NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15224918|ref|NP_181990|]
View 

mitochondrial acyl carrier protein 1 [Arabidopsis thaliana]

Protein Classification

acyl carrier protein( domain architecture ID 516)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

Gene Ontology:  GO:0006633
PubMed:  30543875

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PP-binding super family cl09936
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 32-121 1.89e-28

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


The actual alignment was detected with superfamily member PTZ00171:

Pssm-ID: 447865  Cd Length: 148  Bit Score: 100.93  E-value: 1.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224918   32 RSFSSHDDHLSREAVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLA 111
Cdd:PTZ00171  57 RSSKSKQYLLSKEDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDA 136

                         90
                 ....*....|
gi 15224918  112 IEYVYNHPMS 121
Cdd:PTZ00171 137 IDYIEQNNMA 146
 
Name Accession Description Interval E-value
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 32-121 1.89e-28

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 100.93  E-value: 1.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224918   32 RSFSSHDDHLSREAVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLA 111
Cdd:PTZ00171  57 RSSKSKQYLLSKEDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDA 136

                         90
                 ....*....|
gi 15224918  112 IEYVYNHPMS 121
Cdd:PTZ00171 137 IDYIEQNNMA 146
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 45-119 1.05e-24

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 89.38  E-value: 1.05e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15224918    45 AVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLAIEYVYNHP 119
Cdd:TIGR00517   3 EIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 42-118 2.21e-17

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 70.65  E-value: 2.21e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15224918  42 SREAVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLAIEYVYNH 118
Cdd:COG0236   2 PREELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 48-99 2.54e-08

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 47.17  E-value: 2.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15224918    48 DRVLDVVKSFPKVDPSKVTPEVHFQnDLGLDSLDTVEIVMAIEEEFKLEIPD 99
Cdd:pfam00550   1 ERLRELLAEVLGVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPP 51
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 43-98 9.86e-05

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 38.39  E-value: 9.86e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 15224918     43 REAVVDRVLD-VVKSFPKVDPSKVTPEVHFQnDLGLDSLDTVEIVMAIEEEFKLEIP 98
Cdd:smart00823  10 RRLLLDLVREqVAAVLGHAAAEAIDPDRPFR-DLGLDSLMAVELRNRLEAATGLRLP 65
 
Name Accession Description Interval E-value
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 32-121 1.89e-28

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 100.93  E-value: 1.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224918   32 RSFSSHDDHLSREAVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLA 111
Cdd:PTZ00171  57 RSSKSKQYLLSKEDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDA 136

                         90
                 ....*....|
gi 15224918  112 IEYVYNHPMS 121
Cdd:PTZ00171 137 IDYIEQNNMA 146
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 45-119 1.05e-24

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 89.38  E-value: 1.05e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15224918    45 AVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLAIEYVYNHP 119
Cdd:TIGR00517   3 EIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
acpP PRK00982
acyl carrier protein; Provisional
 43-118 7.56e-23

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 84.45  E-value: 7.56e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15224918   43 REAVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLAIEYVYNH 118
Cdd:PRK00982   1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKH 76
acpP CHL00124
acyl carrier protein; Validated
 46-115 7.44e-21

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 79.68  E-value: 7.44e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224918   46 VVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLAIEYV 115
Cdd:CHL00124   6 IFEKVQSIVAEQLGIEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFI 75
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 42-118 2.21e-17

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 70.65  E-value: 2.21e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15224918  42 SREAVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLAIEYVYNH 118
Cdd:COG0236   2 PREELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
PRK12449 PRK12449
acyl carrier protein; Provisional
 41-118 1.77e-12

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 58.18  E-value: 1.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224918   41 LSREAVVDRVLDVVK---SFPKVDpskVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKEADKIDSCSLAIEYVYN 117
Cdd:PRK12449   1 MTREEIFERLINLIQkqrSYLSLA---ITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQ 77


                 .
gi 15224918  118 H 118
Cdd:PRK12449  78 R 78
PRK06508 PRK06508
acyl carrier protein; Provisional
 48-98 9.20e-11

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 54.05  E-value: 9.20e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15224918   48 DRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIP 98
Cdd:PRK06508   6 DKVADIIAETSDIPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLP 56
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 48-99 2.54e-08

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 47.17  E-value: 2.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15224918    48 DRVLDVVKSFPKVDPSKVTPEVHFQnDLGLDSLDTVEIVMAIEEEFKLEIPD 99
Cdd:pfam00550   1 ERLRELLAEVLGVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPP 51
PRK07081 PRK07081
acyl carrier protein; Provisional
 74-99 4.14e-05

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 39.17  E-value: 4.14e-05
                         10        20
                 ....*....|....*....|....*.
gi 15224918   74 DLGLDSLDTVEIVMAIEEEFKLEIPD 99
Cdd:PRK07081  30 EAGLSSLATVQLMLAIEDAFDIEIPD 55
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 43-98 9.86e-05

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 38.39  E-value: 9.86e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 15224918     43 REAVVDRVLD-VVKSFPKVDPSKVTPEVHFQnDLGLDSLDTVEIVMAIEEEFKLEIP 98
Cdd:smart00823  10 RRLLLDLVREqVAAVLGHAAAEAIDPDRPFR-DLGLDSLMAVELRNRLEAATGLRLP 65
PRK05350 PRK05350
acyl carrier protein; Provisional
 41-94 2.30e-04

acyl carrier protein; Provisional


Pssm-ID: 180033  Cd Length: 82  Bit Score: 37.28  E-value: 2.30e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15224918   41 LSREAVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIE---------EEFK 94
Cdd:PRK05350   2 MTREEILERLRAILVELFEIDPEDITPEANLYEDLDLDSIDAVDLVVHLQkltgkkikpEEFK 64
PRK08172 PRK08172
acyl carrier protein;
49-96 3.09e-04

acyl carrier protein;


Pssm-ID: 181266  Cd Length: 82  Bit Score: 36.79  E-value: 3.09e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 15224918   49 RVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLE 96
Cdd:PRK08172   8 RVKKVITSCIAVDVDSINGQTHLVEDLYADSLDLIDIVFGLSEEFDIS 55
PRK05883 PRK05883
acyl carrier protein; Validated
 42-101 2.64e-03

acyl carrier protein; Validated


Pssm-ID: 180304  Cd Length: 91  Bit Score: 34.43  E-value: 2.64e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224918   42 SREAVVDRVLDVVKSFPKVDPSKVTPEVHFQNDLGLDSLDTVEIVMAIEEEFKLEIPDKE 101
Cdd:PRK05883  11 SPSTVSATLLSILRDDLNVDLTRVTPDARLVDDVGLDSVAFAVGMVAIEERLGVALSEED 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH