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Conserved domains on  [gi|42563460|ref|NP_187001|]
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Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13605777)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and NPH3 domain-containing protein may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 108-337 9.54e-57

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


:

Pssm-ID: 460777  Cd Length: 218  Bit Score: 186.93  E-value: 9.54e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563460   108 DLITLPLRLYEPLILEVSKHNVSLENLVASVCNYANRWV-------FEKDSGDGSVSRNKREGIEAVERLLPHQRGTISS 180
Cdd:pfam03000   6 DLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLpglsrssSSSASRSEDDNSKQRELLETIVSLLPSEKGSVSC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563460   181 GFLFKSLKESIFLGACSDCRKGFEVRISNQLDMARAKDLQILSPTEDGS-YDIELlktilksfysndsvpdlsrfvSVAR 259
Cdd:pfam03000  86 SFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEETlYDVDL---------------------KVAK 144

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563460   260 MLEEFLLEaAASDAGLRVGTFKELAEiAVAASCdvLSYSDGIYRAIDVYLERHRDLIESEKMEACRFLHCKKLSPEAC 337
Cdd:pfam03000 145 LVDGYLAE-IASDPNLKLSKFIALAE-ALPDSA--RPTHDGLYRAIDIYLKAHPGLSESERKRLCRLMDCQKLSLEAC 218
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 5-51 8.00e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18312:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 105  Bit Score: 55.80  E-value: 8.00e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 42563460   5 PSIFHLVTRFCYGYKIELSADNIVSVLCIAYYLEMSDDHSSNNLLNK 51
Cdd:cd18312  59 AEAFELVAKFCYGMPINLTATNVVGLRCAAEYLEMTESGNLGNLIDK 105
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 108-337 9.54e-57

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 186.93  E-value: 9.54e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563460   108 DLITLPLRLYEPLILEVSKHNVSLENLVASVCNYANRWV-------FEKDSGDGSVSRNKREGIEAVERLLPHQRGTISS 180
Cdd:pfam03000   6 DLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLpglsrssSSSASRSEDDNSKQRELLETIVSLLPSEKGSVSC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563460   181 GFLFKSLKESIFLGACSDCRKGFEVRISNQLDMARAKDLQILSPTEDGS-YDIELlktilksfysndsvpdlsrfvSVAR 259
Cdd:pfam03000  86 SFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEETlYDVDL---------------------KVAK 144

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563460   260 MLEEFLLEaAASDAGLRVGTFKELAEiAVAASCdvLSYSDGIYRAIDVYLERHRDLIESEKMEACRFLHCKKLSPEAC 337
Cdd:pfam03000 145 LVDGYLAE-IASDPNLKLSKFIALAE-ALPDSA--RPTHDGLYRAIDIYLKAHPGLSESERKRLCRLMDCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 5-51 8.00e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 55.80  E-value: 8.00e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 42563460   5 PSIFHLVTRFCYGYKIELSADNIVSVLCIAYYLEMSDDHSSNNLLNK 51
Cdd:cd18312  59 AEAFELVAKFCYGMPINLTATNVVGLRCAAEYLEMTESGNLGNLIDK 105
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 108-337 9.54e-57

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 186.93  E-value: 9.54e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563460   108 DLITLPLRLYEPLILEVSKHNVSLENLVASVCNYANRWV-------FEKDSGDGSVSRNKREGIEAVERLLPHQRGTISS 180
Cdd:pfam03000   6 DLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLpglsrssSSSASRSEDDNSKQRELLETIVSLLPSEKGSVSC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563460   181 GFLFKSLKESIFLGACSDCRKGFEVRISNQLDMARAKDLQILSPTEDGS-YDIELlktilksfysndsvpdlsrfvSVAR 259
Cdd:pfam03000  86 SFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEETlYDVDL---------------------KVAK 144

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563460   260 MLEEFLLEaAASDAGLRVGTFKELAEiAVAASCdvLSYSDGIYRAIDVYLERHRDLIESEKMEACRFLHCKKLSPEAC 337
Cdd:pfam03000 145 LVDGYLAE-IASDPNLKLSKFIALAE-ALPDSA--RPTHDGLYRAIDIYLKAHPGLSESERKRLCRLMDCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 5-51 8.00e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 55.80  E-value: 8.00e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 42563460   5 PSIFHLVTRFCYGYKIELSADNIVSVLCIAYYLEMSDDHSSNNLLNK 51
Cdd:cd18312  59 AEAFELVAKFCYGMPINLTATNVVGLRCAAEYLEMTESGNLGNLIDK 105
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 2-37 1.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 43.04  E-value: 1.30e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 42563460   2 DINPSIFHLVTRFCYGYKIELSADNIVSVLCIAYYL 37
Cdd:cd01165  44 DISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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