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Conserved domains on  [gi|15228429|ref|NP_187714|]
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TRICHOME BIREFRINGENCE-LIKE 32 [Arabidopsis thaliana]

Protein Classification

trichome birefringence-like family protein( domain architecture ID 10627628)

trichome birefringence-like (TBL) family protein belongs to the SGNH/GDSL hydrolase superfamily of hydrolytic enzymes

CATH:  3.40.50.1110
SCOP:  3001315

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PC-Esterase pfam13839
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is ...
159-446 3.60e-115

GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1, animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain.


:

Pssm-ID: 463996  Cd Length: 281  Bit Score: 339.17  E-value: 3.60e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429   159 LPSFNATVMLESLRGKKMMFVGDSLNRGMYVSLICLLHSQIPENSK--SMDTFGSLTVFSLKDYNATIEFYWAPFLLESN 236
Cdd:pfam13839   1 LPRFDAAEFLERLRGKRIAFVGDSLARNQWESLLCLLSSAVEDPKSvyKITKDRGFRRFRFPDYNFTVEFYWSPFLVDSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429   237 SDNaTVHRVSDRIVRKGSINKH-GRHWRGADIVVFNTYLWWRTGFKMKILEGSFKDEKKRIVEMESEDAYRMALKTMVKW 315
Cdd:pfam13839  81 EDP-NGPGKGKRVLHLDSIDERwASQWKGADVLVFNTGHWWLRPKIYYEGGDYFGCGGKNYTDMDRLDAYRKALRTWARW 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429   316 VKKNMDPLKTRVFFATMSPTHYKGEDWGgeQGKNCyNQTTPIQDMNHWPSDCSKTLMKVIGEELDQRAEFPVTVLNITQL 395
Cdd:pfam13839 160 VDSNLDPSKTRVFFRTFSPSHFEGGEWN--TGGSC-NRTRPLSEGEYPLGGLDPEMRRIQEEVLRSKMGTPVRLLDITKL 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15228429   396 SGYRKDAHTSIYKKQWSPLtkeqlanPASYSDCIHWCLPGLQDTWNELFFA 446
Cdd:pfam13839 237 SELRKDGHPSVYGGKKPFA-------PKGYNDCSHWCLPGVPDTWNELLYA 280
PMR5N pfam14416
PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich ...
105-158 1.95e-27

PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain.


:

Pssm-ID: 464168 [Multi-domain]  Cd Length: 54  Bit Score: 103.72  E-value: 1.95e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15228429   105 GCDVFKGNWVKDWSTRPLYRESECPYIQPQLTCRTHGRPDSDYQSWRWRPDSCS 158
Cdd:pfam14416   1 ECDLFDGRWVYDEDSYPLYTNSSCPFIDDQFNCQKNGRPDSDYLKWRWQPDGCD 54
 
Name Accession Description Interval E-value
PC-Esterase pfam13839
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is ...
159-446 3.60e-115

GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1, animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain.


Pssm-ID: 463996  Cd Length: 281  Bit Score: 339.17  E-value: 3.60e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429   159 LPSFNATVMLESLRGKKMMFVGDSLNRGMYVSLICLLHSQIPENSK--SMDTFGSLTVFSLKDYNATIEFYWAPFLLESN 236
Cdd:pfam13839   1 LPRFDAAEFLERLRGKRIAFVGDSLARNQWESLLCLLSSAVEDPKSvyKITKDRGFRRFRFPDYNFTVEFYWSPFLVDSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429   237 SDNaTVHRVSDRIVRKGSINKH-GRHWRGADIVVFNTYLWWRTGFKMKILEGSFKDEKKRIVEMESEDAYRMALKTMVKW 315
Cdd:pfam13839  81 EDP-NGPGKGKRVLHLDSIDERwASQWKGADVLVFNTGHWWLRPKIYYEGGDYFGCGGKNYTDMDRLDAYRKALRTWARW 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429   316 VKKNMDPLKTRVFFATMSPTHYKGEDWGgeQGKNCyNQTTPIQDMNHWPSDCSKTLMKVIGEELDQRAEFPVTVLNITQL 395
Cdd:pfam13839 160 VDSNLDPSKTRVFFRTFSPSHFEGGEWN--TGGSC-NRTRPLSEGEYPLGGLDPEMRRIQEEVLRSKMGTPVRLLDITKL 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15228429   396 SGYRKDAHTSIYKKQWSPLtkeqlanPASYSDCIHWCLPGLQDTWNELFFA 446
Cdd:pfam13839 237 SELRKDGHPSVYGGKKPFA-------PKGYNDCSHWCLPGVPDTWNELLYA 280
PLN02629 PLN02629
powdery mildew resistance 5
106-450 1.51e-94

powdery mildew resistance 5


Pssm-ID: 215338 [Multi-domain]  Cd Length: 387  Bit Score: 290.27  E-value: 1.51e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429  106 CDVFKGNWVKDwSTRPLYRESECP-YIQPQLTCRTHGRPDSDYQSWRWRPDSCSLPSFNATVMLESLRGKKMMFVGDSLN 184
Cdd:PLN02629  53 CALFVGTWVRD-DSYPLYQSSDCPgVIDPEFNCQMYGRPDSDYLKYRWQPLNCELPRFNGLEFLLKMKGKTVMFVGDSLG 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429  185 RGMYVSLICLLHSQIPENSKSMDTFGSLTVFSLKDYNATIEFYWAPFLLESNSDNATvhrvsdRIVRKGSINKHGRHWRG 264
Cdd:PLN02629 132 RNQWESLICLISSSVPSTRTQMSRGDPLSTFKFLDYGVSISFYKAPYLVDIDAVQGK------RVLKLEEISGNANAWRD 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429  265 ADIVVFNTYLWWR-----TGFKMKILEGSFKDEKKRIVEMESedayrmALKTMVKWVKKNMDPLKTRVFFATMSPTHYKG 339
Cdd:PLN02629 206 ADVLIFNTGHWWShqgslQGWDYIESGGTYYQDMDRLVALEK------ALRTWAYWVDTNVDRSRTRVFFQSISPTHYNP 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429  340 EDWGG---EQGKNCYNQTTPIQDMNhWPSDCSKTlMKVIGEELDQRAEfPVTVLNITQLSGYRKDAHTSIYKKQWSPltk 416
Cdd:PLN02629 280 SEWSAgasTTTKNCYGETTPMSGMT-YPGAYPDQ-MRVVDEVIRGMHN-PAYLLDITLLSELRKDGHPSIYSGDLSP--- 353
                        330       340       350
                 ....*....|....*....|....*....|....
gi 15228429  417 EQLANPASYSDCIHWCLPGLQDTWNELFFAKLFY 450
Cdd:PLN02629 354 SQRANPDRSADCSHWCLPGLPDTWNQLFYTALFF 387
PMR5N pfam14416
PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich ...
105-158 1.95e-27

PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain.


Pssm-ID: 464168 [Multi-domain]  Cd Length: 54  Bit Score: 103.72  E-value: 1.95e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15228429   105 GCDVFKGNWVKDWSTRPLYRESECPYIQPQLTCRTHGRPDSDYQSWRWRPDSCS 158
Cdd:pfam14416   1 ECDLFDGRWVYDEDSYPLYTNSSCPFIDDQFNCQKNGRPDSDYLKWRWQPDGCD 54
 
Name Accession Description Interval E-value
PC-Esterase pfam13839
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is ...
159-446 3.60e-115

GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1, animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain.


Pssm-ID: 463996  Cd Length: 281  Bit Score: 339.17  E-value: 3.60e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429   159 LPSFNATVMLESLRGKKMMFVGDSLNRGMYVSLICLLHSQIPENSK--SMDTFGSLTVFSLKDYNATIEFYWAPFLLESN 236
Cdd:pfam13839   1 LPRFDAAEFLERLRGKRIAFVGDSLARNQWESLLCLLSSAVEDPKSvyKITKDRGFRRFRFPDYNFTVEFYWSPFLVDSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429   237 SDNaTVHRVSDRIVRKGSINKH-GRHWRGADIVVFNTYLWWRTGFKMKILEGSFKDEKKRIVEMESEDAYRMALKTMVKW 315
Cdd:pfam13839  81 EDP-NGPGKGKRVLHLDSIDERwASQWKGADVLVFNTGHWWLRPKIYYEGGDYFGCGGKNYTDMDRLDAYRKALRTWARW 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429   316 VKKNMDPLKTRVFFATMSPTHYKGEDWGgeQGKNCyNQTTPIQDMNHWPSDCSKTLMKVIGEELDQRAEFPVTVLNITQL 395
Cdd:pfam13839 160 VDSNLDPSKTRVFFRTFSPSHFEGGEWN--TGGSC-NRTRPLSEGEYPLGGLDPEMRRIQEEVLRSKMGTPVRLLDITKL 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15228429   396 SGYRKDAHTSIYKKQWSPLtkeqlanPASYSDCIHWCLPGLQDTWNELFFA 446
Cdd:pfam13839 237 SELRKDGHPSVYGGKKPFA-------PKGYNDCSHWCLPGVPDTWNELLYA 280
PLN02629 PLN02629
powdery mildew resistance 5
106-450 1.51e-94

powdery mildew resistance 5


Pssm-ID: 215338 [Multi-domain]  Cd Length: 387  Bit Score: 290.27  E-value: 1.51e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429  106 CDVFKGNWVKDwSTRPLYRESECP-YIQPQLTCRTHGRPDSDYQSWRWRPDSCSLPSFNATVMLESLRGKKMMFVGDSLN 184
Cdd:PLN02629  53 CALFVGTWVRD-DSYPLYQSSDCPgVIDPEFNCQMYGRPDSDYLKYRWQPLNCELPRFNGLEFLLKMKGKTVMFVGDSLG 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429  185 RGMYVSLICLLHSQIPENSKSMDTFGSLTVFSLKDYNATIEFYWAPFLLESNSDNATvhrvsdRIVRKGSINKHGRHWRG 264
Cdd:PLN02629 132 RNQWESLICLISSSVPSTRTQMSRGDPLSTFKFLDYGVSISFYKAPYLVDIDAVQGK------RVLKLEEISGNANAWRD 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429  265 ADIVVFNTYLWWR-----TGFKMKILEGSFKDEKKRIVEMESedayrmALKTMVKWVKKNMDPLKTRVFFATMSPTHYKG 339
Cdd:PLN02629 206 ADVLIFNTGHWWShqgslQGWDYIESGGTYYQDMDRLVALEK------ALRTWAYWVDTNVDRSRTRVFFQSISPTHYNP 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228429  340 EDWGG---EQGKNCYNQTTPIQDMNhWPSDCSKTlMKVIGEELDQRAEfPVTVLNITQLSGYRKDAHTSIYKKQWSPltk 416
Cdd:PLN02629 280 SEWSAgasTTTKNCYGETTPMSGMT-YPGAYPDQ-MRVVDEVIRGMHN-PAYLLDITLLSELRKDGHPSIYSGDLSP--- 353
                        330       340       350
                 ....*....|....*....|....*....|....
gi 15228429  417 EQLANPASYSDCIHWCLPGLQDTWNELFFAKLFY 450
Cdd:PLN02629 354 SQRANPDRSADCSHWCLPGLPDTWNQLFYTALFF 387
PMR5N pfam14416
PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich ...
105-158 1.95e-27

PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain.


Pssm-ID: 464168 [Multi-domain]  Cd Length: 54  Bit Score: 103.72  E-value: 1.95e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15228429   105 GCDVFKGNWVKDWSTRPLYRESECPYIQPQLTCRTHGRPDSDYQSWRWRPDSCS 158
Cdd:pfam14416   1 ECDLFDGRWVYDEDSYPLYTNSSCPFIDDQFNCQKNGRPDSDYLKWRWQPDGCD 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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