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Conserved domains on  [gi|15227632|ref|NP_180538|]
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Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
81-350 5.01e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.87  E-value: 5.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632  81 LTDSVLYALIGFSPYNTTN-LYILNcniPRNISLhlREIKSLP--PLNHgSAVVTIGYHMYVIGG---HNRLHQPTSNVS 154
Cdd:COG3055  20 LLDGKVYVAGGLSGGSASNsFEVYD---PATNTW--SELAPLPgpPRHH-AAAVAQDGKLYVFGGftgANPSSTPLNDVY 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632 155 IIDLRFHTSCSLPRMQRTRVYAAAGVIDGRIYVIGGC-VKRNDHWIEVFDIENRIWS---SVPHHRycngsslrgEGFVT 230
Cdd:COG3055  94 VYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWdDGGNVAWVEVYDPATGTWTqlaPLPTPR---------DHLAA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632 231 SVVMQNKIYILDslfGFAYEPRHGTLQSLGFETQfmFLWRDPCCVIEGLLYCIDPMCVLGHAIVVYDPNELIWrRVKGAY 310
Cdd:COG3055 165 AVLPDGKILVIG---GRNGSGFSNTWTTLAPLPT--ARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTW-TALGEL 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 15227632 311 ILPKfcyYQCKMANFGGKLAILGCSNSSQRGLKDVWFVEI 350
Cdd:COG3055 239 PTPR---HGHAAVLTDGKVYVIGGETKPGVRTPLVTSAEV 275
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 35-76 4.93e-09

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22152:

Pssm-ID: 459239  Cd Length: 45  Bit Score: 51.42  E-value: 4.93e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15227632  35 GIPDELIESTVLLIRRCHYPTLSLLSKTFRRVISSSELYKSR 76
Cdd:cd22152   4 GLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
81-350 5.01e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.87  E-value: 5.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632  81 LTDSVLYALIGFSPYNTTN-LYILNcniPRNISLhlREIKSLP--PLNHgSAVVTIGYHMYVIGG---HNRLHQPTSNVS 154
Cdd:COG3055  20 LLDGKVYVAGGLSGGSASNsFEVYD---PATNTW--SELAPLPgpPRHH-AAAVAQDGKLYVFGGftgANPSSTPLNDVY 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632 155 IIDLRFHTSCSLPRMQRTRVYAAAGVIDGRIYVIGGC-VKRNDHWIEVFDIENRIWS---SVPHHRycngsslrgEGFVT 230
Cdd:COG3055  94 VYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWdDGGNVAWVEVYDPATGTWTqlaPLPTPR---------DHLAA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632 231 SVVMQNKIYILDslfGFAYEPRHGTLQSLGFETQfmFLWRDPCCVIEGLLYCIDPMCVLGHAIVVYDPNELIWrRVKGAY 310
Cdd:COG3055 165 AVLPDGKILVIG---GRNGSGFSNTWTTLAPLPT--ARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTW-TALGEL 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 15227632 311 ILPKfcyYQCKMANFGGKLAILGCSNSSQRGLKDVWFVEI 350
Cdd:COG3055 239 PTPR---HGHAAVLTDGKVYVIGGETKPGVRTPLVTSAEV 275
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 35-76 4.93e-09

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 51.42  E-value: 4.93e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15227632  35 GIPDELIESTVLLIRRCHYPTLSLLSKTFRRVISSSELYKSR 76
Cdd:cd22152   4 GLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 173-213 3.87e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.15  E-value: 3.87e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15227632   173 RVYAAAGVIDGRIYVIGGCV-KRNDHWIEVFDIENRIWSSVP 213
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDgNQSLNSVEVYDPETNTWSKLP 43
Kelch smart00612
Kelch domain;
136-183 1.52e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 1.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 15227632    136 HMYVIGGHNRlHQPTSNVSIIDLRFHTSCSLPRMQRTRVYAAAGVIDG 183
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA02713 PHA02713
hypothetical protein; Provisional
 95-213 2.72e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 39.61  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632   95 YNTTNLYILNCNIPrniSLHLREIKSLPP--LNHGSAVVTigYHMYVIGGHNRLHQPTSNVSIIDLRFHTSCSLPRMQRT 172
Cdd:PHA02713 267 YNVCNPCILVYNIN---TMEYSVISTIPNhiINYASAIVD--NEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKN 341

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 15227632  173 RVYAAAGVIDGRIYVIGGCVKRN-DHWIEVFDIENRIWSSVP 213
Cdd:PHA02713 342 RCRFSLAVIDDTIYAIGGQNGTNvERTIECYTMGDDKWKMLP 383
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
81-350 5.01e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.87  E-value: 5.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632  81 LTDSVLYALIGFSPYNTTN-LYILNcniPRNISLhlREIKSLP--PLNHgSAVVTIGYHMYVIGG---HNRLHQPTSNVS 154
Cdd:COG3055  20 LLDGKVYVAGGLSGGSASNsFEVYD---PATNTW--SELAPLPgpPRHH-AAAVAQDGKLYVFGGftgANPSSTPLNDVY 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632 155 IIDLRFHTSCSLPRMQRTRVYAAAGVIDGRIYVIGGC-VKRNDHWIEVFDIENRIWS---SVPHHRycngsslrgEGFVT 230
Cdd:COG3055  94 VYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWdDGGNVAWVEVYDPATGTWTqlaPLPTPR---------DHLAA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632 231 SVVMQNKIYILDslfGFAYEPRHGTLQSLGFETQfmFLWRDPCCVIEGLLYCIDPMCVLGHAIVVYDPNELIWrRVKGAY 310
Cdd:COG3055 165 AVLPDGKILVIG---GRNGSGFSNTWTTLAPLPT--ARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTW-TALGEL 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 15227632 311 ILPKfcyYQCKMANFGGKLAILGCSNSSQRGLKDVWFVEI 350
Cdd:COG3055 239 PTPR---HGHAAVLTDGKVYVIGGETKPGVRTPLVTSAEV 275
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 35-76 4.93e-09

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 51.42  E-value: 4.93e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15227632  35 GIPDELIESTVLLIRRCHYPTLSLLSKTFRRVISSSELYKSR 76
Cdd:cd22152   4 GLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
120-241 1.29e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 55.55  E-value: 1.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632 120 SLP-PLNHGSAVVtIGYHMYVIGGHNRLhQPTSNVSIIDLRFHTSCSLPRMQRT-RVYAAAGVIDGRIYVIGGCVKRNDH 197
Cdd:COG3055   8 DLPtPRSEAAAAL-LDGKVYVAGGLSGG-SASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGFTGANPS 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15227632 198 W-----IEVFDIENRIWSSVPhhrycNGSSLRGEGfvTSVVMQNKIYIL 241
Cdd:COG3055  86 StplndVYVYDPATNTWTKLA-----PMPTPRGGA--TALLLDGKIYVV 127
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 173-213 3.87e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.15  E-value: 3.87e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15227632   173 RVYAAAGVIDGRIYVIGGCV-KRNDHWIEVFDIENRIWSSVP 213
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDgNQSLNSVEVYDPETNTWSKLP 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 126-170 4.33e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.37  E-value: 4.33e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15227632   126 HGSAVVTIGYHMYVIGGHNRlHQPTSNVSIIDLRFHTSCSLPRMQ 170
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPSMP 46
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
165-241 2.79e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 45.53  E-value: 2.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632 165 SLPRMQRTRVYAAAGVIDGRIYVIGGCVKRNDHW-IEVFDIENRIWSSVPhhrycngsSLRGEG--FVTSVVMQNKIYIL 241
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNsFEVYDPATNTWSELA--------PLPGPPrhHAAAVAQDGKLYVF 76
Kelch smart00612
Kelch domain;
136-183 1.52e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 1.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 15227632    136 HMYVIGGHNRlHQPTSNVSIIDLRFHTSCSLPRMQRTRVYAAAGVIDG 183
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA02713 PHA02713
hypothetical protein; Provisional
 95-213 2.72e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 39.61  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227632   95 YNTTNLYILNCNIPrniSLHLREIKSLPP--LNHGSAVVTigYHMYVIGGHNRLHQPTSNVSIIDLRFHTSCSLPRMQRT 172
Cdd:PHA02713 267 YNVCNPCILVYNIN---TMEYSVISTIPNhiINYASAIVD--NEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKN 341

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 15227632  173 RVYAAAGVIDGRIYVIGGCVKRN-DHWIEVFDIENRIWSSVP 213
Cdd:PHA02713 342 RCRFSLAVIDDTIYAIGGQNGTNvERTIECYTMGDDKWKMLP 383
PHA03098 PHA03098
kelch-like protein; Provisional
 129-190 6.15e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 38.60  E-value: 6.15e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15227632  129 AVVTIGYHMYVIGGHNRLHQPTSNVSIIDLRFHTSCSLPRMQRTRVYAAAGVIDGRIYVIGG 190
Cdd:PHA03098 289 GSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGG 350
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 172-213 7.55e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 34.23  E-value: 7.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15227632   172 TRVYAAAGVIDGRIYVIGGCVKRNDHW---IEVFDIENRIWSSVP 213
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSssdVLVYDPETNVWTEVP 45
Kelch_4 pfam13418
Galactose oxidase, central domain;
173-213 7.96e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.12  E-value: 7.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15227632   173 RVYAAAGVI-DGRIYVIGGCvKRNDH---WIEVFDIENRIWSSVP 213
Cdd:pfam13418   2 RAYHTSTSIpDDTIYLFGGE-GEDGTllsDLWVFDLSTNEWTRLG 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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