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Conserved domains on  [gi|15225687|ref|NP_180805|]
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myb domain protein 101 [Arabidopsis thaliana]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 1000535)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein may be involved in the regulation of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03212 super family cl31985
Transcription repressor MYB5; Provisional
 17-121 2.57e-43

Transcription repressor MYB5; Provisional


The actual alignment was detected with superfamily member PLN03212:

Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 153.69  E-value: 2.57e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225687   17 GLKKGPWTTTEDAILTEYVRKHGEGNWNAVQKNSGLLRCGKSCRLRWANHLRPNLKKGSFTPDEEKIIIDLHAKLGNKWA 96
Cdd:PLN03212  22 GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWS 101

                         90       100
                 ....*....|....*....|....*
gi 15225687   97 RMASQLPGRTDNEIKNYWNTRMKRR 121
Cdd:PLN03212 102 LIAGRIPGRTDNEIKNYWNTHLRKK 126
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 17-121 2.57e-43

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 153.69  E-value: 2.57e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225687   17 GLKKGPWTTTEDAILTEYVRKHGEGNWNAVQKNSGLLRCGKSCRLRWANHLRPNLKKGSFTPDEEKIIIDLHAKLGNKWA 96
Cdd:PLN03212  22 GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWS 101

                         90       100
                 ....*....|....*....|....*
gi 15225687   97 RMASQLPGRTDNEIKNYWNTRMKRR 121
Cdd:PLN03212 102 LIAGRIPGRTDNEIKNYWNTHLRKK 126
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 18-121 4.21e-18

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 86.77  E-value: 4.21e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225687  18 LKKGPWTTTEDAILTEYVRKHGEGNWNAVQKNSGLlRCGKSCRLRWANHLRPNLKKGSFTPDEEKIIIDLHAKLGNKWAR 97
Cdd:COG5147  18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                        90       100
                ....*....|....*....|....
gi 15225687  98 MASQLPGRTDNEIKNYWNTRMKRR 121
Cdd:COG5147  97 IADYKDRRTAQQCVERYVNTLEDL 120
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 73-116 8.37e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.08  E-value: 8.37e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15225687    73 KGSFTPDEEKIIIDLHAKLGNKWARMASQLPGRTDNEIKNYWNT 116
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
73-120 1.01e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 62.63  E-value: 1.01e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 15225687     73 KGSFTPDEEKIIIDLHAKLG-NKWARMASQLPGRTDNEIKNYWNTRMKR 120
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 75-116 2.76e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 2.76e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15225687  75 SFTPDEEKIIIDLHAKLG-NKWARMASQLPGRTDNEIKNYWNT 116
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRN 43
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 17-121 2.57e-43

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 153.69  E-value: 2.57e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225687   17 GLKKGPWTTTEDAILTEYVRKHGEGNWNAVQKNSGLLRCGKSCRLRWANHLRPNLKKGSFTPDEEKIIIDLHAKLGNKWA 96
Cdd:PLN03212  22 GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWS 101

                         90       100
                 ....*....|....*....|....*
gi 15225687   97 RMASQLPGRTDNEIKNYWNTRMKRR 121
Cdd:PLN03212 102 LIAGRIPGRTDNEIKNYWNTHLRKK 126
PLN03091 PLN03091
hypothetical protein; Provisional
 18-123 2.58e-41

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 153.59  E-value: 2.58e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225687   18 LKKGPWTTTEDAILTEYVRKHGEGNWNAVQKNSGLLRCGKSCRLRWANHLRPNLKKGSFTPDEEKIIIDLHAKLGNKWAR 97
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQ 91

                         90       100
                 ....*....|....*....|....*...
gi 15225687   98 MASQLPGRTDNEIKNYWNTRMKR--RQR 123
Cdd:PLN03091  92 IAAQLPGRTDNEIKNLWNSCLKKklRQR 119
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 18-121 4.21e-18

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 86.77  E-value: 4.21e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225687  18 LKKGPWTTTEDAILTEYVRKHGEGNWNAVQKNSGLlRCGKSCRLRWANHLRPNLKKGSFTPDEEKIIIDLHAKLGNKWAR 97
Cdd:COG5147  18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                        90       100
                ....*....|....*....|....
gi 15225687  98 MASQLPGRTDNEIKNYWNTRMKRR 121
Cdd:COG5147  97 IADYKDRRTAQQCVERYVNTLEDL 120
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 73-116 8.37e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.08  E-value: 8.37e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15225687    73 KGSFTPDEEKIIIDLHAKLGNKWARMASQLPGRTDNEIKNYWNT 116
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
73-120 1.01e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 62.63  E-value: 1.01e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 15225687     73 KGSFTPDEEKIIIDLHAKLG-NKWARMASQLPGRTDNEIKNYWNTRMKR 120
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 20-67 1.00e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 59.44  E-value: 1.00e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 15225687    20 KGPWTTTEDAILTEYVRKHGeGNWNAVQKNSGlLRCGKSCRLRWANHL 67
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLP-GRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
20-69 1.08e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 59.54  E-value: 1.08e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 15225687     20 KGPWTTTEDAILTEYVRKHGEGNWNAVQKNSGlLRCGKSCRLRWANHLRP 69
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 75-116 2.76e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 2.76e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15225687  75 SFTPDEEKIIIDLHAKLG-NKWARMASQLPGRTDNEIKNYWNT 116
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRN 43
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 22-67 1.70e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 56.04  E-value: 1.70e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15225687  22 PWTTTEDAILTEYVRKHGEGNWNAVQKNSGlLRCGKSCRLRWANHL 67
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELP-GRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 23-81 3.25e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 52.70  E-value: 3.25e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15225687    23 WTTTEDAILTEYVRKHGeGNWNAVQKNSGLlRCGKSCRLRWANHLRPNLKKGSFTPDEE 81
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGR-RTPKQCFDRWRRKLNPKISRGPWSKEED 57
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 76-135 2.22e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 44.99  E-value: 2.22e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225687    76 FTPDEEKIIIDLHAKLGNKWARMASQLPGRTDNEIKNYWNtRMKRRQRAGLPLYPHEIQH 135
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWR-RKLNPKISRGPWSKEEDQR 59
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 22-65 1.63e-05

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 42.17  E-value: 1.63e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15225687  22 PWTTTEDAILTEYVRKHGEGNWNAVQKNSGLL--RCGKSCRLRWAN 65
Cdd:cd11660   2 KWTDEEDEALVEGVEKYGVGNWAKILKDYFFVnnRTSVDLKDKWRN 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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