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Insulinase (Peptidase family M16) family protein [Arabidopsis thaliana]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
14-958
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 836.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 14 E I L K PRT D N R E YR M I V L K N L L Q VLL I SDP DT DK C AA SMS V S VGSF S DP QGLE GLAHFLEHMLF YASE KYPE EDS Y SKY I T 93
Cdd:COG1025 34 T I I K SPN D P R Q YR A I T L D N G L K VLL V SDP QA DK S AA ALA V P VGSF D DP DDQQ GLAHFLEHMLF LGTK KYPE PGE Y QEF I S 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 94 E HGGS T NA Y TA S E E TNY H F D V NA D CFD EALDRFA Q FF IK PL MSADATM RE IK AV DS E NQKNLLS DG W RI R Q LQ K HLSKED 173
Cdd:COG1025 114 K HGGS H NA S TA T E R TNY Y F E V EN D ALE EALDRFA D FF AA PL FDPEYVD RE RN AV NA E YTLKRSD DG R RI Y Q VH K ETLNPA 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 174 HP YHK FS T GN MD TL HVR P QA K gvd T R S EL IK FY EEH YSAN I M H LV V Y GKE SLD KIQD L VERM F QE I Q N T N KV VP RFPGQP 253
Cdd:COG1025 194 HP FSR FS V GN LE TL SDK P GS K --- L R D EL LA FY QRY YSAN L M K LV L Y SNQ SLD ELEK L ARQT F GA I P N R N LS VP PITVPL 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 254 C T ADH L Q I LVKAI P I K QGHK L GVSW P VTPSIHH Y DEA P SQ Y LGH L I G H EGEGSL FHA LK TL G W A TG LSAG E G EWTLDYSF 333
Cdd:COG1025 271 Y T PEQ L G I IIHIV P L K PRRQ L RLEF P IPNNQAY Y RSK P LT Y ISY L L G N EGEGSL LDW LK KQ G L A ES LSAG G G ISGRNFGD 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 334 F KV S ID LTD A G HE H MQ EI LGLL F N YI Q L LQ Q T G VCQ W I FDE LSAIC E TK F HY Q D K IP PM S Y IVDIAS NM QI YP TK D W L VG 413
Cdd:COG1025 351 F SI S VS LTD K G LA H RD EI IAAV F A YI E L IR Q Q G IQE W Y FDE QAQLL E LA F RF Q E K TR PM D Y VSWLSD NM LR YP VE D V L DA 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 414 SS L PTK F N PA IVQKVVDE L S P S N F RI FWE S Q kf EGQ TDK AEP WY N T A YS LEK IT SSTIQE W V Q SAPDVH L H LP AP N VF IP 493
Cdd:COG1025 431 DY L MDG F D PA AIRARLAQ L T P E N A RI WLI S P -- DVP TDK TAY WY D T P YS VDP IT QEQLAK W Q Q ASQNPA L S LP EL N PY IP 508
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 494 T D L SL KDA D DKETV P V LL RKT P FS RLWY K PD TM F SK PKA YVKMDFNC P L AV S S PDAA VLT DIFTR LL M D Y LNE YA Y Y A Q V 573
Cdd:COG1025 509 D D F SL IKL D KESAK P E LL VDE P GL RLWY M PD QY F AE PKA DIYLSLRN P Q AV D S ARNQ VLT RLLDY LL N D A LNE LS Y Q A S V 588
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 574 AGL Y Y GVSLSDN G FE L TLL G YNH K LRI LLE TVVGKI A N FE VKPD RFA VI K ETVTKEYQ N YKFRQ PY H Q AMYYC S LI LQ DQ 653
Cdd:COG1025 589 AGL S Y SLYAHQG G LT L SAS G FTQ K QPK LLE ALLDQL A S FE PTEE RFA QA K SQLLRQLD N AEKAK PY S Q LFSPL S RL LQ PP 668
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 654 TWPWT E E L DV L SHLEAE D VAK F VPM LL SRTFI E CYIA GN VENNE A ESMVKHIEDV L FND - PKPIC R plfpsqhlt NR VV K 732
Cdd:COG1025 669 YFERE E L L AA L ESITLQ D LRA F REQ LL QQLHL E MLVV GN LSEEQ A KQLADSLKKQ L APN g TGEEP R --------- RQ VV D 739
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 733 L GEGMKYFYHQDGSNP sde N SAL VH Y I Q VH - RDDF SM N iklq L FG L VAK -- QAT F - H QLRT V EQLGY I --- TALAQRNDS 805
Cdd:COG1025 740 L DKSGSLNLEKACDHT --- D SAL LI Y Y Q SG y DSLA SM A ---- L SS L LGQ ii SPW F f N QLRT E EQLGY V vga GYMPLGRQP 812
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 806 G I ygv Q F II QS S V KG P GHIDS R VESL LK N FE SK L YEM S N E D F KSNVTA LI DMK LE KHK NL K EE SRFY W RE I QS G TLK F NR 885
Cdd:COG1025 813 G L --- G F YV QS P V AS P AYLLE R IDDF LK Q FE ER L LAL S E E E F AQYKQG LI NQL LE PDQ NL S EE AQRL W VD I GN G DFE F DT 889
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227435 886 K E AEVS A L K Q L QKQE LIDFF DE yi K V G A ARKKS L SIRVY G SQ H lkemas D K DEVPSPSVE I E DI VG F R K SQ P L 958
Cdd:COG1025 890 R E KLIA A V K K L TRAD LIDFF QQ -- A V I A PQGLR L LSQSQ G TK H ------ S K ADELKGWKT I T DI SA F Q K TL P V 954
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
14-958
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 836.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 14 E I L K PRT D N R E YR M I V L K N L L Q VLL I SDP DT DK C AA SMS V S VGSF S DP QGLE GLAHFLEHMLF YASE KYPE EDS Y SKY I T 93
Cdd:COG1025 34 T I I K SPN D P R Q YR A I T L D N G L K VLL V SDP QA DK S AA ALA V P VGSF D DP DDQQ GLAHFLEHMLF LGTK KYPE PGE Y QEF I S 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 94 E HGGS T NA Y TA S E E TNY H F D V NA D CFD EALDRFA Q FF IK PL MSADATM RE IK AV DS E NQKNLLS DG W RI R Q LQ K HLSKED 173
Cdd:COG1025 114 K HGGS H NA S TA T E R TNY Y F E V EN D ALE EALDRFA D FF AA PL FDPEYVD RE RN AV NA E YTLKRSD DG R RI Y Q VH K ETLNPA 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 174 HP YHK FS T GN MD TL HVR P QA K gvd T R S EL IK FY EEH YSAN I M H LV V Y GKE SLD KIQD L VERM F QE I Q N T N KV VP RFPGQP 253
Cdd:COG1025 194 HP FSR FS V GN LE TL SDK P GS K --- L R D EL LA FY QRY YSAN L M K LV L Y SNQ SLD ELEK L ARQT F GA I P N R N LS VP PITVPL 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 254 C T ADH L Q I LVKAI P I K QGHK L GVSW P VTPSIHH Y DEA P SQ Y LGH L I G H EGEGSL FHA LK TL G W A TG LSAG E G EWTLDYSF 333
Cdd:COG1025 271 Y T PEQ L G I IIHIV P L K PRRQ L RLEF P IPNNQAY Y RSK P LT Y ISY L L G N EGEGSL LDW LK KQ G L A ES LSAG G G ISGRNFGD 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 334 F KV S ID LTD A G HE H MQ EI LGLL F N YI Q L LQ Q T G VCQ W I FDE LSAIC E TK F HY Q D K IP PM S Y IVDIAS NM QI YP TK D W L VG 413
Cdd:COG1025 351 F SI S VS LTD K G LA H RD EI IAAV F A YI E L IR Q Q G IQE W Y FDE QAQLL E LA F RF Q E K TR PM D Y VSWLSD NM LR YP VE D V L DA 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 414 SS L PTK F N PA IVQKVVDE L S P S N F RI FWE S Q kf EGQ TDK AEP WY N T A YS LEK IT SSTIQE W V Q SAPDVH L H LP AP N VF IP 493
Cdd:COG1025 431 DY L MDG F D PA AIRARLAQ L T P E N A RI WLI S P -- DVP TDK TAY WY D T P YS VDP IT QEQLAK W Q Q ASQNPA L S LP EL N PY IP 508
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 494 T D L SL KDA D DKETV P V LL RKT P FS RLWY K PD TM F SK PKA YVKMDFNC P L AV S S PDAA VLT DIFTR LL M D Y LNE YA Y Y A Q V 573
Cdd:COG1025 509 D D F SL IKL D KESAK P E LL VDE P GL RLWY M PD QY F AE PKA DIYLSLRN P Q AV D S ARNQ VLT RLLDY LL N D A LNE LS Y Q A S V 588
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 574 AGL Y Y GVSLSDN G FE L TLL G YNH K LRI LLE TVVGKI A N FE VKPD RFA VI K ETVTKEYQ N YKFRQ PY H Q AMYYC S LI LQ DQ 653
Cdd:COG1025 589 AGL S Y SLYAHQG G LT L SAS G FTQ K QPK LLE ALLDQL A S FE PTEE RFA QA K SQLLRQLD N AEKAK PY S Q LFSPL S RL LQ PP 668
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 654 TWPWT E E L DV L SHLEAE D VAK F VPM LL SRTFI E CYIA GN VENNE A ESMVKHIEDV L FND - PKPIC R plfpsqhlt NR VV K 732
Cdd:COG1025 669 YFERE E L L AA L ESITLQ D LRA F REQ LL QQLHL E MLVV GN LSEEQ A KQLADSLKKQ L APN g TGEEP R --------- RQ VV D 739
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 733 L GEGMKYFYHQDGSNP sde N SAL VH Y I Q VH - RDDF SM N iklq L FG L VAK -- QAT F - H QLRT V EQLGY I --- TALAQRNDS 805
Cdd:COG1025 740 L DKSGSLNLEKACDHT --- D SAL LI Y Y Q SG y DSLA SM A ---- L SS L LGQ ii SPW F f N QLRT E EQLGY V vga GYMPLGRQP 812
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 806 G I ygv Q F II QS S V KG P GHIDS R VESL LK N FE SK L YEM S N E D F KSNVTA LI DMK LE KHK NL K EE SRFY W RE I QS G TLK F NR 885
Cdd:COG1025 813 G L --- G F YV QS P V AS P AYLLE R IDDF LK Q FE ER L LAL S E E E F AQYKQG LI NQL LE PDQ NL S EE AQRL W VD I GN G DFE F DT 889
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227435 886 K E AEVS A L K Q L QKQE LIDFF DE yi K V G A ARKKS L SIRVY G SQ H lkemas D K DEVPSPSVE I E DI VG F R K SQ P L 958
Cdd:COG1025 890 R E KLIA A V K K L TRAD LIDFF QQ -- A V I A PQGLR L LSQSQ G TK H ------ S K ADELKGWKT I T DI SA F Q K TL P V 954
PRK15101
PRK15101 protease3; Provisional
15-905
3.62e-140
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 443.26
E-value: 3.62e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 15 I L K PRT D N R E Y RM I V L K N LLQ VLL I SDP DTD K CA A SMSVS VGS FS DP QGLE GLAH F LEHM LFYA S E KYP EE DS YSKYITE 94
Cdd:PRK15101 34 I R K SEK D P R Q Y QA I R L D N GMT VLL V SDP QAV K SL A ALALP VGS LE DP DAQQ GLAH Y LEHM VLMG S K KYP QP DS LAEFLKK 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 95 HGGS T NA Y TAS EE T NYHFD V NA D CFDE A L DR F A QFFIK PL MS --- AD atm RE IK AV DS E NQKNLLS DG W R IR Q LQKHLSK 171
Cdd:PRK15101 114 HGGS H NA S TAS YR T AFYLE V EN D ALPP A V DR L A DAIAE PL LD pkn AD --- RE RN AV NA E LTMARSR DG M R MA Q VSAETIN 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 172 ED HP YHK FS T GN MD TL HVR P QA K GV D trs E L IK FY EEH YSAN I M HL V V Y GKES L DKIQD L VERM F QEIQ N T N KV VP RFPG 251
Cdd:PRK15101 191 PA HP GSR FS G GN LE TL SDK P GS K LQ D --- A L VD FY QRY YSAN L M KA V I Y SNQP L PELAK L AADT F GRVP N K N AS VP EITV 267
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 252 QPC T ADHLQ I LVKAI P IKQGHK L G V SWPVTPSIHHYDEAPSQ Y LGH LIG HEGE G S L FHA L KTL G W A T G L SAG e GEWTL D Y 331
Cdd:PRK15101 268 PVV T DAQKG I IIHYV P AQPRKV L R V EFRIDNNSAKFRSKTDE Y ISY LIG NRSP G T L SDW L QKQ G L A E G I SAG - ADPMV D R 346
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 332 S -- F F KV S ID LTD A G HEHMQEILGLL F N Y IQ LL QQT G VCQWI FDEL SAICETK F H Y QDKIPP M S YI VDI A SN M QIY P TKD 409
Cdd:PRK15101 347 N sg V F AI S VS LTD K G LAQRDQVVAAI F S Y LN LL REK G IDKSY FDEL AHVLDLD F R Y PSITRD M D YI EWL A DT M LRV P VEH 426
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 410 W L VGSSLPTKFN P AIVQKVVD E LS P S N F RI FWE S QK fe GQTD K AEPWYNTA Y SLE KI TSS T IQE W V Q S A PDVH L H LP AP N 489
Cdd:PRK15101 427 T L DAPYIADRYD P KAIKARLA E MT P Q N A RI WYI S PQ -- EPHN K TAYFVDAP Y QVD KI SEQ T FAD W Q Q K A QNIA L S LP EL N 504
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 490 VF IP T D L SL KD AD DKETV P V L LRKT P FS R LW Y K P DTM F - SK PKA YVKMDFNC P L A VS S PDAA VL tdi F T rl L M DYL N --- 565
Cdd:PRK15101 505 PY IP D D F SL IK AD KAYKH P E L IVDE P GL R VV Y M P SQY F a DE PKA DISLVLRN P K A MD S ARNQ VL --- F A -- L N DYL A gla 579
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 566 -- EYAYY A Q V A G LYYGVS l SD NG FELTLL GY NHK L RI LL ETVVGKIAN F EVKPDRF A VI K ETVTKEYQNYKFRQP Y H QA M 643
Cdd:PRK15101 580 ld QLSNQ A S V G G ISFSTN - AN NG LMVNAN GY TQR L PQ LL QALLEGYFS F TPTEEQL A QA K SWYREQLDSAEKGKA Y E QA I 658
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 644 YYCSLIL Q dqt W P WT E E --- LDV L SHLEAE DV AKFVPM LLS RTFI E CYIA GN VENNEAESMVKHIEDV L FN D PKPIC R pl 720
Cdd:PRK15101 659 MPAQMLS Q --- V P YF E R der RKL L PSITLK DV LAYRDA LLS GATP E FLVV GN LTEEQVTTLARDVQKQ L GA D GTEWW R -- 733
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 721 fpsqhlt NRV V KLGEGMKYFYHQD GS N psd EN SAL - VH Y IQVHR D DFSMNIKLQ L F G LVAKQATFH QLRT V EQLGY ITAL 799
Cdd:PRK15101 734 ------- GKD V VVDKKQSVNFEKA GS S --- TD SAL a AV Y VPTGY D EYQSSAYSS L L G QIIQPWFYN QLRT E EQLGY AVFA 803
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 800 AQRNDSGIY G VQ F II QS SV K G P GHIDS R VESLLKNF E S KL YE M SN E D F KSNVT ALI DMK L EKHKN L K EE SRFYWREIQS G 879
Cdd:PRK15101 804 FPMSVGRQW G MG F LL QS ND K Q P AYLWQ R YQAFFPQA E A KL RA M KP E E F AQYQQ ALI NQL L QAPQT L G EE ASRLSKDFDR G 883
890 900
....*....|....*....|....*.
gi 15227435 880 TLK F NRKEAEVSAL K Q L QK Q E L I DFF 905
Cdd:PRK15101 884 NMR F DSRDKIIAQI K L L TP Q K L A DFF 909
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
383-663
9.52e-132
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 398.10
E-value: 9.52e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 383 F HY Q D K I PP MS Y IVDI ASNMQ I YP TK D W L V G SS L PTKFN P AIV Q KVV D E L S P S N F RI FWE S QK FEG Q TD KA EPWY N T A YS 462
Cdd:pfam16187 1 F RF Q E K S PP SD Y VSSL ASNMQ P YP PE D I L S G DY L LREYD P ELI Q ELL D Y L T P E N A RI TLV S KE FEG E TD QK EPWY G T E YS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 463 L E K I TSSTIQE W VQSA - P DVH LHLP A PN V FIPTD LS LK DADD KE -- TV PVL L R K TP F SRLWYK P D TM F SK PKA YVKMDFN 539
Cdd:pfam16187 81 V E P I PEELLKK W KNAP e P NPE LHLP E PN P FIPTD FD LK KKEV KE pa KY PVL I R D TP L SRLWYK K D DT F WV PKA NIYLSLR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 540 C PLA V SSP DA AVLT DIFTR LL M D Y LNEYAY Y A QV AGL Y Y GV S LSDN G FE L TLL GYN H KL RI LLE TVVG K IAN FE VK PDRF 619
Cdd:pfam16187 161 S PLA Y SSP RN AVLT RLYVE LL K D S LNEYAY D A EL AGL S Y SL S ATER G LT L SVS GYN D KL PV LLE KILE K LRD FE ID PDRF 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 15227435 620 AV IKE TVTKE Y Q N YKFR QPY H QA MY Y CSLI L QDQT W PWT E E L DV 663
Cdd:pfam16187 241 EI IKE QLLRS Y K N FALE QPY Q QA FD Y LLYL L EERS W TPE E K L EA 284
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
26-365
1.87e-35
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 144.63
E-value: 1.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 26 R M I V L K N L L Q V L L ISD PD TDKC AA SMS V SV GS FSD P QGLE GLAHFLEH M LF YAS E KYPEE D SYSKYITEH GG ST NA Y T AS 105
Cdd:TIGR02110 1 R R I T L P N G L R V H L YHQ PD AKRA AA LLR V AA GS HDE P SAWP GLAHFLEH L LF LGG E RFQGD D RLMPWVQRQ GG QV NA T T LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 106 EE T NYH F DVN A DCFDEA L D R FAQFFIK PL MS A DATM RE IKAVDS E NQ kn LLS - D GWRI R QLQ - KHLSKED HP YHK F ST G N 183
Cdd:TIGR02110 81 RT T AFF F ELP A AALAAG L A R LCDMLAR PL LT A EDQQ RE REVLEA E YI -- AWQ n D ADTL R EAA l LDALQAG HP LRR F HA G S 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 184 M D T L HVRPQ A kgvd TRSE L IK F YEE HY S A NI M H L VVY G KE SLD KIQD L VE R MFQEIQNTNKVVPRF P GQPCTA D H L QILV 263
Cdd:TIGR02110 159 R D S L ALPNT A ---- FQQA L RD F HRR HY Q A GN M Q L WLQ G PQ SLD ELEQ L AA R FGASLAAGGECAQAP P APLLRF D R L TLAG 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 264 KAI P IK qghklgvs W p VTPSIHHYDEAPSQ --- Y L GHLIGH E GE G S L FHA L KTL G W A TGLS A G ----- E G EWT L DYS F fk 335
Cdd:TIGR02110 235 GSE P RL -------- W - LLFALAGLPATARD nvt L L CEFLQD E AP G G L LAQ L RER G L A ESVA A T wlyqd A G QAL L ALE F -- 303
330 340 350
....*....|....*....|....*....|
gi 15227435 336 vsi DLTDAGHEHM Q E I LG LL FNYIQL L QQT 365
Cdd:TIGR02110 304 --- SARCISAAAA Q Q I EQ LL TQWLGA L AEQ 330
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
14-958
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 836.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 14 E I L K PRT D N R E YR M I V L K N L L Q VLL I SDP DT DK C AA SMS V S VGSF S DP QGLE GLAHFLEHMLF YASE KYPE EDS Y SKY I T 93
Cdd:COG1025 34 T I I K SPN D P R Q YR A I T L D N G L K VLL V SDP QA DK S AA ALA V P VGSF D DP DDQQ GLAHFLEHMLF LGTK KYPE PGE Y QEF I S 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 94 E HGGS T NA Y TA S E E TNY H F D V NA D CFD EALDRFA Q FF IK PL MSADATM RE IK AV DS E NQKNLLS DG W RI R Q LQ K HLSKED 173
Cdd:COG1025 114 K HGGS H NA S TA T E R TNY Y F E V EN D ALE EALDRFA D FF AA PL FDPEYVD RE RN AV NA E YTLKRSD DG R RI Y Q VH K ETLNPA 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 174 HP YHK FS T GN MD TL HVR P QA K gvd T R S EL IK FY EEH YSAN I M H LV V Y GKE SLD KIQD L VERM F QE I Q N T N KV VP RFPGQP 253
Cdd:COG1025 194 HP FSR FS V GN LE TL SDK P GS K --- L R D EL LA FY QRY YSAN L M K LV L Y SNQ SLD ELEK L ARQT F GA I P N R N LS VP PITVPL 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 254 C T ADH L Q I LVKAI P I K QGHK L GVSW P VTPSIHH Y DEA P SQ Y LGH L I G H EGEGSL FHA LK TL G W A TG LSAG E G EWTLDYSF 333
Cdd:COG1025 271 Y T PEQ L G I IIHIV P L K PRRQ L RLEF P IPNNQAY Y RSK P LT Y ISY L L G N EGEGSL LDW LK KQ G L A ES LSAG G G ISGRNFGD 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 334 F KV S ID LTD A G HE H MQ EI LGLL F N YI Q L LQ Q T G VCQ W I FDE LSAIC E TK F HY Q D K IP PM S Y IVDIAS NM QI YP TK D W L VG 413
Cdd:COG1025 351 F SI S VS LTD K G LA H RD EI IAAV F A YI E L IR Q Q G IQE W Y FDE QAQLL E LA F RF Q E K TR PM D Y VSWLSD NM LR YP VE D V L DA 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 414 SS L PTK F N PA IVQKVVDE L S P S N F RI FWE S Q kf EGQ TDK AEP WY N T A YS LEK IT SSTIQE W V Q SAPDVH L H LP AP N VF IP 493
Cdd:COG1025 431 DY L MDG F D PA AIRARLAQ L T P E N A RI WLI S P -- DVP TDK TAY WY D T P YS VDP IT QEQLAK W Q Q ASQNPA L S LP EL N PY IP 508
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 494 T D L SL KDA D DKETV P V LL RKT P FS RLWY K PD TM F SK PKA YVKMDFNC P L AV S S PDAA VLT DIFTR LL M D Y LNE YA Y Y A Q V 573
Cdd:COG1025 509 D D F SL IKL D KESAK P E LL VDE P GL RLWY M PD QY F AE PKA DIYLSLRN P Q AV D S ARNQ VLT RLLDY LL N D A LNE LS Y Q A S V 588
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 574 AGL Y Y GVSLSDN G FE L TLL G YNH K LRI LLE TVVGKI A N FE VKPD RFA VI K ETVTKEYQ N YKFRQ PY H Q AMYYC S LI LQ DQ 653
Cdd:COG1025 589 AGL S Y SLYAHQG G LT L SAS G FTQ K QPK LLE ALLDQL A S FE PTEE RFA QA K SQLLRQLD N AEKAK PY S Q LFSPL S RL LQ PP 668
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 654 TWPWT E E L DV L SHLEAE D VAK F VPM LL SRTFI E CYIA GN VENNE A ESMVKHIEDV L FND - PKPIC R plfpsqhlt NR VV K 732
Cdd:COG1025 669 YFERE E L L AA L ESITLQ D LRA F REQ LL QQLHL E MLVV GN LSEEQ A KQLADSLKKQ L APN g TGEEP R --------- RQ VV D 739
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 733 L GEGMKYFYHQDGSNP sde N SAL VH Y I Q VH - RDDF SM N iklq L FG L VAK -- QAT F - H QLRT V EQLGY I --- TALAQRNDS 805
Cdd:COG1025 740 L DKSGSLNLEKACDHT --- D SAL LI Y Y Q SG y DSLA SM A ---- L SS L LGQ ii SPW F f N QLRT E EQLGY V vga GYMPLGRQP 812
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 806 G I ygv Q F II QS S V KG P GHIDS R VESL LK N FE SK L YEM S N E D F KSNVTA LI DMK LE KHK NL K EE SRFY W RE I QS G TLK F NR 885
Cdd:COG1025 813 G L --- G F YV QS P V AS P AYLLE R IDDF LK Q FE ER L LAL S E E E F AQYKQG LI NQL LE PDQ NL S EE AQRL W VD I GN G DFE F DT 889
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227435 886 K E AEVS A L K Q L QKQE LIDFF DE yi K V G A ARKKS L SIRVY G SQ H lkemas D K DEVPSPSVE I E DI VG F R K SQ P L 958
Cdd:COG1025 890 R E KLIA A V K K L TRAD LIDFF QQ -- A V I A PQGLR L LSQSQ G TK H ------ S K ADELKGWKT I T DI SA F Q K TL P V 954
PRK15101
PRK15101 protease3; Provisional
15-905
3.62e-140
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 443.26
E-value: 3.62e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 15 I L K PRT D N R E Y RM I V L K N LLQ VLL I SDP DTD K CA A SMSVS VGS FS DP QGLE GLAH F LEHM LFYA S E KYP EE DS YSKYITE 94
Cdd:PRK15101 34 I R K SEK D P R Q Y QA I R L D N GMT VLL V SDP QAV K SL A ALALP VGS LE DP DAQQ GLAH Y LEHM VLMG S K KYP QP DS LAEFLKK 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 95 HGGS T NA Y TAS EE T NYHFD V NA D CFDE A L DR F A QFFIK PL MS --- AD atm RE IK AV DS E NQKNLLS DG W R IR Q LQKHLSK 171
Cdd:PRK15101 114 HGGS H NA S TAS YR T AFYLE V EN D ALPP A V DR L A DAIAE PL LD pkn AD --- RE RN AV NA E LTMARSR DG M R MA Q VSAETIN 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 172 ED HP YHK FS T GN MD TL HVR P QA K GV D trs E L IK FY EEH YSAN I M HL V V Y GKES L DKIQD L VERM F QEIQ N T N KV VP RFPG 251
Cdd:PRK15101 191 PA HP GSR FS G GN LE TL SDK P GS K LQ D --- A L VD FY QRY YSAN L M KA V I Y SNQP L PELAK L AADT F GRVP N K N AS VP EITV 267
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 252 QPC T ADHLQ I LVKAI P IKQGHK L G V SWPVTPSIHHYDEAPSQ Y LGH LIG HEGE G S L FHA L KTL G W A T G L SAG e GEWTL D Y 331
Cdd:PRK15101 268 PVV T DAQKG I IIHYV P AQPRKV L R V EFRIDNNSAKFRSKTDE Y ISY LIG NRSP G T L SDW L QKQ G L A E G I SAG - ADPMV D R 346
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 332 S -- F F KV S ID LTD A G HEHMQEILGLL F N Y IQ LL QQT G VCQWI FDEL SAICETK F H Y QDKIPP M S YI VDI A SN M QIY P TKD 409
Cdd:PRK15101 347 N sg V F AI S VS LTD K G LAQRDQVVAAI F S Y LN LL REK G IDKSY FDEL AHVLDLD F R Y PSITRD M D YI EWL A DT M LRV P VEH 426
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 410 W L VGSSLPTKFN P AIVQKVVD E LS P S N F RI FWE S QK fe GQTD K AEPWYNTA Y SLE KI TSS T IQE W V Q S A PDVH L H LP AP N 489
Cdd:PRK15101 427 T L DAPYIADRYD P KAIKARLA E MT P Q N A RI WYI S PQ -- EPHN K TAYFVDAP Y QVD KI SEQ T FAD W Q Q K A QNIA L S LP EL N 504
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 490 VF IP T D L SL KD AD DKETV P V L LRKT P FS R LW Y K P DTM F - SK PKA YVKMDFNC P L A VS S PDAA VL tdi F T rl L M DYL N --- 565
Cdd:PRK15101 505 PY IP D D F SL IK AD KAYKH P E L IVDE P GL R VV Y M P SQY F a DE PKA DISLVLRN P K A MD S ARNQ VL --- F A -- L N DYL A gla 579
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 566 -- EYAYY A Q V A G LYYGVS l SD NG FELTLL GY NHK L RI LL ETVVGKIAN F EVKPDRF A VI K ETVTKEYQNYKFRQP Y H QA M 643
Cdd:PRK15101 580 ld QLSNQ A S V G G ISFSTN - AN NG LMVNAN GY TQR L PQ LL QALLEGYFS F TPTEEQL A QA K SWYREQLDSAEKGKA Y E QA I 658
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 644 YYCSLIL Q dqt W P WT E E --- LDV L SHLEAE DV AKFVPM LLS RTFI E CYIA GN VENNEAESMVKHIEDV L FN D PKPIC R pl 720
Cdd:PRK15101 659 MPAQMLS Q --- V P YF E R der RKL L PSITLK DV LAYRDA LLS GATP E FLVV GN LTEEQVTTLARDVQKQ L GA D GTEWW R -- 733
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 721 fpsqhlt NRV V KLGEGMKYFYHQD GS N psd EN SAL - VH Y IQVHR D DFSMNIKLQ L F G LVAKQATFH QLRT V EQLGY ITAL 799
Cdd:PRK15101 734 ------- GKD V VVDKKQSVNFEKA GS S --- TD SAL a AV Y VPTGY D EYQSSAYSS L L G QIIQPWFYN QLRT E EQLGY AVFA 803
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 800 AQRNDSGIY G VQ F II QS SV K G P GHIDS R VESLLKNF E S KL YE M SN E D F KSNVT ALI DMK L EKHKN L K EE SRFYWREIQS G 879
Cdd:PRK15101 804 FPMSVGRQW G MG F LL QS ND K Q P AYLWQ R YQAFFPQA E A KL RA M KP E E F AQYQQ ALI NQL L QAPQT L G EE ASRLSKDFDR G 883
890 900
....*....|....*....|....*.
gi 15227435 880 TLK F NRKEAEVSAL K Q L QK Q E L I DFF 905
Cdd:PRK15101 884 NMR F DSRDKIIAQI K L L TP Q K L A DFF 909
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
383-663
9.52e-132
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 398.10
E-value: 9.52e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 383 F HY Q D K I PP MS Y IVDI ASNMQ I YP TK D W L V G SS L PTKFN P AIV Q KVV D E L S P S N F RI FWE S QK FEG Q TD KA EPWY N T A YS 462
Cdd:pfam16187 1 F RF Q E K S PP SD Y VSSL ASNMQ P YP PE D I L S G DY L LREYD P ELI Q ELL D Y L T P E N A RI TLV S KE FEG E TD QK EPWY G T E YS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 463 L E K I TSSTIQE W VQSA - P DVH LHLP A PN V FIPTD LS LK DADD KE -- TV PVL L R K TP F SRLWYK P D TM F SK PKA YVKMDFN 539
Cdd:pfam16187 81 V E P I PEELLKK W KNAP e P NPE LHLP E PN P FIPTD FD LK KKEV KE pa KY PVL I R D TP L SRLWYK K D DT F WV PKA NIYLSLR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 540 C PLA V SSP DA AVLT DIFTR LL M D Y LNEYAY Y A QV AGL Y Y GV S LSDN G FE L TLL GYN H KL RI LLE TVVG K IAN FE VK PDRF 619
Cdd:pfam16187 161 S PLA Y SSP RN AVLT RLYVE LL K D S LNEYAY D A EL AGL S Y SL S ATER G LT L SVS GYN D KL PV LLE KILE K LRD FE ID PDRF 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 15227435 620 AV IKE TVTKE Y Q N YKFR QPY H QA MY Y CSLI L QDQT W PWT E E L DV 663
Cdd:pfam16187 241 EI IKE QLLRS Y K N FALE QPY Q QA FD Y LLYL L EERS W TPE E K L EA 284
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
14-367
6.23e-47
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 173.96
E-value: 6.23e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 14 EILKPRTDNREYRMIV L K N L L Q V L L IS DP DTDKCAASMS V S VGS FSD P Q G LE GLAHFLEHMLF YASE K YPEED s YSKYIT 93
Cdd:COG0612 4 AAGAAPAAAPDVEEFT L P N G L R V I L VP DP EAPVVSVRLW V R VGS RDE P P G KT GLAHFLEHMLF KGTK K RSAGE - IAEELE 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 94 EH GGS T NA Y T ASEE T N Y HFD V NADCFDE AL DRF A QFFIK P LMSADATM RE IKA V DS E NQKNLLSDGWRI - RQ L QKH L SK e 172
Cdd:COG0612 83 AL GGS L NA F T SFDY T V Y YLS V LSEDLEL AL ELL A DRLLN P TFDEEELE RE RGV V LE E IRRYEDDPDGLA f EA L LAA L YG - 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 173 DHPY HKFST G NMDTL hvrpqa KGV d TR SE L IK FY EEH Y SA N IMH LVV Y G KESLDKIQD LVE RM F QEIQNTNKVVPRF P GQ 252
Cdd:COG0612 162 DHPY GRPII G TEESI ------ EAI - TR ED L RA FY KRY Y RP N NAV LVV V G DVDPEEVLA LVE KY F GDLPAGPAPPRPD P AE 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 253 P CTADHLQIL V KAIPIK Q G H k LGVSW P v T P SIHHY D EAPSQY L GHLI G H e G EG S - LF HA L - KTL G W A TGLSAG e GEWTL D 330
Cdd:COG0612 235 P PQTGPRRVV V DDPDAE Q A H - ILLGY P - G P ARDDP D YYALDV L NEIL G G - G FS S r LF QE L r EKK G L A YSVGSS - FSPYR D 310
330 340 350
....*....|....*....|....*....|....*..
gi 15227435 331 YSF F KVSIDLTD agh EHMQ E I L GLLFNYIQL L QQT GV 367
Cdd:COG0612 311 AGL F TIYAGTAP --- DKLE E A L AAILEELER L AKE GV 344
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
26-365
1.87e-35
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 144.63
E-value: 1.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 26 R M I V L K N L L Q V L L ISD PD TDKC AA SMS V SV GS FSD P QGLE GLAHFLEH M LF YAS E KYPEE D SYSKYITEH GG ST NA Y T AS 105
Cdd:TIGR02110 1 R R I T L P N G L R V H L YHQ PD AKRA AA LLR V AA GS HDE P SAWP GLAHFLEH L LF LGG E RFQGD D RLMPWVQRQ GG QV NA T T LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 106 EE T NYH F DVN A DCFDEA L D R FAQFFIK PL MS A DATM RE IKAVDS E NQ kn LLS - D GWRI R QLQ - KHLSKED HP YHK F ST G N 183
Cdd:TIGR02110 81 RT T AFF F ELP A AALAAG L A R LCDMLAR PL LT A EDQQ RE REVLEA E YI -- AWQ n D ADTL R EAA l LDALQAG HP LRR F HA G S 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 184 M D T L HVRPQ A kgvd TRSE L IK F YEE HY S A NI M H L VVY G KE SLD KIQD L VE R MFQEIQNTNKVVPRF P GQPCTA D H L QILV 263
Cdd:TIGR02110 159 R D S L ALPNT A ---- FQQA L RD F HRR HY Q A GN M Q L WLQ G PQ SLD ELEQ L AA R FGASLAAGGECAQAP P APLLRF D R L TLAG 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 264 KAI P IK qghklgvs W p VTPSIHHYDEAPSQ --- Y L GHLIGH E GE G S L FHA L KTL G W A TGLS A G ----- E G EWT L DYS F fk 335
Cdd:TIGR02110 235 GSE P RL -------- W - LLFALAGLPATARD nvt L L CEFLQD E AP G G L LAQ L RER G L A ESVA A T wlyqd A G QAL L ALE F -- 303
330 340 350
....*....|....*....|....*....|
gi 15227435 336 vsi DLTDAGHEHM Q E I LG LL FNYIQL L QQT 365
Cdd:TIGR02110 304 --- SARCISAAAA Q Q I EQ LL TQWLGA L AEQ 330
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
36-171
4.55e-35
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 130.50
E-value: 4.55e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 36 V LLI SDP DT D KCAASMSVSV GS FSD P QGLE GLAHFLEHM L F YASE KYP E e DSYSKYITEH GGS T NA Y T AS E E T N Y HFD V N 115
Cdd:pfam00675 2 V ASE SDP PA D TSTVGLWIDA GS RYE P DNNN GLAHFLEHM A F KGTK KYP S - NELEEELEKL GGS L NA F T SR E N T V Y YAE V L 80
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227435 116 A D CFDE A L DR F A Q FF IK PL M ------- SADATMR E IK AVDSE N Q K ---- NL LSDGW R IRQ L QKH L SK 171
Cdd:pfam00675 81 N D DLPK A V DR L A D FF RN PL F teseier ERLVVLY E VE AVDSE P Q L vvle NL HAAAY R NTP L GRS L LG 147
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
198-375
2.45e-33
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 126.74
E-value: 2.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 198 TR SE L IK FY EE HYS ANI M H LV VY G KESLDKIQ DL V E RM F QEIQNTN K VV PR F P GQPCTADHLQIL V KAIPIKQGHK L GVS 277
Cdd:pfam05193 3 TR ED L RD FY KK HYS PDN M V LV IV G DVDHEELL DL A E KY F GDLPASP K GK PR P P PLEPAKLKGREV V VPKKDEPQAH L ALA 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 278 W P VT P SIHHY D EAPSQY L GH L I G HEGEGS LF HA L KT - L G W A TGL S AG e GEWTL D YSF F KVSIDLTD agh E HMQ E ILG L LF 356
Cdd:pfam05193 83 F P GP P LNNDE D SLALDV L NE L L G GGMSSR LF QE L RE k E G L A YSV S SF - NDSYS D SGL F GIYATVDP --- E NVD E VIE L IL 158
170
....*....|....*....
gi 15227435 357 NYIQL L Q Q T GV CQWIFDEL 375
Cdd:pfam05193 159 EELEK L A Q E GV TEEELERA 177
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
666-854
1.96e-13
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 69.73
E-value: 1.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 666 H L EA ED VAK F VPMLL S RTFIECY I A G N V ENN E AESMV - K HIE D VLFN - DP KP ICR PL F P SQHLTNR VV K lgegmkyf YHQ 743
Cdd:pfam05193 1 S L TR ED LRD F YKKHY S PDNMVLV I V G D V DHE E LLDLA e K YFG D LPAS p KG KP RPP PL E P AKLKGRE VV V -------- PKK 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227435 744 D GSNPSDENSALVHYIQVHR D DFSMNIKLQ L F G LVAKQAT F HQ LR TV E Q L G Y ITA -- LAQRN DSG IY G VQFIIQ ssvkg P 821
Cdd:pfam05193 73 D EPQAHLALAFPGPPLNNDE D SLALDVLNE L L G GGMSSRL F QE LR EK E G L A Y SVS sf NDSYS DSG LF G IYATVD ----- P 147
170 180 190
....*....|....*....|....*....|....
gi 15227435 822 GHI D SRV E SL L KNF E SKLY E - MSN E DFKSNVTA L 854
Cdd:pfam05193 148 ENV D EVI E LI L EEL E KLAQ E g VTE E ELERAKNQ L 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
