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Conserved domains on  [gi|15231569|ref|NP_189283|]
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tonoplast intrinsic protein 2 [Arabidopsis thaliana]

Protein Classification

TIP-type aquaporin( domain architecture ID 10010587)

TIP (tonoplast intrinsic protein)-type aquaporin is a water channel required to facilitate the transport of water from the vacuolar compartment to the cytoplasm

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|11473620|8849412
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00027 PLN00027
aquaporin TIP; Provisional
 1-253 2.33e-148

aquaporin TIP; Provisional


:

Pssm-ID: 177664  Cd Length: 252  Bit Score: 414.18  E-value: 2.33e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569    1 MPTRNIAIGGVQEeVYHPNALRAALAEFISTLIFVFAGSGSGIAFNKITDNGATTPSGLVAAALAHAFGLFVAVSVGANI 80
Cdd:PLN00027   1 MPIRRIAIGTPGE-ASHPDALKAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALAHAFALFVAVSVGANI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   81 SGGHVNPAVTFGVLLGGNITLLRGILYWIAQLLGSVAACFLLSFATGGEPIPAFGLSAGVGSLNALVFEIVMTFGLVYTV 160
Cdd:PLN00027  80 SGGHVNPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  161 YATAVDPKNGSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIYDFVFI 240
Cdd:PLN00027 160 YATAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFI 239

                        250
                 ....*....|...
gi 15231569  241 DENAHEQLPTTDY 253
Cdd:PLN00027 240 GSTTHEQLPTTDY 252
 
Name Accession Description Interval E-value
PLN00027 PLN00027
aquaporin TIP; Provisional
 1-253 2.33e-148

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 414.18  E-value: 2.33e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569    1 MPTRNIAIGGVQEeVYHPNALRAALAEFISTLIFVFAGSGSGIAFNKITDNGATTPSGLVAAALAHAFGLFVAVSVGANI 80
Cdd:PLN00027   1 MPIRRIAIGTPGE-ASHPDALKAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALAHAFALFVAVSVGANI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   81 SGGHVNPAVTFGVLLGGNITLLRGILYWIAQLLGSVAACFLLSFATGGEPIPAFGLSAGVGSLNALVFEIVMTFGLVYTV 160
Cdd:PLN00027  80 SGGHVNPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  161 YATAVDPKNGSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIYDFVFI 240
Cdd:PLN00027 160 YATAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFI 239

                        250
                 ....*....|...
gi 15231569  241 DENAHEQLPTTDY 253
Cdd:PLN00027 240 GSTTHEQLPTTDY 252
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 14-235 5.12e-81

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 242.61  E-value: 5.12e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569    14 EVYHPNALRAALAEFISTLIFVFAGSGSGIAFNKITDNGAttPSGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGV 93
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLA--VSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569    94 LLGGNITLLRGILYWIAQLLGSVAACFLLSFATGGE---PIPAFGLSAGVGSLNALVFEIVMTFGLVYTVYATAVDPKNG 170
Cdd:pfam00230  79 LVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLqraGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15231569   171 SLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIY 235
Cdd:pfam00230 159 SLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 22-238 5.38e-67

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 207.11  E-value: 5.38e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  22 RAALAEFISTLIFVFAGSGSGIAFNKITdngaTTPSGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGVLLGGNITL 101
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAG----GASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569 102 LRGILYWIAQLLGSVAACFLLSFATGGEPIPAFG------------LSAGVGSLNALVFEIVMTFGLVYTVYATAVDPKN 169
Cdd:cd00333  77 IRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGannivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNG 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15231569 170 GSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWT---WTNHWVYWAGPLIGGGLAGIIYDFV 238
Cdd:cd00333 157 PPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 26-235 1.91e-52

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 169.40  E-value: 1.91e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569    26 AEFISTLIFVFAGSGSGIAFNKITDNGATTPSGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGVLLGGNITLLRGI 105
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   106 LYWIAQLLGSVAACFLLSF----ATGGEPIPAFGLSAGVGSLNALVFEIVMTFGLVYTVYATAVDPKNGSLGTIAPIAIG 181
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGltsgLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15231569   182 FIVGANILAGGAFSGASMNPAVAFGPAVVSWT--WTNHWVYWAGPLIGGGLAGIIY 235
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-239 9.55e-44

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 147.58  E-value: 9.55e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  21 LRAALAEFISTLIFVFAGSGSGIAFNkitdnGATTPSGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGVLLGGNIT 100
Cdd:COG0580   3 MKRLLAEFLGTFILVLLGCGVVAVLA-----GTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569 101 LLRGILYWIAQLLGSVAACFLLSFATGGEPIP-----------AFGLSAGVGSLNALVFEIVMTFGLVYTVYATAVDPKn 169
Cdd:COG0580  78 WKDVLPYIIAQLLGAFLGAALVYLIYGGHFDAtedggaklgvfATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRA- 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231569 170 gSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVV------SWTWTNHWVYWAGPLIGGGLAGIIYDFVF 239
Cdd:COG0580 157 -APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALF 231
 
Name Accession Description Interval E-value
PLN00027 PLN00027
aquaporin TIP; Provisional
 1-253 2.33e-148

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 414.18  E-value: 2.33e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569    1 MPTRNIAIGGVQEeVYHPNALRAALAEFISTLIFVFAGSGSGIAFNKITDNGATTPSGLVAAALAHAFGLFVAVSVGANI 80
Cdd:PLN00027   1 MPIRRIAIGTPGE-ASHPDALKAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALAHAFALFVAVSVGANI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   81 SGGHVNPAVTFGVLLGGNITLLRGILYWIAQLLGSVAACFLLSFATGGEPIPAFGLSAGVGSLNALVFEIVMTFGLVYTV 160
Cdd:PLN00027  80 SGGHVNPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  161 YATAVDPKNGSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIYDFVFI 240
Cdd:PLN00027 160 YATAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFI 239

                        250
                 ....*....|...
gi 15231569  241 DENAHEQLPTTDY 253
Cdd:PLN00027 240 GSTTHEQLPTTDY 252
PLN00166 PLN00166
aquaporin TIP2; Provisional
 6-252 5.48e-94

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 276.43  E-value: 5.48e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569    6 IAIGGVQEEvYHPNALRAALAEFISTLIFVFAGSGSGIAFNKITDNGATTPSGLVAAALAHAFGLFVAVSVGANISGGHV 85
Cdd:PLN00166   4 IEFGSLGDS-FSVASLKAYLSEFIATLLFVFAGVGSAIAFAKLTSDAALDPAGLVAVAVAHAFALFVGVSIAANISGGHL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   86 NPAVTFGVLLGGNITLLRGILYWIAQLLGSVAACFLLSFATGGEPIPAFGLSAGVGSLNALVFEIVMTFGLVYTVYATAV 165
Cdd:PLN00166  83 NPAVTLGLAIGGNITIITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  166 DPKNGSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIYDFVFIDenAH 245
Cdd:PLN00166 163 DPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVFIG--SY 240


                 ....*..
gi 15231569  246 EQLPTTD 252
Cdd:PLN00166 241 AAAPTSE 247
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 14-235 5.12e-81

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 242.61  E-value: 5.12e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569    14 EVYHPNALRAALAEFISTLIFVFAGSGSGIAFNKITDNGAttPSGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGV 93
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLA--VSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569    94 LLGGNITLLRGILYWIAQLLGSVAACFLLSFATGGE---PIPAFGLSAGVGSLNALVFEIVMTFGLVYTVYATAVDPKNG 170
Cdd:pfam00230  79 LVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLqraGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15231569   171 SLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIY 235
Cdd:pfam00230 159 SLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
PLN00167 PLN00167
aquaporin TIP5; Provisional
 13-238 3.84e-70

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 215.92  E-value: 3.84e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   13 EEVYHPNALRAALAEFISTLIFVFAGSGSGIAFNKITDNGATTPSGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFG 92
Cdd:PLN00167  14 QQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   93 VLLGGNITLLRGILYWIAQLLGSVAACFLLSFATGGEPIPAFGLSAGVGSLNALVFEIVMTFGLVYTVYAtAVDPKNGSL 172
Cdd:PLN00167  94 MAVGGHISVPTAMFYWISQMLASVMACLFLKVTTVGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYA-AGDPRRGLL 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231569  173 GTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIYDFV 238
Cdd:PLN00167 173 GAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNV 238
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 22-238 5.38e-67

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 207.11  E-value: 5.38e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  22 RAALAEFISTLIFVFAGSGSGIAFNKITdngaTTPSGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGVLLGGNITL 101
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAG----GASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569 102 LRGILYWIAQLLGSVAACFLLSFATGGEPIPAFG------------LSAGVGSLNALVFEIVMTFGLVYTVYATAVDPKN 169
Cdd:cd00333  77 IRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGannivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNG 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15231569 170 GSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWT---WTNHWVYWAGPLIGGGLAGIIYDFV 238
Cdd:cd00333 157 PPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 26-235 1.91e-52

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 169.40  E-value: 1.91e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569    26 AEFISTLIFVFAGSGSGIAFNKITDNGATTPSGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGVLLGGNITLLRGI 105
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   106 LYWIAQLLGSVAACFLLSF----ATGGEPIPAFGLSAGVGSLNALVFEIVMTFGLVYTVYATAVDPKNGSLGTIAPIAIG 181
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGltsgLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15231569   182 FIVGANILAGGAFSGASMNPAVAFGPAVVSWT--WTNHWVYWAGPLIGGGLAGIIY 235
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-239 9.55e-44

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 147.58  E-value: 9.55e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  21 LRAALAEFISTLIFVFAGSGSGIAFNkitdnGATTPSGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGVLLGGNIT 100
Cdd:COG0580   3 MKRLLAEFLGTFILVLLGCGVVAVLA-----GTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569 101 LLRGILYWIAQLLGSVAACFLLSFATGGEPIP-----------AFGLSAGVGSLNALVFEIVMTFGLVYTVYATAVDPKn 169
Cdd:COG0580  78 WKDVLPYIIAQLLGAFLGAALVYLIYGGHFDAtedggaklgvfATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRA- 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231569 170 gSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVV------SWTWTNHWVYWAGPLIGGGLAGIIYDFVF 239
Cdd:COG0580 157 -APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 25-238 5.03e-26

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 102.68  E-value: 5.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   25 LAEFISTLIFVFAGSGSgIAFNKITDNGATTPSGLVAaalahaFGLFVAVSVGA--NISGGHVNPAVTFGVLLGGNITLL 102
Cdd:PLN00182  46 IAEMIGTYFIIFSGCGV-VVVNVLYGGTITFPGICVT------WGLIVMVMIYStgHISGAHFNPAVTVTFAIFRRFPWY 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  103 RGILYWIAQLLGSVAACFLLSFATGGEPIPAFGLSAGVGSLNALVFEIVMTFGLVYTVYATAVDpkNGSLGTIAPIAIGF 182
Cdd:PLN00182 119 QVPLYIGAQLTGSLLASLTLRLMFNVTPEAFFGTTPTDSSGQALVAEIIISFLLMFVISGVATD--SRAVGELAGIAVGM 196

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15231569  183 IVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIYDFV 238
Cdd:PLN00182 197 TIILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLI 252
PLN00026 PLN00026
aquaporin NIP; Provisional
 26-242 9.63e-24

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 96.85  E-value: 9.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   26 AEFISTLIFVFAGSGSGIAFNKItdNGATTPSGLVAAAlahafGLFVAVSV--GANISGGHVNPAVTFGVLLGGNITLLR 103
Cdd:PLN00026  76 AEFVGTFILIFAATAGPIVNQKY--DGAETLIGNAACA-----GLAVMIVIlsTGHISGAHLNPSLTIAFAALRHFPWKH 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  104 GILYWIAQLLGSVAACFLLS-----FATGGEPIPAFGLSagvgslNALVFEIVMTFGLVYTVYATAVDPKngSLGTIAPI 178
Cdd:PLN00026 149 VPAYIAAQVSASICASFALKgvfhpFMSGGVTVPSVSTG------QAFALEFIITFNLLFVVTAVATDTR--AVGELAGI 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15231569  179 AIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIYDFVFIDE 242
Cdd:PLN00026 221 AVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLRE 284
PLN00184 PLN00184
aquaporin NIP1; Provisional
 21-238 1.10e-23

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 96.63  E-value: 1.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   21 LRAALAEFISTLIFVFAGSGSgIAFNKITDNGATTPsglvaaALAHAFGLFVAVSVGA--NISGGHVNPAVTFGVLLGGN 98
Cdd:PLN00184  54 LQKLIAEVLGTYFLVFTGCAS-VVVNMQNDNVVTLP------GIAIVWGLTIMVLIYSlgHISGAHINPAVTIAFASCGR 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   99 ITLLRGILYWIAQLLGSVAACFLLSFATG-------GEPIPAFGLSAGVGSLNALVFEIVMTFGLVYTVYATAVDpkNGS 171
Cdd:PLN00184 127 FPLKQVPAYVISQVIGSTLAAATLRLLFGldhdvcsGKHDVFIGSSPVGSDLQAFVMEFIVTFYLMFIISGVATD--NRA 204

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15231569  172 LGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIYDFV 238
Cdd:PLN00184 205 IGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTV 271
PRK05420 PRK05420
aquaporin Z; Provisional
 21-239 1.13e-20

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 87.33  E-value: 1.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   21 LRAALAEFISTLIFVFAGSGSGIAFNKITDNGAttpsGLVAAALAhaFGLFV---AVSVGaNISGGHVNPAVTFGVLLGG 97
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAVLAAAFPELGI----GFLGVALA--FGLTVltmAYAVG-HISGGHFNPAVSVGLWAGG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   98 NITLLRGILYWIAQLLGSVAACFLLSFATGGEP---IPAFGLSA---------GVGSLNALVFEIVMTFGLVYTVYAtAV 165
Cdd:PRK05420  75 RFPAKELVPYIIAQVVGGIAAAAVLYLIASGKAgfdLAGSGFASngygehspgGYSLLAALVCEVVLTAFFLLVILG-AT 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231569  166 DpKNGSLGtIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPA--VVSWTWTNHWVYWAGPLIGGGLAGIIYDFVF 239
Cdd:PRK05420 154 D-KRAPAG-FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVAlfVGGWALEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 19-235 1.22e-20

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 87.99  E-value: 1.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   19 NALRAALAEFISTLIFVFAGSGSgIAFNKITDNGAttpsGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGVLLGGN 98
Cdd:PLN00183  43 NPARMVLAEMVGTFILMFCVCGI-IASTQLSGGEV----GLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGH 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   99 ITLLRGILYWIAQLLGSVAACFLLSFATGGEPiPAFGLSAGVGSLNALVFEIVMTFGLVYTVYATAVDPKNgsLGTIAPI 178
Cdd:PLN00183 118 FPWSKVPLYITAQTVGSVLATYVGVSVYGVKA-DLMTTKPAQGCSSAFWVEFIATFIVMFLAASLTSQPQS--LGHLSGF 194

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15231569  179 AIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIY 235
Cdd:PLN00183 195 VIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMF 251
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 21-240 1.42e-15

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 74.39  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569   21 LRAALAEFISTLIFVFAGSGSGIAFNKITDNGattpsGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGVLLGGNIT 100
Cdd:PTZ00016  50 VREYVAEFLGTFVLLFFGEGVVATTHTVGNNG-----DYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFP 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  101 LLRGILYWIAQLLGSV--AACFLLSFA-----TGGEPIPAFGLS----------AGVGSLNALVFEIVMTFGLVYTVYAT 163
Cdd:PTZ00016 125 WKKLPGYFVAQLLGAFvgAACVYGLYYgffkdHGIPELPWETMAngfagvfatyPREGNFYAIFSELILTAILLLVILAI 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231569  164 aVDPKNGSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSW------TWTNH----WVYWAGPLIGGGLAGI 233
Cdd:PTZ00016 205 -TDPNNCPAFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAilwgseVFTKDnyyfWVPLVAPFVGAVLGMF 283


                 ....*..
gi 15231569  234 IYDFVFI 240
Cdd:PTZ00016 284 LYDKFIP 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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