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Conserved domains on  [gi|15229728|ref|NP_189949|]
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Vacuolar iron transporter (VIT) family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CCC1_like super family cl00278
CCC1-related family of proteins; CCC1_like: This protein family includes the proteins related ...
26-166 4.65e-49

CCC1-related family of proteins; CCC1_like: This protein family includes the proteins related to CCC1, a yeast vacuole transmembrane protein responsible for the iron and manganese transport from the cytosol into vacuole. It also includes the proteins similar to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation.


The actual alignment was detected with superfamily member cd02436:

Pssm-ID: 469703  Cd Length: 152  Bit Score: 156.65  E-value: 4.65e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  26 QWLRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVA-----QMKRETGG- 99
Cdd:cd02436   1 QWLRAAVLGANDGLVSVASLMLGVGAVCADEHAMLLSGLAGLVAGACPMAIGEFVRVYRQYRRPRAarclrGRNRARGPa 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15229728 100 -----EIEKEKLPSPTQAAAASALAFSLGAMVPLLAAAFVKEYKVRIGAIVAAvTLALVMFGWLGAVLGKAP 166
Cdd:cd02436  81 pdsepEGLRRQAPSPSSAATASALSFAAGALFPLLAAWFVASYASRRVLPPQS-SAPAAPPGRSPATVTASS 151
 
Name Accession Description Interval E-value
Nodulin-21 cd02436
Nodulin-21; Nodulin-21: This is a family of proteins that may be unique to certain plants. The ...
26-166 4.65e-49

Nodulin-21; Nodulin-21: This is a family of proteins that may be unique to certain plants. The family member in soybean is found to be nodule-specific and is abundant during nodule development. The proteins of this family thus may play a role in symbiotic nitrogen fixation.


Pssm-ID: 153127  Cd Length: 152  Bit Score: 156.65  E-value: 4.65e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  26 QWLRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVA-----QMKRETGG- 99
Cdd:cd02436   1 QWLRAAVLGANDGLVSVASLMLGVGAVCADEHAMLLSGLAGLVAGACPMAIGEFVRVYRQYRRPRAarclrGRNRARGPa 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15229728 100 -----EIEKEKLPSPTQAAAASALAFSLGAMVPLLAAAFVKEYKVRIGAIVAAvTLALVMFGWLGAVLGKAP 166
Cdd:cd02436  81 pdsepEGLRRQAPSPSSAATASALSFAAGALFPLLAAWFVASYASRRVLPPQS-SAPAAPPGRSPATVTASS 151
Ccc1 COG1814
Predicted Fe2+/Mn2+ transporter, VIT1/CCC1 family [Inorganic ion transport and metabolism];
21-193 3.40e-44

Predicted Fe2+/Mn2+ transporter, VIT1/CCC1 family [Inorganic ion transport and metabolism];


Pssm-ID: 441419 [Multi-domain]  Cd Length: 229  Bit Score: 146.82  E-value: 3.40e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  21 YSKRAQWLRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVAQMKRET--- 97
Cdd:COG1814   5 RSERSGWLRAAVLGANDGLVSTAALVAGVAGAGASPSAILLAGLAGLVAGALSMAAGEYVSVSSQRDTEEAELARERrel 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  98 ----GGE------------------------------------------IEKEKLPSPTQAAAASALAFSLGAMVPLLAA 131
Cdd:COG1814  85 aedpEGEreelaeiyrarglspelaeqvaeeltahdaawldahareelgIDEEELASPWQAALASFLAFAVGALLPLLPY 164
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15229728 132 AFVKEYkVRIGAIVAAVTLALVMFGWLGAVLGKAPVVKSSLRVLVGGWLAMAITYGFTKLIG 193
Cdd:COG1814 165 LLAPGA-AALPVSAVLTLLALALTGALKARLGGASPLRAALRTLLIGALAAAVTYLVGLLFG 225
VIT1 pfam01988
VIT family; This family includes the vacuolar Fe2+/Mn2+ uptake transporter Ccc1 and the ...
28-190 4.26e-36

VIT family; This family includes the vacuolar Fe2+/Mn2+ uptake transporter Ccc1 and the vacuolar iron transporter VIT1.


Pssm-ID: 460408 [Multi-domain]  Cd Length: 212  Bit Score: 125.25  E-value: 4.26e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728    28 LRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVAQMKRE-----TGGEIE 102
Cdd:pfam01988   1 LRAAVLGANDGLVSTFALVAGVAGASLSSKVVLLAGLAGLVAGAISMAAGEYVSVSSQRDTEEAELARErreleNDPEAE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728   103 KEKL--------------------------------------PSPTQAAAASALAF------SLGAMVPLLAAAFVKEYK 138
Cdd:pfam01988  81 LEELaeiyearglseelarqvvaellknpdafldammreelgIDPSEALANPKAALtsflsfALGGLIPLLPYLFLPSGI 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15229728   139 VRIGAIVAAVTLALVMFGWLGAVLGKAPVVKSSLRVLVGGWLAMAITYGFTK 190
Cdd:pfam01988 161 PALIVSIILTLLALFLLGAVKARLGGASPLRSALRMLLIGALAAAATYGIGR 212
 
Name Accession Description Interval E-value
Nodulin-21 cd02436
Nodulin-21; Nodulin-21: This is a family of proteins that may be unique to certain plants. The ...
26-166 4.65e-49

Nodulin-21; Nodulin-21: This is a family of proteins that may be unique to certain plants. The family member in soybean is found to be nodule-specific and is abundant during nodule development. The proteins of this family thus may play a role in symbiotic nitrogen fixation.


Pssm-ID: 153127  Cd Length: 152  Bit Score: 156.65  E-value: 4.65e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  26 QWLRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVA-----QMKRETGG- 99
Cdd:cd02436   1 QWLRAAVLGANDGLVSVASLMLGVGAVCADEHAMLLSGLAGLVAGACPMAIGEFVRVYRQYRRPRAarclrGRNRARGPa 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15229728 100 -----EIEKEKLPSPTQAAAASALAFSLGAMVPLLAAAFVKEYKVRIGAIVAAvTLALVMFGWLGAVLGKAP 166
Cdd:cd02436  81 pdsepEGLRRQAPSPSSAATASALSFAAGALFPLLAAWFVASYASRRVLPPQS-SAPAAPPGRSPATVTASS 151
Ccc1 COG1814
Predicted Fe2+/Mn2+ transporter, VIT1/CCC1 family [Inorganic ion transport and metabolism];
21-193 3.40e-44

Predicted Fe2+/Mn2+ transporter, VIT1/CCC1 family [Inorganic ion transport and metabolism];


Pssm-ID: 441419 [Multi-domain]  Cd Length: 229  Bit Score: 146.82  E-value: 3.40e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  21 YSKRAQWLRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVAQMKRET--- 97
Cdd:COG1814   5 RSERSGWLRAAVLGANDGLVSTAALVAGVAGAGASPSAILLAGLAGLVAGALSMAAGEYVSVSSQRDTEEAELARERrel 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  98 ----GGE------------------------------------------IEKEKLPSPTQAAAASALAFSLGAMVPLLAA 131
Cdd:COG1814  85 aedpEGEreelaeiyrarglspelaeqvaeeltahdaawldahareelgIDEEELASPWQAALASFLAFAVGALLPLLPY 164
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15229728 132 AFVKEYkVRIGAIVAAVTLALVMFGWLGAVLGKAPVVKSSLRVLVGGWLAMAITYGFTKLIG 193
Cdd:COG1814 165 LLAPGA-AALPVSAVLTLLALALTGALKARLGGASPLRAALRTLLIGALAAAVTYLVGLLFG 225
Nodulin-21_like_1 cd02432
Nodulin-21 and CCC1-related protein family; Nodulin-21_like_1: This is a family of proteins ...
21-187 8.53e-40

Nodulin-21 and CCC1-related protein family; Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter.


Pssm-ID: 153123 [Multi-domain]  Cd Length: 218  Bit Score: 135.03  E-value: 8.53e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  21 YSKRAQWLRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVAQMKRE---- 96
Cdd:cd02432   1 LIERLNWLRAAVLGANDGIVSVAGLVVGVAAATASSFTILIAGLAGLVAGALSMAAGEYVSVSSQRDTEKADIAKErrel 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  97 -TGGEIEKEKLP------------------------------------------SPTQAAAASALAFSLGAMVPLLAAAF 133
Cdd:cd02432  81 aEDPEAELEELAdiyeerglspelarqvadelmakdaleahardelgitegeyaNPWQAALASAISFSVGALLPLLAILL 160
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 15229728 134 VKEyKVRIGAIVAAVTLALVMFGWLGAVLGKAPVVKSSLRVLVGGWLAMAITYG 187
Cdd:cd02432 161 APA-AWKVPVTIIATLLALALTGYVSARLGGASVLRAILRNVIWGALAMALTYL 213
VIT1 pfam01988
VIT family; This family includes the vacuolar Fe2+/Mn2+ uptake transporter Ccc1 and the ...
28-190 4.26e-36

VIT family; This family includes the vacuolar Fe2+/Mn2+ uptake transporter Ccc1 and the vacuolar iron transporter VIT1.


Pssm-ID: 460408 [Multi-domain]  Cd Length: 212  Bit Score: 125.25  E-value: 4.26e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728    28 LRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVAQMKRE-----TGGEIE 102
Cdd:pfam01988   1 LRAAVLGANDGLVSTFALVAGVAGASLSSKVVLLAGLAGLVAGAISMAAGEYVSVSSQRDTEEAELARErreleNDPEAE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728   103 KEKL--------------------------------------PSPTQAAAASALAF------SLGAMVPLLAAAFVKEYK 138
Cdd:pfam01988  81 LEELaeiyearglseelarqvvaellknpdafldammreelgIDPSEALANPKAALtsflsfALGGLIPLLPYLFLPSGI 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15229728   139 VRIGAIVAAVTLALVMFGWLGAVLGKAPVVKSSLRVLVGGWLAMAITYGFTK 190
Cdd:pfam01988 161 PALIVSIILTLLALFLLGAVKARLGGASPLRSALRMLLIGALAAAATYGIGR 212
CCC1_like cd01059
CCC1-related family of proteins; CCC1_like: This protein family includes the proteins related ...
28-192 1.54e-30

CCC1-related family of proteins; CCC1_like: This protein family includes the proteins related to CCC1, a yeast vacuole transmembrane protein responsible for the iron and manganese transport from the cytosol into vacuole. It also includes the proteins similar to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation.


Pssm-ID: 153121  Cd Length: 143  Bit Score: 108.85  E-value: 1.54e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  28 LRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDievaqmkretggeiekeklp 107
Cdd:cd01059   1 LRAAVLGANDGLVSTFALVAGVAAAGDSTKAILLAGLAGLVAGAISMAAGEYVSVKSQRD-------------------- 60
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728 108 sptQAAAASALAFSLGAMVPLLAAAFVKEYKVRIG-AIVAAVTLALVMFGWLGAVLGKAPVVKSSLRVLVGGWLAMAITY 186
Cdd:cd01059  61 ---KAALASGLSFILGGLLPLLPYLLLPAGSLALAvSVALVVALALFLLGAFVAKLGGAKKIRAALRMVVLGLLAAALTY 137

                ....*.
gi 15229728 187 GFTKLI 192
Cdd:cd01059 138 LLGRLF 143
Nodulin-21_like_2 cd02433
Nodulin-21 and CCC1-related protein family; Nodulin-21_like_2: This is a family of proteins ...
27-193 1.58e-27

Nodulin-21 and CCC1-related protein family; Nodulin-21_like_2: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter.


Pssm-ID: 153124 [Multi-domain]  Cd Length: 234  Bit Score: 104.03  E-value: 1.58e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  27 WLRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVAQMK------------ 94
Cdd:cd02433  19 NLRAAVFGANDGLVSNLALVMGVAGAGVSNQTILLTGLAGLLAGALSMAAGEYVSVTSQRELLEASIPderrelrkhple 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  95 --------------------------------------RETGGeIEKEKLPSPTQAAAASALAFSLGAMVPLLAAAFVKE 136
Cdd:cd02433  99 eaaelaliyrakgldeeeakrvasqlmndpeqaldtlaREELG-LDPELLGNPWSAAVSSFLLFALGALIPVLPFLFGMS 177
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15229728 137 YKVRIGAIVAAVTLALVMFGWLGAVLGKAPVVKSSLRVLVGGWLAMAITYGFTKLIG 193
Cdd:cd02433 178 GLAALVLSVLLVGLALLATGAVTGLLSGRSPGISALRQLAIGGGAAAVTYLLGLLFG 234
Nodulin-21_like_3 cd02434
Nodulin-21 and CCC1-related protein family; Nodulin-21_like_3: This is a family of proteins ...
28-96 2.36e-06

Nodulin-21 and CCC1-related protein family; Nodulin-21_like_3: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter.


Pssm-ID: 153125  Cd Length: 225  Bit Score: 46.57  E-value: 2.36e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  28 LRAAVLGANDGLVSTASLMMG-VGAVKQNVKIMILtGFAGLVAGACSMAIGEFVSVYSQYDIEVAQMKRE 96
Cdd:cd02434   3 LKSIVFGGLDGIVTIFAIVAGvVGAGLSPFVILII-GFANLLADGISMAAGEYVSTKAERDFLHSEKKRE 71
Ferritin_CCC1_C cd02431
CCC1-related domain of ferritin; Ferritin_CCC1_like_C: The proteins of this family contain two ...
28-188 2.58e-05

CCC1-related domain of ferritin; Ferritin_CCC1_like_C: The proteins of this family contain two domains. This is the C-terminal domain that is closely related to the CCC1, a vacuole transmembrane protein functioning as an iron and manganese transporter. The N-terminal domain is similar to ferritin-like diiron-carboxylate proteins, which are involved in a variety of iron ion related functions, such as iron storage and regulation, mono-oxygenation, and reactive radical production. This family may be unique to certain bacteria and archaea.


Pssm-ID: 153122  Cd Length: 149  Bit Score: 42.68  E-value: 2.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  28 LRAAVLGANDGLVSTASLMMGVGAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIevaqmkretggeiekeKLP 107
Cdd:cd02431   1 VGDFVLGLNDALVEITGALAGLTGAINNTILVGLSGLIVGIAAALSMAIGAYLSTKSESGV----------------KES 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728 108 SPTQAAAASALAFSLGAMVPLLAAAFVKEYKVRIGAIVAAVTLALVMFGWLGAVLGKAPVVKSSLRVLVGGWLAMAITYG 187
Cdd:cd02431  65 NPVKSALYTGIAYIIGVVIPILPYLLLSSVYLALALSVTLAVLAILIFNFYISVASGISFRKKFIEMAGLALGAAFISFL 144

                .
gi 15229728 188 F 188
Cdd:cd02431 145 L 145
CCC1_like_1 cd02437
CCC1-related protein family; CCC1_like_1: This is a protein family closely related to CCC1, a ...
29-192 1.25e-04

CCC1-related protein family; CCC1_like_1: This is a protein family closely related to CCC1, a family of proteins involved in iron and manganese transport. Yeast CCC1 is a vacuole transmembrane protein responsible for the iron and manganese accumulation in vacuole.


Pssm-ID: 153128  Cd Length: 175  Bit Score: 40.87  E-value: 1.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  29 RAAVLGANDGLVSTASLMMGV-GAVKQNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVAQMKR--------ETGG 99
Cdd:cd02437   4 RYGIYGLIDGSLSTLGVVFGAsLAFDLDPKIIIAAGLGGAFALGISNGLGAAVAEEGSLRGMLEEKEKillrleqmLTST 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728 100 EIEKEKLPSPTQAAAASALAFSLGAMVPLLaAAFVKEYKVRIGAIVAAVTLALVMFGWLGAVLGKAPVVKSSLRVLVGGW 179
Cdd:cd02437  84 REELAIRKADLPSGLIQGISTTLGGLLPLL-PFLPFDLWLAAGIAVAIVLAILFILGLVIGKISKINVAISFVWAVGMVI 162
                       170
                ....*....|...
gi 15229728 180 LAMAITYGFTKLI 192
Cdd:cd02437 163 TGISLVFSVGKLF 175
CCC1 cd02435
CCC1; CCC1: This domain is present in the CCC1, an iron and manganese transporter of ...
28-97 5.97e-04

CCC1; CCC1: This domain is present in the CCC1, an iron and manganese transporter of Saccharomyces cerevisiae. CCC1 is a transmembrane protein that is located in the vacuole and transfers the iron and manganese ions from the cytosol to the vacuole. This domain may be unique to certain fungi and plants.


Pssm-ID: 153126 [Multi-domain]  Cd Length: 241  Bit Score: 39.61  E-value: 5.97e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229728  28 LRAAVLGANDGLVSTASLMMGVGAVKqNVKIMILTGFAGLVAGACSMAIGEFVSVYSQYDIEVAQMKRET 97
Cdd:cd02435  22 VRDIIIGLSDGLTVPFALTAGLSSLG-DTKLVITGGLAELAAGAISMGLGGYLAAKSERDHYQREHKRKQ 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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