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Conserved domains on  [gi|15233236|ref|NP_188838|]
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cysteine-rich repeat secretory protein, putative (DUF26) [Arabidopsis thaliana]

Protein Classification

cysteine-rich repeat secretory family protein( domain architecture ID 10483325)

cysteine-rich repeat secretory family protein plays a role in salt stress response and has antifungal activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Stress-antifung pfam01657
Salt stress response/antifungal; This domain is often found in association with the kinase ...
 47-134 9.30e-21

Salt stress response/antifungal; This domain is often found in association with the kinase domains pfam00069 or pfam07714. In many proteins it is duplicated. It contains six conserved cysteines which are involved in disulphide bridges. It has a role in salt stress response and has antifungal activity.


:

Pssm-ID: 460284  Cd Length: 96  Bit Score: 84.05  E-value: 9.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233236    47 SEGKYKPGSKYEYILNDYIRFLAAGN---FRSGSMHMTSGLKPNAVTILYQCSGDSYNSKCRSCYAAGISGLRRRCPRNK 123
Cdd:pfam01657   3 STGNYTPNSTYETNLNSLLSSLPASSsnaTPKGGFYNASAGQPDRVYGLAQCRGDLSPSDCRSCLATAVADLLQRCPNKK 82

                          90
                  ....*....|.
gi 15233236   124 GGIIWFDQCFV 134
Cdd:pfam01657  83 GARIWYDGCFL 93
Gnk2-like cd23509
antifungal protein ginkbilobin-2-like domains found in plants; This family includes the ...
 153-261 2.42e-20

antifungal protein ginkbilobin-2-like domains found in plants; This family includes the antifungal protein ginkbilobin found in seeds of Ginkgo biloba. The full-length protein contains a signal peptide and is called ginkbilobin-2 (Gnk2 or stress-antifungal domain). Gnk2 is an extracellular domain harboring a conserved cysteine motif (C-8X-C-2X-C) in its core. This domain is present in three types of plant proteins: cysteine-rich receptor-like secreted proteins (CRRSPs), cysteine-rich receptor-like kinase (CRKs), and plasmodesmata-localized proteins (PDLPs). Gnk2 from Ginkgo biloba and maize AFP1 CRRSPs have been shown to bind mannose. CRKs that typically have two Gnk2 domains in the extracellular region, form part of a large subgroup of receptor-like protein kinases (RLKs) in plants and have been shown to participate in the control of stress responses and development in Arabidopsis. PDLPs contain two Gnk2 domains in their extracellular region and a transmembrane helix, but lack a kinase domain; they associate with plasmodesmata and are involved in symplastic intercellular signaling, pathogen response, systemic signaling, control of callose deposition and are targets for viral movement proteins. No ligand have been identified for PDLPs and CRKs. Although the precise biochemical functions of plant Gnk2 are not known, the conserved C-8X-C-2X-C motif may point to carbohydrate binding, similar to G. biloba Gnk2 inhibiting the growth of several fungi by binding mannose moieties of the fungal cell walls.


:

Pssm-ID: 467874  Cd Length: 100  Bit Score: 83.22  E-value: 2.42e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233236 153 NNFPLHNPNRVSGNIKSFNNETMALLKELALKANNkdnmdngkMALYASGEKRVGTKKVYAMVQCMRDLvKPKMCKECLE 232
Cdd:cd23509   1 PSYIYSNCSGNYTSNSTFEANLNSLLSSLASNASS--------SSGFATGSAGLGPDTVYGLAQCRGDL-SPSDCRSCLA 71

                        90       100
                ....*....|....*....|....*....
gi 15233236 233 SIIKEFPECCDGKQGGRILGTSCDFRYEL 261
Cdd:cd23509  72 TAISQIPSCCPGSKGGRVWYDSCFLRYEN 100
 
Name Accession Description Interval E-value
Stress-antifung pfam01657
Salt stress response/antifungal; This domain is often found in association with the kinase ...
 47-134 9.30e-21

Salt stress response/antifungal; This domain is often found in association with the kinase domains pfam00069 or pfam07714. In many proteins it is duplicated. It contains six conserved cysteines which are involved in disulphide bridges. It has a role in salt stress response and has antifungal activity.


Pssm-ID: 460284  Cd Length: 96  Bit Score: 84.05  E-value: 9.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233236    47 SEGKYKPGSKYEYILNDYIRFLAAGN---FRSGSMHMTSGLKPNAVTILYQCSGDSYNSKCRSCYAAGISGLRRRCPRNK 123
Cdd:pfam01657   3 STGNYTPNSTYETNLNSLLSSLPASSsnaTPKGGFYNASAGQPDRVYGLAQCRGDLSPSDCRSCLATAVADLLQRCPNKK 82

                          90
                  ....*....|.
gi 15233236   124 GGIIWFDQCFV 134
Cdd:pfam01657  83 GARIWYDGCFL 93
Gnk2-like cd23509
antifungal protein ginkbilobin-2-like domains found in plants; This family includes the ...
 153-261 2.42e-20

antifungal protein ginkbilobin-2-like domains found in plants; This family includes the antifungal protein ginkbilobin found in seeds of Ginkgo biloba. The full-length protein contains a signal peptide and is called ginkbilobin-2 (Gnk2 or stress-antifungal domain). Gnk2 is an extracellular domain harboring a conserved cysteine motif (C-8X-C-2X-C) in its core. This domain is present in three types of plant proteins: cysteine-rich receptor-like secreted proteins (CRRSPs), cysteine-rich receptor-like kinase (CRKs), and plasmodesmata-localized proteins (PDLPs). Gnk2 from Ginkgo biloba and maize AFP1 CRRSPs have been shown to bind mannose. CRKs that typically have two Gnk2 domains in the extracellular region, form part of a large subgroup of receptor-like protein kinases (RLKs) in plants and have been shown to participate in the control of stress responses and development in Arabidopsis. PDLPs contain two Gnk2 domains in their extracellular region and a transmembrane helix, but lack a kinase domain; they associate with plasmodesmata and are involved in symplastic intercellular signaling, pathogen response, systemic signaling, control of callose deposition and are targets for viral movement proteins. No ligand have been identified for PDLPs and CRKs. Although the precise biochemical functions of plant Gnk2 are not known, the conserved C-8X-C-2X-C motif may point to carbohydrate binding, similar to G. biloba Gnk2 inhibiting the growth of several fungi by binding mannose moieties of the fungal cell walls.


Pssm-ID: 467874  Cd Length: 100  Bit Score: 83.22  E-value: 2.42e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233236 153 NNFPLHNPNRVSGNIKSFNNETMALLKELALKANNkdnmdngkMALYASGEKRVGTKKVYAMVQCMRDLvKPKMCKECLE 232
Cdd:cd23509   1 PSYIYSNCSGNYTSNSTFEANLNSLLSSLASNASS--------SSGFATGSAGLGPDTVYGLAQCRGDL-SPSDCRSCLA 71

                        90       100
                ....*....|....*....|....*....
gi 15233236 233 SIIKEFPECCDGKQGGRILGTSCDFRYEL 261
Cdd:cd23509  72 TAISQIPSCCPGSKGGRVWYDSCFLRYEN 100
Gnk2-like cd23509
antifungal protein ginkbilobin-2-like domains found in plants; This family includes the ...
 37-134 6.00e-18

antifungal protein ginkbilobin-2-like domains found in plants; This family includes the antifungal protein ginkbilobin found in seeds of Ginkgo biloba. The full-length protein contains a signal peptide and is called ginkbilobin-2 (Gnk2 or stress-antifungal domain). Gnk2 is an extracellular domain harboring a conserved cysteine motif (C-8X-C-2X-C) in its core. This domain is present in three types of plant proteins: cysteine-rich receptor-like secreted proteins (CRRSPs), cysteine-rich receptor-like kinase (CRKs), and plasmodesmata-localized proteins (PDLPs). Gnk2 from Ginkgo biloba and maize AFP1 CRRSPs have been shown to bind mannose. CRKs that typically have two Gnk2 domains in the extracellular region, form part of a large subgroup of receptor-like protein kinases (RLKs) in plants and have been shown to participate in the control of stress responses and development in Arabidopsis. PDLPs contain two Gnk2 domains in their extracellular region and a transmembrane helix, but lack a kinase domain; they associate with plasmodesmata and are involved in symplastic intercellular signaling, pathogen response, systemic signaling, control of callose deposition and are targets for viral movement proteins. No ligand have been identified for PDLPs and CRKs. Although the precise biochemical functions of plant Gnk2 are not known, the conserved C-8X-C-2X-C motif may point to carbohydrate binding, similar to G. biloba Gnk2 inhibiting the growth of several fungi by binding mannose moieties of the fungal cell walls.


Pssm-ID: 467874  Cd Length: 100  Bit Score: 77.06  E-value: 6.00e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233236  37 NEYLHHKCLvseGKYKPGSKYEYILNDYIRFLAA-GNFRSGSMHMTSGLKPNAVTILYQCSGDSYNSKCRSCYAAGISGL 115
Cdd:cd23509   1 PSYIYSNCS---GNYTSNSTFEANLNSLLSSLASnASSSSGFATGSAGLGPDTVYGLAQCRGDLSPSDCRSCLATAISQI 77

                        90
                ....*....|....*....
gi 15233236 116 RRRCPRNKGGIIWFDQCFV 134
Cdd:cd23509  78 PSCCPGSKGGRVWYDSCFL 96
Stress-antifung pfam01657
Salt stress response/antifungal; This domain is often found in association with the kinase ...
 210-260 8.59e-10

Salt stress response/antifungal; This domain is often found in association with the kinase domains pfam00069 or pfam07714. In many proteins it is duplicated. It contains six conserved cysteines which are involved in disulphide bridges. It has a role in salt stress response and has antifungal activity.


Pssm-ID: 460284  Cd Length: 96  Bit Score: 54.77  E-value: 8.59e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15233236   210 KVYAMVQCMRDLvKPKMCKECLESIIKEFPECCDGKQGGRILGTSCDFRYE 260
Cdd:pfam01657  47 RVYGLAQCRGDL-SPSDCRSCLATAVADLLQRCPNKKGARIWYDGCFLRYS 96
 
Name Accession Description Interval E-value
Stress-antifung pfam01657
Salt stress response/antifungal; This domain is often found in association with the kinase ...
 47-134 9.30e-21

Salt stress response/antifungal; This domain is often found in association with the kinase domains pfam00069 or pfam07714. In many proteins it is duplicated. It contains six conserved cysteines which are involved in disulphide bridges. It has a role in salt stress response and has antifungal activity.


Pssm-ID: 460284  Cd Length: 96  Bit Score: 84.05  E-value: 9.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233236    47 SEGKYKPGSKYEYILNDYIRFLAAGN---FRSGSMHMTSGLKPNAVTILYQCSGDSYNSKCRSCYAAGISGLRRRCPRNK 123
Cdd:pfam01657   3 STGNYTPNSTYETNLNSLLSSLPASSsnaTPKGGFYNASAGQPDRVYGLAQCRGDLSPSDCRSCLATAVADLLQRCPNKK 82

                          90
                  ....*....|.
gi 15233236   124 GGIIWFDQCFV 134
Cdd:pfam01657  83 GARIWYDGCFL 93
Gnk2-like cd23509
antifungal protein ginkbilobin-2-like domains found in plants; This family includes the ...
 153-261 2.42e-20

antifungal protein ginkbilobin-2-like domains found in plants; This family includes the antifungal protein ginkbilobin found in seeds of Ginkgo biloba. The full-length protein contains a signal peptide and is called ginkbilobin-2 (Gnk2 or stress-antifungal domain). Gnk2 is an extracellular domain harboring a conserved cysteine motif (C-8X-C-2X-C) in its core. This domain is present in three types of plant proteins: cysteine-rich receptor-like secreted proteins (CRRSPs), cysteine-rich receptor-like kinase (CRKs), and plasmodesmata-localized proteins (PDLPs). Gnk2 from Ginkgo biloba and maize AFP1 CRRSPs have been shown to bind mannose. CRKs that typically have two Gnk2 domains in the extracellular region, form part of a large subgroup of receptor-like protein kinases (RLKs) in plants and have been shown to participate in the control of stress responses and development in Arabidopsis. PDLPs contain two Gnk2 domains in their extracellular region and a transmembrane helix, but lack a kinase domain; they associate with plasmodesmata and are involved in symplastic intercellular signaling, pathogen response, systemic signaling, control of callose deposition and are targets for viral movement proteins. No ligand have been identified for PDLPs and CRKs. Although the precise biochemical functions of plant Gnk2 are not known, the conserved C-8X-C-2X-C motif may point to carbohydrate binding, similar to G. biloba Gnk2 inhibiting the growth of several fungi by binding mannose moieties of the fungal cell walls.


Pssm-ID: 467874  Cd Length: 100  Bit Score: 83.22  E-value: 2.42e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233236 153 NNFPLHNPNRVSGNIKSFNNETMALLKELALKANNkdnmdngkMALYASGEKRVGTKKVYAMVQCMRDLvKPKMCKECLE 232
Cdd:cd23509   1 PSYIYSNCSGNYTSNSTFEANLNSLLSSLASNASS--------SSGFATGSAGLGPDTVYGLAQCRGDL-SPSDCRSCLA 71

                        90       100
                ....*....|....*....|....*....
gi 15233236 233 SIIKEFPECCDGKQGGRILGTSCDFRYEL 261
Cdd:cd23509  72 TAISQIPSCCPGSKGGRVWYDSCFLRYEN 100
Gnk2-like cd23509
antifungal protein ginkbilobin-2-like domains found in plants; This family includes the ...
 37-134 6.00e-18

antifungal protein ginkbilobin-2-like domains found in plants; This family includes the antifungal protein ginkbilobin found in seeds of Ginkgo biloba. The full-length protein contains a signal peptide and is called ginkbilobin-2 (Gnk2 or stress-antifungal domain). Gnk2 is an extracellular domain harboring a conserved cysteine motif (C-8X-C-2X-C) in its core. This domain is present in three types of plant proteins: cysteine-rich receptor-like secreted proteins (CRRSPs), cysteine-rich receptor-like kinase (CRKs), and plasmodesmata-localized proteins (PDLPs). Gnk2 from Ginkgo biloba and maize AFP1 CRRSPs have been shown to bind mannose. CRKs that typically have two Gnk2 domains in the extracellular region, form part of a large subgroup of receptor-like protein kinases (RLKs) in plants and have been shown to participate in the control of stress responses and development in Arabidopsis. PDLPs contain two Gnk2 domains in their extracellular region and a transmembrane helix, but lack a kinase domain; they associate with plasmodesmata and are involved in symplastic intercellular signaling, pathogen response, systemic signaling, control of callose deposition and are targets for viral movement proteins. No ligand have been identified for PDLPs and CRKs. Although the precise biochemical functions of plant Gnk2 are not known, the conserved C-8X-C-2X-C motif may point to carbohydrate binding, similar to G. biloba Gnk2 inhibiting the growth of several fungi by binding mannose moieties of the fungal cell walls.


Pssm-ID: 467874  Cd Length: 100  Bit Score: 77.06  E-value: 6.00e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233236  37 NEYLHHKCLvseGKYKPGSKYEYILNDYIRFLAA-GNFRSGSMHMTSGLKPNAVTILYQCSGDSYNSKCRSCYAAGISGL 115
Cdd:cd23509   1 PSYIYSNCS---GNYTSNSTFEANLNSLLSSLASnASSSSGFATGSAGLGPDTVYGLAQCRGDLSPSDCRSCLATAISQI 77

                        90
                ....*....|....*....
gi 15233236 116 RRRCPRNKGGIIWFDQCFV 134
Cdd:cd23509  78 PSCCPGSKGGRVWYDSCFL 96
Stress-antifung pfam01657
Salt stress response/antifungal; This domain is often found in association with the kinase ...
 210-260 8.59e-10

Salt stress response/antifungal; This domain is often found in association with the kinase domains pfam00069 or pfam07714. In many proteins it is duplicated. It contains six conserved cysteines which are involved in disulphide bridges. It has a role in salt stress response and has antifungal activity.


Pssm-ID: 460284  Cd Length: 96  Bit Score: 54.77  E-value: 8.59e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15233236   210 KVYAMVQCMRDLvKPKMCKECLESIIKEFPECCDGKQGGRILGTSCDFRYE 260
Cdd:pfam01657  47 RVYGLAQCRGDL-SPSDCRSCLATAVADLLQRCPNKKGARIWYDGCFLRYS 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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