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Conserved domains on  [gi|15233016|ref|NP_189495|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

ATP-binding protein( domain architecture ID 16031656)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase, similar to Arabidopsis thaliana BCS1-like protein

CATH:  3.40.50.300
EC:  3.6.1.-
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18466635|16689629
SCOP:  4003976

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 217-391 1.44e-68

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 216.83  E-value: 1.44e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 217 MKKDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMANFLEYDVYDLELTTVKDNSELKKLMLDTKGK-SIVV 295
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 296 IEDIDCSLDLTGQRkkkkeededeeeeekkkeaekLLKRERGERESKVTLSGLLNAIDGLWSacSGEKIIVFTTNYLDKL 375
Cdd:cd19510  81 LEDIDAAFESREHN---------------------KKNPSAYGGLSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERL 137

                       170
                ....*....|....*.
gi 15233016 376 DPALIRRGRMDNHIEM 391
Cdd:cd19510 138 DPALIRPGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 29-125 1.14e-30

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


:

Pssm-ID: 464152  Cd Length: 95  Bit Score: 114.57  E-value: 1.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016    29 VPYQIRDYLEKCFYKMFGLVSNSVHIKFTEYTedkGLKKSQAYDLIRNYLSSKSTARAQR-LKANESKNSKSLVLSLDNH 107
Cdd:pfam14363   1 LPPELRDYLSSKLARLFSRFSPYLTIVIDEFD---GFSRNELYDAAQTYLSTKISPSSARrLKASKSPKSKSLVLSLDDN 77

                          90
                  ....*....|....*...
gi 15233016   108 EAVEDVFQGVKVVWSLSV 125
Cdd:pfam14363  78 EEVTDVFEGVKLWWTLVV 95
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 217-391 1.44e-68

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 216.83  E-value: 1.44e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 217 MKKDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMANFLEYDVYDLELTTVKDNSELKKLMLDTKGK-SIVV 295
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 296 IEDIDCSLDLTGQRkkkkeededeeeeekkkeaekLLKRERGERESKVTLSGLLNAIDGLWSacSGEKIIVFTTNYLDKL 375
Cdd:cd19510  81 LEDIDAAFESREHN---------------------KKNPSAYGGLSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERL 137

                       170
                ....*....|....*.
gi 15233016 376 DPALIRRGRMDNHIEM 391
Cdd:cd19510 138 DPALIRPGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 29-125 1.14e-30

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


Pssm-ID: 464152  Cd Length: 95  Bit Score: 114.57  E-value: 1.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016    29 VPYQIRDYLEKCFYKMFGLVSNSVHIKFTEYTedkGLKKSQAYDLIRNYLSSKSTARAQR-LKANESKNSKSLVLSLDNH 107
Cdd:pfam14363   1 LPPELRDYLSSKLARLFSRFSPYLTIVIDEFD---GFSRNELYDAAQTYLSTKISPSSARrLKASKSPKSKSLVLSLDDN 77

                          90
                  ....*....|....*...
gi 15233016   108 EAVEDVFQGVKVVWSLSV 125
Cdd:pfam14363  78 EEVTDVFEGVKLWWTLVV 95
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 242-393 1.30e-17

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 79.17  E-value: 1.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   242 YLLFGPPGTGKSTMISAMAN-----FLEYDVYDLELTTVKDNSELKKLMLD---TKGKSIVVIEDIDCsldLTGQRKkkk 313
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKelgapFIEISGSELVSKYVGESEKRLRELFEaakKLAPCVIFIDEIDA---LAGSRG--- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   314 eededeeeeekkkeaekllkrERGERESKVTLSGLLNAIDGLWSacSGEKIIVF-TTNYLDKLDPALirRGRMDNHIEMS 392
Cdd:pfam00004  75 ---------------------SGGDSESRRVVNQLLTELDGFTS--SNSKVIVIaATNRPDKLDPAL--LGRFDRIIEFP 129


                  .
gi 15233016   393 Y 393
Cdd:pfam00004 130 L 130
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 209-433 2.36e-14

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 74.95  E-value: 2.36e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 209 MDLEKKEgMKKDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMANFLEYDVYDLELTTVKD----NSElKKL 284
Cdd:COG0464 162 LEEVKEE-LRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSkyvgETE-KNL 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 285 --MLDT---KGKSIVVIEDIDcslDLTGQRkkkkeededeeeeekkkeaekllkRERGERESKVTLSGLLNAIDGLwsac 359
Cdd:COG0464 240 reVFDKargLAPCVLFIDEAD---ALAGKR------------------------GEVGDGVGRRVVNTLLTEMEEL---- 288

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15233016 360 SGEKIIVFTTNYLDKLDPALIRrgRMDNHIEMSYCRFEAFKVLAKNYLEIESHDLFGEIKRLVEETD-MSPADVA 433
Cdd:COG0464 289 RSDVVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDVDLEELAEATEgLSGADIR 361
ftsH CHL00176
cell division protein; Validated
 203-405 3.13e-11

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 65.84  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  203 TFETLA-MDLEKKEgmKKDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMAN-------------FLEYD-- 266
Cdd:CHL00176 181 TFRDIAgIEEAKEE--FEEVVSFLKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGeaevpffsisgseFVEMFvg 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  267 -----VYDLeLTTVKDNSelkklmldtkgKSIVVIEDIDcsldltgqrkkkkeededeeeeekkkeaekLLKRERGER-- 339
Cdd:CHL00176 259 vgaarVRDL-FKKAKENS-----------PCIVFIDEID------------------------------AVGRQRGAGig 296

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15233016  340 ----ESKVTLSGLLNAIDGLwsacSGEK--IIVFTTNYLDKLDPALIRRGRMDNHIEMS----YCRFEAFKVLAKN 405
Cdd:CHL00176 297 ggndEREQTLNQLLTEMDGF----KGNKgvIVIAATNRVDILDAALLRPGRFDRQITVSlpdrEGRLDILKVHARN 368
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 203-414 1.35e-08

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 57.61  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   203 TFETLAmDLEKKEGMKKDLIKF-TKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMAN-----FLEYDVYDLELTTVK 276
Cdd:TIGR01243 176 TYEDIG-GLKEAKEKIREMVELpMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANeagayFISINGPEIMSKYYG 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   277 DNSE-LKKLMLDTK--GKSIVVIEDIDCsldLTGQRKKKKeededeeeeekkkeaekllkrerGERESKVtLSGLLNAID 353
Cdd:TIGR01243 255 ESEErLREIFKEAEenAPSIIFIDEIDA---IAPKREEVT-----------------------GEVEKRV-VAQLLTLMD 307

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15233016   354 GLWSacSGEKIIVFTTNYLDKLDPALIRRGRMDNHIEMSY----CRFEAFKVLAKNYLEIESHDL 414
Cdd:TIGR01243 308 GLKG--RGRVIVIGATNRPDALDPALRRPGRFDREIVIRVpdkrARKEILKVHTRNMPLAEDVDL 370
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 239-395 2.11e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.59  E-value: 2.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016    239 KRGYLLFGPPGTGKSTMISAMANFLEYDvydlelttvkdnselkklmldtkGKSIVViedIDCSLDLTGQRKKKKEEDED 318
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPP-----------------------GGGVIY---IDGEDILEEVLDQLLLIIVG 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016    319 EEEEEKKKEAEKLLKRERGERESKVTL-------------SGLLNAIDGLWSACS----GEKIIVFTTNYLDKLDPALIR 381
Cdd:smart00382  56 GKKASGSGELRLRLALALARKLKPDVLildeitslldaeqEALLLLLEELRLLLLlkseKNLTVILTTNDEKDLGPALLR 135

                          170
                   ....*....|....
gi 15233016    382 RgRMDNHIEMSYCR 395
Cdd:smart00382 136 R-RFDRRIVLLLIL 148
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 217-391 1.44e-68

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 216.83  E-value: 1.44e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 217 MKKDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMANFLEYDVYDLELTTVKDNSELKKLMLDTKGK-SIVV 295
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 296 IEDIDCSLDLTGQRkkkkeededeeeeekkkeaekLLKRERGERESKVTLSGLLNAIDGLWSacSGEKIIVFTTNYLDKL 375
Cdd:cd19510  81 LEDIDAAFESREHN---------------------KKNPSAYGGLSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERL 137

                       170
                ....*....|....*.
gi 15233016 376 DPALIRRGRMDNHIEM 391
Cdd:cd19510 138 DPALIRPGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 29-125 1.14e-30

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


Pssm-ID: 464152  Cd Length: 95  Bit Score: 114.57  E-value: 1.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016    29 VPYQIRDYLEKCFYKMFGLVSNSVHIKFTEYTedkGLKKSQAYDLIRNYLSSKSTARAQR-LKANESKNSKSLVLSLDNH 107
Cdd:pfam14363   1 LPPELRDYLSSKLARLFSRFSPYLTIVIDEFD---GFSRNELYDAAQTYLSTKISPSSARrLKASKSPKSKSLVLSLDDN 77

                          90
                  ....*....|....*...
gi 15233016   108 EAVEDVFQGVKVVWSLSV 125
Cdd:pfam14363  78 EEVTDVFEGVKLWWTLVV 95
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 219-390 2.41e-18

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 81.95  E-value: 2.41e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 219 KDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMANFLEYDVYDLELTTVKDNS------ELKKLM--LDTKG 290
Cdd:cd19481   6 REAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYvgesekNLRKIFerARRLA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 291 KSIVVIEDIDCsldLTGQRKKKKeededeeeeekkkeaekllkrERGERESkvTLSGLLNAIDGLwsaCSGEKIIVF-TT 369
Cdd:cd19481  86 PCILFIDEIDA---IGRKRDSSG---------------------ESGELRR--VLNQLLTELDGV---NSRSKVLVIaAT 136

                       170       180
                ....*....|....*....|.
gi 15233016 370 NYLDKLDPALIRRGRMDNHIE 390
Cdd:cd19481 137 NRPDLLDPALLRPGRFDEVIE 157
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 242-393 1.30e-17

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 79.17  E-value: 1.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   242 YLLFGPPGTGKSTMISAMAN-----FLEYDVYDLELTTVKDNSELKKLMLD---TKGKSIVVIEDIDCsldLTGQRKkkk 313
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKelgapFIEISGSELVSKYVGESEKRLRELFEaakKLAPCVIFIDEIDA---LAGSRG--- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   314 eededeeeeekkkeaekllkrERGERESKVTLSGLLNAIDGLWSacSGEKIIVF-TTNYLDKLDPALirRGRMDNHIEMS 392
Cdd:pfam00004  75 ---------------------SGGDSESRRVVNQLLTELDGFTS--SNSKVIVIaATNRPDKLDPAL--LGRFDRIIEFP 129


                  .
gi 15233016   393 Y 393
Cdd:pfam00004 130 L 130
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 209-433 2.36e-14

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 74.95  E-value: 2.36e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 209 MDLEKKEgMKKDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMANFLEYDVYDLELTTVKD----NSElKKL 284
Cdd:COG0464 162 LEEVKEE-LRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSkyvgETE-KNL 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 285 --MLDT---KGKSIVVIEDIDcslDLTGQRkkkkeededeeeeekkkeaekllkRERGERESKVTLSGLLNAIDGLwsac 359
Cdd:COG0464 240 reVFDKargLAPCVLFIDEAD---ALAGKR------------------------GEVGDGVGRRVVNTLLTEMEEL---- 288

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15233016 360 SGEKIIVFTTNYLDKLDPALIRrgRMDNHIEMSYCRFEAFKVLAKNYLEIESHDLFGEIKRLVEETD-MSPADVA 433
Cdd:COG0464 289 RSDVVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDVDLEELAEATEgLSGADIR 361
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 161-433 6.15e-14

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 72.73  E-value: 6.15e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 161 LREGKEIGLKNRERKLYTNNSSQDYSAWREGRWSNVPFDHPA-TFETLA-MDLEKKEgMKKDLIKFTKGKDYYRKVGKPW 238
Cdd:COG1222  33 LQPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAESPDvTFDDIGgLDEQIEE-IREAVELPLKNPELFRKYGIEP 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 239 KRGYLLFGPPGTGKsTMIS-AMANFLEYDVYDLELTTVKD----NSE--LKKL--MLDTKGKSIVVIEDIDCsldLTGQR 309
Cdd:COG1222 112 PKGVLLYGPPGTGK-TLLAkAVAGELGAPFIRVRGSELVSkyigEGArnVREVfeLAREKAPSIIFIDEIDA---IAARR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 310 KKKkeededeeeeekkkeaekllkRERGEreSKVTLSGLLNAIDGLWSacSGEKIIVFTTNYLDKLDPALIRRGRMDNHI 389
Cdd:COG1222 188 TDD---------------------GTSGE--VQRTVNQLLAELDGFES--RGDVLIIAATNRPDLLDPALLRPGRFDRVI 242

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 15233016 390 EMSY----CRFEAFKVLAKNYLEIESHDLfgeiKRLVEETD-MSPADVA 433
Cdd:COG1222 243 EVPLpdeeAREEILKIHLRDMPLADDVDL----DKLAKLTEgFSGADLK 287
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 229-390 8.63e-14

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 69.29  E-value: 8.63e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 229 DYYRKVGKPWKRGYLLFGPPGTGKSTMISAMAN-----FLEYDVYDLELTTVKDNSELKK---LMLDTKGKSIVVIEDID 300
Cdd:cd19502  27 ELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANhtdatFIRVVGSELVQKYIGEGARLVRelfEMAREKAPSIIFIDEID 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 301 CsldLTGQRKKKKEEdedeeeeekkkeaekllkrerGERESKVTLSGLLNAIDGLWSacSGEKIIVFTTNYLDKLDPALI 380
Cdd:cd19502 107 A---IGAKRFDSGTG---------------------GDREVQRTMLELLNQLDGFDP--RGNIKVIMATNRPDILDPALL 160

                       170
                ....*....|
gi 15233016 381 RRGRMDNHIE 390
Cdd:cd19502 161 RPGRFDRKIE 170
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 203-389 4.98e-13

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 67.26  E-value: 4.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 203 TFETLAMDLEKKEGMKkDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMAN-------------FLEY---- 265
Cdd:cd19501   2 TFKDVAGCEEAKEELK-EVVEFLKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGeagvpffsisgsdFVEMfvgv 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 266 ---DVYDLeLTTVKDNSelkklmldtkgKSIVVIEDIDCsldLTGQRKKKKEEDEdeeeeekkkeaekllkrerGERESk 342
Cdd:cd19501  81 gasRVRDL-FEQAKKNA-----------PCIVFIDEIDA---VGRKRGAGLGGGH-------------------DEREQ- 125

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 15233016 343 vTLSGLLNAIDGLwsaCSGEKIIVF-TTNYLDKLDPALIRRGRMDNHI 389
Cdd:cd19501 126 -TLNQLLVEMDGF---ESNTGVIVIaATNRPDVLDPALLRPGRFDRQV 169
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 219-390 2.38e-11

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 62.31  E-value: 2.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 219 KDLIKFTKGK-DYYRKVGKPWKRGYLLFGPPGTGKSTMISAMANFLEYDVYDLELTTV------KDNSELKKLMLDTK-- 289
Cdd:cd19503  13 KELIELPLKYpELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIvskylgESEKNLREIFEEARsh 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 290 GKSIVVIEDIDCsldLTGQRKKKkeededeeeeekkkeaekllkreRGERESKVtLSGLLNAIDGLWSAcsGEKIIVFTT 369
Cdd:cd19503  93 APSIIFIDEIDA---LAPKREED-----------------------QREVERRV-VAQLLTLMDGMSSR--GKVVVIAAT 143

                       170       180
                ....*....|....*....|.
gi 15233016 370 NYLDKLDPALIRRGRMDNHIE 390
Cdd:cd19503 144 NRPDAIDPALRRPGRFDREVE 164
ftsH CHL00176
cell division protein; Validated
 203-405 3.13e-11

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 65.84  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  203 TFETLA-MDLEKKEgmKKDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMAN-------------FLEYD-- 266
Cdd:CHL00176 181 TFRDIAgIEEAKEE--FEEVVSFLKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGeaevpffsisgseFVEMFvg 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  267 -----VYDLeLTTVKDNSelkklmldtkgKSIVVIEDIDcsldltgqrkkkkeededeeeeekkkeaekLLKRERGER-- 339
Cdd:CHL00176 259 vgaarVRDL-FKKAKENS-----------PCIVFIDEID------------------------------AVGRQRGAGig 296

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15233016  340 ----ESKVTLSGLLNAIDGLwsacSGEK--IIVFTTNYLDKLDPALIRRGRMDNHIEMS----YCRFEAFKVLAKN 405
Cdd:CHL00176 297 ggndEREQTLNQLLTEMDGF----KGNKgvIVIAATNRVDILDAALLRPGRFDRQITVSlpdrEGRLDILKVHARN 368
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 229-391 6.85e-11

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 64.41  E-value: 6.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  229 DYYRKVG-KPWKrGYLLFGPPGTGKSTMISAMAN-----FLEYDVYDLELTTVKDNSELKKLML---DTKGKSIVVIEDI 299
Cdd:PTZ00361 207 ELYDDIGiKPPK-GVILYGPPGTGKTLLAKAVANetsatFLRVVGSELIQKYLGDGPKLVRELFrvaEENAPSIVFIDEI 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  300 DCsldlTGQRKKKKEEDedeeeeekkkeaekllkrerGERESKVTLSGLLNAIDGlWSACSGEKIIVfTTNYLDKLDPAL 379
Cdd:PTZ00361 286 DA----IGTKRYDATSG--------------------GEKEIQRTMLELLNQLDG-FDSRGDVKVIM-ATNRIESLDPAL 339

                        170
                 ....*....|..
gi 15233016  380 IRRGRMDNHIEM 391
Cdd:PTZ00361 340 IRPGRIDRKIEF 351
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
219-434 1.46e-10

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 61.44  E-value: 1.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 219 KDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMANFLEYDVYDLELTTV------KDNSELKKLMLDTK-GK 291
Cdd:COG1223  15 KLIIKELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLigsylgETARNLRKLFDFARrAP 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 292 SIVVIEDIDCsldLTGQRkkkkeededeeeeekkkeaekLLKRERGerESKVTLSGLLNAIDGLwsacSGEKIIVFTTNY 371
Cdd:COG1223  95 CVIFFDEFDA---IAKDR---------------------GDQNDVG--EVKRVVNALLQELDGL----PSGSVVIAATNH 144

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15233016 372 LDKLDPALIRrgRMDNHIEMSYCRFEAFKVLAKNYLEIESHDLFGEIKRLVEET-DMSPADVAE 434
Cdd:COG1223 145 PELLDSALWR--RFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAKKLeGLSGADIEK 206
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 228-389 4.05e-09

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 55.87  E-value: 4.05e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 228 KDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMANFLEYDVYDLELTT----VKDNSELKKLMLDTKGKS----IVVIEDI 299
Cdd:cd19518  23 PEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEivsgVSGESEEKIRELFDQAISnapcIVFIDEI 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 300 DCsldLTGQrkkkkeededeeeeekkkeaekllkRERGERE-SKVTLSGLLNAIDGL-WSACSGEKIIVF-TTNYLDKLD 376
Cdd:cd19518 103 DA---ITPK-------------------------RESAQREmERRIVSQLLTCMDELnNEKTAGGPVLVIgATNRPDSLD 154

                       170
                ....*....|...
gi 15233016 377 PALIRRGRMDNHI 389
Cdd:cd19518 155 PALRRAGRFDREI 167
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 231-391 4.54e-09

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 55.52  E-value: 4.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 231 YRKVGKPWKRGYLLFGPPGTGKSTMISAMANflEYDVYDL-----ELTTV---KDNSELKKLMLDTKGK--SIVVIEDID 300
Cdd:cd19519  26 FKAIGIKPPRGILLYGPPGTGKTLIARAVAN--ETGAFFFlingpEIMSKlagESESNLRKAFEEAEKNapAIIFIDEID 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 301 csldltgqrkkkkeededeeeeekkkeaEKLLKRER--GERESKVtLSGLLNAIDGLWSacSGEKIIVFTTNYLDKLDPA 378
Cdd:cd19519 104 ----------------------------AIAPKREKthGEVERRI-VSQLLTLMDGLKQ--RAHVIVMAATNRPNSIDPA 152

                       170
                ....*....|...
gi 15233016 379 LIRRGRMDNHIEM 391
Cdd:cd19519 153 LRRFGRFDREIDI 165
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 203-414 1.35e-08

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 57.61  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   203 TFETLAmDLEKKEGMKKDLIKF-TKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMAN-----FLEYDVYDLELTTVK 276
Cdd:TIGR01243 176 TYEDIG-GLKEAKEKIREMVELpMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANeagayFISINGPEIMSKYYG 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   277 DNSE-LKKLMLDTK--GKSIVVIEDIDCsldLTGQRKKKKeededeeeeekkkeaekllkrerGERESKVtLSGLLNAID 353
Cdd:TIGR01243 255 ESEErLREIFKEAEenAPSIIFIDEIDA---IAPKREEVT-----------------------GEVEKRV-VAQLLTLMD 307

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15233016   354 GLWSacSGEKIIVFTTNYLDKLDPALIRRGRMDNHIEMSY----CRFEAFKVLAKNYLEIESHDL 414
Cdd:TIGR01243 308 GLKG--RGRVIVIGATNRPDALDPALRRPGRFDREIVIRVpdkrARKEILKVHTRNMPLAEDVDL 370
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 226-389 3.35e-08

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 52.88  E-value: 3.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 226 KGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAM-----ANFLEydVYDLELTTvKDNSELKKLMLDTKGKS------IV 294
Cdd:cd19529  14 LKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVatesnANFIS--VKGPELLS-KWVGESEKAIREIFRKArqvapcVI 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 295 VIEDIDcsldltgqrkkkkeededeeeeekkkeaekLLKRERGER-ESKVT---LSGLLNAIDGLWSAcsGEKIIVFTTN 370
Cdd:cd19529  91 FFDEID------------------------------SIAPRRGTTgDSGVTervVNQLLTELDGLEEM--NGVVVIAATN 138

                       170
                ....*....|....*....
gi 15233016 371 YLDKLDPALIRRGRMDNHI 389
Cdd:cd19529 139 RPDIIDPALLRAGRFDRLI 157
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 231-433 2.92e-07

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 52.53  E-value: 2.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  231 YRKVG-KPWKrGYLLFGPPGTGKSTMISAMAN-----FLEydVYDLELTT---------VKDNSELKKlmldTKGKSIVV 295
Cdd:PRK03992 157 FEEVGiEPPK-GVLLYGPPGTGKTLLAKAVAHetnatFIR--VVGSELVQkfigegarlVRELFELAR----EKAPSIIF 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  296 IEDIDC-----SLDLTGqrkkkkeededeeeeekkkeaekllkrerGERESKVTLSGLLNAIDGLWSacSGEKIIVFTTN 370
Cdd:PRK03992 230 IDEIDAiaakrTDSGTS-----------------------------GDREVQRTLMQLLAEMDGFDP--RGNVKIIAATN 278

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15233016  371 YLDKLDPALIRRGRMDNHIEMSY----CRFEAFKVLAKNYLEIESHDLfgeiKRLVEETD-MSPADVA 433
Cdd:PRK03992 279 RIDILDPAILRPGRFDRIIEVPLpdeeGRLEILKIHTRKMNLADDVDL----EELAELTEgASGADLK 342
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 226-433 5.10e-07

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 52.60  E-value: 5.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   226 KGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMANFLEYDvydleLTTVKDNSELKKLMLDTK-------------GKS 292
Cdd:TIGR01243 474 KHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGAN-----FIAVRGPEILSKWVGESEkaireifrkarqaAPA 548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   293 IVVIEDIDCsldltgqrkkkkeededeeeeekkkeaeklLKRERGERE-SKVT---LSGLLNAIDGLWSacSGEKIIVFT 368
Cdd:TIGR01243 549 IIFFDEIDA------------------------------IAPARGARFdTSVTdriVNQLLTEMDGIQE--LSNVVVIAA 596

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016   369 TNYLDKLDPALIRRGRMDNHIEM----SYCRFEAFKVLAKNYLEIESHDLfgeiKRLVEETD-MSPADVA 433
Cdd:TIGR01243 597 TNRPDILDPALLRPGRFDRLILVpppdEEARKEIFKIHTRSMPLAEDVDL----EELAEMTEgYTGADIE 662
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 214-382 1.02e-06

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 48.50  E-value: 1.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 214 KEGMKKDLIKFTKGKDYYRKVGKPWkRGYLLFGPPGTGKSTMISAMAN-----FLEYDVYDLELTTVKDNSELKKLMLDT 288
Cdd:cd19509   8 KEALKEAVILPSLRPDLFPGLRGPP-RGILLYGPPGTGKTLLARAVASesgstFFSISASSLVSKWVGESEKIVRALFAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 289 KGK---SIVVIEDIDCsldLTGQRKKkkeededeeeeekkkeaekllkrerGERESKVTL-SGLLNAIDGLWSACSGEKI 364
Cdd:cd19509  87 ARElqpSIIFIDEIDS---LLSERGS-------------------------GEHEASRRVkTEFLVQMDGVLNKPEDRVL 138

                       170
                ....*....|....*...
gi 15233016 365 IVFTTNYLDKLDPALIRR 382
Cdd:cd19509 139 VLGATNRPWELDEAFLRR 156
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 239-393 1.16e-06

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 48.30  E-value: 1.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 239 KRGYLLFGPPGTGKSTMISAMANFLEYDVYDL------ELTTVKDNSELKKLMLDT--------KGKSIVVIEDIDcsld 304
Cdd:cd00009  19 PKNLLLYGPPGTGKTTLARAIANELFRPGAPFlylnasDLLEGLVVAELFGHFLVRllfelaekAKPGVLFIDEID---- 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 305 ltgqrkkkkeededeeeeekkkeaekllkrergeRESKVTLSGLLNAIDGL--WSACSGEKIIVFTTNYLDKLDPALIRR 382
Cdd:cd00009  95 ----------------------------------SLSRGAQNALLRVLETLndLRIDRENVRVIGATNRPLLGDLDRALY 140

                       170
                ....*....|.
gi 15233016 383 GRMDNHIEMSY 393
Cdd:cd00009 141 DRLDIRIVIPL 151
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 209-393 1.42e-06

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 50.53  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  209 MDLEKKEgMKKDLIKFTKGKDYYRKVGKPWKRGYLLFGPPGTGKSTMISAMAN-------------FLE----------Y 265
Cdd:PTZ00454 150 LDIQKQE-IREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHhttatfirvvgseFVQkylgegprmvR 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  266 DVYDLelttVKDNSelkklmldtkgKSIVVIEDIDCsldLTGQRKKKkeededeeeeekkkeaekllkRERGERESKVTL 345
Cdd:PTZ00454 229 DVFRL----ARENA-----------PSIIFIDEVDS---IATKRFDA---------------------QTGADREVQRIL 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 15233016  346 SGLLNAIDGlWSACSGEKIIVfTTNYLDKLDPALIRRGRMDNHIEMSY 393
Cdd:PTZ00454 270 LELLNQMDG-FDQTTNVKVIM-ATNRADTLDPALLRPGRLDRKIEFPL 315
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 229-389 1.55e-06

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 48.05  E-value: 1.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 229 DYYRKVGKPWKRGYLLFGPPGTGKSTMISAMA-----NFLEydVYDLELTTvKDNSELKKLMLDTKGK------SIVVIE 297
Cdd:cd19511  17 DAFKRLGIRPPKGVLLYGPPGCGKTLLAKALAseaglNFIS--VKGPELFS-KYVGESERAVREIFQKarqaapCIIFFD 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 298 DIDCsldLTGQRKkkkeededeeeeekkkeaekllkrerGERESKVT---LSGLLNAIDGLWSAcsGEKIIVFTTNYLDK 374
Cdd:cd19511  94 EIDS---LAPRRG--------------------------QSDSSGVTdrvVSQLLTELDGIESL--KGVVVIAATNRPDM 142

                       170
                ....*....|....*
gi 15233016 375 LDPALIRRGRMDNHI 389
Cdd:cd19511 143 IDPALLRPGRLDKLI 157
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 229-382 4.88e-06

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 46.90  E-value: 4.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 229 DYYRKVGKPWKrGYLLFGPPGTGKSTMISAMANFLEYDVYDLELTTVK-----DNSELKKLMLDTK---GKSIVVIEDID 300
Cdd:cd19522  24 EFFKGIRRPWK-GVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTskyrgESEKLVRLLFEMArfyAPTTIFIDEID 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 301 --CSLDLTGqrkkkkeededeeeeekkkeaekllkrerGERE-SKVTLSGLLNAIDGLWSACSGEK-----IIVFTTNYL 372
Cdd:cd19522 103 siCSRRGTS-----------------------------EEHEaSRRVKSELLVQMDGVGGASENDDpskmvMVLAATNFP 153

                       170
                ....*....|
gi 15233016 373 DKLDPALIRR 382
Cdd:cd19522 154 WDIDEALRRR 163
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 214-309 1.08e-05

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 46.01  E-value: 1.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 214 KEGMKKDLIKFTKGKDYYRKVGKPWkRGYLLFGPPGTGKSTMISAMA-----NFLEYDVYDLELTTVKDNSELKK---LM 285
Cdd:cd19521  16 KEALKEAVILPVKFPHLFTGNRKPW-SGILLYGPPGTGKSYLAKAVAteansTFFSVSSSDLVSKWMGESEKLVKqlfAM 94

                        90       100
                ....*....|....*....|....
gi 15233016 286 LDTKGKSIVVIEDIDcslDLTGQR 309
Cdd:cd19521  95 ARENKPSIIFIDEVD---SLCGTR 115
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 240-386 1.13e-05

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 45.96  E-value: 1.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 240 RGYLLFGPPGTGKSTMISAMAN----------FLEYDVYDLELTTVKDNSELKKLMLDTKGK---SIVVIEDIDcslDLT 306
Cdd:cd19517  35 RGVLFHGPPGTGKTLMARALAAecskggqkvsFFMRKGADCLSKWVGEAERQLRLLFEEAYRmqpSIIFFDEID---GLA 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 307 GQRKkkkeededeeeeekkkeaekllkrERGERESKVTLSGLLNAIDGLWSacSGEKIIVFTTNYLDKLDPALIRRGRMD 386
Cdd:cd19517 112 PVRS------------------------SKQEQIHASIVSTLLALMDGLDN--RGQVVVIGATNRPDALDPALRRPGRFD 165
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 228-389 4.27e-05

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 44.04  E-value: 4.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 228 KDYYRKVGKPWKRGYLLFGPPGTGKSTMISAM-----ANFLEydVYDLELTTV---KDNSELKKLMLDTKGKS--IVVIE 297
Cdd:cd19528  16 PDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIanecqANFIS--VKGPELLTMwfgESEANVRDIFDKARAAApcVLFFD 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 298 DIDcslDLTGQRKKKKEededeeeeekkkeaekllkrERGERESKVtLSGLLNAIDGLwsacsGEKIIVF---TTNYLDK 374
Cdd:cd19528  94 ELD---SIAKARGGNIG--------------------DAGGAADRV-INQILTEMDGM-----NTKKNVFiigATNRPDI 144

                       170
                ....*....|....*
gi 15233016 375 LDPALIRRGRMDNHI 389
Cdd:cd19528 145 IDPAILRPGRLDQLI 159
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 239-395 2.11e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.59  E-value: 2.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016    239 KRGYLLFGPPGTGKSTMISAMANFLEYDvydlelttvkdnselkklmldtkGKSIVViedIDCSLDLTGQRKKKKEEDED 318
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPP-----------------------GGGVIY---IDGEDILEEVLDQLLLIIVG 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016    319 EEEEEKKKEAEKLLKRERGERESKVTL-------------SGLLNAIDGLWSACS----GEKIIVFTTNYLDKLDPALIR 381
Cdd:smart00382  56 GKKASGSGELRLRLALALARKLKPDVLildeitslldaeqEALLLLLEELRLLLLlkseKNLTVILTTNDEKDLGPALLR 135

                          170
                   ....*....|....
gi 15233016    382 RgRMDNHIEMSYCR 395
Cdd:smart00382 136 R-RFDRRIVLLLIL 148
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 240-382 3.93e-03

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 38.29  E-value: 3.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 240 RGYLLFGPPGTGKSTMISAMA-----NFLEYDVYDLELTTVKDNSELKKLMLDTKGK---SIVVIEDIDCSLdltgqrkk 311
Cdd:cd19524  34 RGLLLFGPPGNGKTMLAKAVAaesnaTFFNISAASLTSKYVGEGEKLVRALFAVARElqpSIIFIDEVDSLL-------- 105

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15233016 312 kkeededeeeeekkkeaeklLKRERGERESKVTL-SGLLNAIDGLWSAcSGEKIIVF-TTNYLDKLDPALIRR 382
Cdd:cd19524 106 --------------------SERSEGEHEASRRLkTEFLIEFDGVQSN-GDDRVLVMgATNRPQELDDAVLRR 157
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 243-277 4.01e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 39.68  E-value: 4.01e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 15233016  243 LLFGPPGTGKSTMISAMANFLEYDVYDLELTT--VKD 277
Cdd:PRK13342  40 ILWGPPGTGKTTLARIIAGATDAPFEALSAVTsgVKD 76
PRK04195 PRK04195
replication factor C large subunit; Provisional
 201-270 4.75e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 39.52  E-value: 4.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016  201 PATFETLAMDLEKKEGMKKDLIKFTKGKDyyrkvgkpwKRGYLLFGPPGTGKSTMISAMANFLEYDVYDL 270
Cdd:PRK04195  10 PKTLSDVVGNEKAKEQLREWIESWLKGKP---------KKALLLYGPPGVGKTSLAHALANDYGWEVIEL 70
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 210-382 6.97e-03

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 37.66  E-value: 6.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 210 DLEKKEGMKKDLIKFT----KGKDYYRKVGKPWKrGYLLFGPPGTGKsTMI------SAMANFLEYDVYDLELTTVKDNS 279
Cdd:cd19525  23 DIAGLEFAKKTIKEIVvwpmLRPDIFTGLRGPPK-GILLFGPPGTGK-TLIgkciasQSGATFFSISASSLTSKWVGEGE 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233016 280 ELKKLMLDT---KGKSIVVIEDIDCSLDltgqrkkkkeededeeeeekkkeaekllKRERGERESKVTL-SGLLNAIDGL 355
Cdd:cd19525 101 KMVRALFSVarcKQPAVIFIDEIDSLLS----------------------------QRGEGEHESSRRIkTEFLVQLDGA 152

                       170       180
                ....*....|....*....|....*..
gi 15233016 356 WSACSGEKIIVFTTNYLDKLDPALIRR 382
Cdd:cd19525 153 TTSSEDRILVVGATNRPQEIDEAARRR 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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