|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
466-848 |
1.74e-81 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 264.46 E-value: 1.74e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 466 FNAPQLAAIHWAAMHTaagtssgvkkqepWPFTLVQGPPGTGKTHTVWGMLNVIHLVQYQQYYTSLLKKLApetynqane 545
Cdd:cd18042 1 LNESQLEAIASALQNS-------------PGITLIQGPPGTGKTKTIVGILSVLLAGKYRKYYEKVKKKLR--------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 546 csssdnilsgsidevlqnmdhNLFRTLPKLCAKPRMLVCAPSNAATDELLSRVLDRGFIDGEMRVYRPDVARVGvdsqsr 625
Cdd:cd18042 59 ---------------------KLQRNLNNKKKKNRILVCAPSNAAVDEIVLRLLSEGFLDGDGRSYKPNVVRVG------ 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 626 aaqavsverrsdqllaisrdeilrhmrnlrlqetqisqniaglkrelnaaafatrsqgsvgvdpevlisrdqkrdallqh 705
Cdd:cd18042 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 706 laavveardkvlveisrllivegkfragnnfnleeaRASLEASFANEAEIVFTTVSSSGRKLFSRLTHGFDMVVIDEAAQ 785
Cdd:cd18042 112 ------------------------------------RQELRASILNEADIVCTTLSSSGSDLLESLPRGFDTVIIDEAAQ 155
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15224719 786 ASEVGVLPPLALGAARCVLVGDPQQLPATVISKAAGTLLYSRSLFERFQLAGCPTLLLTVQYR 848
Cdd:cd18042 156 AVELSTLIPLRLGCKRLILVGDPKQLPATVFSKVAQKLGYDRSLFERLQLAGYPVLMLTTQYR 218
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
825-1022 |
1.15e-77 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 253.24 E-value: 1.15e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 825 YSRSLFERFQLAG-CPTLLLTVQYRMHPQIRDFPSRYFYQGRLKDSESISS-APDEIYYKDPVLRPYLFFNISHGRESHR 902
Cdd:pfam13087 1 LDRSLFERLQELGpSAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAErPLPDDFHLPDPLGPLVFIDVDGSEEEES 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 903 GGSVSYENVDEARFCVGvymHLQKTLKSLGAGKVSVGVITPYKLQLKCLKHEFGNALGqdELKEIYINTVDAFQGQERDV 982
Cdd:pfam13087 81 DGGTSYSNEAEAELVVQ---LVEKLIKSGPEEPSDIGVITPYRAQVRLIRKLLKRKLG--GKLEIEVNTVDGFQGREKDV 155
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15224719 983 IIMSCVRASG-HGVGFVSDIRRMNVALTRARRALWVMGNAS 1022
Cdd:pfam13087 156 IIFSCVRSNEkGGIGFLSDPRRLNVALTRAKRGLIIVGNAK 196
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
496-818 |
1.20e-61 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 210.66 E-value: 1.20e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 496 PFTLVQGPPGTGKTHTVWGMLNVIHLvqyqqyytsllkklapetynqanecsssdnilsgsidevlqnmdhnlfRTLPKL 575
Cdd:pfam13086 14 HFTLIQGPPGTGKTTTIVELIRQLLS------------------------------------------------YPATSA 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 576 CAKPRMLVCAPSNAATDELLSRVLDRGfidgemRVYRPDVARVGVDsqsraaqavsvERRSDQLLAISRDEILRHMRNLR 655
Cdd:pfam13086 46 AAGPRILVCAPSNAAVDNILERLLRKG------QKYGPKIVRIGHP-----------AAISEAVLPVSLDYLVESKLNNE 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 656 lQETQISQNIaglKRELNAAAFATRSQGSVGVDPEVLISRDQKRDALLQHLAAVVEARDKvlveisrllivegkfragNN 735
Cdd:pfam13086 109 -EDAQIVKDI---SKELEKLAKALRAFEKEIIVEKLLKSRNKDKSKLEQERRKLRSERKE------------------LR 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 736 FNLEEARASLEASFANEAEIVFTTVSSSGRKLFSRLThGFDMVVIDEAAQASEVGVLPPLALGAARCVLVGDPQQLPATV 815
Cdd:pfam13086 167 KELRRREQSLEREILDEAQIVCSTLSGAGSRLLSSLA-NFDVVIIDEAAQALEPSTLIPLLRGPKKVVLVGDPKQLPPTV 245
|
...
gi 15224719 816 ISK 818
Cdd:pfam13086 246 ISK 248
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
410-1024 |
9.33e-61 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 220.07 E-value: 9.33e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 410 TTQREYVALHAFSRLNPQMQNAILnpspeqfpSYEEQTPAtPDCFTTSFVDhlhRSFNAPQLAAIHWAamhtaagtssgV 489
Cdd:TIGR00376 114 TFKRMKEALRALTENHSRLLEFLL--------GREAPSKA-SEIHDFQFFD---PNLNESQKEAVLFA-----------L 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 490 KKQEpwpFTLVQGPPGTGKTHTVwgmlnvIHLVQyqqyytsllkklapetynqanecsssdnilsgsiDEVLQNmdhnlf 569
Cdd:TIGR00376 171 SSKD---LFLIHGPPGTGKTRTV------VELIR----------------------------------QLVKRG------ 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 570 rtlpklcakPRMLVCAPSNAATDELLSRVldrgfIDGEMRVYR---PdvARVGVDSQSRAAQAVSVERRSDQLLAISRDE 646
Cdd:TIGR00376 202 ---------LRVLVTAPSNIAVDNLLERL-----ALCDQKIVRlghP--ARLLKSNKQHSLDYLIENHPKYQIVADIREK 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 647 I--LRHMRNLRLQET-QISQNIAGLKRELNAaafaTRSQGSVGVDPEVLISRdqkrdallqhlAAVVEARDKvlveISRL 723
Cdd:TIGR00376 266 IdeLIEERNKKTKPSpQKRRGLSDIKILRKA----LKKREARGIESLKIASM-----------AEWIETNKS----IDRL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 724 LIvegkfragnnfNLEEARASLEASFANEAEIVFTTVSSSGRKLFSrlthgFDMVVIDEAAQASEVGVLPPLaLGAARCV 803
Cdd:TIGR00376 327 LK-----------LLPESEERIMNEILAESDATNSMAGSEILNGQY-----FDVAVIDEASQAMEPSCLIPL-LKARKLI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 804 LVGDPQQLPATVISKAAGTLlySRSLFERF-QLAGCPTLLLTVQYRMHPQIRDFPSRYFYQGRLKDSESISS-------- 874
Cdd:TIGR00376 390 LAGDHKQLPPTILSHDAEEL--SLTLFERLiKEYPERSRTLNVQYRMNQKIMEFPSREFYNGKLTAHESVANillrdlpk 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 875 -APDEIYYKDPVLRPYLFFNIS--HGRESHRGGSVSYENVDEARFcvgVYMHLQKtLKSLGAGKVSVGVITPYKLQLKCL 951
Cdd:TIGR00376 468 vEATESEDDLETGIPLLFIDTSgcELFELKEADSTSKYNPGEAEL---VSEIIQA-LVKMGVPANDIGVITPYDAQVDLL 543
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15224719 952 KHEFgnalgQDELKEIYINTVDAFQGQERDVIIMSCVRASGHG-VGFVSDIRRMNVALTRARRALWVMGNASAL 1024
Cdd:TIGR00376 544 RQLL-----EHRHIDIEVSSVDGFQGREKEVIIISFVRSNRKGeVGFLKDLRRLNVALTRARRKLIVIGDSRTL 612
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
849-1038 |
6.08e-60 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 203.23 E-value: 6.08e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 849 MHPQIRDFPSRYFYQGRLKDSESISSAPDeIYYKDPVLRPYLFFNISHGRESHRGGSvSYENVDEARFCVGVYMHLQKTL 928
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAARLN-PPPLPGPSKPLVFVDVSGGEEREESGT-SKSNEAEAELVVELVKYLLKSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 929 KSLGagkvSVGVITPYKLQLKCLKHEFGNALGqdELKEIYINTVDAFQGQERDVIIMSCVRA--SGHGVGFVSDIRRMNV 1006
Cdd:cd18808 79 VKPS----SIGVITPYRAQVALIRELLRKRGG--LLEDVEVGTVDNFQGREKDVIILSLVRSneSGGSIGFLSDPRRLNV 152
|
170 180 190
....*....|....*....|....*....|..
gi 15224719 1007 ALTRARRALWVMGNASALMKSEDWAALISDAR 1038
Cdd:cd18808 153 ALTRAKRGLIIVGNPDTLSKDPLWKKLLEYLE 184
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
589-1024 |
8.70e-59 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 217.69 E-value: 8.70e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 589 AATDELLSRVLDRGFIDGEMRVYRPDVARVGVDSQSRAAQAVSVERRSDQLLAISRDEILRHMRNLRLQETQISQNIAGL 668
Cdd:COG1112 368 ALLLLLALEELLLLALLRLLAEGLALLLLLLLAALLRLARALLLLALLLAAAAAALAALLLLALALLAALLALLLLLAAA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 669 KRELNAAAFATRSQGSVGVDPEVLISRDQKRDALLQHLAAVVEARDKVLVEISRLLIVEGKFRAG---NNFNLEEARASL 745
Cdd:COG1112 448 LAALLALLLLLLLALAALLLLLAAAAALLALALLESLLEELIEEHPEELEKLIAELREAARLRRAlrrELKKRRELRKLL 527
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 746 EASFANEAEIVFTTVSSSGRKLFSRLTHgFDMVVIDEAAQASEVGVLPPLALgAARCVLVGDPQQLPATVIS---KAAGT 822
Cdd:COG1112 528 WDALLELAPVVGMTPASVARLLPLGEGS-FDLVIIDEASQATLAEALGALAR-AKRVVLVGDPKQLPPVVFGeeaEEVAE 605
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 823 LLYSRSLFER-FQLAGCPTLLLTVQYRMHPQIRDFPSRYFYQGRLKDSESIssAPDEIYYKDPVLRpylFFNIShGRESH 901
Cdd:COG1112 606 EGLDESLLDRlLARLPERGVMLREHYRMHPEIIAFSNRLFYDGKLVPLPSP--KARRLADPDSPLV---FIDVD-GVYER 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 902 RGGSvsYENVDEARFCVgvymHLQKTLKSLGAGKVSVGVITPYKLQLKCLKHEFGNALGqDELKEIYINTVDAFQGQERD 981
Cdd:COG1112 680 RGGS--RTNPEEAEAVV----ELVRELLEDGPDGESIGVITPYRAQVALIRELLREALG-DGLEPVFVGTVDRFQGDERD 752
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 15224719 982 VIIMSCVRASGHGV----GFVS-DIRRMNVALTRARRALWVMGNASAL 1024
Cdd:COG1112 753 VIIFSLVYSNDEDVprnfGFLNgGPRRLNVAVSRARRKLIVVGSRELL 800
|
|
| PRK13889 |
PRK13889 |
conjugal transfer relaxase TraA; Provisional |
764-832 |
8.79e-03 |
|
conjugal transfer relaxase TraA; Provisional
Pssm-ID: 237546 [Multi-domain] Cd Length: 988 Bit Score: 40.06 E-value: 8.79e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15224719 764 GRKLfsrLTHGfDMVVIDEAAQaseVG------VLPPLALGAARCVLVGDPQQLPATviskAAGTLLysRSLFER 832
Cdd:PRK13889 427 GRDL---LTSR-DVLVIDEAGM---VGtrqlerVLSHAADAGAKVVLVGDPQQLQAI----EAGAAF--RSIHER 488
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
466-848 |
1.74e-81 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 264.46 E-value: 1.74e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 466 FNAPQLAAIHWAAMHTaagtssgvkkqepWPFTLVQGPPGTGKTHTVWGMLNVIHLVQYQQYYTSLLKKLApetynqane 545
Cdd:cd18042 1 LNESQLEAIASALQNS-------------PGITLIQGPPGTGKTKTIVGILSVLLAGKYRKYYEKVKKKLR--------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 546 csssdnilsgsidevlqnmdhNLFRTLPKLCAKPRMLVCAPSNAATDELLSRVLDRGFIDGEMRVYRPDVARVGvdsqsr 625
Cdd:cd18042 59 ---------------------KLQRNLNNKKKKNRILVCAPSNAAVDEIVLRLLSEGFLDGDGRSYKPNVVRVG------ 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 626 aaqavsverrsdqllaisrdeilrhmrnlrlqetqisqniaglkrelnaaafatrsqgsvgvdpevlisrdqkrdallqh 705
Cdd:cd18042 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 706 laavveardkvlveisrllivegkfragnnfnleeaRASLEASFANEAEIVFTTVSSSGRKLFSRLTHGFDMVVIDEAAQ 785
Cdd:cd18042 112 ------------------------------------RQELRASILNEADIVCTTLSSSGSDLLESLPRGFDTVIIDEAAQ 155
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15224719 786 ASEVGVLPPLALGAARCVLVGDPQQLPATVISKAAGTLLYSRSLFERFQLAGCPTLLLTVQYR 848
Cdd:cd18042 156 AVELSTLIPLRLGCKRLILVGDPKQLPATVFSKVAQKLGYDRSLFERLQLAGYPVLMLTTQYR 218
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
825-1022 |
1.15e-77 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 253.24 E-value: 1.15e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 825 YSRSLFERFQLAG-CPTLLLTVQYRMHPQIRDFPSRYFYQGRLKDSESISS-APDEIYYKDPVLRPYLFFNISHGRESHR 902
Cdd:pfam13087 1 LDRSLFERLQELGpSAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAErPLPDDFHLPDPLGPLVFIDVDGSEEEES 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 903 GGSVSYENVDEARFCVGvymHLQKTLKSLGAGKVSVGVITPYKLQLKCLKHEFGNALGqdELKEIYINTVDAFQGQERDV 982
Cdd:pfam13087 81 DGGTSYSNEAEAELVVQ---LVEKLIKSGPEEPSDIGVITPYRAQVRLIRKLLKRKLG--GKLEIEVNTVDGFQGREKDV 155
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15224719 983 IIMSCVRASG-HGVGFVSDIRRMNVALTRARRALWVMGNAS 1022
Cdd:pfam13087 156 IIFSCVRSNEkGGIGFLSDPRRLNVALTRAKRGLIIVGNAK 196
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
496-818 |
1.20e-61 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 210.66 E-value: 1.20e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 496 PFTLVQGPPGTGKTHTVWGMLNVIHLvqyqqyytsllkklapetynqanecsssdnilsgsidevlqnmdhnlfRTLPKL 575
Cdd:pfam13086 14 HFTLIQGPPGTGKTTTIVELIRQLLS------------------------------------------------YPATSA 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 576 CAKPRMLVCAPSNAATDELLSRVLDRGfidgemRVYRPDVARVGVDsqsraaqavsvERRSDQLLAISRDEILRHMRNLR 655
Cdd:pfam13086 46 AAGPRILVCAPSNAAVDNILERLLRKG------QKYGPKIVRIGHP-----------AAISEAVLPVSLDYLVESKLNNE 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 656 lQETQISQNIaglKRELNAAAFATRSQGSVGVDPEVLISRDQKRDALLQHLAAVVEARDKvlveisrllivegkfragNN 735
Cdd:pfam13086 109 -EDAQIVKDI---SKELEKLAKALRAFEKEIIVEKLLKSRNKDKSKLEQERRKLRSERKE------------------LR 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 736 FNLEEARASLEASFANEAEIVFTTVSSSGRKLFSRLThGFDMVVIDEAAQASEVGVLPPLALGAARCVLVGDPQQLPATV 815
Cdd:pfam13086 167 KELRRREQSLEREILDEAQIVCSTLSGAGSRLLSSLA-NFDVVIIDEAAQALEPSTLIPLLRGPKKVVLVGDPKQLPPTV 245
|
...
gi 15224719 816 ISK 818
Cdd:pfam13086 246 ISK 248
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
410-1024 |
9.33e-61 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 220.07 E-value: 9.33e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 410 TTQREYVALHAFSRLNPQMQNAILnpspeqfpSYEEQTPAtPDCFTTSFVDhlhRSFNAPQLAAIHWAamhtaagtssgV 489
Cdd:TIGR00376 114 TFKRMKEALRALTENHSRLLEFLL--------GREAPSKA-SEIHDFQFFD---PNLNESQKEAVLFA-----------L 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 490 KKQEpwpFTLVQGPPGTGKTHTVwgmlnvIHLVQyqqyytsllkklapetynqanecsssdnilsgsiDEVLQNmdhnlf 569
Cdd:TIGR00376 171 SSKD---LFLIHGPPGTGKTRTV------VELIR----------------------------------QLVKRG------ 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 570 rtlpklcakPRMLVCAPSNAATDELLSRVldrgfIDGEMRVYR---PdvARVGVDSQSRAAQAVSVERRSDQLLAISRDE 646
Cdd:TIGR00376 202 ---------LRVLVTAPSNIAVDNLLERL-----ALCDQKIVRlghP--ARLLKSNKQHSLDYLIENHPKYQIVADIREK 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 647 I--LRHMRNLRLQET-QISQNIAGLKRELNAaafaTRSQGSVGVDPEVLISRdqkrdallqhlAAVVEARDKvlveISRL 723
Cdd:TIGR00376 266 IdeLIEERNKKTKPSpQKRRGLSDIKILRKA----LKKREARGIESLKIASM-----------AEWIETNKS----IDRL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 724 LIvegkfragnnfNLEEARASLEASFANEAEIVFTTVSSSGRKLFSrlthgFDMVVIDEAAQASEVGVLPPLaLGAARCV 803
Cdd:TIGR00376 327 LK-----------LLPESEERIMNEILAESDATNSMAGSEILNGQY-----FDVAVIDEASQAMEPSCLIPL-LKARKLI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 804 LVGDPQQLPATVISKAAGTLlySRSLFERF-QLAGCPTLLLTVQYRMHPQIRDFPSRYFYQGRLKDSESISS-------- 874
Cdd:TIGR00376 390 LAGDHKQLPPTILSHDAEEL--SLTLFERLiKEYPERSRTLNVQYRMNQKIMEFPSREFYNGKLTAHESVANillrdlpk 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 875 -APDEIYYKDPVLRPYLFFNIS--HGRESHRGGSVSYENVDEARFcvgVYMHLQKtLKSLGAGKVSVGVITPYKLQLKCL 951
Cdd:TIGR00376 468 vEATESEDDLETGIPLLFIDTSgcELFELKEADSTSKYNPGEAEL---VSEIIQA-LVKMGVPANDIGVITPYDAQVDLL 543
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15224719 952 KHEFgnalgQDELKEIYINTVDAFQGQERDVIIMSCVRASGHG-VGFVSDIRRMNVALTRARRALWVMGNASAL 1024
Cdd:TIGR00376 544 RQLL-----EHRHIDIEVSSVDGFQGREKEVIIISFVRSNRKGeVGFLKDLRRLNVALTRARRKLIVIGDSRTL 612
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
849-1038 |
6.08e-60 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 203.23 E-value: 6.08e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 849 MHPQIRDFPSRYFYQGRLKDSESISSAPDeIYYKDPVLRPYLFFNISHGRESHRGGSvSYENVDEARFCVGVYMHLQKTL 928
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAARLN-PPPLPGPSKPLVFVDVSGGEEREESGT-SKSNEAEAELVVELVKYLLKSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 929 KSLGagkvSVGVITPYKLQLKCLKHEFGNALGqdELKEIYINTVDAFQGQERDVIIMSCVRA--SGHGVGFVSDIRRMNV 1006
Cdd:cd18808 79 VKPS----SIGVITPYRAQVALIRELLRKRGG--LLEDVEVGTVDNFQGREKDVIILSLVRSneSGGSIGFLSDPRRLNV 152
|
170 180 190
....*....|....*....|....*....|..
gi 15224719 1007 ALTRARRALWVMGNASALMKSEDWAALISDAR 1038
Cdd:cd18808 153 ALTRAKRGLIIVGNPDTLSKDPLWKKLLEYLE 184
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
589-1024 |
8.70e-59 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 217.69 E-value: 8.70e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 589 AATDELLSRVLDRGFIDGEMRVYRPDVARVGVDSQSRAAQAVSVERRSDQLLAISRDEILRHMRNLRLQETQISQNIAGL 668
Cdd:COG1112 368 ALLLLLALEELLLLALLRLLAEGLALLLLLLLAALLRLARALLLLALLLAAAAAALAALLLLALALLAALLALLLLLAAA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 669 KRELNAAAFATRSQGSVGVDPEVLISRDQKRDALLQHLAAVVEARDKVLVEISRLLIVEGKFRAG---NNFNLEEARASL 745
Cdd:COG1112 448 LAALLALLLLLLLALAALLLLLAAAAALLALALLESLLEELIEEHPEELEKLIAELREAARLRRAlrrELKKRRELRKLL 527
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 746 EASFANEAEIVFTTVSSSGRKLFSRLTHgFDMVVIDEAAQASEVGVLPPLALgAARCVLVGDPQQLPATVIS---KAAGT 822
Cdd:COG1112 528 WDALLELAPVVGMTPASVARLLPLGEGS-FDLVIIDEASQATLAEALGALAR-AKRVVLVGDPKQLPPVVFGeeaEEVAE 605
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 823 LLYSRSLFER-FQLAGCPTLLLTVQYRMHPQIRDFPSRYFYQGRLKDSESIssAPDEIYYKDPVLRpylFFNIShGRESH 901
Cdd:COG1112 606 EGLDESLLDRlLARLPERGVMLREHYRMHPEIIAFSNRLFYDGKLVPLPSP--KARRLADPDSPLV---FIDVD-GVYER 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 902 RGGSvsYENVDEARFCVgvymHLQKTLKSLGAGKVSVGVITPYKLQLKCLKHEFGNALGqDELKEIYINTVDAFQGQERD 981
Cdd:COG1112 680 RGGS--RTNPEEAEAVV----ELVRELLEDGPDGESIGVITPYRAQVALIRELLREALG-DGLEPVFVGTVDRFQGDERD 752
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 15224719 982 VIIMSCVRASGHGV----GFVS-DIRRMNVALTRARRALWVMGNASAL 1024
Cdd:COG1112 753 VIIFSLVYSNDEDVprnfGFLNgGPRRLNVAVSRARRKLIVVGSRELL 800
|
|
| DEXXQc_UPF1 |
cd18039 |
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ... |
496-848 |
4.85e-28 |
|
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350797 [Multi-domain] Cd Length: 234 Bit Score: 113.50 E-value: 4.85e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 496 PFTLVQGPPGTGKTHTVWGMlnVIHLVQyqqyytsllkklapetynqanecsssdnilsgsidevlQNMDhnlfrtlpkl 575
Cdd:cd18039 17 PLSLIQGPPGTGKTVTSATI--VYHLVK--------------------------------------QGNG---------- 46
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 576 cakpRMLVCAPSNAATDELLSRVLDRGfidgeMRVYRpdvarvgVDSQSRAAQAVSVErrsdqllaisrdeilrhmrNLR 655
Cdd:cd18039 47 ----PVLVCAPSNVAVDQLTEKIHQTG-----LKVVR-------LCAKSREAVESPVS-------------------FLA 91
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 656 LQEtQISQNIAGLKRELNAaaFATRSQGSvgvdpevlisrdqkrdallqhLAAVVEARDKVLVEisrllivegkfragnn 735
Cdd:cd18039 92 LHN-QVRNLDSAEKLELLK--LLKLETGE---------------------LSSADEKRYRKLKR---------------- 131
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 736 fnleearaSLEASFANEAEIVFTTVSSSGRKLFSRLThgFDMVVIDEAAQASEVGVLPPLALGAARCVLVGDPQQLPATV 815
Cdd:cd18039 132 --------KAERELLRNADVICCTCVGAGDPRLSKMK--FRTVLIDEATQATEPECLIPLVHGAKQVILVGDHCQLGPVV 201
|
330 340 350
....*....|....*....|....*....|...
gi 15224719 816 ISKAAGTLLYSRSLFERFQLAGCPTLLLTVQYR 848
Cdd:cd18039 202 MCKKAAKAGLSQSLFERLVQLGIRPIRLQVQYR 234
|
|
| DEXXQc_SMUBP2 |
cd18044 |
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, ... |
731-848 |
3.02e-21 |
|
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, or IGHMBP2) is a 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. It is a DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence (5'-GGGCT-3') related to the immunoglobulin mu chain switch region. The IGHMBP2 gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). It is also thought to play a role in frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) and major depressive disorder (MDD). SMUBP2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350802 [Multi-domain] Cd Length: 191 Bit Score: 92.67 E-value: 3.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 731 RAGNNFNLEEA--RASLEASFanEAEIVFTTVSSSGRKLFsRLTHGFDMVVIDEAAQASEVGVLPPLaLGAARCVLVGDP 808
Cdd:cd18044 74 RIGHPARLLESvlDHSLDALV--AAQVVLATNTGAGSRQL-LPNELFDVVVIDEAAQALEASCWIPL-LKARRCILAGDH 149
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 15224719 809 QQLPATVISKAAGTLLYSRSLFERF--QLAGCPTLLLTVQYR 848
Cdd:cd18044 150 KQLPPTILSDKAARGGLGVTLFERLvnLYGESVVRMLTVQYR 191
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
775-848 |
1.94e-16 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 76.50 E-value: 1.94e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15224719 775 FDMVVIDEAAQASEVGVLPPLaLGAARCVLVGDPQQLPATVISKAAGTLL----YSRSLFERFQLAGCPTLLLTVQYR 848
Cdd:cd17934 45 VDVVIIDEASQITEPELLIAL-IRAKKVVLVGDPKQLPPVVQEDHAALLGlsfiLSLLLLFRLLLPGSPKVMLDTQYR 121
|
|
| DEXXQc_DNA2 |
cd18041 |
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses ... |
748-848 |
1.37e-14 |
|
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350799 [Multi-domain] Cd Length: 203 Bit Score: 73.81 E-value: 1.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 748 SFANEAEIVFTTVSSSGRKLFSRLThgFDMVVIDEAAQASEVGVLPPLALgAARCVLVGDPQQLPATVISKAAGTLLYSR 827
Cdd:cd18041 105 SKYESVSVVATTCLGINHPIFRRRT--FDYCIVDEASQITLPICLGPLRL-AKKFVLVGDHYQLPPLVKSREARELGMDE 181
|
90 100
....*....|....*....|..
gi 15224719 828 SLFERFQLAGCPTLL-LTVQYR 848
Cdd:cd18041 182 SLFKRLSEAHPDAVVqLTIQYR 203
|
|
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
467-852 |
1.55e-14 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 74.19 E-value: 1.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 467 NAPQLAAIhwaaMHTAAGTSSgvkkqePWPFtLVQGPPGTGKTHTvwgmlnvihLVqyqqyytsllkklapetynqanEC 546
Cdd:cd18038 3 NDEQKLAV----RNIVTGTSR------PPPY-IIFGPPGTGKTVT---------LV----------------------EA 40
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 547 sssdnilsgsideVLQnmdhnLFRTLPKlcakPRMLVCAPSNAATDELLSRVLDrgfidgemrvyrpdvarvgvdsqsra 626
Cdd:cd18038 41 -------------ILQ-----VLRQPPE----ARILVCAPSNSAADLLAERLLN-------------------------- 72
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 627 aqAVSVERrsdqllaisrdEILRhmrnlrlqetqisqniaglkreLNAAafaTRSQGSVgvdpevlisrdqkrdallqhl 706
Cdd:cd18038 73 --ALVTKR-----------EILR----------------------LNAP---SRDRASV--------------------- 93
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 707 aavvearDKVLVEISRLlIVEGKFRAGNNFNLEEARasleasfaneaeIVFTTVSSSGR--KLFSRLTHgFDMVVIDEAA 784
Cdd:cd18038 94 -------PPELLPYCNS-KAEGTFRLPSLEELKKYR------------IVVCTLMTAGRlvQAGVPNGH-FTHIFIDEAG 152
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15224719 785 QASEVGVLPPLALGAA---RCVLVGDPQQLPATVISKAAGTLLYSRSLFERfqlagcptLLLTVQYRMHPQ 852
Cdd:cd18038 153 QATEPEALIPLSELASkntQIVLAGDPKQLGPVVRSPLARKYGLGKSLLER--------LMERPLYYKDGE 215
|
|
| DEXXc_HELZ2-C |
cd18040 |
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
496-848 |
6.29e-13 |
|
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350798 [Multi-domain] Cd Length: 271 Bit Score: 70.25 E-value: 6.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 496 PFTLVQGPPGTGKTHTVwgmlnvIHLVQYqqyytsllkklapetynqanecsssdnilsgsidevLQNMDHNLFRTLPKL 575
Cdd:cd18040 17 PFTLIQGPPGTGKTVTG------VHIAYW------------------------------------FAKQNREIQSVSGEG 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 576 CAKPRMLVCAPSNAATDELLSRVLDRGFIDgEMRVYRP-------DVARVGVDSQSRAAQavsvERRSDQLLaisrDEIL 648
Cdd:cd18040 55 DGGPCVLYCGPSNKSVDVVAELLLKVPGLK-ILRVYSEqietteyPIPNEPRHPNKKSER----ESKPNSEL----SSIT 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 649 RHMRnLRLQETQISQNIAGLKRELNaaafatRSQgsvgvdpEVLISRDQKrdallQHLAAVVEARdkvlveisrllIVEG 728
Cdd:cd18040 126 LHHR-IRQPSNPHSQQIKAFEARFE------RTQ-------EKITEEDIK-----TYKILIWEAR-----------FEEL 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 729 KfragnnfnleearasleasfanEAEIVFTTVSSSGRKLFSRLTHgFDMVVIDEAAQASEVGVLPPL--ALGAARCVLVG 806
Cdd:cd18040 176 E----------------------TVDVILCTCSEAASQKMRTHAN-VKQCIVDECGMCTEPESLIPIvsAPRAEQVVLIG 232
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 15224719 807 DPQQLPATVISKAAGTLLYSRSLFERFQLAGCptlLLTVQYR 848
Cdd:cd18040 233 DHKQLRPVVQNKEAQKLGLGRSLFERYAEKAC---MLDTQYR 271
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
934-1015 |
9.04e-13 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 64.77 E-value: 9.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 934 GKVSVGVITPYKLQL-KCLKHEFGNALGQDELKEIYINTVDAFQGQERDVIIMSCVRASGHgvgfvsDIRRMNVALTRAR 1012
Cdd:cd18786 9 GLYKGVVLTPYHRDRaYLNQYLQGLSLDEFDLQLVGAITIDSSQGLTFDVVTLYLPTANSL------TPRRLYVALTRAR 82
|
...
gi 15224719 1013 RAL 1015
Cdd:cd18786 83 KRL 85
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
752-860 |
1.17e-10 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 62.44 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 752 EAEIVFTTVSSSG--RKLFSRLTHGFDMVVIDEAAQASEVGVLPPLALGAA--------RCVLVGDPQQLPATVISKAAG 821
Cdd:cd17935 86 GAKIIAMTCTHAAlkRGELVELGFKYDNILMEEAAQILEIETFIPLLLQNPedgpnrlkRLIMIGDHHQLPPVIKNMAFQ 165
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 15224719 822 TLLYS-RSLFERFQLAGCPTLLLTVQYRMHPQI-RDFPSRY 860
Cdd:cd17935 166 KYSNMeQSLFTRLVRLGVPTVDLDAQGRARASIsSLYNWRY 206
|
|
| DEXXQc_Mov10L1 |
cd18078 |
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ... |
493-833 |
2.01e-08 |
|
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350836 [Multi-domain] Cd Length: 230 Bit Score: 56.22 E-value: 2.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 493 EPWPFTLVqGPPGTGKTHTVwgmlnvihlvqyqqyytsllkklapetynqanecsssdnilsgsIDEVLQnmdhnLFRTL 572
Cdd:cd18078 19 RPLPYILF-GPPGTGKTVTI--------------------------------------------IEAILQ-----VVYNL 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 573 PKLcakpRMLVCAPSNAATDELLSRVLDRGFID-GEMrvyrpdvARVgvdsqsraaqaVSVerrsdqllaisrdeilrhm 651
Cdd:cd18078 49 PRS----RILVCAPSNSAADLVTSRLHESKVLKpGDM-------VRL-----------NAV------------------- 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 652 rnLRLQETQISQNIAGLKrelnaaafatrsqgsvgvdpevliSRDQKRDAllqhlaavveardkvlveisrlliveGKFR 731
Cdd:cd18078 88 --NRFESTVIDARKLYCR------------------------LGEDLSKA--------------------------SRHR 115
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 732 agnnfnleearasleasfaneaeIVFTTVSSSGRKLFSRLTHG-FDMVVIDEAAQASEVGVLPPLAL---GAARCVLVGD 807
Cdd:cd18078 116 -----------------------IVISTCSTAGLLYQMGLPVGhFTHVFVDEAGQATEPESLIPLGLissRDGQIILAGD 172
|
330 340
....*....|....*....|....*.
gi 15224719 808 PQQLPATVISKAAGTLLYSRSLFERF 833
Cdd:cd18078 173 PMQLGPVIKSRLASAYGLGVSFLERL 198
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
775-847 |
2.18e-08 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 53.64 E-value: 2.18e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15224719 775 FDMVVIDEAAQASEV--GVLPPLALGAARCVLVGDPQQLPATVISKAAGTLLYSRSLFERFQLAGCPTLLLTVQY 847
Cdd:cd17914 47 LDNILVDEAAQILEPetSRLIDLALDQGRVILVGDHDQLGPVWRGAVLAKICNEQSLFTRLVRLGVSLIRLQVQY 121
|
|
| betaCoV_Nsp13-helicase |
cd21722 |
helicase domain of betacoronavirus non-structural protein 13; This model represents the ... |
776-1033 |
2.37e-08 |
|
helicase domain of betacoronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from betacoronavirus, including pathogenic human viruses such as Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV2 (also called 2019 novel CoV or 2019-nCoV), and Middle East respiratory syndrome-related (MERS) CoV. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Pssm-ID: 409655 [Multi-domain] Cd Length: 340 Bit Score: 57.12 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 776 DMVVIDEAAQAS--EVGVLPPlALGAARCVLVGDPQQLPA--TVISKaaGTL--LYSRSLfERFQLAGCPTLLLTVQYRM 849
Cdd:cd21722 119 DILVVDEVSMCTnyDLSVINA-RVRAKHIVYIGDPAQLPAprTLLTK--GTLepEYFNSV-TRLMCCLGPDIFLGTCYRC 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 850 HPQIRDFPSRYFYQGRLKDSESISSAPDEIYYKdpvlrpylffnishGRESHRggSVSYENVDEARFcvgvymhLQKTLK 929
Cdd:cd21722 195 PKEIVDTVSALVYDNKLKAKKDNSGQCFKVYYK--------------GSVTHD--SSSAINRPQIYL-------VKKFLK 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 930 SLGAGKVSVgVITPYKLQlkclkhefgNALGQDELKeIYINTVDAFQGQERDVIIMSCVRASGHGVgfvsDIRRMNVALT 1009
Cdd:cd21722 252 ANPAWSKAV-FISPYNSQ---------NAVARRVLG-LQTQTVDSSQGSEYDYVIYCQTAETAHSV----NVNRFNVAIT 316
|
250 260
....*....|....*....|....
gi 15224719 1010 RARRALWVMGNASALMKSEDWAAL 1033
Cdd:cd21722 317 RAKKGILCVMSSMQLFESLQFTEL 340
|
|
| CoV_Nsp13-helicase |
cd21718 |
helicase domain of coronavirus non-structural protein 13; This model represents the helicase ... |
776-1018 |
1.20e-07 |
|
helicase domain of coronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from alpha-, beta-, gamma-, and deltacoronavirus, including pathogenic human viruses such as Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV2 (also called 2019 novel CoV or 2019-nCoV), and Middle East respiratory syndrome-related (MERS) CoV. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Pssm-ID: 409652 [Multi-domain] Cd Length: 341 Bit Score: 54.84 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 776 DMVVIDEAAQAS--EVGVLPPlALGAARCVLVGDPQQLPATVISKAAGTLL---YSRslFERFQLAGCPTLLLTVQYRMH 850
Cdd:cd21718 119 DIVVVDEVSMCTnyDLSVVNA-RLKYKHIVYVGDPAQLPAPRTLLTEGSLEpkdYNV--VTRLMVGSGPDVFLSKCYRCP 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 851 PQIRDFPSRYFYQGRLKDSESISSAPDEIYYKDPVlrpylffnishgreSHRGGSvSYeNVDEARFcvgVYMHLQKTLKS 930
Cdd:cd21718 196 KEIVDTVSKLVYDNKLKAIKPKSRQCFKTFGKGDV--------------RHDNGS-AI-NRPQLEF---VKRFLDRNPRW 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 931 LGAGkvsvgVITPYKLQLKCLKHEFGnalgqdelkeIYINTVDAFQGQERDVIIMSCVRASGHGvgfvSDIRRMNVALTR 1010
Cdd:cd21718 257 RKAV-----FISPYNAMNNRASRLLG----------LSTQTVDSSQGSEYDYVIFCQTTDTAHA----LNINRFNVAITR 317
|
....*...
gi 15224719 1011 ARRALWVM 1018
Cdd:cd21718 318 AKHGILVI 325
|
|
| DEXXQc_SF1 |
cd18043 |
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ... |
775-812 |
1.24e-06 |
|
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350801 [Multi-domain] Cd Length: 127 Bit Score: 48.73 E-value: 1.24e-06
10 20 30
....*....|....*....|....*....|....*...
gi 15224719 775 FDMVVIDEAAQASEVGVLPPLALGaARCVLVGDPQQLP 812
Cdd:cd18043 81 FDLVIFDEASQIPIEEALPALFRG-KQVVVVGDDKQLP 117
|
|
| gammaCoV_Nsp13-helicase |
cd21720 |
helicase domain of gammacoronavirus non-structural protein 13; This model represents the ... |
803-1018 |
2.07e-05 |
|
helicase domain of gammacoronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from gammacoronavirus, including Avian infectious bronchitis virus. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. Coronavirus (CoV) Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Pssm-ID: 409653 [Multi-domain] Cd Length: 343 Bit Score: 47.99 E-value: 2.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 803 VLVGDPQQLPA--TVISKAAGTLLYSrsLFERFQLAGCPTLLLTVQYRMHPQIRDFPSRYFYQGrlkdsESISSAPDE-I 879
Cdd:cd21720 147 VYVGDPAQLPAprTLLNGSLSPKDYN--VVTNLMVCVKPDIFLAKCYRCPKEIVDTVSTLVYDG-----KFIANNPESrQ 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 880 YYKdpvlrpyLFFNISHGRESHRGGSVSyeNVDEARFCVGVYMHLQKTLKSLgagkvsvgVITPYklqlkclkhefgNAL 959
Cdd:cd21720 220 CFK-------VIVNNGNSDVGHESGSAY--NTTQLEFVKDFVCRNKEWREAT--------FISPY------------NAM 270
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15224719 960 GQDELKEIYIN--TVDAFQGQERDVIIMsCVRA-SGHGVgfvsDIRRMNVALTRARRALWVM 1018
Cdd:cd21720 271 NQRAYRMLGLNvqTVDSSQGSEYDYVIF-CVTAdSQHAL----NINRFNVALTRAKRGILVV 327
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
497-605 |
2.60e-05 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 44.53 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 497 FTLVQGPPGTGKTHTvwgmlnVIHLVQYqqyytsllkklapetynqanecsssdnilsgsidevlqnmdhnlfrtLPKLC 576
Cdd:cd17934 1 ISLIQGPPGTGKTTT------IAAIVLQ-----------------------------------------------LLKGL 27
|
90 100
....*....|....*....|....*....
gi 15224719 577 AKPRMLVCAPSNAATDellsrVLDRGFID 605
Cdd:cd17934 28 RGKRVLVTAQSNVAVD-----NVDVVIID 51
|
|
| deltaCoV_Nsp13-helicase |
cd21721 |
helicase domain of deltacoronavirus non-structural protein 13; This model represents the ... |
776-1027 |
4.56e-05 |
|
helicase domain of deltacoronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from deltacoronavirus, including Bulbul coronavirus (CoV) HKU11 and Common moorhen CoV HKU21. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Pssm-ID: 409654 [Multi-domain] Cd Length: 342 Bit Score: 46.84 E-value: 4.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 776 DMVVIDEAAQASEVGVLPPLA-LGAARCVLVGDPQQLPATVISKAAGTLL-YSRSLFERFQLAGCPTLLLTVQYRMHPQI 853
Cdd:cd21721 119 DIVVVDEVSMLTNYELSSVNArLVYNHIVYVGDPYQLPSPRTMLTTGQLSpADYNVVTDIMVHAGADVMLDMCYRCPREI 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 854 RDFPSRYFYQGRLKDSESISSApdeiYYKdpvlrpyLFFNISHGRESHRGGSVSyeNVDEARFCVGVYMHLQKTlkslga 933
Cdd:cd21721 199 VDTVSKLVYDNKLKAAKPNSRQ----CYK-------TIINNGNNDIAHEGQSAY--NEPQLRFALAFRQYKRWD------ 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 934 gkvSVGVITPYK-LQLKCLKHEFGNalgqdelkeiyiNTVDAFQGQERDVIIMSCVRASGHGVgfvsDIRRMNVALTRAR 1012
Cdd:cd21721 260 ---NVTFISPYNaMNVKAAMAGFST------------QTVDSSQGSEYDYVIFCVTTDSAHAL----NMSRLNVALTRAK 320
|
250
....*....|....*.
gi 15224719 1013 RA-LWVMGNASALMKS 1027
Cdd:cd21721 321 IGiLVVFRQANELYNS 336
|
|
| DEXXQc_HELZ |
cd18077 |
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that ... |
753-832 |
8.13e-05 |
|
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. HELZ is a member of the family I class of RNA helicases of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350835 [Multi-domain] Cd Length: 226 Bit Score: 45.17 E-value: 8.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 753 AEIVFTTVSSSGRKLFSRLTHG-FDMVVIDEAAQASEVGVLPPLALGAA--RCVLVGDPQQLPATVISKAAGTLLYSRSL 829
Cdd:cd18077 124 HRVVVVTLSTSQYLCQLDLEPGfFTHILLDEAAQAMECEAIMPLALATKstRIVLAGDHMQLSPEVYSEFARERNLHISL 203
|
...
gi 15224719 830 FER 832
Cdd:cd18077 204 LER 206
|
|
| EEXXEc_NFX1 |
cd17936 |
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that ... |
758-847 |
5.63e-04 |
|
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that represses class II MHC (major histocompatibility complex) gene expression. NFX1 binds a conserved cis-acting element, termed the X-box, in promoters of human class II MHC genes. The Cys-rich region contains several NFX1-type zinc finger domains. Frequently, a R3H domain is present in the C-terminus, and a RING finger domain and a PAM2 motif are present in the N-terminus. The lack of R3H and PAM2 motifs in the plant proteins indicates functional differences. Plant NFX1-like proteins are proposed to modulate growth and survival by coordinating reactive oxygen species, salicylic acid, further biotic stress and abscisic acid responses. A common feature of all members may be E3 ubiquitin ligase, due to the presence of a RING finger domain, as well as DNA binding. NFX1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350694 [Multi-domain] Cd Length: 178 Bit Score: 42.15 E-value: 5.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 758 TTVSSSGRKLFSRLthGFDMVVIDEAAQASEVGVLPPLALGAARCVLVGDPQQL-PATVISKAAGTLL-YSRSLFERFQL 835
Cdd:cd17936 89 TTGAAKYRELLQAL--GPKVVIVEEAAEVLEAHILAALTPSTEHLILIGDHKQLrPKVNVYELTAKKYnLDVSLFERLVK 166
|
90
....*....|..
gi 15224719 836 AGCPTLLLTVQY 847
Cdd:cd17936 167 NGLPFVTLNVQR 178
|
|
| DEXXQc_SF1 |
cd18043 |
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ... |
467-512 |
1.44e-03 |
|
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350801 [Multi-domain] Cd Length: 127 Bit Score: 39.87 E-value: 1.44e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 15224719 467 NAPQLAAIHWAAMHTAagtssgvkkqepwpfTLVQGPPGTGKTHTV 512
Cdd:cd18043 1 DSSQEAAIISARNGKN---------------VVIQGPPGTGKSQTI 31
|
|
| AAA_30 |
pfam13604 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
776-855 |
1.45e-03 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.
Pssm-ID: 433343 [Multi-domain] Cd Length: 191 Bit Score: 41.01 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224719 776 DMVVIDEAAQASE---VGVLPPLALGAARCVLVGDPQQLPATviskAAGTLLysRSLFErfqlAGCPTLLLTVQYRM-HP 851
Cdd:pfam13604 90 TLLIVDEAGMVGTrqmARLLKLAEDAGARVILVGDPRQLPSV----EAGGAF--RDLLA----AGIGTAELTEIVRQrDP 159
|
....
gi 15224719 852 QIRD 855
Cdd:pfam13604 160 WQRA 163
|
|
| EEXXEc_NFX1 |
cd17936 |
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that ... |
467-511 |
1.53e-03 |
|
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that represses class II MHC (major histocompatibility complex) gene expression. NFX1 binds a conserved cis-acting element, termed the X-box, in promoters of human class II MHC genes. The Cys-rich region contains several NFX1-type zinc finger domains. Frequently, a R3H domain is present in the C-terminus, and a RING finger domain and a PAM2 motif are present in the N-terminus. The lack of R3H and PAM2 motifs in the plant proteins indicates functional differences. Plant NFX1-like proteins are proposed to modulate growth and survival by coordinating reactive oxygen species, salicylic acid, further biotic stress and abscisic acid responses. A common feature of all members may be E3 ubiquitin ligase, due to the presence of a RING finger domain, as well as DNA binding. NFX1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350694 [Multi-domain] Cd Length: 178 Bit Score: 40.61 E-value: 1.53e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 15224719 467 NAPQLAAIHWAAMHtaagtssgvkkqepwPFTLVQGPPGTGKTHT 511
Cdd:cd17936 3 DPSQLEALKHALTS---------------ELALIQGPPGTGKTFL 32
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
466-520 |
6.91e-03 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 39.33 E-value: 6.91e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 15224719 466 FNAPQLAAIHwaamhtaAGTSSGVkkqepwpfTLVQGPPGTGKTHTVWGMLNVIH 520
Cdd:cd17935 6 FTPTQIEAIR-------SGMQPGL--------TMVVGPPGTGKTDVAVQIISNLY 45
|
|
| PRK13889 |
PRK13889 |
conjugal transfer relaxase TraA; Provisional |
764-832 |
8.79e-03 |
|
conjugal transfer relaxase TraA; Provisional
Pssm-ID: 237546 [Multi-domain] Cd Length: 988 Bit Score: 40.06 E-value: 8.79e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15224719 764 GRKLfsrLTHGfDMVVIDEAAQaseVG------VLPPLALGAARCVLVGDPQQLPATviskAAGTLLysRSLFER 832
Cdd:PRK13889 427 GRDL---LTSR-DVLVIDEAGM---VGtrqlerVLSHAADAGAKVVLVGDPQQLQAI----EAGAAF--RSIHER 488
|
|
| |
