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Conserved domains on  [gi|15228447|ref|NP_186954|]
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F-box/RNI-like superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/FBD/LRR-repeat protein( domain architecture ID 17779756)

F-box/FBD/LRR-repeat protein may be a component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50|3.80.10.10
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  31898225|11178263|10581972|14747988|7583641|11751054
SCOP:  4001927|4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FBD smart00579
domain in FBox and BRCT domain containing plant proteins;
382-462 1.23e-12

domain in FBox and BRCT domain containing plant proteins;


:

Pssm-ID: 214730  Cd Length: 72  Bit Score: 62.93  E-value: 1.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228447    382 RSLKSCpVKVVEINGFGVTMKEKYLIEHFLDYFSCLKEMKIYINCEEDgvtqqvmknREVSKLVLDEMEEYNEFYSCNVK 461
Cdd:smart00579   1 ECLLSS-LEVLEIKGYRGTEEEKELVKYFLENAPCLKKLTISVETSDD---------EEKLEILKELLSLPRASSSCQVQ 70


                   .
gi 15228447    462 L 462
Cdd:smart00579  71 F 71
F-box_AtFBL13-like cd22160
F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) ...
 4-39 5.22e-11

F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438931  Cd Length: 36  Bit Score: 57.30  E-value: 5.22e-11
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15228447   4 LSSLPDEVRCLILSFLTTKESASTSVLSKKWRNLFA 39
Cdd:cd22160   1 ISDLPDELLCHILSFLPTKDAVKTSVLSKRWRHLWR 36
 
Name Accession Description Interval E-value
FBD smart00579
domain in FBox and BRCT domain containing plant proteins;
382-462 1.23e-12

domain in FBox and BRCT domain containing plant proteins;


Pssm-ID: 214730  Cd Length: 72  Bit Score: 62.93  E-value: 1.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228447    382 RSLKSCpVKVVEINGFGVTMKEKYLIEHFLDYFSCLKEMKIYINCEEDgvtqqvmknREVSKLVLDEMEEYNEFYSCNVK 461
Cdd:smart00579   1 ECLLSS-LEVLEIKGYRGTEEEKELVKYFLENAPCLKKLTISVETSDD---------EEKLEILKELLSLPRASSSCQVQ 70


                   .
gi 15228447    462 L 462
Cdd:smart00579  71 F 71
F-box_AtFBL13-like cd22160
F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) ...
 4-39 5.22e-11

F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438931  Cd Length: 36  Bit Score: 57.30  E-value: 5.22e-11
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15228447   4 LSSLPDEVRCLILSFLTTKESASTSVLSKKWRNLFA 39
Cdd:cd22160   1 ISDLPDELLCHILSFLPTKDAVKTSVLSKRWRHLWR 36
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 4-38 8.45e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.83  E-value: 8.45e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15228447     4 LSSLPDEVRCLILSFLTTKESASTSVLSKKWRNLF 38
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLV 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
7-38 7.65e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 34.33  E-value: 7.65e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 15228447      7 LPDEVRCLILSFLTTKESASTSVLSKKWRNLF 38
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLI 32
 
Name Accession Description Interval E-value
FBD smart00579
domain in FBox and BRCT domain containing plant proteins;
382-462 1.23e-12

domain in FBox and BRCT domain containing plant proteins;


Pssm-ID: 214730  Cd Length: 72  Bit Score: 62.93  E-value: 1.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228447    382 RSLKSCpVKVVEINGFGVTMKEKYLIEHFLDYFSCLKEMKIYINCEEDgvtqqvmknREVSKLVLDEMEEYNEFYSCNVK 461
Cdd:smart00579   1 ECLLSS-LEVLEIKGYRGTEEEKELVKYFLENAPCLKKLTISVETSDD---------EEKLEILKELLSLPRASSSCQVQ 70


                   .
gi 15228447    462 L 462
Cdd:smart00579  71 F 71
F-box_AtFBL13-like cd22160
F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) ...
 4-39 5.22e-11

F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438931  Cd Length: 36  Bit Score: 57.30  E-value: 5.22e-11
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15228447   4 LSSLPDEVRCLILSFLTTKESASTSVLSKKWRNLFA 39
Cdd:cd22160   1 ISDLPDELLCHILSFLPTKDAVKTSVLSKRWRHLWR 36
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 4-38 8.45e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.83  E-value: 8.45e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15228447     4 LSSLPDEVRCLILSFLTTKESASTSVLSKKWRNLF 38
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLV 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
7-38 7.65e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 34.33  E-value: 7.65e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 15228447      7 LPDEVRCLILSFLTTKESASTSVLSKKWRNLF 38
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLI 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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