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Conserved domains on  [gi|15231962|ref|NP_187487|]
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F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 198-364 3.13e-39

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


:

Pssm-ID: 254394  Cd Length: 159  Bit Score: 136.97  E-value: 3.13e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962   198 GVSVKGKMYWIAKKKEDFT---IIRFDFSTETFKEICVCPY----TLVTRLGCFDGDRLSLLLQGEESQGIEVWMTNKLS 270
Cdd:pfam07734   1 GVSLKGNTYWLAREKETNEedfLLSFDFTTERFGPRLPLPFqspdLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962   271 DKVVSFSQYFNVTTPDLPALHLQSCmaCPGYSIGKRRNIRVWCEgsvdvDDKSYVIITFYEIDEGGVIKQIETasygqfE 350
Cdd:pfam07734  81 PNAVSWSKFLTVDMPPLPGLFFHFF--AGSFFIDEEKKVAVVCD-----KDKEKKTNTIYIIGEDGYFKEVDS------S 147

                         170
                  ....*....|....
gi 15231962   351 YDDPFICcyVYVPS 364
Cdd:pfam07734 148 YCSPLVC--SYVPS 159
F_box_assoc_1 super family cl44343
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 95-290 2.73e-34

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


The actual alignment was detected with superfamily member TIGR01640:

Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 126.32  E-value: 2.73e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962    95 MVHCDGLMlctCRKWDNSLAVWNPVLREIKWI---KPSVCYLHTDYVGIGYDDnvSRDNYKILKLLGRlpKDDDSDPNCE 171
Cdd:TIGR01640   1 VVPCDGLI---CFSYGKRLVVWNPSTGQSRWLptpKSRRSNKESDTYFLGYDP--IEKQYKVLCFSDR--SGNRNQSEHQ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962   172 IYEFKSDSWKTLVAKFDWDIDirCNNGVSVKGKMYWIAKKKEDFT---IIRFDFSTETFKEICVCPYTLVTRLGCFD--- 245
Cdd:TIGR01640  74 VYTLGSNSWRTIECSPPHHPL--KSRGVCINGVLYYLAYTLKTNPdyfIVSFDVSSERFKEFIPLPCGNSDSVDYLSlin 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 15231962   246 -GDRLSLLLQGEESQGIEVWMTNKLsdKVVSFSQYFNVTTPDLPAL 290
Cdd:TIGR01640 152 yKGKLAVLKQKKDTNNFDLWVLNDA--GKQEWSKLFTVPIPPLPDL 195
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 10-48 2.47e-13

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438928  Cd Length: 39  Bit Score: 63.63  E-value: 2.47e-13
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15231962  10 PSLPFELIEEILYKIPAESLIRFKSTCKKWYNLITEKRF 48
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
 
Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 198-364 3.13e-39

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 136.97  E-value: 3.13e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962   198 GVSVKGKMYWIAKKKEDFT---IIRFDFSTETFKEICVCPY----TLVTRLGCFDGDRLSLLLQGEESQGIEVWMTNKLS 270
Cdd:pfam07734   1 GVSLKGNTYWLAREKETNEedfLLSFDFTTERFGPRLPLPFqspdLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962   271 DKVVSFSQYFNVTTPDLPALHLQSCmaCPGYSIGKRRNIRVWCEgsvdvDDKSYVIITFYEIDEGGVIKQIETasygqfE 350
Cdd:pfam07734  81 PNAVSWSKFLTVDMPPLPGLFFHFF--AGSFFIDEEKKVAVVCD-----KDKEKKTNTIYIIGEDGYFKEVDS------S 147

                         170
                  ....*....|....
gi 15231962   351 YDDPFICcyVYVPS 364
Cdd:pfam07734 148 YCSPLVC--SYVPS 159
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 95-290 2.73e-34

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 126.32  E-value: 2.73e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962    95 MVHCDGLMlctCRKWDNSLAVWNPVLREIKWI---KPSVCYLHTDYVGIGYDDnvSRDNYKILKLLGRlpKDDDSDPNCE 171
Cdd:TIGR01640   1 VVPCDGLI---CFSYGKRLVVWNPSTGQSRWLptpKSRRSNKESDTYFLGYDP--IEKQYKVLCFSDR--SGNRNQSEHQ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962   172 IYEFKSDSWKTLVAKFDWDIDirCNNGVSVKGKMYWIAKKKEDFT---IIRFDFSTETFKEICVCPYTLVTRLGCFD--- 245
Cdd:TIGR01640  74 VYTLGSNSWRTIECSPPHHPL--KSRGVCINGVLYYLAYTLKTNPdyfIVSFDVSSERFKEFIPLPCGNSDSVDYLSlin 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 15231962   246 -GDRLSLLLQGEESQGIEVWMTNKLsdKVVSFSQYFNVTTPDLPAL 290
Cdd:TIGR01640 152 yKGKLAVLKQKKDTNNFDLWVLNDA--GKQEWSKLFTVPIPPLPDL 195
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 10-48 2.47e-13

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 63.63  E-value: 2.47e-13
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15231962  10 PSLPFELIEEILYKIPAESLIRFKSTCKKWYNLITEKRF 48
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 9-48 1.06e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 44.84  E-value: 1.06e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15231962     9 LPSLPFELIEEILYKIPAESLIRFKSTCKKWYNLITEKRF 48
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
FBOX smart00256
A Receptor for Ubiquitination Targets;
12-52 6.69e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.42  E-value: 6.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15231962     12 LPFELIEEILYKIPAESLIRFKSTCKKWYNLITEKRFMYNH 52
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 198-364 3.13e-39

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 136.97  E-value: 3.13e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962   198 GVSVKGKMYWIAKKKEDFT---IIRFDFSTETFKEICVCPY----TLVTRLGCFDGDRLSLLLQGEESQGIEVWMTNKLS 270
Cdd:pfam07734   1 GVSLKGNTYWLAREKETNEedfLLSFDFTTERFGPRLPLPFqspdLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962   271 DKVVSFSQYFNVTTPDLPALHLQSCmaCPGYSIGKRRNIRVWCEgsvdvDDKSYVIITFYEIDEGGVIKQIETasygqfE 350
Cdd:pfam07734  81 PNAVSWSKFLTVDMPPLPGLFFHFF--AGSFFIDEEKKVAVVCD-----KDKEKKTNTIYIIGEDGYFKEVDS------S 147

                         170
                  ....*....|....
gi 15231962   351 YDDPFICcyVYVPS 364
Cdd:pfam07734 148 YCSPLVC--SYVPS 159
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 95-290 2.73e-34

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 126.32  E-value: 2.73e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962    95 MVHCDGLMlctCRKWDNSLAVWNPVLREIKWI---KPSVCYLHTDYVGIGYDDnvSRDNYKILKLLGRlpKDDDSDPNCE 171
Cdd:TIGR01640   1 VVPCDGLI---CFSYGKRLVVWNPSTGQSRWLptpKSRRSNKESDTYFLGYDP--IEKQYKVLCFSDR--SGNRNQSEHQ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231962   172 IYEFKSDSWKTLVAKFDWDIDirCNNGVSVKGKMYWIAKKKEDFT---IIRFDFSTETFKEICVCPYTLVTRLGCFD--- 245
Cdd:TIGR01640  74 VYTLGSNSWRTIECSPPHHPL--KSRGVCINGVLYYLAYTLKTNPdyfIVSFDVSSERFKEFIPLPCGNSDSVDYLSlin 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 15231962   246 -GDRLSLLLQGEESQGIEVWMTNKLsdKVVSFSQYFNVTTPDLPAL 290
Cdd:TIGR01640 152 yKGKLAVLKQKKDTNNFDLWVLNDA--GKQEWSKLFTVPIPPLPDL 195
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 10-48 2.47e-13

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 63.63  E-value: 2.47e-13
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15231962  10 PSLPFELIEEILYKIPAESLIRFKSTCKKWYNLITEKRF 48
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 9-48 1.06e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 44.84  E-value: 1.06e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15231962     9 LPSLPFELIEEILYKIPAESLIRFKSTCKKWYNLITEKRF 48
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
FBOX smart00256
A Receptor for Ubiquitination Targets;
12-52 6.69e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.42  E-value: 6.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15231962     12 LPFELIEEILYKIPAESLIRFKSTCKKWYNLITEKRFMYNH 52
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 11-44 2.92e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 40.51  E-value: 2.92e-05
                        10        20        30
                ....*....|....*....|....*....|....
gi 15231962  11 SLPFELIEEILYKIPAESLIRFKSTCKKWYNLIT 44
Cdd:cd09917   2 DLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBA cd22083
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ...
 11-44 2.27e-03

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438855  Cd Length: 37  Bit Score: 35.44  E-value: 2.27e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15231962  11 SLPFELIEEILYKIPAESLI-RFKSTCKKWYNLIT 44
Cdd:cd22083   3 EIPEELLLEILTHVPATSLItNCRLVCTLWRDIID 37
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 11-43 5.46e-03

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 34.60  E-value: 5.46e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 15231962  11 SLPFELIEEILYKIPAESLIRFKSTCKKWYNLI 43
Cdd:cd22113   3 LLPPEMSLRIFSQLDVQSLCRASQTCKTWNDLI 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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