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Conserved domains on  [gi|15225787|ref|NP_180866|]
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nitrile specifier protein 2 [Arabidopsis thaliana]

Protein Classification

Kelch domain-containing protein; kelch repeat and BTB domain-containing protein( domain architecture ID 11476525)

Kelch domain-containing protein is a protein that contains one or more kelch domains which play a role in a variety of cellular processes, including cell signaling, transcription regulation, and protein degradation.| kelch repeat and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02193 PLN02193
nitrile-specifier protein
1-471 0e+00

nitrile-specifier protein


:

Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 957.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787    1 MVQKVEARGGEIGDVWDDGAYDGVRKVYVGQGEDGIAFVKFEYVNGSQEVVGDERGKKTLLGAEEFEVDPDDYIVYVEGY 80
Cdd:PLN02193   1 MAQKLEAKGGETGDVWDDGVYDNVRKVYVGQGQYGIAFVKFEYVNGSQVVVGDEHGKKTELGVEEFEIDADDYIVYVEGY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787   81 HEKVFGVTTkEIISTLTFKTYKGKTSPPFGIVSGTKFVLQGGKIVGFHGRSTDVLHSLGAYISSPATPKLRGKWIKVEQK 160
Cdd:PLN02193  81 REKVNDMTS-EMITFLSFKTYKGKTSHPIEKRPGVKFVLQGGKIVGFHGRSTDVLHSLGAYISLPSTPKLLGKWIKVEQK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  161 GEGPGPRCSHDIAQVGNKIFSFGGELTPNQPIDKHLYVFDLETRTWSISPATGDVPNLSCLGVRMVSIGSSLYVFGGRDA 240
Cdd:PLN02193 160 GEGPGLRCSHGIAQVGNKIYSFGGEFTPNQPIDKHLYVFDLETRTWSISPATGDVPHLSCLGVRMVSIGSTLYVFGGRDA 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  241 SRKYNGFYSFDTTKNEWKLLTPVEQGPTPRSFHSMTADENNVYVFGGVSATVRLKTLDAYNIVDHKWVQCSTPGGSCSVR 320
Cdd:PLN02193 240 SRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSFSIR 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  321 GGAGLEVVQGKVWVVYGFNGCEVDDVHCYDPAQDKWTQVETFGEKPCARSVFASAVVGKHILVFGGEIAMDPKAHEGPGQ 400
Cdd:PLN02193 320 GGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGGEIAMDPLAHVGPGQ 399
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15225787  401 LSGGTFALDTETLKWEKLDKLGEEEETPSIRGWSASTTGTIDGKKGLVMFGGKAQTNDRFGDLFFYGVDSA 471
Cdd:PLN02193 400 LTDGTFALDTETLQWERLDKFGEEEETPSSRGWTASTTGTIDGKKGLVMHGGKAPTNDRFDDLFFYGIDSA 470
 
Name Accession Description Interval E-value
PLN02193 PLN02193
nitrile-specifier protein
1-471 0e+00

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 957.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787    1 MVQKVEARGGEIGDVWDDGAYDGVRKVYVGQGEDGIAFVKFEYVNGSQEVVGDERGKKTLLGAEEFEVDPDDYIVYVEGY 80
Cdd:PLN02193   1 MAQKLEAKGGETGDVWDDGVYDNVRKVYVGQGQYGIAFVKFEYVNGSQVVVGDEHGKKTELGVEEFEIDADDYIVYVEGY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787   81 HEKVFGVTTkEIISTLTFKTYKGKTSPPFGIVSGTKFVLQGGKIVGFHGRSTDVLHSLGAYISSPATPKLRGKWIKVEQK 160
Cdd:PLN02193  81 REKVNDMTS-EMITFLSFKTYKGKTSHPIEKRPGVKFVLQGGKIVGFHGRSTDVLHSLGAYISLPSTPKLLGKWIKVEQK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  161 GEGPGPRCSHDIAQVGNKIFSFGGELTPNQPIDKHLYVFDLETRTWSISPATGDVPNLSCLGVRMVSIGSSLYVFGGRDA 240
Cdd:PLN02193 160 GEGPGLRCSHGIAQVGNKIYSFGGEFTPNQPIDKHLYVFDLETRTWSISPATGDVPHLSCLGVRMVSIGSTLYVFGGRDA 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  241 SRKYNGFYSFDTTKNEWKLLTPVEQGPTPRSFHSMTADENNVYVFGGVSATVRLKTLDAYNIVDHKWVQCSTPGGSCSVR 320
Cdd:PLN02193 240 SRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSFSIR 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  321 GGAGLEVVQGKVWVVYGFNGCEVDDVHCYDPAQDKWTQVETFGEKPCARSVFASAVVGKHILVFGGEIAMDPKAHEGPGQ 400
Cdd:PLN02193 320 GGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGGEIAMDPLAHVGPGQ 399
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15225787  401 LSGGTFALDTETLKWEKLDKLGEEEETPSIRGWSASTTGTIDGKKGLVMFGGKAQTNDRFGDLFFYGVDSA 471
Cdd:PLN02193 400 LTDGTFALDTETLQWERLDKFGEEEETPSSRGWTASTTGTIDGKKGLVMHGGKAPTNDRFDDLFFYGIDSA 470
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
13-143 1.60e-61

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 196.73  E-value: 1.60e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787    13 GDVWDDGAYDGVRKVYVGQGEDGIAFVKFEYVNGSQEVVGDERGKKTLLGAEEFEVD-PDDYIVYVEGYHEKVFGVTTkE 91
Cdd:pfam01419   1 GASWDDGVYDGVRKVYVGQGGDGITYIKFEYVKGGGKVEGDEHGKKGLLGPEEFEIDyPDEYITSVEGTYDKVFGSDS-E 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15225787    92 IISTLTFKTYKGKTSPPFGIVSGTKFVL--QGGKIVGFHGRSTDVLHSLGAYIS 143
Cdd:pfam01419  80 VITSLTFKTNKGRTSPFFGTPSGTKFSLevKGKKIVGFHGRAGNALNALGAYFA 133
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
13-143 3.14e-47

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 159.32  E-value: 3.14e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787     13 GDVWDDGAYDGVRKVYVGQGEDGIAFVKFEYVNGsQEVVGDERGKKTLLGaEEFEVDPDDYIVYVEGYHEKVfgvttkEI 92
Cdd:smart00915   1 GTEWDDGAFDGVRKIYVGQGGEGIKSIQFDYDKG-GKVWGDEHGGKGGTG-EEILLYPGEYITSVEGTYDKS------GV 72
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 15225787     93 ISTLTFKTYKGKTSPPFGIVSGTKFVLQ---GGKIVGFHGR-STDVLHSLGAYIS 143
Cdd:smart00915  73 ITSLTFKTNKGRTSPFGGYEGGTKFVLEskeGKKIVGFHGRsSGDGLDSLGAYFS 127
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
13-143 1.47e-43

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 149.64  E-value: 1.47e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  13 GDVWDDGAY-DGVRKVYVGQGEDGIAFVKFEYVNGSQEVVGDERGKKTlLGAEEFEVD-PDDYIVYVEGYHEKVFGVTtk 90
Cdd:cd09612   1 GSAWDDGVFpDGLRKITVRSGENGIDSIKFEYDKDGQHVVGPWHGGGG-GTPEEIVLDyPDEYITSVSGTYGPVSGSN-- 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15225787  91 eIISTLTFKTYKgKTSPPFGIVSGTKFVLQ--GGKIVGFHGRSTDVLHSLGAYIS 143
Cdd:cd09612  78 -VITSLTFKTNK-RTYGPFGVESGTPFSLPveGGKIVGFHGRSGDYLDAIGVYVS 130
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
164-452 3.86e-29

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 115.64  E-value: 3.86e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787 164 PGPRCSHDIAQVGNKIFSFGGeLTPNQPIDKhLYVFDLETRTWSispATGDVPNLSCLGVRMVSIGSSLYVFGGRDASRK 243
Cdd:COG3055  10 PTPRSEAAAALLDGKVYVAGG-LSGGSASNS-FEVYDPATNTWS---ELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANP 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787 244 ----YNGFYSFDTTKNEWKLLTPVeqgPTPRSFHSMTADENNVYVFGGVSATVRLKTLDAYNIVDHKWVQCSTPGGscSV 319
Cdd:COG3055  85 sstpLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPT--PR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787 320 RGGAGLEVVQGKVWVVYGFNGcevddvhcyDPAQDKWTQVETFgekPCARSVFASAVVGKHILVFGGEiamdpkahegpG 399
Cdd:COG3055 160 DHLAAAVLPDGKILVIGGRNG---------SGFSNTWTTLAPL---PTARAGHAAAVLGGKILVFGGE-----------S 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 15225787 400 QLSGGTFALDTETLKWEKLDKLgeeeetPSIRGWSAstTGTIDGKkgLVMFGG 452
Cdd:COG3055 217 GFSDEVEAYDPATNTWTALGEL------PTPRHGHA--AVLTDGK--VYVIGG 259
 
Name Accession Description Interval E-value
PLN02193 PLN02193
nitrile-specifier protein
1-471 0e+00

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 957.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787    1 MVQKVEARGGEIGDVWDDGAYDGVRKVYVGQGEDGIAFVKFEYVNGSQEVVGDERGKKTLLGAEEFEVDPDDYIVYVEGY 80
Cdd:PLN02193   1 MAQKLEAKGGETGDVWDDGVYDNVRKVYVGQGQYGIAFVKFEYVNGSQVVVGDEHGKKTELGVEEFEIDADDYIVYVEGY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787   81 HEKVFGVTTkEIISTLTFKTYKGKTSPPFGIVSGTKFVLQGGKIVGFHGRSTDVLHSLGAYISSPATPKLRGKWIKVEQK 160
Cdd:PLN02193  81 REKVNDMTS-EMITFLSFKTYKGKTSHPIEKRPGVKFVLQGGKIVGFHGRSTDVLHSLGAYISLPSTPKLLGKWIKVEQK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  161 GEGPGPRCSHDIAQVGNKIFSFGGELTPNQPIDKHLYVFDLETRTWSISPATGDVPNLSCLGVRMVSIGSSLYVFGGRDA 240
Cdd:PLN02193 160 GEGPGLRCSHGIAQVGNKIYSFGGEFTPNQPIDKHLYVFDLETRTWSISPATGDVPHLSCLGVRMVSIGSTLYVFGGRDA 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  241 SRKYNGFYSFDTTKNEWKLLTPVEQGPTPRSFHSMTADENNVYVFGGVSATVRLKTLDAYNIVDHKWVQCSTPGGSCSVR 320
Cdd:PLN02193 240 SRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSFSIR 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  321 GGAGLEVVQGKVWVVYGFNGCEVDDVHCYDPAQDKWTQVETFGEKPCARSVFASAVVGKHILVFGGEIAMDPKAHEGPGQ 400
Cdd:PLN02193 320 GGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGGEIAMDPLAHVGPGQ 399
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15225787  401 LSGGTFALDTETLKWEKLDKLGEEEETPSIRGWSASTTGTIDGKKGLVMFGGKAQTNDRFGDLFFYGVDSA 471
Cdd:PLN02193 400 LTDGTFALDTETLQWERLDKFGEEEETPSSRGWTASTTGTIDGKKGLVMHGGKAPTNDRFDDLFFYGIDSA 470
PLN02153 PLN02153
epithiospecifier protein
148-471 3.05e-150

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 431.33  E-value: 3.05e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  148 PKLRGKWIKVEQKG-EGPGPRCSHDIAQVGNKIFSFGGELTPNQPIDKHLYVFDLETRTWSISPATGDVPNLSCLGVRMV 226
Cdd:PLN02153   3 PTLQGGWIKVEQKGgKGPGPRCSHGIAVVGDKLYSFGGELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  227 SIGSSLYVFGGRDASRKYNGFYSFDTTKNEWKLLTP--VEQGPTPRSFHSMTADENNVYVFGGVS------ATVRLKTLD 298
Cdd:PLN02153  83 AVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKldEEGGPEARTFHSMASDENHVYVFGGVSkgglmkTPERFRTIE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  299 AYNIVDHKWVQCSTPGGSCSVRGGAGLEVVQGKVWVVYGF---------NGCEVDDVHCYDPAQDKWTQVETFGEKPCAR 369
Cdd:PLN02153 163 AYNIADGKWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFatsilpggkSDYESNAVQFFDPASGKWTEVETTGAKPSAR 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  370 SVFASAVVGKHILVFGGEIAMDPKAHEGPGQLSGGTFALDTETLKWEkldKLGEEEETPSIRGWSASTTGTIDGKKGLVM 449
Cdd:PLN02153 243 SVFAHAVVGKYIIIFGGEVWPDLKGHLGPGTLSNEGYALDTETLVWE---KLGECGEPAMPRGWTAYTTATVYGKNGLLM 319
                        330       340
                 ....*....|....*....|..
gi 15225787  450 FGGKAQTNDRFGDLFFYGVDSA 471
Cdd:PLN02153 320 HGGKLPTNERTDDLYFYAVNSA 341
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
13-143 1.60e-61

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 196.73  E-value: 1.60e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787    13 GDVWDDGAYDGVRKVYVGQGEDGIAFVKFEYVNGSQEVVGDERGKKTLLGAEEFEVD-PDDYIVYVEGYHEKVFGVTTkE 91
Cdd:pfam01419   1 GASWDDGVYDGVRKVYVGQGGDGITYIKFEYVKGGGKVEGDEHGKKGLLGPEEFEIDyPDEYITSVEGTYDKVFGSDS-E 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15225787    92 IISTLTFKTYKGKTSPPFGIVSGTKFVL--QGGKIVGFHGRSTDVLHSLGAYIS 143
Cdd:pfam01419  80 VITSLTFKTNKGRTSPFFGTPSGTKFSLevKGKKIVGFHGRAGNALNALGAYFA 133
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
13-143 3.14e-47

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 159.32  E-value: 3.14e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787     13 GDVWDDGAYDGVRKVYVGQGEDGIAFVKFEYVNGsQEVVGDERGKKTLLGaEEFEVDPDDYIVYVEGYHEKVfgvttkEI 92
Cdd:smart00915   1 GTEWDDGAFDGVRKIYVGQGGEGIKSIQFDYDKG-GKVWGDEHGGKGGTG-EEILLYPGEYITSVEGTYDKS------GV 72
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 15225787     93 ISTLTFKTYKGKTSPPFGIVSGTKFVLQ---GGKIVGFHGR-STDVLHSLGAYIS 143
Cdd:smart00915  73 ITSLTFKTNKGRTSPFGGYEGGTKFVLEskeGKKIVGFHGRsSGDGLDSLGAYFS 127
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
13-143 1.47e-43

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 149.64  E-value: 1.47e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  13 GDVWDDGAY-DGVRKVYVGQGEDGIAFVKFEYVNGSQEVVGDERGKKTlLGAEEFEVD-PDDYIVYVEGYHEKVFGVTtk 90
Cdd:cd09612   1 GSAWDDGVFpDGLRKITVRSGENGIDSIKFEYDKDGQHVVGPWHGGGG-GTPEEIVLDyPDEYITSVSGTYGPVSGSN-- 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15225787  91 eIISTLTFKTYKgKTSPPFGIVSGTKFVLQ--GGKIVGFHGRSTDVLHSLGAYIS 143
Cdd:cd09612  78 -VITSLTFKTNK-RTYGPFGVESGTPFSLPveGGKIVGFHGRSGDYLDAIGVYVS 130
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
164-452 3.86e-29

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 115.64  E-value: 3.86e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787 164 PGPRCSHDIAQVGNKIFSFGGeLTPNQPIDKhLYVFDLETRTWSispATGDVPNLSCLGVRMVSIGSSLYVFGGRDASRK 243
Cdd:COG3055  10 PTPRSEAAAALLDGKVYVAGG-LSGGSASNS-FEVYDPATNTWS---ELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANP 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787 244 ----YNGFYSFDTTKNEWKLLTPVeqgPTPRSFHSMTADENNVYVFGGVSATVRLKTLDAYNIVDHKWVQCSTPGGscSV 319
Cdd:COG3055  85 sstpLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPT--PR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787 320 RGGAGLEVVQGKVWVVYGFNGcevddvhcyDPAQDKWTQVETFgekPCARSVFASAVVGKHILVFGGEiamdpkahegpG 399
Cdd:COG3055 160 DHLAAAVLPDGKILVIGGRNG---------SGFSNTWTTLAPL---PTARAGHAAAVLGGKILVFGGE-----------S 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 15225787 400 QLSGGTFALDTETLKWEKLDKLgeeeetPSIRGWSAstTGTIDGKkgLVMFGG 452
Cdd:COG3055 217 GFSDEVEAYDPATNTWTALGEL------PTPRHGHA--AVLTDGK--VYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
99-386 2.96e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 65.56  E-value: 2.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787   99 KTYKGKTSPPFGIVSGTKFVLQGGKIVGFHGRSTDVLHSLGAYISSPATPKlrGKWIKVEQKGEGPGPRCSHDIAqVGNK 178
Cdd:PHA03098 220 KKIVFNKRCIKIIYSKKYNLNKILPRSSTFGSIIYIHITMSIFTYNYITNY--SPLSEINTIIDIHYVYCFGSVV-LNNV 296
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  179 IFSFGGELTPNQPIDKhLYVFDLETRTWsispatGDVPNL----SCLGVrmVSIGSSLYVFGGRDASRKYNGFYSFDTTK 254
Cdd:PHA03098 297 IYFIGGMNKNNLSVNS-VVSYDTKTKSW------NKVPELiyprKNPGV--TVFNNRIYVIGGIYNSISLNTVESWKPGE 367
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  255 NEWKLLTPVEQgptPRSFHSMTADENNVYVFGGVSAT-VRLKTLDAYNIVDHKWVQCS-TP----GGSCSVRGGaglevv 328
Cdd:PHA03098 368 SKWREEPPLIF---PRYNPCVVNVNNLIYVIGGISKNdELLKTVECFSLNTNKWSKGSpLPishyGGCAIYHDG------ 438
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15225787  329 qgKVWVVYGF----NGCEVDDVHCYDPAQDKWTQvetfgEKPCARSVFASAV--VGKHILVFGG 386
Cdd:PHA03098 439 --KIYVIGGIsyidNIKVYNIVESYNPVTNKWTE-----LSSLNFPRINASLciFNNKIYVVGG 495
PHA03098 PHA03098
kelch-like protein; Provisional
166-307 2.20e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 59.40  E-value: 2.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  166 PRCSHDIAQVGNKIFSFGGeLTPNQPIDKHLYVFDLETRTWSISPATgdvpNLSCLGVRMVSIGSSLYVFGGR---DASR 242
Cdd:PHA03098 379 PRYNPCVVNVNNLIYVIGG-ISKNDELLKTVECFSLNTNKWSKGSPL----PISHYGGCAIYHDGKIYVIGGIsyiDNIK 453
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15225787  243 KYNGFYSFDTTKNEWKLLTPVEQgptPRSFHSMTADENNVYVFGGVSATVRLKTLDAYNIVDHKW 307
Cdd:PHA03098 454 VYNIVESYNPVTNKWTELSSLNF---PRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
Kelch_3 pfam13415
Galactose oxidase, central domain;
229-278 2.61e-08

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 49.98  E-value: 2.61e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15225787   229 GSSLYVFGGRDASR--KYNGFYSFDTTKNEWKlltPVEQGPTPRSFHSMTAD 278
Cdd:pfam13415   1 GDKLYIFGGLGFDGqtRLNDLYVYDLDTNTWT---QIGDLPPPRSGHSATYI 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
320-359 1.86e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.53  E-value: 1.86e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15225787   320 RGGAGLEVVQGKVWVVYGFNG-CEVDDVHCYDPAQDKWTQV 359
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGnQSLNSVEVYDPETNTWSKL 42
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
269-314 3.01e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.14  E-value: 3.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15225787   269 PRSFHSMTADENNVYVFGGVSATVRLKTLDAYNIVDHKWVQCSTPG 314
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
166-207 4.95e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.78  E-value: 4.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15225787   166 PRCSHDIAQVGNKIFSFGGELTPNQPIDKhLYVFDLETRTWS 207
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNK-LEVYNPLTKSWE 41
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
220-262 5.85e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.29  E-value: 5.85e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15225787   220 CLGVRMVSIGSSLYVFGGRDASRKYNGFYSFDTTKNEWKLLTP 262
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
269-313 9.77e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.90  E-value: 9.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 15225787   269 PRSFHSMTADENN-VYVFGG-VSATVRLKTLDAYNIVDHKWVQCSTP 313
Cdd:pfam13418   1 PRAYHTSTSIPDDtIYLFGGeGEDGTLLSDLWVFDLSTNEWTRLGSL 47
PRK14131 PRK14131
N-acetylneuraminate epimerase;
225-454 1.57e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 43.85  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  225 MVSIGSSLYVFGG-----RDAS-RKYNGFYSFDTTKNEW-KLLTpveqgPTPRSF---HSMTADENNVYVFGGVSAtvrl 294
Cdd:PRK14131  80 AAFIDGKLYVFGGigktnSEGSpQVFDDVYKYDPKTNSWqKLDT-----RSPVGLaghVAVSLHNGKAYITGGVNK---- 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  295 ktldayNIVDHKWVQCSTPGGSCSVRGgaglEVVQ---GKVWVVYGFNgcevDDVHCYDPAQDKWTQVETFGEKPCARSv 371
Cdd:PRK14131 151 ------NIFDGYFEDLAAAGKDKTPKD----KINDayfDKKPEDYFFN----KEVLSYDPSTNQWKNAGESPFLGTAGS- 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  372 fASAVVGKHILVFGGEIAmdpkahegPGQLSGGTFALDT--ETLKWEKLDKLGEEEETPSIRGWSASTTGTIDGKkglVM 449
Cdd:PRK14131 216 -AVVIKGNKLWLINGEIK--------PGLRTDAVKQGKFtgNNLKWQKLPDLPPAPGGSSQEGVAGAFAGYSNGV---LL 283

                 ....*
gi 15225787  450 FGGKA 454
Cdd:PRK14131 284 VAGGA 288
Jacalin_like cd09302
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
27-139 2.89e-04

Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.


Pssm-ID: 187706  Cd Length: 128  Bit Score: 40.85  E-value: 2.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  27 VYVGQGEDGIAFVkfeyvngSQEVVGDERGKKTLLGAEEFEVDPDDYIVYVEGYHEKVFGVTtkeIISTLTFKTYKGkTS 106
Cdd:cd09302  19 VRSGGAVDAIRVV-------LRDYTDGRHGGNGGPNTSSVFLDPGEYITITSVSSGDNGGGT---RIDAIQFTTNKG-RS 87
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15225787 107 PPFG---IVSGTKFVLQ-GGKIVGFHGRSTDVLHSLG 139
Cdd:cd09302  88 GTYGttsGALGTEFTVPvGGEIVGIYGRAGDDVDAFG 124
Kelch_4 pfam13418
Galactose oxidase, central domain;
166-211 5.98e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 5.98e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 15225787   166 PRCSHDIAQVGN-KIFSFGGELTPNQPIDkHLYVFDLETRTWSISPA 211
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGGEGEDGTLLS-DLWVFDLSTNEWTRLGS 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
355-471 2.03e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.38  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  355 KWTQVETFGEKPcaRSVFASAVVGKHILVFGGeiaMDPKAHEGPGQLSGGTFALDTETLKWEKLDklgeeeeTPSIRGWS 434
Cdd:PRK14131  63 GWTKIAAFPGGP--REQAVAAFIDGKLYVFGG---IGKTNSEGSPQVFDDVYKYDPKTNSWQKLD-------TRSPVGLA 130
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 15225787  435 ASTTGTIDGKKGLVmFGG--KAQTNDRFGDLFFYGVDSA 471
Cdd:PRK14131 131 GHVAVSLHNGKAYI-TGGvnKNIFDGYFEDLAAAGKDKT 168
PRK14131 PRK14131
N-acetylneuraminate epimerase;
278-386 2.46e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.00  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  278 DENNVYVFGGvSATVRLKTLDAyNIVDHKWVQCST-PGGScsvRGGAGLEVVQGKVWVVYGFNGCE-------VDDVHCY 349
Cdd:PRK14131  37 DNNTVYVGLG-SAGTSWYKLDL-NAPSKGWTKIAAfPGGP---REQAVAAFIDGKLYVFGGIGKTNsegspqvFDDVYKY 111
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 15225787  350 DPAQDKWTQVETfgEKPCARSVFASAVV-GKHILVFGG 386
Cdd:PRK14131 112 DPKTNSWQKLDT--RSPVGLAGHVAVSLhNGKAYITGG 147
Kelch_6 pfam13964
Kelch motif;
269-311 2.86e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.77  E-value: 2.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15225787   269 PRSFHSMTADENNVYVFGG-VSATVRLKTLDAYNIVDHKWVQCS 311
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELP 44
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
64-141 3.93e-03

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 37.30  E-value: 3.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225787  64 EEFEVDPDDYIVYVEGYhekvfgvtTKEIISTLTFKTYKGKTsPPFGIVSGTKFVLQGG----KIVGFHGRS-TDVLHSL 138
Cdd:cd09611  53 QEIVLEPGESITKVSGS--------YKIYLHGLVFTTNKGRY-LSFGKLRGRSFNATPPpsnyVLRGISGRYgGLGIKSI 123

                ...
gi 15225787 139 GAY 141
Cdd:cd09611 124 GFH 126
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
166-210 4.50e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.90  E-value: 4.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15225787   166 PRCSHDIAQVGNKIFSFGGeLTPNQPIDKhLYVFDLETRTWSISP 210
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG-FDGNQSLNS-VEVYDPETNTWSKLP 43
Kelch smart00612
Kelch domain;
232-277 6.55e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.46  E-value: 6.55e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 15225787    232 LYVFGGRDASRKYNGFYSFDTTKNEWKLLTPVeqgPTPRSFHSMTA 277
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSM---PTPRSGHGVAV 44
Kelch_6 pfam13964
Kelch motif;
225-270 8.88e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 8.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 15225787   225 MVSIGSSLYVFGGR-DASRKYNGFYSFDTTKNEWKLLTPVeqgPTPR 270
Cdd:pfam13964   7 VVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPL---PTPR 50
Kelch smart00612
Kelch domain;
331-379 9.44e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.07  E-value: 9.44e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 15225787    331 KVWVVYGFNGCEVDD-VHCYDPAQDKWTQVetfGEKPCARSVFASAVVGK 379
Cdd:smart00612   1 KIYVVGGFDGGQRLKsVEVYDPETNKWTPL---PSMPTPRSGHGVAVING 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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