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Conserved domains on  [gi|15225727|ref|NP_180827|]
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receptor like protein 23 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 144-810 1.62e-66

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 240.52  E-value: 1.62e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  144 SNLTMLAQLDLSYNKLTGSF-PLVRGLRKLIVLDLSYNHFSGTLnPNSSLFELHQLRYLNLAFNNFSSSLPSkfGNLHRL 222
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKIsSAIFRLPYIQTINLSNNQLSGPI-PDDIFTTSSSLRYLNLSNNNFTGSIPR--GSIPNL 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  223 ENLILSSNGFSGQVPSTISNLTRLTKLYLDQNKLTSSFPL-VQNLTNLYELDLSYNKFFGVIPSSLLTLpflahlalren 301
Cdd:PLN00113 143 ETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNsLTNLTSLEFLTLASNQLVGQIPRELGQM----------- 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  302 nlagsvevsnsstsSRLEIMYLGSNHFEGQILEPISKLINLKHLDLSFLNTSYPIDlklfSSLKSLRSLDlsgnsissas 381
Cdd:PLN00113 212 --------------KSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIP----SSLGNLKNLQ---------- 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  382 lssdsYIPLTLEMLTlrhcdiNEFPNILKTLKELVYIDISNNRMKGKIPEWLWSLPLLQSVTLGNNYFTGfqgsaeilvn 461
Cdd:PLN00113 264 -----YLFLYQNKLS------GPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTG---------- 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  462 ssvlllyldsnNFEGALPDLPlSIKGFGVASNSFTSEIPLSICNRSSLAAIDLSYNNFTGPIPPCL---RNLELVYLRNN 538
Cdd:PLN00113 323 -----------KIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLcssGNLFKLILFSN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  539 NLEGSIPDALCDGASLRTLDVSHNRLTGKLPRSFVNCSSLKFLSVINNRIEDTFPFWLKALPNLQVLTLRSNRFYGPISp 618
Cdd:PLN00113 391 SLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLP- 469

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  619 phqGPLGFPELRIFEISDNKFTGSLPPNYfvnwkassrtmnqdgglymvyeeklfdeggygytdaldlqykglhmeqaKA 698
Cdd:PLN00113 470 ---DSFGSKRLENLDLSRNQFSGAVPRKL-------------------------------------------------GS 497

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  699 LTSYAAIDFSGNRLEGQIPESIGLLKALIAVNISNNAFTGHIPLSMANLENLESLDMSRNQLSGTIPNGLGSISFLAYIN 778
Cdd:PLN00113 498 LSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVN 577

                        650       660       670
                 ....*....|....*....|....*....|..
gi 15225727  779 VSHNQLTGEIPQGTQITGQSKSSFEGNAGLCG 810
Cdd:PLN00113 578 ISHNHLHGSLPSTGAFLAINASAVAGNIDLCG 609
LRR_8 pfam13855
Leucine rich repeat;
99-159 2.25e-05

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15225727    99 QLRYVDLQNNNLTSSSlPSGFGNLKRLEGLFLSSNGFLGQVPSSFSNLTMLAQLDLSYNKL 159
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 144-810 1.62e-66

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 240.52  E-value: 1.62e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  144 SNLTMLAQLDLSYNKLTGSF-PLVRGLRKLIVLDLSYNHFSGTLnPNSSLFELHQLRYLNLAFNNFSSSLPSkfGNLHRL 222
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKIsSAIFRLPYIQTINLSNNQLSGPI-PDDIFTTSSSLRYLNLSNNNFTGSIPR--GSIPNL 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  223 ENLILSSNGFSGQVPSTISNLTRLTKLYLDQNKLTSSFPL-VQNLTNLYELDLSYNKFFGVIPSSLLTLpflahlalren 301
Cdd:PLN00113 143 ETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNsLTNLTSLEFLTLASNQLVGQIPRELGQM----------- 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  302 nlagsvevsnsstsSRLEIMYLGSNHFEGQILEPISKLINLKHLDLSFLNTSYPIDlklfSSLKSLRSLDlsgnsissas 381
Cdd:PLN00113 212 --------------KSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIP----SSLGNLKNLQ---------- 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  382 lssdsYIPLTLEMLTlrhcdiNEFPNILKTLKELVYIDISNNRMKGKIPEWLWSLPLLQSVTLGNNYFTGfqgsaeilvn 461
Cdd:PLN00113 264 -----YLFLYQNKLS------GPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTG---------- 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  462 ssvlllyldsnNFEGALPDLPlSIKGFGVASNSFTSEIPLSICNRSSLAAIDLSYNNFTGPIPPCL---RNLELVYLRNN 538
Cdd:PLN00113 323 -----------KIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLcssGNLFKLILFSN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  539 NLEGSIPDALCDGASLRTLDVSHNRLTGKLPRSFVNCSSLKFLSVINNRIEDTFPFWLKALPNLQVLTLRSNRFYGPISp 618
Cdd:PLN00113 391 SLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLP- 469

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  619 phqGPLGFPELRIFEISDNKFTGSLPPNYfvnwkassrtmnqdgglymvyeeklfdeggygytdaldlqykglhmeqaKA 698
Cdd:PLN00113 470 ---DSFGSKRLENLDLSRNQFSGAVPRKL-------------------------------------------------GS 497

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  699 LTSYAAIDFSGNRLEGQIPESIGLLKALIAVNISNNAFTGHIPLSMANLENLESLDMSRNQLSGTIPNGLGSISFLAYIN 778
Cdd:PLN00113 498 LSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVN 577

                        650       660       670
                 ....*....|....*....|....*....|..
gi 15225727  779 VSHNQLTGEIPQGTQITGQSKSSFEGNAGLCG 810
Cdd:PLN00113 578 ISHNHLHGSLPSTGAFLAINASAVAGNIDLCG 609
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-407 1.00e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.04  E-value: 1.00e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  58 NNSDTFNGVWCDNSTGAVAVLQLRKCLSGTLKSNSSLFGFHQLRYVDLQNNNLTSssLPSGFGNLKRLEGLFLSSNGfLG 137
Cdd:COG4886  73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQ-LT 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 138 QVPSSFSNLTMLAQLDLSYNKLTGSFPLVRGLRKLIVLDLSYNHFSgtlNPNSSLFELHQLRYLNLAFNNFSSsLPSKFG 217
Cdd:COG4886 150 DLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT---DLPEPLGNLTNLEELDLSGNQLTD-LPEPLA 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 218 NLHRLENLILSSNGFSgQVPStISNLTRLTKLYLDQNKLTSsFPLVQNLTNLYELDLSYNKFFGVIPSSLLTLPFLAHLA 297
Cdd:COG4886 226 NLTNLETLDLSNNQLT-DLPE-LGNLTNLEELDLSNNQLTD-LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 298 LRENNLAGSVEVSNSSTSSRLEIMYLGSNHFEGQILEPISKLINLKHLDLSFLNTSYPIDLKLFSSLKSLRSLDLSGNSI 377
Cdd:COG4886 303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382

                       330       340       350
                ....*....|....*....|....*....|
gi 15225727 378 SSASLSSDSYIPLTLEMLTLRHCDINEFPN 407
Cdd:COG4886 383 ALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 88-254 6.07e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 6.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  88 LKSNSSLFGFHQLRYVDLQNNNLTSSSlpsGFGNLKRLEGLFLSSNGFlgQVPSSFSNLTMLAQLDLSYNKLTGSFPLvr 167
Cdd:cd21340  36 ITKIENLEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRI--SVVEGLENLTNLEELHIENQRLPPGEKL-- 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 168 glrklivldlsynhfsgTLNPNSSLFELHQLRYLNLAFNNFSSslPSKFGNLHRLENLILSSNGFS--GQVPSTISNLTR 245
Cdd:cd21340 109 -----------------TFDPRSLAALSNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISdlEELLDLLSSWPS 169


                ....*....
gi 15225727 246 LTKLYLDQN 254
Cdd:cd21340 170 LRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
528-588 3.28e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 3.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15225727   528 RNLELVYLRNNNLEGSIPDALCDGASLRTLDVSHNRLTGKLPRSFVNCSSLKFLSVINNRI 588
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
99-159 2.25e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15225727    99 QLRYVDLQNNNLTSSSlPSGFGNLKRLEGLFLSSNGFLGQVPSSFSNLTMLAQLDLSYNKL 159
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 144-810 1.62e-66

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 240.52  E-value: 1.62e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  144 SNLTMLAQLDLSYNKLTGSF-PLVRGLRKLIVLDLSYNHFSGTLnPNSSLFELHQLRYLNLAFNNFSSSLPSkfGNLHRL 222
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKIsSAIFRLPYIQTINLSNNQLSGPI-PDDIFTTSSSLRYLNLSNNNFTGSIPR--GSIPNL 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  223 ENLILSSNGFSGQVPSTISNLTRLTKLYLDQNKLTSSFPL-VQNLTNLYELDLSYNKFFGVIPSSLLTLpflahlalren 301
Cdd:PLN00113 143 ETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNsLTNLTSLEFLTLASNQLVGQIPRELGQM----------- 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  302 nlagsvevsnsstsSRLEIMYLGSNHFEGQILEPISKLINLKHLDLSFLNTSYPIDlklfSSLKSLRSLDlsgnsissas 381
Cdd:PLN00113 212 --------------KSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIP----SSLGNLKNLQ---------- 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  382 lssdsYIPLTLEMLTlrhcdiNEFPNILKTLKELVYIDISNNRMKGKIPEWLWSLPLLQSVTLGNNYFTGfqgsaeilvn 461
Cdd:PLN00113 264 -----YLFLYQNKLS------GPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTG---------- 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  462 ssvlllyldsnNFEGALPDLPlSIKGFGVASNSFTSEIPLSICNRSSLAAIDLSYNNFTGPIPPCL---RNLELVYLRNN 538
Cdd:PLN00113 323 -----------KIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLcssGNLFKLILFSN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  539 NLEGSIPDALCDGASLRTLDVSHNRLTGKLPRSFVNCSSLKFLSVINNRIEDTFPFWLKALPNLQVLTLRSNRFYGPISp 618
Cdd:PLN00113 391 SLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLP- 469

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  619 phqGPLGFPELRIFEISDNKFTGSLPPNYfvnwkassrtmnqdgglymvyeeklfdeggygytdaldlqykglhmeqaKA 698
Cdd:PLN00113 470 ---DSFGSKRLENLDLSRNQFSGAVPRKL-------------------------------------------------GS 497

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  699 LTSYAAIDFSGNRLEGQIPESIGLLKALIAVNISNNAFTGHIPLSMANLENLESLDMSRNQLSGTIPNGLGSISFLAYIN 778
Cdd:PLN00113 498 LSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVN 577

                        650       660       670
                 ....*....|....*....|....*....|..
gi 15225727  779 VSHNQLTGEIPQGTQITGQSKSSFEGNAGLCG 810
Cdd:PLN00113 578 ISHNHLHGSLPSTGAFLAINASAVAGNIDLCG 609
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-407 1.00e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.04  E-value: 1.00e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  58 NNSDTFNGVWCDNSTGAVAVLQLRKCLSGTLKSNSSLFGFHQLRYVDLQNNNLTSssLPSGFGNLKRLEGLFLSSNGfLG 137
Cdd:COG4886  73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQ-LT 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 138 QVPSSFSNLTMLAQLDLSYNKLTGSFPLVRGLRKLIVLDLSYNHFSgtlNPNSSLFELHQLRYLNLAFNNFSSsLPSKFG 217
Cdd:COG4886 150 DLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT---DLPEPLGNLTNLEELDLSGNQLTD-LPEPLA 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 218 NLHRLENLILSSNGFSgQVPStISNLTRLTKLYLDQNKLTSsFPLVQNLTNLYELDLSYNKFFGVIPSSLLTLPFLAHLA 297
Cdd:COG4886 226 NLTNLETLDLSNNQLT-DLPE-LGNLTNLEELDLSNNQLTD-LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 298 LRENNLAGSVEVSNSSTSSRLEIMYLGSNHFEGQILEPISKLINLKHLDLSFLNTSYPIDLKLFSSLKSLRSLDLSGNSI 377
Cdd:COG4886 303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382

                       330       340       350
                ....*....|....*....|....*....|
gi 15225727 378 SSASLSSDSYIPLTLEMLTLRHCDINEFPN 407
Cdd:COG4886 383 ALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-375 8.02e-28

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 121.11  E-value: 8.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727   93 SLFGFHQLRYVDLQNNNLtSSSLPSGFGNLKRLEGLFLSSNGFLGQVPSSFSNLTMLAQLDLSYNKLTGSFPLVRGLRK- 171
Cdd:PLN00113 279 SIFSLQKLISLDLSDNSL-SGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNn 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  172 LIVLDLSYNHFSG----TLNPNSSLFEL------------------HQLRYLNLAFNNFSSSLPSKFGNLHRLENLILSS 229
Cdd:PLN00113 358 LTVLDLSTNNLTGeipeGLCSSGNLFKLilfsnslegeipkslgacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISN 437

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  230 NGFSGQVPSTISNLTRLTKLYLDQNKLTSSFPLVQNLTNLYELDLSYNKFFGVIPSSLLTLPFLAHLALRENNLAGSVEv 309
Cdd:PLN00113 438 NNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIP- 516

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15225727  310 SNSSTSSRLEIMYLGSNHFEGQILEPISKLINLKHLDLSFLNTSYPIDLKLfSSLKSLRSLDLSGN 375
Cdd:PLN00113 517 DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNL-GNVESLVQVNISHN 581
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-541 1.06e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 1.06e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 107 NNNLTSSSLPSGFGNLKRLEGLFLSSNGFLGQVPSSFSNLTMLAQLDLSYNKLTGSFPLVRGLRKLIVLDLSYNHFSGTL 186
Cdd:COG4886   7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 187 NPNSSLFELHQLRYLNLAFNNFssslpskFGNLHRLENLILSSNGFSgQVPSTISNLTRLTKLYLDQNKLTSSFPLVQNL 266
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTDLPEPLGNL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 267 TNLYELDLSYNKfFGVIPSSLLTLPFLAHLALRENNLAgsvEVSNS-STSSRLEIMYLGSNHFEgQILEPISKLINLKHL 345
Cdd:COG4886 159 TNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQIT---DLPEPlGNLTNLEELDLSGNQLT-DLPEPLANLTNLETL 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 346 DLSFLNTSypiDLKLFSSLKSLRSLDLSGNSissaslssdsyipltlemltlrhcdINEFPNiLKTLKELVYIDISNNRM 425
Cdd:COG4886 234 DLSNNQLT---DLPELGNLTNLEELDLSNNQ-------------------------LTDLPP-LANLTNLKTLDLSNNQL 284

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 426 KGKIPEWLWSLPLLQSVTLGNNYFTGFQGSAEILVNSSVLLLYLDSNNFEGALPDLPLSIKGFGVASNSFTSEIPLSICN 505
Cdd:COG4886 285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 15225727 506 RSSLAAIDLSYNNFTGPIPPCLRNLELVYLRNNNLE 541
Cdd:COG4886 365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
PLN03150 PLN03150
hypothetical protein; Provisional
 712-817 2.14e-18

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 89.87  E-value: 2.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  712 LEGQIPESIGLLKALIAVNISNNAFTGHIPLSMANLENLESLDMSRNQLSGTIPNGLGSISFLAYINVSHNQLTGEIPQ- 790
Cdd:PLN03150 430 LRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAa 509

                         90       100
                 ....*....|....*....|....*...
gi 15225727  791 -GTQITGQSKSSFEGNAGLCGLPLKESC 817
Cdd:PLN03150 510 lGGRLLHRASFNFTDNAGLCGIPGLRAC 537
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 84-239 2.02e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.60  E-value: 2.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727   84 LSGTLksNSSLFGFHQLRYVDLQNNNLtSSSLPSGFGNlKRLEGLFLSSNGFLGQVPSSFSNLTMLAQLDLSYNKLTGSF 163
Cdd:PLN00113 440 LQGRI--NSRKWDMPSLQMLSLARNKF-FGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEI 515

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15225727  164 P-LVRGLRKLIVLDLSYNHFSGTLNpnSSLFELHQLRYLNLAFNNFSSSLPSKFGNLHRLENLILSSNGFSGQVPST 239
Cdd:PLN00113 516 PdELSSCKKLVSLDLSHNQLSGQIP--ASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPST 590
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
242-612 2.22e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 2.22e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 242 NLTRLTKLYLDQNKLTSSFPLVQNLTNLYELDLSYNKFFGVIPSSLLTLPFLAHLALRENNLAGSVEVSNSSTSSRLEIM 321
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 322 YLGSNhfeGQILEPISKLINLKHLDLSflntsypiDLKLFSSLKSLRSLDLSGNSISSASLSSDSyipLT-LEMLTLRHC 400
Cdd:COG4886  81 LLSLL---LLGLTDLGDLTNLTELDLS--------GNEELSNLTNLESLDLSGNQLTDLPEELAN---LTnLKELDLSNN 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 401 DINEFPNILKTLKELVYIDISNNRMKGkIPEWLWSLPLLQSVTLGNNYFTGFqgSAEILVNSSVLLLYLDSNNFegalpd 480
Cdd:COG4886 147 QLTDLPEPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDL--PEPLGNLTNLEELDLSGNQL------ 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 481 lplsikgfgvasnsftSEIPLSICNRSSLAAIDLSYNNFTG-PIPPCLRNLELVYLRNNNLEgSIPDaLCDGASLRTLDV 559
Cdd:COG4886 218 ----------------TDLPEPLANLTNLETLDLSNNQLTDlPELGNLTNLEELDLSNNQLT-DLPP-LANLTNLKTLDL 279

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 15225727 560 SHNRLTGKLPRSFVNCSSLKFLSVINNRIEDTFPFWLKALPNLQVLTLRSNRF 612
Cdd:COG4886 280 SNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
301-641 2.78e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 2.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 301 NNLAGSVEVSNSSTSSRLEIMYLGSNHFEGQILEPISKLINLKHLDLSFLNTSYPIDLKLFSSLKSLRSLDLSGNSISSA 380
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 381 SLSSDSYIPLTLEMLTLRHCDINEFPNILKTLKELVYIDISNNRMKgKIPEWLWSLPLLQSVTLGNNYFTgfqgsaeilv 460
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT---------- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 461 nssvlllyldsnnfegalpdlplsikgfgvasnsftsEIPLSICNRSSLAAIDLSYNNFTGpIPP---CLRNLELVYLRN 537
Cdd:COG4886 150 -------------------------------------DLPEPLGNLTNLKSLDLSNNQLTD-LPEelgNLTNLKELDLSN 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 538 NNLEgSIPDALCDGASLRTLDVSHNRLTgKLPRSFVNCSSLKFLSVINNRIEDtFPfWLKALPNLQVLTLRSNRFYGpIS 617
Cdd:COG4886 192 NQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLTD-LP-ELGNLTNLEELDLSNNQLTD-LP 266

                       330       340
                ....*....|....*....|....
gi 15225727 618 PPHQgplgFPELRIFEISDNKFTG 641
Cdd:COG4886 267 PLAN----LTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
435-789 7.98e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 7.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 435 SLPLLQSVTLGNNYFTGFQGSAEILVNSSVLLLYLDSNNFEGALPDLPLSIKGFGVASNSFTSEIPLSICNRSSLAAIDL 514
Cdd:COG4886  24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 515 SYNNFTGPippcLRNLELVYLRNNNLEgSIPDALCDGASLRTLDVSHNRLTgKLPRSFVNCSSLKFLSVINNRIEDtFPF 594
Cdd:COG4886 104 SGNEELSN----LTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-LPE 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 595 WLKALPNLQVLTLRSNRFY---GPISpphqgplGFPELRIFEISDNKFTgSLPPNyfvnwkassrtmnqdgglymvyeek 671
Cdd:COG4886 177 ELGNLTNLKELDLSNNQITdlpEPLG-------NLTNLEELDLSGNQLT-DLPEP------------------------- 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 672 lfdeggygytdaldlqykglhMEQAKALTSyaaIDFSGNRLEgQIPEsIGLLKALIAVNISNNAFTgHIPLSmANLENLE 751
Cdd:COG4886 224 ---------------------LANLTNLET---LDLSNNQLT-DLPE-LGNLTNLEELDLSNNQLT-DLPPL-ANLTNLK 275

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 15225727 752 SLDMSRNQLSGTIPNGLGSISFLAYINVSHNQLTGEIP 789
Cdd:COG4886 276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
PLN03150 PLN03150
hypothetical protein; Provisional
 222-307 3.32e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 60.60  E-value: 3.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  222 LENLILSSNGFSGQVPSTISNLTRLTKLYLDQNKLTSSFPL-VQNLTNLYELDLSYNKFFGVIPSSLLTLPFLAHLALRE 300
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPsLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNG 499


                 ....*..
gi 15225727  301 NNLAGSV 307
Cdd:PLN03150 500 NSLSGRV 506
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 88-254 6.07e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 6.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  88 LKSNSSLFGFHQLRYVDLQNNNLTSSSlpsGFGNLKRLEGLFLSSNGFlgQVPSSFSNLTMLAQLDLSYNKLTGSFPLvr 167
Cdd:cd21340  36 ITKIENLEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRI--SVVEGLENLTNLEELHIENQRLPPGEKL-- 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 168 glrklivldlsynhfsgTLNPNSSLFELHQLRYLNLAFNNFSSslPSKFGNLHRLENLILSSNGFS--GQVPSTISNLTR 245
Cdd:cd21340 109 -----------------TFDPRSLAALSNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISdlEELLDLLSSWPS 169


                ....*....
gi 15225727 246 LTKLYLDQN 254
Cdd:cd21340 170 LRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 103-221 7.51e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.44  E-value: 7.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  103 VDLQNNNLtSSSLPSGFGNLKRLEGLFLSSNGFLGQVPSSFSNLTMLAQLDLSYNKLTGSFPlvrglrklivldlsynhf 182
Cdd:PLN03150 423 LGLDNQGL-RGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP------------------ 483

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 15225727  183 sgtlnpnSSLFELHQLRYLNLAFNNFSSSLPSKFGN--LHR 221
Cdd:PLN03150 484 -------ESLGQLTSLRILNLNGNSLSGRVPAALGGrlLHR 517
PLN03150 PLN03150
hypothetical protein; Provisional
 125-240 1.20e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.67  E-value: 1.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  125 LEGLFLSSNGFLGQVPSSFSNLTMLAQLDLSYNKLTGSFPLVRG-LRKLIVLDLSYNHFSGtlnpnsslfelhqlrylnl 203
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGsITSLEVLDLSYNSFNG------------------- 480

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 15225727  204 afnnfssSLPSKFGNLHRLENLILSSNGFSGQVPSTI 240
Cdd:PLN03150 481 -------SIPESLGQLTSLRILNLNGNSLSGRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 511-600 5.31e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 56.75  E-value: 5.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  511 AIDLSYNNFTGPIP---PCLRNLELVYLRNNNLEGSIPDALCDGASLRTLDVSHNRLTGKLPRSFVNCSSLKFLSVINNR 587
Cdd:PLN03150 422 GLGLDNQGLRGFIPndiSKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501

                         90
                 ....*....|...
gi 15225727  588 IEDTFPFWLKALP 600
Cdd:PLN03150 502 LSGRVPAALGGRL 514
PLN03150 PLN03150
hypothetical protein; Provisional
 485-571 6.52e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 56.36  E-value: 6.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  485 IKGFGVASNSFTSEIPLSICNRSSLAAIDLSYNNFTGPIPPCLRN---LELVYLRNNNLEGSIPDALCDGASLRTLDVSH 561
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSitsLEVLDLSYNSFNGSIPESLGQLTSLRILNLNG 499

                         90
                 ....*....|
gi 15225727  562 NRLTGKLPRS 571
Cdd:PLN03150 500 NSLSGRVPAA 509
PLN03150 PLN03150
hypothetical protein; Provisional
 195-261 1.79e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.82  E-value: 1.79e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15225727  195 LHQLRYLNLAFNNFSSSLPSKFGNLHRLENLILSSNGFSGQVPSTISNLTRLTKLYLDQNKLTSSFP 261
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVP 507
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 196-375 2.37e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 2.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 196 HQLRYLNLaFNNFSSSLPsKFGNLHRLENLILSSN------GFSgqvpstisNLTRLTKLYLDQNKLTssfplV----QN 265
Cdd:cd21340  24 KNLKVLYL-YDNKITKIE-NLEFLTNLTHLYLQNNqiekieNLE--------NLVNLKKLYLGGNRIS-----VveglEN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 266 LTNLYELDLSYNK-------FFGviPSSLLTL-PFLAHLALRENNLagsvevsnsstssrleimylgsnhfegQILEPIS 337
Cdd:cd21340  89 LTNLEELHIENQRlppgeklTFD--PRSLAALsNSLRVLNISGNNI---------------------------DSLEPLA 139

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 15225727 338 KLINLKHLDLSFLNTSYPIDLK-LFSSLKSLRSLDLSGN 375
Cdd:cd21340 140 PLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
403-612 3.07e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 3.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  403 NEFPNILKTLKELVYI-DISNNRMKgKIPEWLWSLplLQSVTLGNNYFTGFqgsAEILVNSsvlLLYLD--SNNFEgALP 479
Cdd:PRK15370 230 NQLTSIPATLPDTIQEmELSINRIT-ELPERLPSA--LQSLDLFHNKISCL---PENLPEE---LRYLSvyDNSIR-TLP 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  480 D-LPLSIKGFGVASNSFTSeIPLSI-CNRSSLAAIDLSYNNFTGPIPPCLRNLELvylrNNNLEGSIPDALcdGASLRTL 557
Cdd:PRK15370 300 AhLPSGITHLNVQSNSLTA-LPETLpPGLKTLEAGENALTSLPASLPPELQVLDV----SKNQITVLPETL--PPTITTL 372

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15225727  558 DVSHNRLTgKLPRSFVncSSLKFLSVINN---RIEDTFPFWLKALPNLQVLTLRSNRF 612
Cdd:PRK15370 373 DVSRNALT-NLPENLP--AALQIMQASRNnlvRLPESLPHFRGEGPQPTRIIVEYNPF 427
LRR_8 pfam13855
Leucine rich repeat;
528-588 3.28e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 3.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15225727   528 RNLELVYLRNNNLEGSIPDALCDGASLRTLDVSHNRLTGKLPRSFVNCSSLKFLSVINNRI 588
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 392-612 5.96e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.28  E-value: 5.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 392 LEMLTLRHCDINE-----FPNILKTLKELVYIDISNNRMKGK------IPEWLWSLPLLQSVTLGNNYFT--GFQGSAEI 458
Cdd:cd00116  25 LQVLRLEGNTLGEeaakaLASALRPQPSLKELCLSLNETGRIprglqsLLQGLTKGCGLQELDLSDNALGpdGCGVLESL 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 459 LVNSSVLLLYLdSNNFEG---------ALPDLPLSIKGFGVASNSFTSE--IPLS---ICNRSsLAAIDLSYNNFTGP-I 523
Cdd:cd00116 105 LRSSSLQELKL-NNNGLGdrglrllakGLKDLPPALEKLVLGRNRLEGAscEALAkalRANRD-LKELNLANNGIGDAgI 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 524 P------PCLRNLELVYLRNNNLE----GSIPDALCDGASLRTLDVSHNRLTGKLPRSFVN-----CSSLKFLSVINNRI 588
Cdd:cd00116 183 RalaeglKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALASallspNISLLTLSLSCNDI 262

                       250       260
                ....*....|....*....|....*...
gi 15225727 589 ED----TFPFWLKALPNLQVLTLRSNRF 612
Cdd:cd00116 263 TDdgakDLAEVLAEKESLLELDLRGNKF 290
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
464-645 6.40e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 6.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  464 VLLLYLDSNNFEGALPDLPLSIKGFGVASNSFTSeIPLSICNrsSLAAIDLSYNNFTgpippclrnlelvylrnnnlegS 543
Cdd:PRK15370 201 ITTLILDNNELKSLPENLQGNIKTLYANSNQLTS-IPATLPD--TIQEMELSINRIT----------------------E 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  544 IPDALcdGASLRTLDVSHNRLTGkLPRSFVNcsSLKFLSVINNRIE-------------DTFPFWLKALP-----NLQVL 605
Cdd:PRK15370 256 LPERL--PSALQSLDLFHNKISC-LPENLPE--ELRYLSVYDNSIRtlpahlpsgithlNVQSNSLTALPetlppGLKTL 330

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 15225727  606 TLRSNRFYG-PISPPhqgplgfPELRIFEISDNKFT---GSLPP 645
Cdd:PRK15370 331 EAGENALTSlPASLP-------PELQVLDVSKNQITvlpETLPP 367
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
616-786 1.02e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 1.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 616 ISPPHQGPLGFPELRIFEISDNKFTGSLPPNYFVNWKASSRTMNQDGGLYMVYEEKLFDEGGYGYTDALDLQYKGLHMEQ 695
Cdd:COG4886  12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 696 AKALTSYAAIDFSGNrlegqipESIGLLKALIAVNISNNAFTgHIPLSMANLENLESLDMSRNQLSgTIPNGLGSISFLA 775
Cdd:COG4886  92 LGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLK 162

                       170
                ....*....|.
gi 15225727 776 YINVSHNQLTG 786
Cdd:COG4886 163 SLDLSNNQLTD 173
LRR_8 pfam13855
Leucine rich repeat;
99-159 2.25e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15225727    99 QLRYVDLQNNNLTSSSlPSGFGNLKRLEGLFLSSNGFLGQVPSSFSNLTMLAQLDLSYNKL 159
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 243-423 2.42e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 243 LTRLTKLYLDQNKLTS--SFPLVQNLTNLYeldLsYNKFFGVIPSsLLTLPFLAHLALRENNLAgsvEVSNSSTSSRLEI 320
Cdd:cd21340   1 LKRITHLYLNDKNITKidNLSLCKNLKVLY---L-YDNKITKIEN-LEFLTNLTHLYLQNNQIE---KIENLENLVNLKK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 321 MYLGSNHFEgqILEPISKLINLKHLDLSflNTSYPIDLKLFSSLKSLRSLDLSgnsissaslssdsyipltLEMLTLRHC 400
Cdd:cd21340  73 LYLGGNRIS--VVEGLENLTNLEELHIE--NQRLPPGEKLTFDPRSLAALSNS------------------LRVLNISGN 130

                       170       180
                ....*....|....*....|...
gi 15225727 401 DINEfPNILKTLKELVYIDISNN 423
Cdd:cd21340 131 NIDS-LEPLAPLRNLEQLDASNN 152
LRR_8 pfam13855
Leucine rich repeat;
553-612 2.63e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727   553 SLRTLDVSHNRLTGKLPRSFVNCSSLKFLSVINNRIEDTFPFWLKALPNLQVLTLRSNRF 612
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 535-637 4.65e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 4.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  535 LRNNNLEGSIPDALCDGASLRTLDVSHNRLTGKLPRSFVNCSSLKFLSVINNRIEDTFPFWLKALPNLQVLTLRSNRFYG 614
Cdd:PLN03150 425 LDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSG 504

                         90       100
                 ....*....|....*....|....*
gi 15225727  615 PISpphqGPLGFPELR--IFEISDN 637
Cdd:PLN03150 505 RVP----AALGGRLLHraSFNFTDN 525
LRR_8 pfam13855
Leucine rich repeat;
197-256 1.79e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727   197 QLRYLNLAFNNFSSSLPSKFGNLHRLENLILSSNGFSGQVPSTISNLTRLTKLYLDQNKL 256
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
507-564 6.16e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 6.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15225727   507 SSLAAIDLSYNNFTGpIPP----CLRNLELVYLRNNNLEGSIPDALCDGASLRTLDVSHNRL 564
Cdd:pfam13855   1 PNLRSLDLSNNRLTS-LDDgafkGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 66-278 7.96e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 7.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  66 VWCDNSTGAVaVLQLRKCLSGTLKSNsslfgfhQLRYVDLQNNNLtSSSLPSGFGNLKR---LEGLFLSSNGfLGQVPSS 142
Cdd:cd00116  57 CLSLNETGRI-PRGLQSLLQGLTKGC-------GLQELDLSDNAL-GPDGCGVLESLLRsssLQELKLNNNG-LGDRGLR 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 143 FS--NLTMLA----QLDLSYNKLT--GSFPL---VRGLRKLIVLDLSYNHFSGTLnpnsslfelhqLRYLNLAFNNFSSs 211
Cdd:cd00116 127 LLakGLKDLPpaleKLVLGRNRLEgaSCEALakaLRANRDLKELNLANNGIGDAG-----------IRALAEGLKANCN- 194

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15225727 212 lpskfgnlhrLENLILSSNGF----SGQVPSTISNLTRLTKLYLDQNKLTS------SFPLVQNLTNLYELDLSYNK 278
Cdd:cd00116 195 ----------LEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCND 261
LRR_8 pfam13855
Leucine rich repeat;
124-182 1.47e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727   124 RLEGLFLSSNGFLGQVPSSFSNLTMLAQLDLSYNKLTGSFPLV-RGLRKLIVLDLSYNHF 182
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 699-744 1.81e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 15225727  699 LTSYAAIDFSGNRLEGQIPESIGLLKALIAVNISNNAFTGHIPLSM 744
Cdd:PLN03150 465 ITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAAL 510
LRR_8 pfam13855
Leucine rich repeat;
316-375 1.99e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15225727   316 SRLEIMYLGSNHFEGQILEPISKLINLKHLDLSF--LNTsypIDLKLFSSLKSLRSLDLSGN 375
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNnlLTT---LSPGAFSGLPSLRYLDLSGN 59
PLN03150 PLN03150
hypothetical protein; Provisional
 557-644 2.11e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  557 LDVSHNRLTGKLPRSFVNCSSLKFLSVINNRIEDTFPFWLKALPNLQVLTLRSNRFYGPIsPPHQGPLgfPELRIFEISD 636
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSI-PESLGQL--TSLRILNLNG 499


                 ....*...
gi 15225727  637 NKFTGSLP 644
Cdd:PLN03150 500 NSLSGRVP 507
LRR_8 pfam13855
Leucine rich repeat;
221-279 2.19e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727   221 RLENLILSSNGFSGQVPSTISNLTRLTKLYLDQNKLTSSFPLV-QNLTNLYELDLSYNKF 279
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 272-347 4.59e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 4.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15225727  272 LDLSYNKFFGVIPSSLLTLPFLAHLALRENNLAGSVEVSNSSTSSrLEIMYLGSNHFEGQILEPISKLINLKHLDL 347
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITS-LEVLDLSYNSFNGSIPESLGQLTSLRILNL 497
PLN03150 PLN03150
hypothetical protein; Provisional
 405-500 5.69e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 5.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727  405 FPNILKTLKELVYIDISNNRMKGKIPEWLWSLPLLQSVTLGNNYFTGFQgSAEILVNSSVLLLYLDSNNFEGALP----D 480
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSI-PESLGQLTSLRILNLNGNSLSGRVPaalgG 512

                         90       100
                 ....*....|....*....|
gi 15225727  481 LPLSIKGFGVASNSFTSEIP 500
Cdd:PLN03150 513 RLLHRASFNFTDNAGLCGIP 532
LRR_8 pfam13855
Leucine rich repeat;
170-232 6.05e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 6.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15225727   170 RKLIVLDLSYNHFSGTlnPNSSLFELHQLRYLNLAFNNFSSSLPSKFGNLHRLENLILSSNGF 232
Cdd:pfam13855   1 PNLRSLDLSNNRLTSL--DDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 264-475 6.88e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 6.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 264 QNLTNLYELDLSYNKFFGVIP---SSLLTLPFLAHLALRENNLAGS----VEVSNSSTSSRLEIMYLGSNHFEGQILEPI 336
Cdd:cd00116  78 TKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLGDRglrlLAKGLKDLPPALEKLVLGRNRLEGASCEAL 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 337 SKLI--------------------------------NLKHLDL--SFLNTSYPIDL-KLFSSLKSLRSLDLSGNsissas 381
Cdd:cd00116 158 AKALranrdlkelnlanngigdagiralaeglkancNLEVLDLnnNGLTDEGASALaETLASLKSLEVLNLGDN------ 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225727 382 lssdsyiPLTLE-MLTLrhCDINEFPNIlkTLKELvyiDISNNRMK----GKIPEWLWSLPLLQSVTLGNNYFT--GFQG 454
Cdd:cd00116 232 -------NLTDAgAAAL--ASALLSPNI--SLLTL---SLSCNDITddgaKDLAEVLAEKESLLELDLRGNKFGeeGAQL 297

                       250       260
                ....*....|....*....|.
gi 15225727 455 SAEILVNSSVLLLYLDSNNFE 475
Cdd:cd00116 298 LAESLLEPGNELESLWVKDDS 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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