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Conserved domains on  [gi|15230244|ref|NP_188525|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 130-463 3.94e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 3.94e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 130 LIGTIVRQDGHVYSLAAS--GDLLFTGSDSKNIRVW--------KDLKDHTGFkstsgLVKAIVITGDNRIFTGHQDGKI 199
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWdletgellRTLKGHTGP-----VRDVAASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 200 RVWRGSKRRTggysrigslptLKEFLTksvnpknyvevrrrknvlkirHYDAVSCLSLNEELGLLYSGSWDKTLKVWRLS 279
Cdd:cd00200  76 RLWDLETGEC-----------VRTLTG---------------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 280 DSKCLESIQAHDDAINTVA-AGFDDLLFTGSADGTLKVWkrelqgKGTKHFLVNVLMKQENAVTALAVNITAAVVYCGSS 358
Cdd:cd00200 124 TGKCLTTLRGHTDWVNSVAfSPDGTFVASSSQDGTIKLW------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 359 DGTVNFWEGQKyLSHGGTLRGHRLAVLCLAAA--GSLVLSGGADKNICVWRRNgdgSHSCLSVLMDHVGPVKCLtAVEDD 436
Cdd:cd00200 198 DGTIKLWDLST-GKCLGTLRGHENGVNSVAFSpdGYLLASGSEDGTIRVWDLR---TGECVQTLSGHTNSVTSL-AWSPD 272

                       330       340
                ....*....|....*....|....*..
gi 15230244 437 GEghrekgdqkwIVYSGSLDKSVKVWR 463
Cdd:cd00200 273 GK----------RLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 130-463 3.94e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 3.94e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 130 LIGTIVRQDGHVYSLAAS--GDLLFTGSDSKNIRVW--------KDLKDHTGFkstsgLVKAIVITGDNRIFTGHQDGKI 199
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWdletgellRTLKGHTGP-----VRDVAASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 200 RVWRGSKRRTggysrigslptLKEFLTksvnpknyvevrrrknvlkirHYDAVSCLSLNEELGLLYSGSWDKTLKVWRLS 279
Cdd:cd00200  76 RLWDLETGEC-----------VRTLTG---------------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 280 DSKCLESIQAHDDAINTVA-AGFDDLLFTGSADGTLKVWkrelqgKGTKHFLVNVLMKQENAVTALAVNITAAVVYCGSS 358
Cdd:cd00200 124 TGKCLTTLRGHTDWVNSVAfSPDGTFVASSSQDGTIKLW------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 359 DGTVNFWEGQKyLSHGGTLRGHRLAVLCLAAA--GSLVLSGGADKNICVWRRNgdgSHSCLSVLMDHVGPVKCLtAVEDD 436
Cdd:cd00200 198 DGTIKLWDLST-GKCLGTLRGHENGVNSVAFSpdGYLLASGSEDGTIRVWDLR---TGECVQTLSGHTNSVTSL-AWSPD 272

                       330       340
                ....*....|....*....|....*..
gi 15230244 437 GEghrekgdqkwIVYSGSLDKSVKVWR 463
Cdd:cd00200 273 GK----------RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
125-465 1.22e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 1.22e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 125 DTDNG-LIGTIVRQDGHVYSLAAS--GDLLFTGSDSKNIRVWkDLKD----HTgFKSTSGLVKAIVITGDNR-IFTGHQD 196
Cdd:COG2319 106 DLATGlLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLW-DLATgkllRT-LTGHSGAVTSVAFSPDGKlLASGSDD 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 197 GKIRVWRGSKRRTggysrigsLPTLKEfltksvnpknyvevrrrknvlkirHYDAVSCLSLNEELGLLYSGSWDKTLKVW 276
Cdd:COG2319 184 GTVRLWDLATGKL--------LRTLTG------------------------HTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 277 RLSDSKCLESIQAHDDAINTVAAGFDD-LLFTGSADGTLKVWKRElQGKgtkhfLVNVLMKQENAVTALAVNITAAVVYC 355
Cdd:COG2319 232 DLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDLA-TGE-----LLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 356 GSSDGTVNFWEgqkyLSHG---GTLRGHRLAVLCLA--AAGSLVLSGGADKNICVWRRNGDGshsCLSVLMDHVGPVKCL 430
Cdd:COG2319 306 GSDDGTVRLWD----LATGkllRTLTGHTGAVRSVAfsPDGKTLASGSDDGTVRLWDLATGE---LLRTLTGHTGAVTSV 378

                       330       340       350
                ....*....|....*....|....*....|....*
gi 15230244 431 tAVEDDGeghrekgdqKWIVySGSLDKSVKVWRVT 465
Cdd:COG2319 379 -AFSPDG---------RTLA-SGSADGTVRLWDLA 402
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 263-364 6.34e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.14  E-value: 6.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244   263 LLYSGSWDKTLKVWRLSDSKCLESIQAHDDAINTVAAGFD-DLLFTGSADGTLKVWK-----------RELQGKGTKHFL 330
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDgSILATGSYDTTVMVWEvlrgrssekrsRNTQTEFPRKDH 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 15230244   331 V------NVLMKQENAVTALAVNITAAVVYCGSSDGTVNF 364
Cdd:pfam20426 176 ViaetpfHILCGHDDIITCLYVSVELDIVISGSKDGTCIF 215
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 280-318 6.37e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 6.37e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15230244    280 DSKCLESIQAHDDAINTVA-AGFDDLLFTGSADGTLKVWK 318
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAfSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 130-463 3.94e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 3.94e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 130 LIGTIVRQDGHVYSLAAS--GDLLFTGSDSKNIRVW--------KDLKDHTGFkstsgLVKAIVITGDNRIFTGHQDGKI 199
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWdletgellRTLKGHTGP-----VRDVAASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 200 RVWRGSKRRTggysrigslptLKEFLTksvnpknyvevrrrknvlkirHYDAVSCLSLNEELGLLYSGSWDKTLKVWRLS 279
Cdd:cd00200  76 RLWDLETGEC-----------VRTLTG---------------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 280 DSKCLESIQAHDDAINTVA-AGFDDLLFTGSADGTLKVWkrelqgKGTKHFLVNVLMKQENAVTALAVNITAAVVYCGSS 358
Cdd:cd00200 124 TGKCLTTLRGHTDWVNSVAfSPDGTFVASSSQDGTIKLW------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 359 DGTVNFWEGQKyLSHGGTLRGHRLAVLCLAAA--GSLVLSGGADKNICVWRRNgdgSHSCLSVLMDHVGPVKCLtAVEDD 436
Cdd:cd00200 198 DGTIKLWDLST-GKCLGTLRGHENGVNSVAFSpdGYLLASGSEDGTIRVWDLR---TGECVQTLSGHTNSVTSL-AWSPD 272

                       330       340
                ....*....|....*....|....*..
gi 15230244 437 GEghrekgdqkwIVYSGSLDKSVKVWR 463
Cdd:cd00200 273 GK----------RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
125-465 1.22e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 1.22e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 125 DTDNG-LIGTIVRQDGHVYSLAAS--GDLLFTGSDSKNIRVWkDLKD----HTgFKSTSGLVKAIVITGDNR-IFTGHQD 196
Cdd:COG2319 106 DLATGlLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLW-DLATgkllRT-LTGHSGAVTSVAFSPDGKlLASGSDD 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 197 GKIRVWRGSKRRTggysrigsLPTLKEfltksvnpknyvevrrrknvlkirHYDAVSCLSLNEELGLLYSGSWDKTLKVW 276
Cdd:COG2319 184 GTVRLWDLATGKL--------LRTLTG------------------------HTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 277 RLSDSKCLESIQAHDDAINTVAAGFDD-LLFTGSADGTLKVWKRElQGKgtkhfLVNVLMKQENAVTALAVNITAAVVYC 355
Cdd:COG2319 232 DLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDLA-TGE-----LLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 356 GSSDGTVNFWEgqkyLSHG---GTLRGHRLAVLCLA--AAGSLVLSGGADKNICVWRRNGDGshsCLSVLMDHVGPVKCL 430
Cdd:COG2319 306 GSDDGTVRLWD----LATGkllRTLTGHTGAVRSVAfsPDGKTLASGSDDGTVRLWDLATGE---LLRTLTGHTGAVTSV 378

                       330       340       350
                ....*....|....*....|....*....|....*
gi 15230244 431 tAVEDDGeghrekgdqKWIVySGSLDKSVKVWRVT 465
Cdd:COG2319 379 -AFSPDG---------RTLA-SGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
125-410 3.81e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 3.81e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 125 DTDNG-LIGTIVRQDGHVYSLAAS--GDLLFTGSDSKNIRVWkDLKD----HTgFKSTSGLVKAIVITGD-NRIFTGHQD 196
Cdd:COG2319 148 DLATGkLLRTLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLW-DLATgkllRT-LTGHTGAVRSVAFSPDgKLLASGSAD 225

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 197 GKIRVWrgskrrtggysrigslptlkefltksvnpknyvEVRRRKNVLKIR-HYDAVSCLSLNEELGLLYSGSWDKTLKV 275
Cdd:COG2319 226 GTVRLW---------------------------------DLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRL 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 276 WRLSDSKCLESIQAHDDAINTVAAGFD-DLLFTGSADGTLKVWKRElQGKgtkhfLVNVLMKQENAVTALAVNITAAVVY 354
Cdd:COG2319 273 WDLATGELLRTLTGHSGGVNSVAFSPDgKLLASGSDDGTVRLWDLA-TGK-----LLRTLTGHTGAVRSVAFSPDGKTLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15230244 355 CGSSDGTVNFWEGQKyLSHGGTLRGHRLAVLCLAAA--GSLVLSGGADKNICVWRRNG 410
Cdd:COG2319 347 SGSDDGTVRLWDLAT-GELLRTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 248-464 4.84e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.04  E-value: 4.84e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 248 HYDAVSCLSLNEELGLLYSGSWDKTLKVWRLSDSKCLESIQAHDDAINTVAA-GFDDLLFTGSADGTLKVWKRELQGkgt 326
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsADGTYLASGSSDKTIRLWDLETGE--- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 327 khfLVNVLMKQENAVTALAVNITAAVVYCGSSDGTVNFWEGQKYlSHGGTLRGHRLAVLCLAAAGS--LVLSGGADKNIC 404
Cdd:cd00200  85 ---CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTDWVNSVAFSPDgtFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 405 VWRrngDGSHSCLSVLMDHVGPVKCLTAVED---------DG----------------EGHREK-------GDQKWIVyS 452
Cdd:cd00200 161 LWD---LRTGKCVATLTGHTGEVNSVAFSPDgekllssssDGtiklwdlstgkclgtlRGHENGvnsvafsPDGYLLA-S 236

                       250
                ....*....|..
gi 15230244 453 GSLDKSVKVWRV 464
Cdd:cd00200 237 GSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 124-366 4.42e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.34  E-value: 4.42e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 124 DDTDNGLIGTIVRQDGHVYSLA--ASGDLLFTGSDSKNIRVW--------KDLKDHTGFkstsglVKAIVITGDNR-IFT 192
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSVAfsPDGRILSSSSRDKTIKVWdvetgkclTTLRGHTDW------VNSVAFSPDGTfVAS 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 193 GHQDGKIRVWRgskrrtggysrIGSLPTLKEFLTksvnpknyvevrrrknvlkirHYDAVSCLSLNEELGLLYSGSWDKT 272
Cdd:cd00200 153 SSQDGTIKLWD-----------LRTGKCVATLTG---------------------HTGEVNSVAFSPDGEKLLSSSSDGT 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 273 LKVWRLSDSKCLESIQAHDDAINTVAAGFDDLLFT-GSADGTLKVW---KRELQGKGTKHflvnvlmkqENAVTALAVNI 348
Cdd:cd00200 201 IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAsGSEDGTIRVWdlrTGECVQTLSGH---------TNSVTSLAWSP 271

                       250
                ....*....|....*...
gi 15230244 349 TAAVVYCGSSDGTVNFWE 366
Cdd:cd00200 272 DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
248-465 1.11e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 1.11e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 248 HYDAVSCLSLNEELGLLYSGSWDKTLKVWRLSDSKCLESIQAHDDAINTVAAGFD-DLLFTGSADGTLKVWKRElQGKgt 326
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDgKTLASGSADGTVRLWDLA-TGK-- 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 327 khfLVNVLMKQENAVTALAVNITAAVVYCGSSDGTVNFWEGQKyLSHGGTLRGHRLAVLCLA--AAGSLVLSGGADKNIC 404
Cdd:COG2319 154 ---LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAfsPDGKLLASGSADGTVR 229

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15230244 405 VWRRNGDgshSCLSVLMDHVGPVKCLtAVEDDGeghrekgdqKWIVySGSLDKSVKVWRVT 465
Cdd:COG2319 230 LWDLATG---KLLRTLTGHSGSVRSV-AFSPDG---------RLLA-SGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
124-365 1.86e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 1.86e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 124 DDTDNGLIGTIVRQDGHVYSLAAS--GDLLFTGSDSKNIRVWkDLKdhTG-----FKSTSGLVKAIVITGDNR-IFTGHQ 195
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLW-DLA--TGkllrtLTGHSGSVRSVAFSPDGRlLASGSA 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 196 DGKIRVWRgskrrTGGYSRIGSLPTlkefltksvnpknyvevrrrknvlkirHYDAVSCLSLNEELGLLYSGSWDKTLKV 275
Cdd:COG2319 267 DGTVRLWD-----LATGELLRTLTG---------------------------HSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 276 WRLSDSKCLESIQAHDDAINTVAAGFDD-LLFTGSADGTLKVWkrELQGKGtkhfLVNVLMKQENAVTALAVNITAAVVY 354
Cdd:COG2319 315 WDLATGKLLRTLTGHTGAVRSVAFSPDGkTLASGSDDGTVRLW--DLATGE----LLRTLTGHTGAVTSVAFSPDGRTLA 388

                       250
                ....*....|.
gi 15230244 355 CGSSDGTVNFW 365
Cdd:COG2319 389 SGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
247-465 2.47e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 2.47e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 247 RHYDAVSCLSLNEELGLLYSGSWDKTLKVWRLSDSKCLESIQAHDDAINTVAAGFDD-LLFTGSADGTLKVWkrELQGKG 325
Cdd:COG2319  34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGrLLASASADGTVRLW--DLATGL 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 326 TKHFLVnvlmKQENAVTALAVNITAAVVYCGSSDGTVNFWEgqkyLSHG---GTLRGHRLAVLCLA--AAGSLVLSGGAD 400
Cdd:COG2319 112 LLRTLT----GHTGAVRSVAFSPDGKTLASGSADGTVRLWD----LATGkllRTLTGHSGAVTSVAfsPDGKLLASGSDD 183

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15230244 401 KNICVWRRNgdgSHSCLSVLMDHVGPVKCLtAVEDDGeghrekgdqKWIVySGSLDKSVKVWRVT 465
Cdd:COG2319 184 GTVRLWDLA---TGKLLRTLTGHTGAVRSV-AFSPDG---------KLLA-SGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 330-465 6.73e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 6.73e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 330 LVNVLMKQENAVTALAVNITAAVVYCGSSDGTVNFW--EGQKYLShggTLRGHRLAVLCLA--AAGSLVLSGGADKNICV 405
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWdlETGELLR---TLKGHTGPVRDVAasADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244 406 WRRNGDgshSCLSVLMDHVGPVKCLTAVEDDGeghrekgdqkwIVYSGSLDKSVKVWRVT 465
Cdd:cd00200  78 WDLETG---ECVRTLTGHTSYVSSVAFSPDGR-----------ILSSSSRDKTIKVWDVE 123
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 263-364 6.34e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.14  E-value: 6.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230244   263 LLYSGSWDKTLKVWRLSDSKCLESIQAHDDAINTVAAGFD-DLLFTGSADGTLKVWK-----------RELQGKGTKHFL 330
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDgSILATGSYDTTVMVWEvlrgrssekrsRNTQTEFPRKDH 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 15230244   331 V------NVLMKQENAVTALAVNITAAVVYCGSSDGTVNF 364
Cdd:pfam20426 176 ViaetpfHILCGHDDIITCLYVSVELDIVISGSKDGTCIF 215
WD40 pfam00400
WD domain, G-beta repeat;
281-317 3.18e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 15230244   281 SKCLESIQAHDDAINTVAAGFD-DLLFTGSADGTLKVW 317
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 280-318 6.37e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 6.37e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15230244    280 DSKCLESIQAHDDAINTVA-AGFDDLLFTGSADGTLKVWK 318
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAfSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 248-276 2.27e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.27e-03
                           10        20
                   ....*....|....*....|....*....
gi 15230244    248 HYDAVSCLSLNEELGLLYSGSWDKTLKVW 276
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
248-276 3.19e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.19e-03
                          10        20
                  ....*....|....*....|....*....
gi 15230244   248 HYDAVSCLSLNEELGLLYSGSWDKTLKVW 276
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 376-406 9.66e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 9.66e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15230244    376 TLRGHRLAVLCLA--AAGSLVLSGGADKNICVW 406
Cdd:smart00320   7 TLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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