YLSIVYVVGHALLS-----------FGAI-PSSGHPLHDLLDLLGLALIALGTGGI 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   155 RVALASAGANQY--DKPRDKGSFFNWYFLTVNTGAIISATAIVYTQENAS-------WRLGFGLCAAANLISFIVFISGK 225
Cdd:TIGR00926 103 KPCVSAFGGDQFeeRQLSLRSRFFSFFYFAINAGSLISTIITPILRGDVGcfgcqdcYPLAFGVPAILMILALIVFMAGS 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   226 RFYKHDKPMGSPFTSLIRVLVAAILKiKVVTSSKEEDYHrevekesktcigmpsksfrFLNRAALKSEKDLnqedglchn 305
Cdd:TIGR00926 183 KMYKKKPPKGNIVSKVIKCIVTALRK-RFSTRSEHWPLH-------------------WLDYAKDKHDIRM--------- 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   306 pwrlcsveeVEDFKSVLRVLPLWLAILFVGTSIGVQASMTVLQAlvtdRGLDSK---FKVPAGSLQVIVLIsscVFLVLN 382
Cdd:TIGR00926 234 ---------IRSTKRLLRVLVLFIPLPMFWALFDQQGSRWTLQA----TRMDGDvggFEIQPDQMQVVNPL---LILIFV 297
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   383 NWTIYPIYQKIT--HKQLTPLQQVGIGQVFNILSMAISAIVEAKRLKTVENEHPMSVLWL 440
Cdd:TIGR00926 298 PIFDYIVYPAIAkcGTRFTSLRKMAVGGLLAALSFFVAALVQLKVNPTLPEEPSANEIFL 357
MFS_SLC15A5 cd17349
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute ...
39-535 8.02e-12

Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 5 (SLC15A5) is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. The specific function of SLC15A5 is unknown. SLC15A5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340907 [Multi-domain]  Cd Length: 437  Bit Score: 67.47  E-value: 8.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  39 TSYGWVLNLIVFLIEEYNIKSIAAAqisnIVNGCL---SML-PVVTAILADSFFGNIPVISASAFISLLGIFLLTLIS-S 113
Cdd:cd17349  17 TFFGIVCNMILFCTIKLGYRNHQAA----IVNLCFvgtSTLtPVFVGWLAEECMGRNKLVYICLFLHFLGTALLPVVAfP 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 114 FENLRprpCETGSILCQSPSKLHLGVLYAALALVTAGTSGTR--VALASAGANQYDKPRDKGSFFNWYFLTVNTGAIISA 191
Cdd:cd17349  93 FEDFY---IDTHHIIHTLAKREQTLLFYVALLTASLGTGGIRaiVCPLSAYGLQDYGSRKLMSFFNWFYWLVNLNSAVVF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 192 TAIVYTQENASWRLGFglcaaanLIsfivfisgkrfykhdkpmgsPFTSLIRVLVAAILKikvvtsskeedyhrevekes 271
Cdd:cd17349 170 VGISYIQQSVAKNLGF-------LI--------------------PFMSVLMALITLHMV-------------------- 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 272 ktcigmpsksfrflnraalksekdlnqedglcHNpwrlcsveEVEDFKSVLRVLPLWLAILFVGTSIGVQASMTVLQALV 351
Cdd:cd17349 203 --------------------------------RN--------DLINTKNLVRLFPLFAFQILYRTCIMQIPSGYYLQTMN 242
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 352 TDRGLDSkFKVPAGSLQVIVLISSCV---FLVLNNWTIYPIYQkithKQLTPLQQVGIGQVFNILSMAISAIVEAKRLKT 428
Cdd:cd17349 243 SNLNLGG-FLLPIAAMNVISIIPLLIlapFLEYFSSCLFSSKR----YGPFLSACIIAGHLCAALSVMVAGFSEIHRKRF 317
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 429 VENEHP----------MSVLWLLPPLVIVGIGDAFHYMANVAVFYGEFPESMRNTATSVTSVAFGISFYLSTALINLIQR 498
Cdd:cd17349 318 PLVEQTlsgkvllvssMPCFQLAPQYVLLGVAEALVTPACSLITFRLVPSSIRGISMHFLTLFNGAGCFMGALLIQLVYL 397
                       490       500       510
                ....*....|....*....|....*....|....*....
gi 15231221 499 TTA--WLPDDINHGRVDNVYWVLVIGGVLNLGYFFVCSW 535
Cdd:cd17349 398 ISEgnWFPNTLNKGNLERFFFFLASLMLLNALGFWRISH 436
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
47-234 2.38e-11

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 65.67  E-value: 2.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  47 LIVFLIEEYN--IKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIFLLTLissfenlrprpcet 124
Cdd:cd17346  25 LILYLTAQLGdgFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIGGILMALGYLLLAL-------------- 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 125 gsilcqspSKLHLGVLYAALALVTAGTSGTRVALASAGANQYDKP---RDKGsfFNWYFLTVNTGAIISATAIVYTQENA 201
Cdd:cd17346  91 --------SPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENdprRDSG--FSIFYMGINLGAFLAPLLCGTLGDNY 160
                       170       180       190
                ....*....|....*....|....*....|...
gi 15231221 202 SWRLGFGLCAAANLISFIVFISGKRFYKHDKPM 234
Cdd:cd17346 161 GYHYGFGLAAVGMLLGLLIFLLGRKKLLERKKM 193
MFS_SLC15A1 cd17412
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ...
77-232 2.43e-10

Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340970 [Multi-domain]  Cd Length: 415  Bit Score: 62.55  E-value: 2.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  77 PVVTAILADSFFGNIPVISASAFISLLGIFLLTlISSFENL--RPRPCETGSIlcqspsKLHLGVLYAALALVTAGTSGT 154
Cdd:cd17412  55 PILGAIIADSWLGKFKTIVYLSIVYTIGQAVMA-VSAIHDLtdANRDGTPDNL------TLHVALSMIGLLLIALGTGGI 127
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 155 RVALASAGANQYDKPRDK--GSFFNWYFLTVNTGAIISA--TAIVYTQE------NASWRLGFGLCAAANLISFIVFISG 224
Cdd:cd17412 128 KPCVAAFGGDQFEEHQEKqrSRFFSIFYLSINAGSLLSTiiTPILRSQEcgihskQKCYPLAFGVPAALMVVALIVFILG 207

                ....*...
gi 15231221 225 KRFYKHDK 232
Cdd:cd17412 208 SKMYKQIK 215
PRK15462 PRK15462
dipeptide permease;
41-232 1.38e-08

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 57.27  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   41 YGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIFLLtlissfenlrpr 120
Cdd:PRK15462  26 YGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLMAIGHVVL------------ 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  121 pcetgsilcqSPSKLHLGVLYAALALVTAGTSGTRVALASAGANQY---DKPRDKGsfFNWYFLTVNTGAIISATAIVYT 197
Cdd:PRK15462  94 ----------GASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYeptDPRRDGG--FSLMYAAGNVGSIIAPIACGYA 161
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 15231221  198 QENASWRLGFGLCAAANLISFIVFISGKRFYKHDK 232
Cdd:PRK15462 162 QEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFTHTR 196
MFS_PTR2 cd17350
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ...
61-230 8.25e-07

Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340908 [Multi-domain]  Cd Length: 438  Bit Score: 51.70  E-value: 8.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  61 AAAQISNIVNGCLSMLPVVTAILADSFFGNIPVISASAFISLLGIFLLTLISSfenlrPRPCETGSilcqspsklHLGVL 140
Cdd:cd17350  47 GATGLSNFFTFWCYVTPVIGAYVADQFLGRYNTIVCGAVIYFVGILILTCTSI-----PSVIDAGA---------GLGGF 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 141 YAALALVTAGTSGTRVALASAGANQYDKPRD------KGS------------FFNWYFLTVNTGAIiSATAIVYTQENAS 202
Cdd:cd17350 113 VVAIIIIGLGTGGIKSNVSPLIADQLPKIKPyvktlkNGErvivdpvvtlsrIYMIFYWAINVGSL-SLLATTYLERTKG 191
                       170       180
                ....*....|....*....|....*...
gi 15231221 203 WRLGFGLCAAANLISFIVFISGKRFYKH 230
Cdd:cd17350 192 FWYAYLLPLCVFVIPLIILAFGKKFYKI 219
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
24-222 1.23e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.64  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  24 ITFPFMIATLLGISVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFF-GNIPVISASAFISL 102
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrRRKLVLAIGLLLAA 259
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 103 LGIFLLTLISSfenlrprpcetgsilcqspsklhLGVLYAALALVTAGTSGTRVALASAGANQYDkPRDKGSFFNWYFLT 182
Cdd:COG2271 260 LALLLLALLPS-----------------------PALAIALLFLAGFGLGGAFGLLWALAAELFP-KKARGTASGLVNTF 315
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15231221 183 VNTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFI 222
Cdd:COG2271 316 GFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
MFS_SLC15A2 cd17411
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ...
77-232 2.71e-06

Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340969 [Multi-domain]  Cd Length: 403  Bit Score: 49.82  E-value: 2.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  77 PVVTAILADSFFGNIPVISASAFISLLGifllTLISSfenlrprpceTGSILCQSPSKLHLGVLYAALALVTAGTSGTRV 156
Cdd:cd17411  55 PVLGALIADSWLGKFKTIIYLSIVYVVG----HVIKS----------VGAIPTVGDQQVHVVLSMIGLFLIALGTGGIKP 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 157 ALASAGANQYDKP--RDKGSFFNWYFLTVNTGAIISA------TAIVYTQENASWRLGFGLCAAANLISFIVFISGKRFY 228
Cdd:cd17411 121 CVAAFGGDQFEEEhaRERSKFFSIFYLSINAGSLISTfvtpilRGDVQCFGGDCYALAFGVPAALMVVALVVFIAGSGMY 200

                ....
gi 15231221 229 KHDK 232
Cdd:cd17411 201 KEVK 204
yjdL_sub1_fam TIGR00924
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ...
137-230 1.25e-05

amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273342 [Multi-domain]  Cd Length: 475  Bit Score: 47.91  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   137 LGVLYAALALVTAGTSGTRVALASAGANQYDKP----RDKGsfFNWYFLTVNTGAIISATAIVYTQENASWRLGFGLCAA 212
Cdd:TIGR00924 102 PDLIFYGLGTIAVGSGLFKANPSSMVGKLYERGdmprRDGG--FTLFYMSINIGSFISPLLAGVIAENYGYHVGFNLAAV 179
                          90
                  ....*....|....*...
gi 15231221   213 ANLISFIVFISGKRFYKH 230
Cdd:TIGR00924 180 GMVIGLLTFFAGRHMLRD 197
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
28-222 2.30e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 2.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221  28 FMIATLLGISVTSYGWVLNLIVFLIEEYNIKSIAAAQISNIVNGCLSMLPVVTAILADSFfGNIPVISASAFISLLGIFL 107
Cdd:COG2814  13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFALGSLL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221 108 LTLISSFenlrprpcetgsilcqspsklhlGVLYAALALVTAGTSGTRVALASAGANQYDkPRDKGSFFNWYFLTVNTGA 187
Cdd:COG2814  92 CALAPSL-----------------------WLLLAARFLQGLGAGALFPAALALIADLVP-PERRGRALGLLGAGLGLGP 147
                       170       180       190
                ....*....|....*....|....*....|....*
gi 15231221 188 IISATAIVYTQENASWRLGFGLCAAANLISFIVFI 222
Cdd:COG2814 148 ALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLL 182
MFS_1 pfam07690
Major Facilitator Superfamily;
24-222 5.93e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221    24 ITFPFMIATLLGISVTSYGWVLNLivflieeynikSIAAAQISNIVNGCLSmlpvvtailadSFFGNIPVISASAFISLL 103
Cdd:pfam07690  17 PALPLLLAEDLGISPTEIGLLLTL-----------FSLGYALAQPLAGRLS-----------DRFGRRRVLLIGLLLFAL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231221   104 GIFLLTLISSFenlrprpcetgsilcqspsklhlgVLYAALALVTAGTSGTRVALASAGANQYDKPRDKGSFFNWYFLTV 183
Cdd:pfam07690  75 GLLLLLFASSL------------------------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGF 130
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 15231221   184 NTGAIISATAIVYTQENASWRLGFGLCAAANLISFIVFI 222
Cdd:pfam07690 131 GLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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