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Conserved domains on  [gi|15232603|ref|NP_187531|]
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Ribosomal protein L10 family protein [Arabidopsis thaliana]

Protein Classification

uL10 family ribosomal protein( domain architecture ID 11488073)

uL10 family ribosomal protein is an essential element of the ribosomal GTPase-associated center responsible for the interplay with translational factors during various stages of protein synthesis

Gene Ontology:  GO:0003735|GO:0000027
PubMed:  24524803

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 1-277 2.38e-131

60S acidic ribosomal protein P0; Provisional


:

Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 376.28  E-value: 2.38e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603    1 MVKATKAEKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVRIHSENTGNtaILNL 80
Cdd:PTZ00135   1 MAKPEKKAKKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALKQRLEELPE--LEKL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   81 LPLLQGNVGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPV 160
Cdd:PTZ00135  79 LPHVKGNVGFVFTKDDLFEVKPVILENKVPAPARAGVIAPIDVVIPAGPTGMDPSQTSFFQALGIATKIVKGQIEITNEV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603  161 ELIKQGDKVGSSEAALLAKLGIRPFSYGLVVQSVYDNGSVFSPEVLDLTEDQLVEKFASGISMVTSLALAVSYPTLAAAP 240
Cdd:PTZ00135 159 HLIKEGQKVGASQAVLLQKLNIKPFSYGLEVLSIYDNGSIYDAKVLDITDEDIVAKFQEGVQNVAAISLAAGYPTEASAP 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 15232603  241 HMFINAYKNALAIAVATEYTFPQAEKVKEYLKDPSKF 277
Cdd:PTZ00135 239 HSILNAFKNLAAIGLESGFTFPLAEKIKEALANPSAA 275
 
Name Accession Description Interval E-value
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 1-277 2.38e-131

60S acidic ribosomal protein P0; Provisional


Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 376.28  E-value: 2.38e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603    1 MVKATKAEKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVRIHSENTGNtaILNL 80
Cdd:PTZ00135   1 MAKPEKKAKKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALKQRLEELPE--LEKL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   81 LPLLQGNVGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPV 160
Cdd:PTZ00135  79 LPHVKGNVGFVFTKDDLFEVKPVILENKVPAPARAGVIAPIDVVIPAGPTGMDPSQTSFFQALGIATKIVKGQIEITNEV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603  161 ELIKQGDKVGSSEAALLAKLGIRPFSYGLVVQSVYDNGSVFSPEVLDLTEDQLVEKFASGISMVTSLALAVSYPTLAAAP 240
Cdd:PTZ00135 159 HLIKEGQKVGASQAVLLQKLNIKPFSYGLEVLSIYDNGSIYDAKVLDITDEDIVAKFQEGVQNVAAISLAAGYPTEASAP 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 15232603  241 HMFINAYKNALAIAVATEYTFPQAEKVKEYLKDPSKF 277
Cdd:PTZ00135 239 HSILNAFKNLAAIGLESGFTFPLAEKIKEALANPSAA 275
Ribosomal_P0_L10e cd05795
Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal ...
 8-184 6.42e-84

Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These eukaryotic and archaeal P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240221 [Multi-domain]  Cd Length: 175  Bit Score: 250.57  E-value: 6.42e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   8 EKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVRIHSENtgNTAILNLLPLLQGN 87
Cdd:cd05795   1 EWKKEYVEKLTELLKSYPKVLIVDADNVGSKQLQKIRRSLRGKAEILMGKNTLIRRALRNLGDE--NPELEKLLPYLKGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603  88 VGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPVELIKQGD 167
Cdd:cd05795  79 VGFIFTNGDPFEIRKILEENKVPAPAKPGAIAPCDVVVPAGPTGMPPGPTSFFQALGIPTKIEKGKIEIISDVVVVKKGE 158

                       170
                ....*....|....*..
gi 15232603 168 KVGSSEAALLAKLGIRP 184
Cdd:cd05795 159 KVGASEATLLNKLNIKP 175
RL10P_insert pfam17777
Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and ...
 113-182 1.11e-21

Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and archaeal ribosomal L10 protein.


Pssm-ID: 465500 [Multi-domain]  Cd Length: 71  Bit Score: 86.88  E-value: 1.11e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15232603   113 ARVGLVAPIDVVVQPGNTGLDPSQT-SFFQVLNIPTKINKGTVEIITPVELIKQGDKVGSSEAALLAKLGI 182
Cdd:pfam17777   1 ARAGAIATEDVVLPAGPTGLAPGPIePQLRALGIPTKIKKGKIEITKDYTVCKEGEKLTPEQANLLKLLGI 71
 
Name Accession Description Interval E-value
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 1-277 2.38e-131

60S acidic ribosomal protein P0; Provisional


Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 376.28  E-value: 2.38e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603    1 MVKATKAEKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVRIHSENTGNtaILNL 80
Cdd:PTZ00135   1 MAKPEKKAKKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALKQRLEELPE--LEKL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   81 LPLLQGNVGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPV 160
Cdd:PTZ00135  79 LPHVKGNVGFVFTKDDLFEVKPVILENKVPAPARAGVIAPIDVVIPAGPTGMDPSQTSFFQALGIATKIVKGQIEITNEV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603  161 ELIKQGDKVGSSEAALLAKLGIRPFSYGLVVQSVYDNGSVFSPEVLDLTEDQLVEKFASGISMVTSLALAVSYPTLAAAP 240
Cdd:PTZ00135 159 HLIKEGQKVGASQAVLLQKLNIKPFSYGLEVLSIYDNGSIYDAKVLDITDEDIVAKFQEGVQNVAAISLAAGYPTEASAP 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 15232603  241 HMFINAYKNALAIAVATEYTFPQAEKVKEYLKDPSKF 277
Cdd:PTZ00135 239 HSILNAFKNLAAIGLESGFTFPLAEKIKEALANPSAA 275
Ribosomal_P0_L10e cd05795
Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal ...
 8-184 6.42e-84

Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These eukaryotic and archaeal P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240221 [Multi-domain]  Cd Length: 175  Bit Score: 250.57  E-value: 6.42e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   8 EKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVRIHSENtgNTAILNLLPLLQGN 87
Cdd:cd05795   1 EWKKEYVEKLTELLKSYPKVLIVDADNVGSKQLQKIRRSLRGKAEILMGKNTLIRRALRNLGDE--NPELEKLLPYLKGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603  88 VGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPVELIKQGD 167
Cdd:cd05795  79 VGFIFTNGDPFEIRKILEENKVPAPAKPGAIAPCDVVVPAGPTGMPPGPTSFFQALGIPTKIEKGKIEIISDVVVVKKGE 158

                       170
                ....*....|....*..
gi 15232603 168 KVGSSEAALLAKLGIRP 184
Cdd:cd05795 159 KVGASEATLLNKLNIKP 175
PTZ00240 PTZ00240
60S ribosomal protein P0; Provisional
 7-263 1.08e-74

60S ribosomal protein P0; Provisional


Pssm-ID: 140267 [Multi-domain]  Cd Length: 323  Bit Score: 232.55  E-value: 1.08e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603    7 AEKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVRIHSENTGNTAILNLL----- 81
Cdd:PTZ00240   5 TTAKREYEERLVDCLTKYSCVLFVGMDNVRSQQVHDVRRALRGKAEFVMGKKTLQAKIVEKRAQAKKASAEAKLFndqce 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   82 --PLLQGNVGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITP 159
Cdd:PTZ00240  85 ekNLLSGNTGLIFTNNEVQEITSVLDSHRVKAPARVGAIAPCDVIVPAGSTGMEPTQTSFFQALNIATKIAKGMVEIVTE 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603  160 VELIKQGDKVGSSEAALLAKLGIRPFSYGLVVQSVYDNGSVFSPEVLDLTEDqLVEKF-ASGISMVTSLALAVSYPTLAA 238
Cdd:PTZ00240 165 KKVLSVGDKVDNSTATLLQKLNISPFYYQVEVLSVWDRGVLFTREDLSMTED-VVEKMlMEGLSNVAAMSLGAGIPTAAT 243

                        250       260
                 ....*....|....*....|....*
gi 15232603  239 APHMFINAYKNALAIAVATEYTFPQ 263
Cdd:PTZ00240 244 IGPMLVDAFKNLLAVSVATSYEFEE 268
rplP0 PRK04019
acidic ribosomal protein P0; Validated
 16-259 1.03e-49

acidic ribosomal protein P0; Validated


Pssm-ID: 179712 [Multi-domain]  Cd Length: 330  Bit Score: 168.12  E-value: 1.03e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   16 KLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVrihsENTGNTAILNLLPLLQGNVGLIFTKG 95
Cdd:PRK04019  14 ELKELIKSYPVVGIVDLEGIPARQLQEIRRKLRGKAELKVSKNTLIKRAL----EEAGEEDLEKLEDYLEGQVALIFTNM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   96 DLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQ-TSFFQVLNIPTKINKGTVEIITPVELIKQGDKVGSSEA 174
Cdd:PRK04019  90 NPFKLYKLLEKSKTPAPAKPGDIAPEDIVVPAGPTGFPPGPiLSELQKLGIPARIQKGKIVIKKDTVVAKAGEVISPELA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603  175 ALLAKLGIRPFSYGLVVQSVYDNGSVFSPEVLDLTEDQLVEKFASGISMVTSLALAVSYPTLAAAPHMFINAYKNALAIA 254
Cdd:PRK04019 170 NVLQKLGIKPIEVGLDLKAAYEDGVIYTPEVLAIDEEKYRSDIQEAAQNAFNLAVNAAYPTPETLETLIQKAFREAKALA 249


                 ....*
gi 15232603  255 VATEY 259
Cdd:PRK04019 250 VEAGI 254
Ribosomal_L10_P0 cd00379
Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in ...
 8-164 9.87e-24

Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). Some eukaryotic P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 238222 [Multi-domain]  Cd Length: 155  Bit Score: 94.94  E-value: 9.87e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   8 EKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVL-MGKNTMMKRSVrihsentGNTAILNLLPLLQG 86
Cdd:cd00379   1 EKKEELVEELKELLKKYKSVVVVDYRGLTVAQLTELRKELRESGAKLkVGKNTLMRRAL-------KGTGFEELKPLLKG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603  87 NVGLIFTKGDLKEVSEEVAKYKVG---APARVGLVApIDVVVQPGNTGLDPSQTsffQVLNIPTKINKGTVEIITPVELI 163
Cdd:cd00379  74 PTALAFTNEDPVEVAKVLKDFAKEnkkLFAKGGVVA-GKVLDPAGVTALAKLPS---REELLAMLIGLLKAPIAKLARLL 149


                .
gi 15232603 164 K 164
Cdd:cd00379 150 N 150
RL10P_insert pfam17777
Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and ...
 113-182 1.11e-21

Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and archaeal ribosomal L10 protein.


Pssm-ID: 465500 [Multi-domain]  Cd Length: 71  Bit Score: 86.88  E-value: 1.11e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15232603   113 ARVGLVAPIDVVVQPGNTGLDPSQT-SFFQVLNIPTKINKGTVEIITPVELIKQGDKVGSSEAALLAKLGI 182
Cdd:pfam17777   1 ARAGAIATEDVVLPAGPTGLAPGPIePQLRALGIPTKIKKGKIEITKDYTVCKEGEKLTPEQANLLKLLGI 71
Ribosomal_P0_like cd05796
Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized ...
 8-169 3.00e-18

Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be involved in mRNA decay. P0 forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. It occupies the L7/L12 stalk of the ribosome. The stalk is known to contain the binding site for elongation factors EF-G and EF-Tu; however, there is disagreement as to whether or not P0 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, P0 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). Some eukaryotic P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240222 [Multi-domain]  Cd Length: 163  Bit Score: 80.31  E-value: 3.00e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   8 EKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRgDSVVLMGKNTMMKRSVRIHSENTGNTAILNLLPLLQGN 87
Cdd:cd05796   1 ELKQKLVENIREAVDKYKYIYVFSVDNMRNNKLKDIRQEWK-DSRFFFGKNKVMQVALGRTPEDEYKPNLHKLSKYLKGQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603  88 VGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNtgLDP---SQTSFFQVLNIPTKINKGTVEIITPVELIK 164
Cdd:cd05796  80 VGLLFTNEPPEEVIEYFDSYSEPDFARAGSIATETVTLPEGP--LEQfphSMEPQLRKLGLPTKLKKGVITLEADYVVCE 157


                ....*
gi 15232603 165 QGDKV 169
Cdd:cd05796 158 EGKVL 162
Ribosomal_L10 pfam00466
Ribosomal protein L10;
8-107 3.47e-16

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 72.96  E-value: 3.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603     8 EKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVL-MGKNTMMKRSVrihsentGNTAILNLLPLLQG 86
Cdd:pfam00466   4 EKKEELVEELKELLKEYKSVVVVDYRGLTVAQLTELRKKLRENGAELkVGKNTLMRRAL-------EETGEEKLEDYLKG 76

                          90       100
                  ....*....|....*....|.
gi 15232603    87 NVGLIFTKGDLKEVSEEVAKY 107
Cdd:pfam00466  77 PTALLFTNEDPVAVAKVLEDF 97
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 5-108 1.50e-05

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


Pssm-ID: 240223  Cd Length: 157  Bit Score: 44.42  E-value: 1.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232603   5 TKAEKKiaydtklcQLIDEYTQIL-----VVAADNVGST--QLQNIRKGLRGDSVVLM-GKNTMMKRSVRihsentgNTA 76
Cdd:cd05797   1 NREKKE--------EIVAELKEKLkeaksVVVADYRGLTvaQLTELRKELREAGVKLKvVKNTLAKRALE-------GTG 65

                        90       100       110
                ....*....|....*....|....*....|..
gi 15232603  77 ILNLLPLLQGNVGLIFTKGDLKEVSEEVAKYK 108
Cdd:cd05797  66 FEDLDDLLKGPTAIAFSEEDPVAAAKVLKDFA 97
Ribosomal_60s pfam00428
60s Acidic ribosomal protein; This family includes archaebacterial L12, eukaryotic P0, P1 and ...
 233-299 1.14e-03

60s Acidic ribosomal protein; This family includes archaebacterial L12, eukaryotic P0, P1 and P2.


Pssm-ID: 459808  Cd Length: 87  Bit Score: 37.24  E-value: 1.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15232603   233 YPTLAAAPHMFINAYKNALAIAVATEYTFPQAEKVKEYLKDPSKFAVASVAAVSADAGGGAPAAAKV 299
Cdd:pfam00428   1 EPTAANIKKVLKAAGVNVEAVRVKLFAKALEGKNIKELLANGGAKAAAAAAAAAAAAAAAAAAAAAE 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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