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Conserved domains on  [gi|30685713|ref|NP_180904|]
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ROP-interactive CRIB motif-containing protein 1 [Arabidopsis thaliana]

Protein Classification

Wiskott-Aldrich syndrome protein; serine/threonine-protein kinase PAK 3( domain architecture ID 10645184)

Wiskott-Aldrich syndrome protein (WASp) acts as an effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex| serine/threonine-protein kinase PAK 3 (p21-activated kinase 3) catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates; PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 29-59 6.69e-06

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


:

Pssm-ID: 197628  Cd Length: 36  Bit Score: 41.81  E-value: 6.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 30685713     29 IGFPTDVKHVAHIGSDG----PTNTTPSWMNDFKT 59
Cdd:smart00285   1 ISTPTNFKHIAHVGFDGqtggFTGLPTEWKSLLKT 35
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 100-209 2.60e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685713   100 PKQKTRRKPGGAASPNHNGSPPRKSSGNAASSDEPSKHSRhnrSAHGSTDSSNDQEPSVRRRRGGIPAPDTEVPNQIPDG 179
Cdd:PHA03307  286 SSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESS---SSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADP 362

                          90       100       110
                  ....*....|....*....|....*....|
gi 30685713   180 SAPPRKATSRPRKLKGSSAGGEGSIKKSSK 209
Cdd:PHA03307  363 SSPRKRPRPSRAPSSPAASAGRPTRRRARA 392
 
Name Accession Description Interval E-value
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 29-59 6.69e-06

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 41.81  E-value: 6.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 30685713     29 IGFPTDVKHVAHIGSDG----PTNTTPSWMNDFKT 59
Cdd:smart00285   1 ISTPTNFKHIAHVGFDGqtggFTGLPTEWKSLLKT 35
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 100-209 2.60e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685713   100 PKQKTRRKPGGAASPNHNGSPPRKSSGNAASSDEPSKHSRhnrSAHGSTDSSNDQEPSVRRRRGGIPAPDTEVPNQIPDG 179
Cdd:PHA03307  286 SSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESS---SSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADP 362

                          90       100       110
                  ....*....|....*....|....*....|
gi 30685713   180 SAPPRKATSRPRKLKGSSAGGEGSIKKSSK 209
Cdd:PHA03307  363 SSPRKRPRPSRAPSSPAASAGRPTRRRARA 392
CRIB cd00132
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 27-61 8.66e-05

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


Pssm-ID: 238077  Cd Length: 42  Bit Score: 38.96  E-value: 8.66e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 30685713  27 MQIGFPTDVKHVAHIGSDGP----TNTTPSWMNDFKTQE 61
Cdd:cd00132   1 MEISTPTDFKHISHVGWDGVgfdgANLPPDLQSLFQTAG 39
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 28-70 4.47e-03

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 34.59  E-value: 4.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 30685713    28 QIGFPTDVKHVAHIGSDGP----TNTTPSWMNDFKTQEHEKGQVVSR 70
Cdd:pfam00786   1 MISAPTNFKHTVHVGFDPDtgffTGLPPEWAKLLDSSGITEDEQKEN 47
 
Name Accession Description Interval E-value
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 29-59 6.69e-06

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 41.81  E-value: 6.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 30685713     29 IGFPTDVKHVAHIGSDG----PTNTTPSWMNDFKT 59
Cdd:smart00285   1 ISTPTNFKHIAHVGFDGqtggFTGLPTEWKSLLKT 35
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 100-209 2.60e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685713   100 PKQKTRRKPGGAASPNHNGSPPRKSSGNAASSDEPSKHSRhnrSAHGSTDSSNDQEPSVRRRRGGIPAPDTEVPNQIPDG 179
Cdd:PHA03307  286 SSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESS---SSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADP 362

                          90       100       110
                  ....*....|....*....|....*....|
gi 30685713   180 SAPPRKATSRPRKLKGSSAGGEGSIKKSSK 209
Cdd:PHA03307  363 SSPRKRPRPSRAPSSPAASAGRPTRRRARA 392
CRIB cd00132
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 27-61 8.66e-05

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


Pssm-ID: 238077  Cd Length: 42  Bit Score: 38.96  E-value: 8.66e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 30685713  27 MQIGFPTDVKHVAHIGSDGP----TNTTPSWMNDFKTQE 61
Cdd:cd00132   1 MEISTPTDFKHISHVGWDGVgfdgANLPPDLQSLFQTAG 39
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 106-200 4.46e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 37.84  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685713   106 RKPGGAASPnhngsPPRKSSGNAASSDEPSkhsrhnRSAHGSTDSSNDQEPSVRRRRGGIPAPDTEVPNQIPDGSAPPRK 185
Cdd:PHA03307  837 RPPGAAARP-----PPARSSESSKSKPAAA------GGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRP 905

                          90
                  ....*....|....*
gi 30685713   186 ATSRPRKLKGSSAGG 200
Cdd:PHA03307  906 RPAPRVKLGPMPPGG 920
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 28-70 4.47e-03

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 34.59  E-value: 4.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 30685713    28 QIGFPTDVKHVAHIGSDGP----TNTTPSWMNDFKTQEHEKGQVVSR 70
Cdd:pfam00786   1 MISAPTNFKHTVHVGFDPDtgffTGLPPEWAKLLDSSGITEDEQKEN 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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