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Conserved domains on  [gi|15229884|ref|NP_187157|]
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NOP56-like pre RNA processing ribonucleoprotein [Arabidopsis thaliana]

Protein Classification

NOP5/NOP56 family protein( domain architecture ID 12087092)

NOP5/NOP56 family protein similar to human nucleolar protein 58 (NOP58, also known as NOP5) which is a core component of box C/D small nucleolar ribonucleoparticles

CATH:  1.10.246.90
Gene Ontology:  GO:0005730|GO:0030515|GO:0006364

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Nop pfam01798
snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ...
168-395 1.37e-116

snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.


:

Pssm-ID: 460335 [Multi-domain]  Cd Length: 229  Bit Score: 343.67  E-value: 1.37e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884   168 LDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGN-RVNAAKLDFSEILADEIEADLKDAAVISMGTEVS 246
Cdd:pfam01798   1 LDDIDKEINLVHMRIREWYSWHFPELESLVPDPLDYAKVVKLIGNdREDLTKIDPDLELAKAIIMAASVTASTSMGTELS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884   247 DLDLLHIRELCDQVLSLSEYRAQLYDYLKSRMNTIAPNLTALVGELVGARLISHGGSLLNLSKQPGSTVQILGAEKALFR 326
Cdd:pfam01798  81 EEDLENILEACDRVLELDEYRKKLLEYLESRMSAIAPNLTALVGPLVAARLISHAGGLTNLAKMPASNIQILGAEKALFR 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15229884   327 ALKTKHATPKYGLIFHASLVGQAAPKHKGKISRSLAAKTVLAIRVDALGDSqDNTMGLENRAKLEARLR 395
Cdd:pfam01798 161 ALKTGFNTPKYGLIYHSPLVQATPPKLRGKAARLLAAKCALAARVDAFSEP-DGSYGEKLREEIEKRLE 228
NOP5NT pfam08156
NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 ...
3-67 6.00e-20

NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 family.


:

Pssm-ID: 462382  Cd Length: 66  Bit Score: 83.66  E-value: 6.00e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15229884     3 LVLYETAAGFALFKVKDEGKMAN-VEDLCKEFDTPDSARKMVKLKAFEKFDNTSEALEAVAKLLEG 67
Cdd:pfam08156   1 LVLFETAAGYALFKVKDEEEIGKkLKEVQESFQDLEKFSKMVKLKAFSPFKSAAEALENANAISEG 66
 
Name Accession Description Interval E-value
Nop pfam01798
snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ...
168-395 1.37e-116

snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.


Pssm-ID: 460335 [Multi-domain]  Cd Length: 229  Bit Score: 343.67  E-value: 1.37e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884   168 LDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGN-RVNAAKLDFSEILADEIEADLKDAAVISMGTEVS 246
Cdd:pfam01798   1 LDDIDKEINLVHMRIREWYSWHFPELESLVPDPLDYAKVVKLIGNdREDLTKIDPDLELAKAIIMAASVTASTSMGTELS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884   247 DLDLLHIRELCDQVLSLSEYRAQLYDYLKSRMNTIAPNLTALVGELVGARLISHGGSLLNLSKQPGSTVQILGAEKALFR 326
Cdd:pfam01798  81 EEDLENILEACDRVLELDEYRKKLLEYLESRMSAIAPNLTALVGPLVAARLISHAGGLTNLAKMPASNIQILGAEKALFR 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15229884   327 ALKTKHATPKYGLIFHASLVGQAAPKHKGKISRSLAAKTVLAIRVDALGDSqDNTMGLENRAKLEARLR 395
Cdd:pfam01798 161 ALKTGFNTPKYGLIYHSPLVQATPPKLRGKAARLLAAKCALAARVDAFSEP-DGSYGEKLREEIEKRLE 228
SIK1 COG1498
Box C/D ribonucleoprotein Nop56/Prp31/SIK1 subunit [Translation, ribosomal structure and ...
145-394 3.65e-76

Box C/D ribonucleoprotein Nop56/Prp31/SIK1 subunit [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441107 [Multi-domain]  Cd Length: 352  Bit Score: 244.09  E-value: 3.65e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884 145 LARYKLKFSSDKVDTMIIQAIGLLDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGNRVNAAKLDFSEI 224
Cdd:COG1498 108 ATRRKVREAAQARDLQIIQAIRALDDIDKTANLLAERLREWYGLHFPELDTGVKDHEEYARIVAELGPRENITKENLAEK 187
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884 225 LADeieadlkdAAVISMGTEVSDLDLLHIRELCDQVLSLSEYRAQLYDYLKSRMNTIAPNLTALVGELVGARLISHGGSL 304
Cdd:COG1498 188 IAE--------AAKKSMGADLSDEDLEIIKSLAERILDLYDERKSLEEYIERVMPEVAPNLTALAGPVLGARLISLAGGL 259
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884 305 LNLSKQPGSTVQILGAEKALFRALKTKHATPKYGLIFHASLVgQAAPK-HKGKISRSLAAKTVLAIRVDALGdsqdNTMG 383
Cdd:COG1498 260 ERLAKLPASTIQVLGAEKALFRHLRGGAPPPKHGVIFQHPAI-HGSPRwQRGKIARALAAKLAIAARIDHYS----GEIG 334
                       250
                ....*....|.
gi 15229884 384 LENRAKLEARL 394
Cdd:COG1498 335 PELKEELEKRI 345
PRK14552 PRK14552
C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Provisional
141-373 4.63e-72

C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Provisional


Pssm-ID: 237753 [Multi-domain]  Cd Length: 414  Bit Score: 235.63  E-value: 4.63e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884  141 LSHSLARYKLKFSSDKVDTMIIQAIGLLDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGNRVNAA--- 217
Cdd:PRK14552 121 WSVELTRRKLRSAAQKRDKLAIQAIRAIDDIDKTINLFSERLREWYSLHFPELDELVKKHEEYVKLVSELGDRENYTrek 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884  218 --KLDFSEILADEIeadlKDAAVISMGTEVSDLDLLHIRELCDQVLSLSEYRAQLYDYLKSRMNTIAPNLTALVGELVGA 295
Cdd:PRK14552 201 lkKLGLPENKARKI----AEAAKKSMGADLSEFDLEAIKKLANEILDLYKLREELEDYLETVMKEVAPNLTALVGPSLGA 276
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15229884  296 RLISHGGSLLNLSKQPGSTVQILGAEKALFRALKTKHATPKYGLIFHASLVgQAAPK-HKGKISRSLAAKTVLAIRVDA 373
Cdd:PRK14552 277 RLISLAGGLEELAKMPASTIQVLGAEKALFRHLRTGAKPPKHGVIFQYPAI-HGSPWwQRGKIARALAAKLAIAARVDY 354
NOSIC smart00931
NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.
161-212 1.07e-27

NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.


Pssm-ID: 197999 [Multi-domain]  Cd Length: 52  Bit Score: 104.94  E-value: 1.07e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 15229884    161 IIQAIGLLDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGN 212
Cdd:smart00931   1 IIQAINLLDDIDKEINLFHMRVREWYSWHFPELEKLVPDPLDYAKVVKLLGN 52
NOP5NT pfam08156
NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 ...
3-67 6.00e-20

NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 family.


Pssm-ID: 462382  Cd Length: 66  Bit Score: 83.66  E-value: 6.00e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15229884     3 LVLYETAAGFALFKVKDEGKMAN-VEDLCKEFDTPDSARKMVKLKAFEKFDNTSEALEAVAKLLEG 67
Cdd:pfam08156   1 LVLFETAAGYALFKVKDEEEIGKkLKEVQESFQDLEKFSKMVKLKAFSPFKSAAEALENANAISEG 66
 
Name Accession Description Interval E-value
Nop pfam01798
snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ...
168-395 1.37e-116

snoRNA binding domain, fibrillarin; This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.


Pssm-ID: 460335 [Multi-domain]  Cd Length: 229  Bit Score: 343.67  E-value: 1.37e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884   168 LDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGN-RVNAAKLDFSEILADEIEADLKDAAVISMGTEVS 246
Cdd:pfam01798   1 LDDIDKEINLVHMRIREWYSWHFPELESLVPDPLDYAKVVKLIGNdREDLTKIDPDLELAKAIIMAASVTASTSMGTELS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884   247 DLDLLHIRELCDQVLSLSEYRAQLYDYLKSRMNTIAPNLTALVGELVGARLISHGGSLLNLSKQPGSTVQILGAEKALFR 326
Cdd:pfam01798  81 EEDLENILEACDRVLELDEYRKKLLEYLESRMSAIAPNLTALVGPLVAARLISHAGGLTNLAKMPASNIQILGAEKALFR 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15229884   327 ALKTKHATPKYGLIFHASLVGQAAPKHKGKISRSLAAKTVLAIRVDALGDSqDNTMGLENRAKLEARLR 395
Cdd:pfam01798 161 ALKTGFNTPKYGLIYHSPLVQATPPKLRGKAARLLAAKCALAARVDAFSEP-DGSYGEKLREEIEKRLE 228
SIK1 COG1498
Box C/D ribonucleoprotein Nop56/Prp31/SIK1 subunit [Translation, ribosomal structure and ...
145-394 3.65e-76

Box C/D ribonucleoprotein Nop56/Prp31/SIK1 subunit [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441107 [Multi-domain]  Cd Length: 352  Bit Score: 244.09  E-value: 3.65e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884 145 LARYKLKFSSDKVDTMIIQAIGLLDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGNRVNAAKLDFSEI 224
Cdd:COG1498 108 ATRRKVREAAQARDLQIIQAIRALDDIDKTANLLAERLREWYGLHFPELDTGVKDHEEYARIVAELGPRENITKENLAEK 187
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884 225 LADeieadlkdAAVISMGTEVSDLDLLHIRELCDQVLSLSEYRAQLYDYLKSRMNTIAPNLTALVGELVGARLISHGGSL 304
Cdd:COG1498 188 IAE--------AAKKSMGADLSDEDLEIIKSLAERILDLYDERKSLEEYIERVMPEVAPNLTALAGPVLGARLISLAGGL 259
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884 305 LNLSKQPGSTVQILGAEKALFRALKTKHATPKYGLIFHASLVgQAAPK-HKGKISRSLAAKTVLAIRVDALGdsqdNTMG 383
Cdd:COG1498 260 ERLAKLPASTIQVLGAEKALFRHLRGGAPPPKHGVIFQHPAI-HGSPRwQRGKIARALAAKLAIAARIDHYS----GEIG 334
                       250
                ....*....|.
gi 15229884 384 LENRAKLEARL 394
Cdd:COG1498 335 PELKEELEKRI 345
PRK14552 PRK14552
C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Provisional
141-373 4.63e-72

C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Provisional


Pssm-ID: 237753 [Multi-domain]  Cd Length: 414  Bit Score: 235.63  E-value: 4.63e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884  141 LSHSLARYKLKFSSDKVDTMIIQAIGLLDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGNRVNAA--- 217
Cdd:PRK14552 121 WSVELTRRKLRSAAQKRDKLAIQAIRAIDDIDKTINLFSERLREWYSLHFPELDELVKKHEEYVKLVSELGDRENYTrek 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229884  218 --KLDFSEILADEIeadlKDAAVISMGTEVSDLDLLHIRELCDQVLSLSEYRAQLYDYLKSRMNTIAPNLTALVGELVGA 295
Cdd:PRK14552 201 lkKLGLPENKARKI----AEAAKKSMGADLSEFDLEAIKKLANEILDLYKLREELEDYLETVMKEVAPNLTALVGPSLGA 276
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15229884  296 RLISHGGSLLNLSKQPGSTVQILGAEKALFRALKTKHATPKYGLIFHASLVgQAAPK-HKGKISRSLAAKTVLAIRVDA 373
Cdd:PRK14552 277 RLISLAGGLEELAKMPASTIQVLGAEKALFRHLRTGAKPPKHGVIFQYPAI-HGSPWwQRGKIARALAAKLAIAARVDY 354
NOSIC smart00931
NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.
161-212 1.07e-27

NOSIC (NUC001) domain; This is the central domain in Nop56/SIK1-like proteins.


Pssm-ID: 197999 [Multi-domain]  Cd Length: 52  Bit Score: 104.94  E-value: 1.07e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 15229884    161 IIQAIGLLDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGN 212
Cdd:smart00931   1 IIQAINLLDDIDKEINLFHMRVREWYSWHFPELEKLVPDPLDYAKVVKLLGN 52
NOP5NT pfam08156
NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 ...
3-67 6.00e-20

NOP5NT (NUC127) domain; This N terminal domain is found in RNA-binding proteins of the NOP5 family.


Pssm-ID: 462382  Cd Length: 66  Bit Score: 83.66  E-value: 6.00e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15229884     3 LVLYETAAGFALFKVKDEGKMAN-VEDLCKEFDTPDSARKMVKLKAFEKFDNTSEALEAVAKLLEG 67
Cdd:pfam08156   1 LVLFETAAGYALFKVKDEEEIGKkLKEVQESFQDLEKFSKMVKLKAFSPFKSAAEALENANAISEG 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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