Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];

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                ....*....|....*....|....*....|....*...
gi 15231969 332 KVVSRIKTPHKVLLTGSLYQNNIKEVFNILDVAFPEFL 369
Cdd:COG0553 379 KAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLL 416

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231969 305 RDILLNIL-SVVVFGRGTDPRNEMMSFLKVVSRIKTPHKVLLTGSLYQNNIKEVFNILDVAFPEFL 369
Cdd:cd18000 125 KDLLLNHNwQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

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                ....*....|....*....|....*....|....*....|....
gi 15231969 324 RNEMMSFLKVVSRIKTPHKVLLTGSLYQNNIKEVFNILDVAFPE 367
Cdd:cd17994 118 KNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPE 161

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15231969 324 RNEMMSFLKVVSRIKTPHKVLLTGSLYQNNIKEVFNILDVAFPE 367
Cdd:cd18057 154 KNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPE 197

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231969 315 VVFGRGTDPRNEMMSFLKVVSRIKTPHKVLLTGSLYQNNIKEVFNILDvafpeFLKHNQIG--KNFR-KFLNVEADGPST 391
Cdd:cd18068 159 VVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVN-----FVKPNLLGtiKEFRnRFVNPIQNGQCA 233

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gi 15231969 392 N 392
Cdd:cd18068 234 D 234

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

                        10        20        30
                ....*....|....*....|....*....|....*
gi 15231969 332 KVVSRIKTPHKVLLTGSLYQNNIKEVFNILDVAFP 366
Cdd:cd18005 160 QAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVP 194