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Conserved domains on  [gi|30688506|ref|NP_181637|]
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S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 178-296 4.91e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 103.92  E-value: 4.91e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 178 EYFKEAEGGLLVDVSCGSGLFSRKFAQSGKYsgVIALDYSENMLRQCKEFIKndntfDNSTNIAVVRADVSRLPFPSGSV 257
Cdd:COG2226  16 AALGLRPGARVLDLGCGTGRLALALAERGAR--VTGVDISPEMLELARERAA-----EAGLNVEFVVGDAEDLPFPDGSF 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 30688506 258 DAVHAGAALHCWPSPTNAIAEICRVLRSGGVFVGTTFLR 296
Cdd:COG2226  89 DLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 178-296 4.91e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 103.92  E-value: 4.91e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 178 EYFKEAEGGLLVDVSCGSGLFSRKFAQSGKYsgVIALDYSENMLRQCKEFIKndntfDNSTNIAVVRADVSRLPFPSGSV 257
Cdd:COG2226  16 AALGLRPGARVLDLGCGTGRLALALAERGAR--VTGVDISPEMLELARERAA-----EAGLNVEFVVGDAEDLPFPDGSF 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 30688506 258 DAVHAGAALHCWPSPTNAIAEICRVLRSGGVFVGTTFLR 296
Cdd:COG2226  89 DLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 189-290 5.08e-25

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 96.97  E-value: 5.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   189 VDVSCGSGLFSRKFAQSGKYsgVIALDYSENMLRQCKEFIKNDNtfdnstnIAVVRADVSRLPFPSGSVDAVHAGAALHC 268
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR--VTGVDISPEMLELAREKAPREG-------LTFVVGDAEDLPFPDNSFDLVLSSEVLHH 71

                          90       100
                  ....*....|....*....|..
gi 30688506   269 WPSPTNAIAEICRVLRSGGVFV 290
Cdd:pfam08241  72 VEDPERALREIARVLKPGGILI 93
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 190-344 3.95e-18

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 82.33  E-value: 3.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   190 DVSCGSGLFSRKFAQSGKYSGVIALDYSENMLRQCKEfikndntfDNSTNIAVVRADVSRLPFPSGSVDAVHAGAALHCW 269
Cdd:TIGR02072  40 DIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKT--------KLSENVQFICGDAEKLPLEDSSFDLIVSNLALQWC 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30688506   270 PSPTNAIAEICRVLRSGGVFVGTTFLrySPSTPWIIRPFQSRILqsyNYLMQDEIKDVCTSCG--LTDYEDYIQDSF 344
Cdd:TIGR02072 112 DDLSQALSELARVLKPGGLLAFSTFG--PGTLHELRQSFGQHGL---RYLSLDELKALLKNSFelLTLEEELITLSF 183
PRK08317 PRK08317
hypothetical protein; Provisional
 184-287 1.07e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 81.14  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506  184 EGGLLVDVSCGSGLFSRKFA-QSGKYSGVIALDYSENMLRQCKEFIKNDNTfdnstNIAVVRADVSRLPFPSGSVDAVHA 262
Cdd:PRK08317  19 PGDRVLDVGCGPGNDARELArRVGPEGRVVGIDRSEAMLALAKERAAGLGP-----NVEFVRGDADGLPFPDGSFDAVRS 93

                         90       100
                 ....*....|....*....|....*
gi 30688506  263 GAALHCWPSPTNAIAEICRVLRSGG 287
Cdd:PRK08317  94 DRVLQHLEDPARALAEIARVLRPGG 118
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 188-295 3.91e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.06  E-value: 3.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 188 LVDVSCGSGLFSRKFAQSGKYSgVIALDYSENMLRQCKEFIKNDNTFdnstNIAVVRADVSRLPF-PSGSVDAVHAGAAL 266
Cdd:cd02440   2 VLDLGCGTGALALALASGPGAR-VTGVDISPVALELARKAAAALLAD----NVEVLKGDAEELPPeADESFDVIISDPPL 76

                        90       100       110
                ....*....|....*....|....*....|
gi 30688506 267 HCWPSPTNAIAEIC-RVLRSGGVFVGTTFL 295
Cdd:cd02440  77 HHLVEDLARFLEEArRLLKPGGVLVLTLVL 106
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 178-296 4.91e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 103.92  E-value: 4.91e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 178 EYFKEAEGGLLVDVSCGSGLFSRKFAQSGKYsgVIALDYSENMLRQCKEFIKndntfDNSTNIAVVRADVSRLPFPSGSV 257
Cdd:COG2226  16 AALGLRPGARVLDLGCGTGRLALALAERGAR--VTGVDISPEMLELARERAA-----EAGLNVEFVVGDAEDLPFPDGSF 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 30688506 258 DAVHAGAALHCWPSPTNAIAEICRVLRSGGVFVGTTFLR 296
Cdd:COG2226  89 DLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 189-290 5.08e-25

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 96.97  E-value: 5.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   189 VDVSCGSGLFSRKFAQSGKYsgVIALDYSENMLRQCKEFIKNDNtfdnstnIAVVRADVSRLPFPSGSVDAVHAGAALHC 268
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR--VTGVDISPEMLELAREKAPREG-------LTFVVGDAEDLPFPDNSFDLVLSSEVLHH 71

                          90       100
                  ....*....|....*....|..
gi 30688506   269 WPSPTNAIAEICRVLRSGGVFV 290
Cdd:pfam08241  72 VEDPERALREIARVLKPGGILI 93
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 190-287 1.19e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 93.40  E-value: 1.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   190 DVSCGSGLFSRKFAQSGKYSgVIALDYSENMLRQCKEFIKndntfDNSTNIAVVRADVSRLPFPSGSVDAVHAGAALHCW 269
Cdd:pfam13649   3 DLGCGTGRLTLALARRGGAR-VTGVDLSPEMLERARERAA-----EAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHL 76

                          90       100
                  ....*....|....*....|
gi 30688506   270 PSP--TNAIAEICRVLRSGG 287
Cdd:pfam13649  77 PDPdlEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 183-293 2.62e-18

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 79.68  E-value: 2.62e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 183 AEGGLLVDVSCGSGLFSRKFAQSGkYSgVIALDYSENMLRQCKEFIKndntfdnSTNIAVVRADVSRLPFPSGSVDAVHA 262
Cdd:COG2227  23 PAGGRVLDVGCGTGRLALALARRG-AD-VTGVDISPEALEIARERAA-------ELNVDFVQGDLEDLPLEDGSFDLVIC 93

                        90       100       110
                ....*....|....*....|....*....|.
gi 30688506 263 GAALHCWPSPTNAIAEICRVLRSGGVFVGTT 293
Cdd:COG2227  94 SEVLEHLPDPAALLRELARLLKPGGLLLLST 124
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 190-344 3.95e-18

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 82.33  E-value: 3.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   190 DVSCGSGLFSRKFAQSGKYSGVIALDYSENMLRQCKEfikndntfDNSTNIAVVRADVSRLPFPSGSVDAVHAGAALHCW 269
Cdd:TIGR02072  40 DIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKT--------KLSENVQFICGDAEKLPLEDSSFDLIVSNLALQWC 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30688506   270 PSPTNAIAEICRVLRSGGVFVGTTFLrySPSTPWIIRPFQSRILqsyNYLMQDEIKDVCTSCG--LTDYEDYIQDSF 344
Cdd:TIGR02072 112 DDLSQALSELARVLKPGGLLAFSTFG--PGTLHELRQSFGQHGL---RYLSLDELKALLKNSFelLTLEEELITLSF 183
PRK08317 PRK08317
hypothetical protein; Provisional
 184-287 1.07e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 81.14  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506  184 EGGLLVDVSCGSGLFSRKFA-QSGKYSGVIALDYSENMLRQCKEFIKNDNTfdnstNIAVVRADVSRLPFPSGSVDAVHA 262
Cdd:PRK08317  19 PGDRVLDVGCGPGNDARELArRVGPEGRVVGIDRSEAMLALAKERAAGLGP-----NVEFVRGDADGLPFPDGSFDAVRS 93

                         90       100
                 ....*....|....*....|....*
gi 30688506  263 GAALHCWPSPTNAIAEICRVLRSGG 287
Cdd:PRK08317  94 DRVLQHLEDPARALAEIARVLRPGG 118
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
184-290 3.34e-17

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 76.02  E-value: 3.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 184 EGGLLVDVSCGSGLFSRKFAQSGKYSGVIALDYSENMLRQCKEfikndntfdNSTNIAVVRADVSRLPFPsGSVDAVHAG 263
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARA---------RLPNVRFVVADLRDLDPP-EPFDLVVSN 70

                        90       100
                ....*....|....*....|....*..
gi 30688506 264 AALHCWPSPTNAIAEICRVLRSGGVFV 290
Cdd:COG4106  71 AALHWLPDHAALLARLAAALAPGGVLA 97
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 155-290 1.62e-16

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 77.89  E-value: 1.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506  155 RGWRQAF-KRSGFPgpdeefrmaeeyfkeaEGGLLVDVSCGSGLFSRKFAQSGKYSG-VIALDYSENMLRQCKEFIKNDN 232
Cdd:PRK00216  37 RVWRRKTiKWLGVR----------------PGDKVLDLACGTGDLAIALAKAVGKTGeVVGLDFSEGMLAVGREKLRDLG 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 30688506  233 TFDNstnIAVVRADVSRLPFPSGSVDAVHAGAALHCWPSPTNAIAEICRVLRSGGVFV 290
Cdd:PRK00216 101 LSGN---VEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLV 155
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
163-352 1.38e-14

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 71.18  E-value: 1.38e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 163 RSGFPGPDEEFRMAEEYFKEAEGGLLVDVSCGSGLFSRKFAQSGKYsgVIALDYSENMLRQCKEfikndntfdNSTNIAV 242
Cdd:COG4976  25 DLGYEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYR--LTGVDLSEEMLAKARE---------KGVYDRL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 243 VRADVSRLPFPSGSVDAVHAGAALHCWPSPTNAIAEICRVLRSGGVFVGTtflryspstpwiIRPFQSRILQSYNylmQD 322
Cdd:COG4976  94 LVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFS------------VEDADGSGRYAHS---LD 158

                       170       180       190
                ....*....|....*....|....*....|
gi 30688506 323 EIKDVCTSCGLTDYedyiqdsFIMFTARKP 352
Cdd:COG4976 159 YVRDLLAAAGFEVP-------GLLVVARKP 181
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 148-309 2.76e-14

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 71.14  E-value: 2.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   148 LVSFLYERGWRQAFKRSGFPGPDEEfrmaeeyfkeaegglLVDVSCGSGLFSRKFAQSGKYSG-VIALDYSENMLRQCKE 226
Cdd:TIGR01934  18 LLSFGLHRLWRRRAVKLIGVFKGQK---------------VLDVACGTGDLAIELAKSAPDRGkVTGVDFSSEMLEVAKK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   227 FIKNDNtfdnstNIAVVRADVSRLPFPSGSVDAVHAGAALHCWPSPTNAIAEICRVLRSGGVFVgttFLRYSPSTPWIIR 306
Cdd:TIGR01934  83 KSELPL------NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLV---ILEFSKPANALLK 153


                  ...
gi 30688506   307 PFQ 309
Cdd:TIGR01934 154 KFY 156
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 188-295 3.91e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.06  E-value: 3.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 188 LVDVSCGSGLFSRKFAQSGKYSgVIALDYSENMLRQCKEFIKNDNTFdnstNIAVVRADVSRLPF-PSGSVDAVHAGAAL 266
Cdd:cd02440   2 VLDLGCGTGALALALASGPGAR-VTGVDISPVALELARKAAAALLAD----NVEVLKGDAEELPPeADESFDVIISDPPL 76

                        90       100       110
                ....*....|....*....|....*....|
gi 30688506 267 HCWPSPTNAIAEIC-RVLRSGGVFVGTTFL 295
Cdd:cd02440  77 HHLVEDLARFLEEArRLLKPGGVLVLTLVL 106
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 189-289 1.39e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 60.46  E-value: 1.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   189 VDVSCGSGLFSRKFAQSGKYSGVIALDYSENMLRQCKEFIKnDNTFDNSTNIAVVRADVSRLPFPsgSVDAVHAGAALHC 268
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLA-ALGLLNAVRVELFQLDLGELDPG--SFDVVVASNVLHH 77

                          90       100
                  ....*....|....*....|.
gi 30688506   269 WPSPTNAIAEICRVLRSGGVF 289
Cdd:pfam08242  78 LADPRAVLRNIRRLLKPGGVL 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 184-290 4.20e-11

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 61.47  E-value: 4.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 184 EGGLLVDVSCGSGLFSRKFAQSGKYSgVIALDYSENMLRQCKEFIKNDNTfdnsTNIAVVRADVSRL-PFPSGSVDAVHA 262
Cdd:COG0500  26 KGGRVLDLGCGTGRNLLALAARFGGR-VIGIDLSPEAIALARARAAKAGL----GNVEFLVADLAELdPLPAESFDLVVA 100

                        90       100       110
                ....*....|....*....|....*....|.
gi 30688506 263 GAALHcWPSPTN---AIAEICRVLRSGGVFV 290
Cdd:COG0500 101 FGVLH-HLPPEEreaLLRELARALKPGGVLL 130
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
184-326 1.27e-10

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 60.53  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   184 EGGLLVDVSCGSGLFSRKFAQSGKYSG-VIALDYSENMLRQCKEFIKNDNTFdnstNIAVVRADVSRLPFPSGSVDAVHA 262
Cdd:pfam01209  42 RGNKFLDVAGGTGDWTFGLSDSAGSSGkVVGLDINENMLKEGEKKAKEEGKY----NIEFLQGNAEELPFEDDSFDIVTI 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30688506   263 GAALHCWPSPTNAIAEICRVLRSGGVFVGTTFLRysPSTPWI----------IRPFQSRIL----QSYNYLmQDEIKD 326
Cdd:pfam01209 118 SFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEFSK--PENPLLsqayelyfkyVMPFMGKMFaksyKSYQYL-QESIRD 192
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 188-290 1.83e-10

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 58.58  E-value: 1.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   188 LVDVSCGSGLFSRKFAQ-SGKYSGVIALDYSENMLRQCKEfIKNDNTFDNstnIAVVRADVSRLP--FPSGSVDAVHAGA 264
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARE-NAQKLGFDN---VEFEQGDIEELPelLEDDKFDVVISNC 82

                          90       100
                  ....*....|....*....|....*.
gi 30688506   265 ALHCWPSPTNAIAEICRVLRSGGVFV 290
Cdd:pfam13847  83 VLNHIPDPDKVLQEILRVLKPGGRLI 108
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 190-298 1.38e-09

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 57.85  E-value: 1.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506  190 DVSCGSGLFSRKFAQSGkySGVIALDYSENMLRQCKEFIKNDNtfdnstniaVVRADVSRLPFPSGSVDAVHAGAALHCW 269
Cdd:PRK10258  48 DAGCGPGWMSRYWRERG--SQVTALDLSPPMLAQARQKDAADH---------YLAGDIESLPLATATFDLAWSNLAVQWC 116

                         90       100
                 ....*....|....*....|....*....
gi 30688506  270 PSPTNAIAEICRVLRSGGVFVGTTFLRYS 298
Cdd:PRK10258 117 GNLSTALRELYRVVRPGGVVAFTTLVQGS 145
PRK05785 PRK05785
hypothetical protein; Provisional
 186-284 1.05e-07

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 52.00  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506  186 GLLVDVSCGSGLFSRKFAQSGKYSgVIALDYSENMLRQckEFIKNDNtfdnstniavVRADVSRLPFPSGSVDAVHAGAA 265
Cdd:PRK05785  53 KKVLDVAAGKGELSYHFKKVFKYY-VVALDYAENMLKM--NLVADDK----------VVGSFEALPFRDKSFDVVMSSFA 119

                         90
                 ....*....|....*....
gi 30688506  266 LHCWPSPTNAIAEICRVLR 284
Cdd:PRK05785 120 LHASDNIEKVIAEFTRVSR 138
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 166-290 8.66e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 48.00  E-value: 8.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 166 FPGPDEEFRMAEEYFKEA--------EGGLLVDVSCGSGLFSRKFAQSGKYSgVIALDYSENMLRQCKEFIKNDNTFDNs 237
Cdd:COG2230  25 FEDPDDTLEEAQEAKLDLilrklglkPGMRVLDIGCGWGGLALYLARRYGVR-VTGVTLSPEQLEYARERAAEAGLADR- 102

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30688506 238 tnIAVVRADVSRLPFPsGSVDAVHAGAALHCWPSP--TNAIAEICRVLRSGGVFV 290
Cdd:COG2230 103 --VEVRLADYRDLPAD-GQFDAIVSIGMFEHVGPEnyPAYFAKVARLLKPGGRLL 154
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 174-343 9.41e-07

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 49.50  E-value: 9.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506  174 RMAEEYFKEAEGGLLVDVSCGSG----LFSRKFAQSGKysgVIALDYS-ENMLRQCKEfiKNDNTFDNSTNIAVVRADVS 248
Cdd:PLN02233  63 RMAVSWSGAKMGDRVLDLCCGSGdlafLLSEKVGSDGK---VMGLDFSsEQLAVAASR--QELKAKSCYKNIEWIEGDAT 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506  249 RLPFPSGSVDAVHAGAALHCWPSPTNAIAEICRVLRSGGvfvGTTFLRYSPSTPWIIRPFQSrilqsynYLMQDEIKDVC 328
Cdd:PLN02233 138 DLPFDDCYFDAITMGYGLRNVVDRLKAMQEMYRVLKPGS---RVSILDFNKSTQPFTTSMQE-------WMIDNVVVPVA 207

                        170
                 ....*....|....*
gi 30688506  329 TSCGLTDYEDYIQDS 343
Cdd:PLN02233 208 TGYGLAKEYEYLKSS 222
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 187-288 2.38e-05

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 45.65  E-value: 2.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506  187 LLVDVSCGSGLFSRKFAQSGKYSGVIALDYSENMLRQC--KEFIKNdntfdnstnIAVVRADVSRLPFPSGSVDAVHAGA 264
Cdd:PLN02490 116 KVVDVGGGTGFTTLGIVKHVDAKNVTILDQSPHQLAKAkqKEPLKE---------CKIIEGDAEDLPFPTDYADRYVSAG 186

                         90       100
                 ....*....|....*....|....
gi 30688506  265 ALHCWPSPTNAIAEICRVLRSGGV 288
Cdd:PLN02490 187 SIEYWPDPQRGIKEAYRVLKIGGK 210
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
170-253 2.39e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 45.03  E-value: 2.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 170 DEEfRMAEeyFKEA------EGGLLVDVSCGSGLFSRKFAQSGKySGVIALDYSENMLRQCKEFIKNdntFDNSTNIAVV 243
Cdd:COG4076  18 DVE-RNDA--FKAAiervvkPGDVVLDIGTGSGLLSMLAARAGA-KKVYAVEVNPDIAAVARRIIAA---NGLSDRITVI 90

                        90
                ....*....|
gi 30688506 244 RADVSRLPFP 253
Cdd:COG4076  91 NADATDLDLP 100
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 188-337 5.46e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 43.19  E-value: 5.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   188 LVDVSCGSGLFSRKFAQSGKysGVIALDYSENMLRQCKEFIKNDNTFDNStniavvradvsrLPFPSGSVDAVHAGAALH 267
Cdd:pfam13489  26 VLDFGCGTGIFLRLLRAQGF--SVTGVDPSPIAIERALLNVRFDQFDEQE------------AAVPAGKFDVIVAREVLE 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30688506   268 CWPSPTNAIAEICRVLRSGGVFVGTTFLRYSPSTPWIIR-PFQSRILQSYNYLMQDEIKDVCTSCGLTDYE 337
Cdd:pfam13489  92 HVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRLLLEwPYLRPRNGHISLFSARSLKRLLEEAGFEVVS 162
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 178-297 1.33e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 42.10  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 178 EYFKEAEGGLLVDVSCGSGLFSRKFAQSGKYSGVIALDYSENMLRQCKEfikndNTFDNS-TNIAVVRADVsRLPFPSGS 256
Cdd:COG2813  43 EHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARA-----NAAANGlENVEVLWSDG-LSGVPDGS 116

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 30688506 257 VDAV------HAGAALHcwPSPTNA-IAEICRVLRSGG--VFVGTTFLRY 297
Cdd:COG2813 117 FDLIlsnppfHAGRAVD--KEVAHAlIADAARHLRPGGelWLVANRHLPY 164
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
236-289 1.89e-04

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 41.39  E-value: 1.89e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506 236 NSTNIAVVRADVS-RLPFPSGSVDAVHAGaalHCW-----PSPTNAIAEICRVLRSGGVF 289
Cdd:COG4627  25 VPAPGVDIVGDLTdPLPFPDNSVDAIYSS---HVLehldyEEAPLALKECYRVLKPGGIL 81
Pox_MCEL pfam03291
mRNA capping enzyme; This family of enzymes are related to pfam03919.
 190-293 5.71e-03

mRNA capping enzyme; This family of enzymes are related to pfam03919.


Pssm-ID: 281307 [Multi-domain]  Cd Length: 332  Bit Score: 38.18  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688506   190 DVSCGSGLFSRKFaQSGKYSGVIALDYSENMLRQCKE-FIK---NDNTFDNSTNIAVVRAD------VSRLPFPSGSVDA 259
Cdd:pfam03291  69 DLGCGKGGDLEKW-FKGGISQLIGTDIAEVSIEQCRErYNKlrsGNKSKYYKFDAEFITGDcfvsslREVFEDPFGKFDI 147

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 30688506   260 VHAGAALH-CWPSPTNA---IAEICRVLRSGGVFVGTT 293
Cdd:pfam03291 148 VSCQFAIHySFESEEKArtmLRNVAELLASGGVFIGTT 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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