|
Name |
Accession |
Description |
Interval |
E-value |
| PRP40 |
COG5104 |
Splicing factor [RNA processing and modification]; |
249-625 |
4.95e-16 |
|
Splicing factor [RNA processing and modification];
Pssm-ID: 227435 [Multi-domain] Cd Length: 590 Bit Score: 82.44 E-value: 4.95e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 249 WTAHKSEAGVLYYYNSVTGQSTYEKPPG-FGGEPDKVPVQPipvsmeslpgtdWALVSTNDGKKYYYNNKTKVSSWQIPa 327
Cdd:COG5104 17 WEELKAPDGRIYYYNKRTGKSSWEKPKElLKGSEEDLDVDP------------WKECRTADGKVYYYNSITRESRWKIP- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 328 evkDFGKKLEERAMESVASVPSADLTEKGSDLTSLSApaiSNGGRDAASLKTTNFGSSALDLVKKKLHDSGMPVSSTITS 407
Cdd:COG5104 84 ---PERKKVEPIAEQKHDERSMIGGNGNDMAITDHET---SEPKYLLGRLMSQYGITSTKDAVYRLTKEEAEKEFITMLK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 408 EANSGKTTEVTPSGESGNSTG--KVKDAPG--AGALSDSSSDSEDEDSGPSKEECSK---QFKEMLK-ERGIAPFSKWEK 479
Cdd:COG5104 158 ENQVDSTWPIFRAIEELRDPRywMVDTDPLwrKDLFKKYFENQEKDQREEEENKQRKyinEFCKMLAgNSHIKYYTDWFT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 480 ELPKIIFDPRFKAIPSHSVRRSLFEQYVKTRAEEERREKRAAHKAAIEGFRQLLDdaSTDIDQHTDYRAFKKKWGNDLRF 559
Cdd:COG5104 238 FKSIFSKHPYYSSVVNEKTKRQTFQKYKDKLGCYEKYVGKHMGGTALGRLEEVLR--SLGSETFIIWLLNHYVFDSVVRY 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 560 EAIERKE---REGLLNE---RVLSLKRSAEQKAQEIRAAAAS-------DFKTMLR----EREISINSHWSKVKDSLRNE 622
Cdd:COG5104 316 LKNKEMKpldRKDILFSfirYVRRLEKELLSAIEERKAAAAQnarhhrdEFRTLLRklysEGKIYYRMKWKNAYPLIKDD 395
|
...
gi 334185482 623 PRY 625
Cdd:COG5104 396 PRF 398
|
|
| FF |
pfam01846 |
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ... |
460-506 |
5.64e-15 |
|
FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.
Pssm-ID: 426471 [Multi-domain] Cd Length: 50 Bit Score: 69.41 E-value: 5.64e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 334185482 460 KQFKEMLKERGIAPFSKWEKELPKIIFDPRFKAIPSHSVRRSLFEQY 506
Cdd:pfam01846 4 EAFKELLKEHKITPYSTWSEIKKKIENDPRYKALLDGSEREELFEDY 50
|
|
| FF |
smart00441 |
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ... |
456-508 |
9.73e-09 |
|
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.
Pssm-ID: 128718 [Multi-domain] Cd Length: 55 Bit Score: 52.19 E-value: 9.73e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 334185482 456 EECSKQFKEMLKE-RGIAPFSKWEKELPKIIFDPRFKAIPSHSVRRSLFEQYVK 508
Cdd:smart00441 1 EEAKEAFKELLKEhEVITPDTTWSEARKKLKNDPRYKALLSESEREQLFEDHIE 54
|
|
| FF |
pfam01846 |
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ... |
693-745 |
4.17e-07 |
|
FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.
Pssm-ID: 426471 [Multi-domain] Cd Length: 50 Bit Score: 47.07 E-value: 4.17e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 334185482 693 EASSSYQALLVEKIRDPEASWTESKPILERDPQKRASNPdlePADKEKLFRDH 745
Cdd:pfam01846 1 KAREAFKELLKEHKITPYSTWSEIKKKIENDPRYKALLD---GSEREELFEDY 50
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
24-230 |
4.43e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.71 E-value: 4.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 24 RPPPIAPVLATTSNFSQSELKELHSMSiASTGFVSqSVPYSVTAQWGTNAAASSNVNPIPQASPMLANAPFG------RP 97
Cdd:PHA03247 2684 RRRAARPTVGSLTSLADPPPPPPTPEP-APHALVS-ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGparparPP 2761
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 98 GTLAPPGlmTSPPAFPGSNPFSTTPRPGMS-------AGPAQMNPGIHPH-MYPPYHSLPGTPQGMWLQPPSMGGIPRAP 169
Cdd:PHA03247 2762 TTAGPPA--PAPPAAPAAGPPRRLTRPAVAslsesreSLPSPWDPADPPAaVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185482 170 flSHPTTFPGSYPFPVRGISPNLPYSGSHPLGASPMGSVGNVHALPGRQPDISPGRKTEEL 230
Cdd:PHA03247 2840 --PPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898
|
|
| WW |
cd00201 |
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ... |
249-276 |
1.17e-05 |
|
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
Pssm-ID: 238122 [Multi-domain] Cd Length: 31 Bit Score: 42.52 E-value: 1.17e-05
10 20
....*....|....*....|....*...
gi 334185482 249 WTAHKSEAGVLYYYNSVTGQSTYEKPPG 276
Cdd:cd00201 4 WEERWDPDGRVYYYNHNTKETQWEDPRE 31
|
|
| SSDP |
pfam04503 |
Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA ... |
77-290 |
2.13e-05 |
|
Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene.
Pssm-ID: 461334 [Multi-domain] Cd Length: 293 Bit Score: 47.26 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 77 SNVNPIPQASPMLANAP--FGRPGTLAPPGLMTSPPAFPGSNPfSTTPRPGMSAGPAQMNPGIHPHMYPPYHSLPGTPQG 154
Cdd:pfam04503 13 SFVSSAAAPSPVMGQMPpgDGMPGGPMPPGFFQSPPSHPSSQP-SPHAQPPPHNPATMMGPHSQPFMGPRYPGGPRPSVR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 155 MwlqpPSMGGIPRAPflshpttfPGSYPFPVRGISPNLPysGSHPLGASPMGSVGnvhalPGRQPDISPGRKTEELSGID 234
Cdd:pfam04503 92 M----PQQGNDFNGP--------PGQQPMMPNSMDPTRP--GGHPNMGGPMQRMN-----PPRGPGMGPMGPQSYGPGMR 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334185482 235 DRAGSQLV------------GNRLDAWTAHKSEAgvLYYYNSVTGqsTYEKPPGFGGEPDKVPVQPIP 290
Cdd:pfam04503 153 GPPPNSTDgpggmppmnmgpGGRRPWPQPNASNP--LPYSSSSPG--SYGGPPGGGGPPGPTPIMPSP 216
|
|
| FF |
smart00441 |
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ... |
692-747 |
4.23e-03 |
|
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.
Pssm-ID: 128718 [Multi-domain] Cd Length: 55 Bit Score: 36.01 E-value: 4.23e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 334185482 692 KEASSSYQALLVEKIRD-PEASWTESKPILERDPQKRASnpdLEPADKEKLFRDHVK 747
Cdd:smart00441 1 EEAKEAFKELLKEHEVItPDTTWSEARKKLKNDPRYKAL---LSESEREQLFEDHIE 54
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRP40 |
COG5104 |
Splicing factor [RNA processing and modification]; |
249-625 |
4.95e-16 |
|
Splicing factor [RNA processing and modification];
Pssm-ID: 227435 [Multi-domain] Cd Length: 590 Bit Score: 82.44 E-value: 4.95e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 249 WTAHKSEAGVLYYYNSVTGQSTYEKPPG-FGGEPDKVPVQPipvsmeslpgtdWALVSTNDGKKYYYNNKTKVSSWQIPa 327
Cdd:COG5104 17 WEELKAPDGRIYYYNKRTGKSSWEKPKElLKGSEEDLDVDP------------WKECRTADGKVYYYNSITRESRWKIP- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 328 evkDFGKKLEERAMESVASVPSADLTEKGSDLTSLSApaiSNGGRDAASLKTTNFGSSALDLVKKKLHDSGMPVSSTITS 407
Cdd:COG5104 84 ---PERKKVEPIAEQKHDERSMIGGNGNDMAITDHET---SEPKYLLGRLMSQYGITSTKDAVYRLTKEEAEKEFITMLK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 408 EANSGKTTEVTPSGESGNSTG--KVKDAPG--AGALSDSSSDSEDEDSGPSKEECSK---QFKEMLK-ERGIAPFSKWEK 479
Cdd:COG5104 158 ENQVDSTWPIFRAIEELRDPRywMVDTDPLwrKDLFKKYFENQEKDQREEEENKQRKyinEFCKMLAgNSHIKYYTDWFT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 480 ELPKIIFDPRFKAIPSHSVRRSLFEQYVKTRAEEERREKRAAHKAAIEGFRQLLDdaSTDIDQHTDYRAFKKKWGNDLRF 559
Cdd:COG5104 238 FKSIFSKHPYYSSVVNEKTKRQTFQKYKDKLGCYEKYVGKHMGGTALGRLEEVLR--SLGSETFIIWLLNHYVFDSVVRY 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 560 EAIERKE---REGLLNE---RVLSLKRSAEQKAQEIRAAAAS-------DFKTMLR----EREISINSHWSKVKDSLRNE 622
Cdd:COG5104 316 LKNKEMKpldRKDILFSfirYVRRLEKELLSAIEERKAAAAQnarhhrdEFRTLLRklysEGKIYYRMKWKNAYPLIKDD 395
|
...
gi 334185482 623 PRY 625
Cdd:COG5104 396 PRF 398
|
|
| FF |
pfam01846 |
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ... |
460-506 |
5.64e-15 |
|
FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.
Pssm-ID: 426471 [Multi-domain] Cd Length: 50 Bit Score: 69.41 E-value: 5.64e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 334185482 460 KQFKEMLKERGIAPFSKWEKELPKIIFDPRFKAIPSHSVRRSLFEQY 506
Cdd:pfam01846 4 EAFKELLKEHKITPYSTWSEIKKKIENDPRYKALLDGSEREELFEDY 50
|
|
| FF |
pfam01846 |
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ... |
593-640 |
1.30e-09 |
|
FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.
Pssm-ID: 426471 [Multi-domain] Cd Length: 50 Bit Score: 54.39 E-value: 1.30e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 334185482 593 AASDFKTMLREREISINSHWSKVKDSLRNEPRYRSV-AHEDREVFYYEY 640
Cdd:pfam01846 2 AREAFKELLKEHKITPYSTWSEIKKKIENDPRYKALlDGSEREELFEDY 50
|
|
| FF |
smart00441 |
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ... |
456-508 |
9.73e-09 |
|
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.
Pssm-ID: 128718 [Multi-domain] Cd Length: 55 Bit Score: 52.19 E-value: 9.73e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 334185482 456 EECSKQFKEMLKE-RGIAPFSKWEKELPKIIFDPRFKAIPSHSVRRSLFEQYVK 508
Cdd:smart00441 1 EEAKEAFKELLKEhEVITPDTTWSEARKKLKNDPRYKALLSESEREQLFEDHIE 54
|
|
| PRP40 |
COG5104 |
Splicing factor [RNA processing and modification]; |
299-725 |
1.45e-08 |
|
Splicing factor [RNA processing and modification];
Pssm-ID: 227435 [Multi-domain] Cd Length: 590 Bit Score: 58.17 E-value: 1.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 299 TDWALVSTNDGKKYYYNNKTKVSSWQIPAEV-KDFGKKLEERAMESVAsvpsadlTEKGSDLTSLSAPAISNGGRDAASL 377
Cdd:COG5104 15 SEWEELKAPDGRIYYYNKRTGKSSWEKPKELlKGSEEDLDVDPWKECR-------TADGKVYYYNSITRESRWKIPPERK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 378 KTTNFGSSALDLVKK-KLHDSGMPVSSTITSEanSGKTTEVTPSGESGNSTgkvKDApgagalsdsssdsedeDSGPSKE 456
Cdd:COG5104 88 KVEPIAEQKHDERSMiGGNGNDMAITDHETSE--PKYLLGRLMSQYGITST---KDA----------------VYRLTKE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 457 ECSKQFKEMLKERGIAPFSKWEKELpKIIFDPRFKAIPSHSV-RRSLFEQYVKTRAEEERREKRAAHKAAIEGFrQLLDD 535
Cdd:COG5104 147 EAEKEFITMLKENQVDSTWPIFRAI-EELRDPRYWMVDTDPLwRKDLFKKYFENQEKDQREEEENKQRKYINEF-CKMLA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 536 ASTDIDQHTDYRAFKKKWGNDLRFEAI-ERKEREGLLNERVLSLKRSAEQKAQEIRAAAASDFKTMLREREISINSHW-- 612
Cdd:COG5104 225 GNSHIKYYTDWFTFKSIFSKHPYYSSVvNEKTKRQTFQKYKDKLGCYEKYVGKHMGGTALGRLEEVLRSLGSETFIIWll 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 613 -----SKVKDSLRNEpRYRSVAHEDREVFYYEYIAELKAAQRGDDHEMKARDEEdklrererelrkrkerevqevervRQ 687
Cdd:COG5104 305 nhyvfDSVVRYLKNK-EMKPLDRKDILFSFIRYVRRLEKELLSAIEERKAAAAQ------------------------NA 359
|
410 420 430
....*....|....*....|....*....|....*...
gi 334185482 688 KIRRKEASSSYQALLVEKIRDPEASWTESKPILERDPQ 725
Cdd:COG5104 360 RHHRDEFRTLLRKLYSEGKIYYRMKWKNAYPLIKDDPR 397
|
|
| FF |
pfam01846 |
FF domain; This domain has been predicted to be involved in protein-protein interaction. This ... |
693-745 |
4.17e-07 |
|
FF domain; This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.
Pssm-ID: 426471 [Multi-domain] Cd Length: 50 Bit Score: 47.07 E-value: 4.17e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 334185482 693 EASSSYQALLVEKIRDPEASWTESKPILERDPQKRASNPdlePADKEKLFRDH 745
Cdd:pfam01846 1 KAREAFKELLKEHKITPYSTWSEIKKKIENDPRYKALLD---GSEREELFEDY 50
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
24-230 |
4.43e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.71 E-value: 4.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 24 RPPPIAPVLATTSNFSQSELKELHSMSiASTGFVSqSVPYSVTAQWGTNAAASSNVNPIPQASPMLANAPFG------RP 97
Cdd:PHA03247 2684 RRRAARPTVGSLTSLADPPPPPPTPEP-APHALVS-ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGparparPP 2761
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 98 GTLAPPGlmTSPPAFPGSNPFSTTPRPGMS-------AGPAQMNPGIHPH-MYPPYHSLPGTPQGMWLQPPSMGGIPRAP 169
Cdd:PHA03247 2762 TTAGPPA--PAPPAAPAAGPPRRLTRPAVAslsesreSLPSPWDPADPPAaVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185482 170 flSHPTTFPGSYPFPVRGISPNLPYSGSHPLGASPMGSVGNVHALPGRQPDISPGRKTEEL 230
Cdd:PHA03247 2840 --PPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898
|
|
| WW |
pfam00397 |
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ... |
249-274 |
5.90e-06 |
|
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.
Pssm-ID: 459800 [Multi-domain] Cd Length: 30 Bit Score: 43.65 E-value: 5.90e-06
10 20
....*....|....*....|....*.
gi 334185482 249 WTAHKSEAGVLYYYNSVTGQSTYEKP 274
Cdd:pfam00397 5 WEERWDPDGRVYYYNHETGETQWEKP 30
|
|
| WW |
cd00201 |
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ... |
249-276 |
1.17e-05 |
|
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
Pssm-ID: 238122 [Multi-domain] Cd Length: 31 Bit Score: 42.52 E-value: 1.17e-05
10 20
....*....|....*....|....*...
gi 334185482 249 WTAHKSEAGVLYYYNSVTGQSTYEKPPG 276
Cdd:cd00201 4 WEERWDPDGRVYYYNHNTKETQWEDPRE 31
|
|
| WW |
cd00201 |
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ... |
299-328 |
2.07e-05 |
|
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
Pssm-ID: 238122 [Multi-domain] Cd Length: 31 Bit Score: 42.13 E-value: 2.07e-05
10 20 30
....*....|....*....|....*....|
gi 334185482 299 TDWALVSTNDGKKYYYNNKTKVSSWQIPAE 328
Cdd:cd00201 2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
|
|
| SSDP |
pfam04503 |
Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA ... |
77-290 |
2.13e-05 |
|
Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene.
Pssm-ID: 461334 [Multi-domain] Cd Length: 293 Bit Score: 47.26 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 77 SNVNPIPQASPMLANAP--FGRPGTLAPPGLMTSPPAFPGSNPfSTTPRPGMSAGPAQMNPGIHPHMYPPYHSLPGTPQG 154
Cdd:pfam04503 13 SFVSSAAAPSPVMGQMPpgDGMPGGPMPPGFFQSPPSHPSSQP-SPHAQPPPHNPATMMGPHSQPFMGPRYPGGPRPSVR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 155 MwlqpPSMGGIPRAPflshpttfPGSYPFPVRGISPNLPysGSHPLGASPMGSVGnvhalPGRQPDISPGRKTEELSGID 234
Cdd:pfam04503 92 M----PQQGNDFNGP--------PGQQPMMPNSMDPTRP--GGHPNMGGPMQRMN-----PPRGPGMGPMGPQSYGPGMR 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334185482 235 DRAGSQLV------------GNRLDAWTAHKSEAgvLYYYNSVTGqsTYEKPPGFGGEPDKVPVQPIP 290
Cdd:pfam04503 153 GPPPNSTDgpggmppmnmgpGGRRPWPQPNASNP--LPYSSSSPG--SYGGPPGGGGPPGPTPIMPSP 216
|
|
| WW |
pfam00397 |
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ... |
296-326 |
3.22e-05 |
|
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.
Pssm-ID: 459800 [Multi-domain] Cd Length: 30 Bit Score: 41.34 E-value: 3.22e-05
10 20 30
....*....|....*....|....*....|.
gi 334185482 296 LPgTDWALVSTNDGKKYYYNNKTKVSSWQIP 326
Cdd:pfam00397 1 LP-PGWEERWDPDGRVYYYNHETGETQWEKP 30
|
|
| WW |
smart00456 |
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ... |
249-276 |
1.08e-04 |
|
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.
Pssm-ID: 197736 [Multi-domain] Cd Length: 33 Bit Score: 39.89 E-value: 1.08e-04
10 20
....*....|....*....|....*...
gi 334185482 249 WTAHKSEAGVLYYYNSVTGQSTYEKPPG 276
Cdd:smart00456 6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
|
|
| Jun |
pfam03957 |
Jun-like transcription factor; |
79-190 |
2.30e-04 |
|
Jun-like transcription factor;
Pssm-ID: 461108 [Multi-domain] Cd Length: 231 Bit Score: 43.36 E-value: 2.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 79 VNPIPQASPmlANAPFGRPGTLAPPGLMTSPPAFPGSNPFSTTPRPGMSAGPAQMNPGIhphmypPYHSLPGTPQgMWLQ 158
Cdd:pfam03957 131 ATPAPQALA--AGGGGSGPGALAAGGIATEPPVYANLSSFNPAAAPASGAAPAQPPQPV------SYAAEPPPFA-VPVQ 201
|
90 100 110
....*....|....*....|....*....|...
gi 334185482 159 PPSMGGIPR-APFLSHPTTFPgsyPFPVRGISP 190
Cdd:pfam03957 202 HPPPGRPPRlQALKEEPQTVP---EVPSFGETP 231
|
|
| FF |
smart00441 |
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ... |
595-643 |
3.86e-04 |
|
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.
Pssm-ID: 128718 [Multi-domain] Cd Length: 55 Bit Score: 39.09 E-value: 3.86e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 334185482 595 SDFKTMLREREISI-NSHWSKVKDSLRNEPRYRSVAHED-REVFYYEYIAE 643
Cdd:smart00441 5 EAFKELLKEHEVITpDTTWSEARKKLKNDPRYKALLSESeREQLFEDHIEE 55
|
|
| WW |
smart00456 |
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ... |
301-328 |
5.11e-04 |
|
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.
Pssm-ID: 197736 [Multi-domain] Cd Length: 33 Bit Score: 37.97 E-value: 5.11e-04
10 20
....*....|....*....|....*...
gi 334185482 301 WALVSTNDGKKYYYNNKTKVSSWQIPAE 328
Cdd:smart00456 6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
62-164 |
6.26e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 43.52 E-value: 6.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 62 PYSVTAQWGTNAAASSNVNPiPQASPMLANAPFGRPGTLAPPGLMTSPPAFPGSNPFSTTPRPGMSAGPA-QMNPGIHPH 140
Cdd:PHA03378 717 PAAATGRARPPAAAPGRARP-PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPApQQRPRGAPT 795
|
90 100
....*....|....*....|....
gi 334185482 141 MYPPYHSLPGTPQGMWLQPPSMGG 164
Cdd:PHA03378 796 PQPPPQAGPTSMQLMPRAAPGQQG 819
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
9-194 |
1.48e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 42.17 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 9 PPYTTAASSGQSIFVRPPPIA------PVLATTSNFSQSELKELHSMSIASTGFVSQSVPYSVTAQWGTNAAASSNVNPI 82
Cdd:PRK12323 401 APPAAPAAAPAAAAAARAVAAaparrsPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAP 480
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 83 PQASPMLANAPFGR--------PGTLAPPGLMTSPPAFPGSNPFSTtPRPGMSAGPAQMnpgihPHMYPPYHSLPGTPQG 154
Cdd:PRK12323 481 ARAAPAAAPAPADDdpppweelPPEFASPAPAQPDAAPAGWVAESI-PDPATADPDDAF-----ETLAPAPAAAPAPRAA 554
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 334185482 155 MWLQPPSMGGIPRAPFLSHPTTFPGSYP-----FPVRGISPNLPY 194
Cdd:PRK12323 555 AATEPVVAPRPPRASASGLPDMFDGDWPalaarLPVRGLAQQLAR 599
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
6-219 |
1.81e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.06 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 6 TTDPPYTTAASSGQSIFVRPPPIAPVLATTSNFSQSELKELHSMSIAStgfvsqsvPYSvTAQWGTNAAASSNVNPIPQA 85
Cdd:pfam03154 197 AGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPS--------PHP-PLQPMTQPPPPSQVSPQPLP 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 86 SPMLANapfgrPGTLAPPGLMTSPPAFP---GSNPFSTTPRPGMSAGPAQMNPGIHPHMYPPYHSLPGTPQGMWLQPPSM 162
Cdd:pfam03154 268 QPSLHG-----QMPPMPHSLQTGPSHMQhpvPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPRE 342
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185482 163 GGIPRAPFlshptTFPGSYPFPVRGISP-NLPYSGSHP---LGASPMGSVGNVHALPGRQP 219
Cdd:pfam03154 343 QPLPPAPL-----SMPHIKPPPTTPIPQlPNPQSHKHPphlSGPSPFQMNSNLPPPPALKP 398
|
|
| FF |
smart00441 |
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often ... |
692-747 |
4.23e-03 |
|
Contains two conserved F residues; A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.
Pssm-ID: 128718 [Multi-domain] Cd Length: 55 Bit Score: 36.01 E-value: 4.23e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 334185482 692 KEASSSYQALLVEKIRD-PEASWTESKPILERDPQKRASnpdLEPADKEKLFRDHVK 747
Cdd:smart00441 1 EEAKEAFKELLKEHEVItPDTTWSEARKKLKNDPRYKAL---LSESEREQLFEDHIE 54
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
3-231 |
4.94e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 40.69 E-value: 4.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 3 GENTTDPPYTTAASSGQSIfVRPPPIAPVLATTSNFSQSELKELHSMSIASTgfvSQSVPYSVTAQWGTNAAASSNVNPI 82
Cdd:PHA03247 2753 GPARPARPPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASLSESRESLPSPWD---PADPPAAVLAPAAALPPAASPAGPL 2828
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 83 P------QASPMLANAPFGRPGTL-------------APPGLMTSPPAFPGSNPFSTTPRPGMSAGP---AQMNPGIHPH 140
Cdd:PHA03247 2829 PpptsaqPTAPPPPPGPPPPSLPLggsvapggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTesfALPPDQPERP 2908
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 141 MYPPYHSLPgTPQGMWLQPPSMGGIPRAPFLSHPTTFPGSYPFPVRGISPNLPysgSHPLGASPMGSVGNVHAlpgRQPD 220
Cdd:PHA03247 2909 PQPQAPPPP-QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP---QPWLGALVPGRVAVPRF---RVPQ 2981
|
250
....*....|.
gi 334185482 221 ISPGRKTEELS 231
Cdd:PHA03247 2982 PAPSREAPASS 2992
|
|
| Gag_spuma |
pfam03276 |
Spumavirus gag protein; |
31-223 |
5.35e-03 |
|
Spumavirus gag protein;
Pssm-ID: 460872 [Multi-domain] Cd Length: 614 Bit Score: 40.50 E-value: 5.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 31 VLATTSNFSQSELKELHSMSIASTGfvSQSVPYSVTAQWGTNAAASSNVNPIPQASPMLANAPFGRPGTLAPPGLMTSPP 110
Cdd:pfam03276 166 QEAEALRIGLAEISPGAQGGIPPGA--SFSGLPSLPAIGGIHLPAIPGIHARAPPGNIARSLGDDIMPSLGDAGMPQPRF 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 111 AFPGSNPFSTTP--RPGMSAGPAQMNPGIHPHMYPPYHSLPGTPQgmWLQPPSMGGIPRAPFLSHPTTFPGSYPFPVRGI 188
Cdd:pfam03276 244 AFHPGNPFAEAEghPFAEAEGERPRDIPRAPRIDAPSAPAIPAIQ--PIAPPMIPPIGAPIPIPHGASIPGEHIRNPREE 321
|
170 180 190
....*....|....*....|....*....|....*
gi 334185482 189 SPNLPYSGSHPLGASPMgsvgnvhALPGRQPDISP 223
Cdd:pfam03276 322 PIRLGREAPAIDGRFAP-------AIDDLFCRIIN 349
|
|
| TYA |
pfam01021 |
Ty transposon capsid protein; Ty are yeast transposons. A 5.7kb transcript codes for p3 a ... |
65-179 |
8.62e-03 |
|
Ty transposon capsid protein; Ty are yeast transposons. A 5.7kb transcript codes for p3 a fusion protein of TYA and TYB. The TYA protein is analogous to the gag protein of retroviruses. TYA a is cleaved to form 46kd protein which can form mature virion like particles. This entry corresponds to the capsid protein from Ty1 and Ty2 transposons.
Pssm-ID: 425992 Cd Length: 384 Bit Score: 39.56 E-value: 8.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185482 65 VTAQWGTNAAASSNVNPIPQASPMLANAPFGRPGTLAPPGLMTSPPAFPGSNPFSTTPRPgMSAGPAQMNPgihphMYPP 144
Cdd:pfam01021 34 ANSQQTTTPGSSAVPENHHHASPQPASVPPPQNGPYSQQCMMTPNQANPSGWPFYGHPSM-MPYTPYQMSP-----MYFP 107
|
90 100 110
....*....|....*....|....*....|....*
gi 334185482 145 yhslPGtPQGMWLQPPSMGGIPrapfLSHPTTFPG 179
Cdd:pfam01021 108 ----PG-PQSQFPQYPSSVGTP----LSTPSPESG 133
|
|
| |
