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Conserved domains on  [gi|15229588|ref|NP_188440|]
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F-box associated ubiquitination effector family protein [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 10543963)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 21-150 1.07e-60

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


:

Pssm-ID: 254394  Cd Length: 159  Bit Score: 184.73  E-value: 1.07e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229588    21 GVSLKGNT------QQKHLPEFLLCYDFTREIFGPPLSLPFHSFNEDTVTLSSVRDEQLTVLFERDDTLQMEIWITTKIE 94
Cdd:pfam07734   1 GVSLKGNTywlareKETNEEDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15229588    95 PETASWSKlFLAVGMEPLTGLQFQVAAGNFFVDEEKKVVVFLDKDTEtRERYIAFI 150
Cdd:pfam07734  81 PNAVSWSK-FLTVDMPPLPGLFFHFFAGSFFIDEEKKVAVVCDKDKE-KKTNTIYI 134
 
Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 21-150 1.07e-60

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 184.73  E-value: 1.07e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229588    21 GVSLKGNT------QQKHLPEFLLCYDFTREIFGPPLSLPFHSFNEDTVTLSSVRDEQLTVLFERDDTLQMEIWITTKIE 94
Cdd:pfam07734   1 GVSLKGNTywlareKETNEEDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15229588    95 PETASWSKlFLAVGMEPLTGLQFQVAAGNFFVDEEKKVVVFLDKDTEtRERYIAFI 150
Cdd:pfam07734  81 PNAVSWSK-FLTVDMPPLPGLFFHFFAGSFFIDEEKKVAVVCDKDKE-KKTNTIYI 134
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 20-135 2.63e-14

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 67.38  E-value: 2.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229588    20 RGVSLKGNT----QQKHLPE--FLLCYDFTREIFGPPLSLPFH-SFNEDTVTLSSVRDeQLTVLFERDDTLQMEIWITT- 91
Cdd:TIGR01640  97 RGVCINGVLyylaYTLKTNPdyFIVSFDVSSERFKEFIPLPCGnSDSVDYLSLINYKG-KLAVLKQKKDTNNFDLWVLNd 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15229588    92 KIEPEtasWSKLFlAVGMEPLTGLqFQVAAGNFFVDEEKKVVVF 135
Cdd:TIGR01640 176 AGKQE---WSKLF-TVPIPPLPDL-VDDNFLSGFTDKGEIVLCC 214
 
Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 21-150 1.07e-60

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 184.73  E-value: 1.07e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229588    21 GVSLKGNT------QQKHLPEFLLCYDFTREIFGPPLSLPFHSFNEDTVTLSSVRDEQLTVLFERDDTLQMEIWITTKIE 94
Cdd:pfam07734   1 GVSLKGNTywlareKETNEEDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15229588    95 PETASWSKlFLAVGMEPLTGLQFQVAAGNFFVDEEKKVVVFLDKDTEtRERYIAFI 150
Cdd:pfam07734  81 PNAVSWSK-FLTVDMPPLPGLFFHFFAGSFFIDEEKKVAVVCDKDKE-KKTNTIYI 134
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 20-135 2.63e-14

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 67.38  E-value: 2.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229588    20 RGVSLKGNT----QQKHLPE--FLLCYDFTREIFGPPLSLPFH-SFNEDTVTLSSVRDeQLTVLFERDDTLQMEIWITT- 91
Cdd:TIGR01640  97 RGVCINGVLyylaYTLKTNPdyFIVSFDVSSERFKEFIPLPCGnSDSVDYLSLINYKG-KLAVLKQKKDTNNFDLWVLNd 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15229588    92 KIEPEtasWSKLFlAVGMEPLTGLqFQVAAGNFFVDEEKKVVVF 135
Cdd:TIGR01640 176 AGKQE---WSKLF-TVPIPPLPDL-VDDNFLSGFTDKGEIVLCC 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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