|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
19-448 |
1.86e-59 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 200.54 E-value: 1.86e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 19 NLATMMQRADEKLIPSTAKELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVS 98
Cdd:cd17328 5 FLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 99 RYFIQVTLGVAFNGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHdffgISGWRCAFILS 178
Cdd:cd17328 85 PNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQA----TGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 179 ATLSTIVGILVFFFVSDPREKktssvivhHDDQHERDennggtmmespsSSVWKESWVAIKDVTKLRTFQIIVLQGIVGS 258
Cdd:cd17328 161 GVLGVLLAILLLLFVREPPRG--------AAEGGVMA------------KSTATSFLADLKALAKNPSFILSTLGFTAVS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 259 VPWNAMLFWTMWFELIGF------DHNQAALLNGIFATGQAIGSLVGGIIADKMSRvFPNSGRLICAQFSVFMGAMFSIV 332
Cdd:cd17328 221 FVTGALAFWAPTFFLRAFgvgdlsSADVGLIFGAITCIAGVLGVLLGGILADRLRR-KTPRADPLVCAVGLLAAAPFLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 333 LLRMIPQSVNSFYIFL-VTLFLmgLTITWcgpAINSPILAEIVPAKHRTMVYAFDRALEVTFSSFGAPLVGIMSEKLFGf 411
Cdd:cd17328 300 ALVLALSNLLLAWVLLfLGEFL--LSLNW---APVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLR- 373
|
410 420 430
....*....|....*....|....*....|....*..
gi 240254471 412 dakgiDHVNDSGREAEALGKGIMWMMALPFGLCCLCY 448
Cdd:cd17328 374 -----QNKDSPLAEAASLQYALLLCSFVLVLGGFFFL 405
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-385 |
1.28e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 95.81 E-value: 1.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 20 LATMMQRADEKLIPSTAKELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSR 99
Cdd:COG2814 17 LGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 100 YFIQVTLGVAFNGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHdffgiSGWRCAFILSA 179
Cdd:COG2814 97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-----FGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 180 TLSTIVGILVFFFVSDPREKKTSSVivhhddqherdennggtmmespsssvwkesWVAIKDVTKLRTFQIIVLQGIVGSV 259
Cdd:COG2814 172 VLALLALLLLLRLLPESRPAARARL------------------------------RGSLRELLRRPRLLLLLLLAFLLGF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 260 PWNAMLFW--TMWFELIGFDHNQAALLNGIFATGQAIGSLVGGIIADKMSRvfpnsgRLICAQFSVFMGAMFSIVLLrmi 337
Cdd:COG2814 222 GFFALFTYlpLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR------RRLLLIGLLLLALGLLLLAL--- 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 240254471 338 pqsVNSFYIFLVTLFLMGLTITWCGPAINSpILAEIVPAKHRTMVYAF 385
Cdd:COG2814 293 ---AGSLWLLLLALFLLGFGFGLLFPLLQA-LVAELAPPEARGRASGL 336
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-413 |
3.07e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 91.86 E-value: 3.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 20 LATMMQRADEKLIPSTAKELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSR 99
Cdd:COG2271 17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 100 YFIQVTLGVAFNGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHDffgisGWRCAFILSA 179
Cdd:COG2271 97 SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-----GWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 180 TLSTIVGILVFFfvsdprekktssvivhhddqherdennggtmmespsssvwkeswvaikdvtklrtfqIIVLQGIVGSV 259
Cdd:COG2271 172 LPGLLLALLRFW---------------------------------------------------------LLALAYFLVYF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 260 PWNAMLFW--TMWFELIGFDHNQAALLNGIFATGQAIGSLVGGIIADKMSRVFPNsgrlicaqfsVFMGAMFSIVLLRMI 337
Cdd:COG2271 195 ALYGFLTWlpTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL----------VLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 240254471 338 PQSVNSFYIFLVTLFLMGLTITWCGPAINSpILAEIVPAKHRTMVYAFDRALEVTFSSFGAPLVGIMSEkLFGFDA 413
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWA-LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD-ATGYQA 338
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-385 |
5.10e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 90.94 E-value: 5.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 31 LIPSTAKELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAF 110
Cdd:pfam07690 15 LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 111 NGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHdffgiSGWRCAFILSATLSTIVGILVF 190
Cdd:pfam07690 95 QGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-----FGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 191 FFVSDPREKKtssvivhhddqherdennggtmmESPSSSVWKESWVAIKDVTKLRTFQIIVLQGIVGSVpWNAMLFWTMW 270
Cdd:pfam07690 170 LPRPPPESKR-----------------------PKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFA-FFGLLTYLPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 271 F-ELIGFDHNQAALLNGIFATGQAIGSLVGGIIADKMSRVFPnsgrlicaqFSVFMGAMFSIVLLRMIPQSVNSFYIFLV 349
Cdd:pfam07690 226 YqEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRR---------LLLALLLLILAALGLLLLSLTLSSLWLLL 296
|
330 340 350
....*....|....*....|....*....|....*.
gi 240254471 350 TLFLMGLTITWCGPAINSpILAEIVPAKHRTMVYAF 385
Cdd:pfam07690 297 ALLLLGFGFGLVFPALNA-LVSDLAPKEERGTASGL 331
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-411 |
2.65e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.17 E-value: 2.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 31 LIPSTAKELkeafHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAF 110
Cdd:cd17325 18 ILPLYAESL----GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 111 NGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNligTVGGIGGTVVPTVmaGHDFFGISGWRCAFILSATLSTIVGILVF 190
Cdd:cd17325 94 QGLASAAVWPAAMALIADIAPPEERGRAMGIFS---SAIGLGFLIGPLL--GGLLADALGYRAPFLVCAALALLALVLAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 191 FFVSDPREKKTSSvivhhddqherdennggtmmESPSSSVWKESWVAIKDVTKLRTFQIIVLQGIVGSVpwNAMLFWTMW 270
Cdd:cd17325 169 LLLPEPRPPPNKR--------------------AVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGA--LEPFLPLYA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 271 FELIGFDHNQAALLNGIFATGQAIGSLVGGIIADKMSRVfpnsgRLICAQFSVFMGAMFSIVLlrmipqsVNSFYIFLVT 350
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK-----PLILIGLLLSAVALLLLPL-------ATSFWLLLLL 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240254471 351 LFLMGLTITWCGPAINsPILAEIVPAKHRTMVYAFDRALEVTFSSFGAPLVGIMSEkLFGF 411
Cdd:cd17325 295 LALLGLGLGLVFPATL-ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGF 353
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-411 |
1.57e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.02 E-value: 1.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 31 LIPSTAKELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAF 110
Cdd:cd06174 14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 111 NGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHDFFgisGWRCAFILSATLSTIVGILVF 190
Cdd:cd06174 94 LGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF---GWRAVFLIAAALALLAAILLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 191 FFVSDPREKKTSSVIVHHddqherdennggtmmespSSSVWKESWVAIKDvtkLRTFQIIVLQGIVGSVPWNAMLFWTMW 270
Cdd:cd06174 171 LVVPDPPESARAKNEEAS------------------SKSVLKLLKRVLKN---PGLWLLLLAIFLVNLAYYSFSTLLPLF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 271 F-ELIGFDHNQAALLNGIFATGQAIGSLVGGIIADKmsrvfpNSGRLICAQFSVFMGAMFSIVLLRMIPQSVnsfyiFLV 349
Cdd:cd06174 230 LlDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR------LIGRKPLLLIGLLLMALGLALLLLAPSLLL-----LLL 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 240254471 350 TLFLMGLTITWCGPAINSpILAEIVPAKHRTMVYAFDRALEVTFSSFGAPLVGIMSEKLFGF 411
Cdd:cd06174 299 LLLLLGFGLGGLLPLSFA-LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
31-385 |
1.02e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 78.77 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 31 LIPSTAKELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAF 110
Cdd:COG2223 23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 111 NGVGHAIVYPVLQSIIADSFKESSRGFGFGLwnLIGTVGGIGGTVVPTVMAghdFFGISGWRCAFILSATLSTIVGILVF 190
Cdd:COG2223 103 LGIGGGGSFAVGIALVSKWFPPDRRGLALGL--AAGGGNLGAAVAAFLAPL---LIAAFGWRNAFLILGILLLVVAVLAW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 191 FFVSDPREKKTSSVivhhddqherdennggtmmespsssvwKESWVAIKDVTKLRTFQIIVLQGIVGSVPWNAMLFW--T 268
Cdd:COG2223 178 LFLRDPPAGAAAAA---------------------------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWlpP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 269 MWFELIGFDHNQAALLNGIFATGQAIGSLVGGIIADKMSRVFPNsgrlicaqFSVFMGAMFSIVLLRMIPQSVNSFYIFL 348
Cdd:COG2223 231 YLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVL--------LIVFALMALGLLLLALALGSLWLFLVLF 302
|
330 340 350
....*....|....*....|....*....|....*...
gi 240254471 349 VTLFL-MGLtitwcGPAINSPILAEIVPAKHRTMVYAF 385
Cdd:COG2223 303 LLLGLaLGG-----GNGAVFALVPDIFPTKNAGAVYGL 335
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-367 |
6.72e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 63.72 E-value: 6.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 38 ELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAI 117
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 118 VYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHdffgiSGWRCAFILSATLSTIVGILVFFFVSDPR 197
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQL-----LGWRAAFLAIAVLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 198 EKKtssvivhhddqherdennggtmmeSPSSSVWKESWVAIKDVTKLRTFQIIVLQGIVGSVPWNAMLFWTMwfELIGFD 277
Cdd:cd17324 179 PKK------------------------PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLT--DVPGFS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 278 HNQAALLNGIFATGQAIGSLVGGIIADKMSRvfpnsgrlicaqFSVFMGAMFSIVLLRMIPQSVNSFYIFLVTLFLMGLT 357
Cdd:cd17324 233 SSAIIGLLLLFGVAGVVGSPLAGRLADRGGR------------RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLG 300
|
330
....*....|
gi 240254471 358 ITWCGPAINS 367
Cdd:cd17324 301 FFAAHSALQT 310
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
38-377 |
7.57e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 54.30 E-value: 7.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 38 ELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAI 117
Cdd:TIGR00881 20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGM 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 118 VYPVLQSIIADSFKESSRGFGFGLWNliGTVGGIGGTVVPTVMAGHDFFGisGWRCAFILSATLSTIVGILVFFFVSDPR 197
Cdd:TIGR00881 100 GWPPCGRTVTKWFSRSERGTWVSFWN--CSHNVGGGLLPPLVLFGIAELY--SWHWVFIVPGIIAIIVSLICFLLLRDSP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 198 EKKTSSvivhHDDQHERDENNGGTMMESPSSSVWKeswvaIKDVTKLRTFQIIVL---QGIVGSVPWnAMLFW--TMWFE 272
Cdd:TIGR00881 176 QSCGLP----PAEEMPNEEPDGDAEKKEEELTKKQ-----IFLQYVLLNKVLWYIslgYVFVYVVRT-GILDWspLYLTQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 273 LIGFDHNQAALLNGIFATGQAIGSLVGGIIADKmsrVFPNSGRLICAQFSVFMgaMFSIVLLRMIPQSvnSFYIFLVTLF 352
Cdd:TIGR00881 246 EKGFSKEKASWAFTLYELGGLVGTLLAGWLSDK---LFNGRRGPLAVFFMALI--IVSLLVYWLNPAA--NPLMDLICLF 318
|
330 340
....*....|....*....|....*.
gi 240254471 353 LMGLTITwcGPA-INSPILAEIVPAK 377
Cdd:TIGR00881 319 ALGFLVY--GPQmLIGVIASELAPKK 342
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
39-377 |
2.61e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 52.63 E-value: 2.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 39 LKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAisyDR--PTVF-------------AFGSFFWVSSTVATGVSRYFIq 103
Cdd:cd17345 29 LIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLS---DRsnPKRFlaiglilsaiiniLIGFVPSATSSVGLMFILLFL- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 104 vtlgvafNGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTvvPTVMAGHDFFGISGWRCAFILSATLST 183
Cdd:cd17345 105 -------NGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVG--PLAGLGLAIFGDGWWRGAFIFPAIIAI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 184 IVGILVFFFVSD--------PREKKTSSVIVHHDDQHERDENNGGTMMES---PSSSVWkesWVAIKDVtklrtFQIIVL 252
Cdd:cd17345 176 IVAVIVLFLGKDtpeseglpPIEEYKGDYPEEADGEEEEQELSAWEIFVKyvlKNKLLW---YIAIANV-----FVYLVR 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 253 QGIVGSVPwnamlfwTMWFELIGFDHNQAALLNGIFATGQAIGSLVGGIIADKmsrVFPNSgRLICAqfsvfMGAMFSIV 332
Cdd:cd17345 248 YGILDWAP-------TYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDK---LFKGR-RAPTG-----IIFMILVI 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 240254471 333 LLRMIPQSVNSFYIFLVTLFLMGLTITwcGPAINSPILA-EIVPAK 377
Cdd:cd17345 312 VALIVYWLAPNVLVDLIALIALGFLIY--GPVMLIGLQAlELVPKK 355
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
174-408 |
4.97e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.85 E-value: 4.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 174 AFILSATLSTIVGILVFFFVSDPREKKTSSVIVHHDDqherdennggtmmespsssVWKESWVAIKDVTKLRTFQIIVLQ 253
Cdd:cd06173 160 AFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRD-------------------LREGLRYLRRSPLLRLLLLALALF 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 254 GIVGSVPWNAMLFWTMwfELIGFDHNQAALLNGIFAtgqaIGSLVGGIIADKMSRVFpNSGRLICAQFSVFMGAMFSIVL 333
Cdd:cd06173 221 ALLGGALTVLLPLLAK--EVLGGGAAGYGLLLAAFG----VGALLGALLLGRLSKRR-RRGRLLLIGALLLGLALLVLGL 293
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 240254471 334 lrmipqsVNSFYIFLVTLFLMGLTITWCGPAINSpILAEIVPAKHRTMVYAFDRALEVTFSSFGAPLVGIMSEKL 408
Cdd:cd06173 294 -------SPSLWLLLAALFLLGLAGGLFNVPLNT-LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
38-413 |
1.55e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 50.26 E-value: 1.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 38 ELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAI 117
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 118 VYPVLQSIIADSFKESSRGFGFGLwnlIGTVGGIGGTVVPtVMAGhdFFGISGWRCAFILSATLSTIVGILVFFFVSDPR 197
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAMGL---YEAALGLGIAVGP-LLGG--LLAAISWRYPFFLLAALIPVAFLAILFLLPEPK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 198 EKKTSSVIVHHDDQHErdennggtmmespsssvwkeswvaikdVTKLRTFQIIVLQGIVGSVPWNAMLFWTMwfELIGFD 277
Cdd:cd17474 178 EKAKSSSATKLRDLKK---------------------------ALRGRGLLTFLVSAFLYFFLYFAFLTYLP--FLLELL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 278 HNQAALLNGIFATGQAIGSLVGGIIADKMSRVFPNSGRLICAQFSVFMGAMFSIVLlrmipqsVNSFYIFLVTLFLMGLT 357
Cdd:cd17474 229 YGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGF-------VPSLALLLIAIVLFGLG 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 240254471 358 ITWCGPAINSpILAEIVPAKHRTMV---YAFDRALEVTfssFGAPLVGIMSEkLFGFDA 413
Cdd:cd17474 302 LGLNLPLLTT-LVTELAPEEERGTAsslYNFVRFLGQA---VGPLLFGLLLE-IFGLSA 355
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
39-144 |
1.59e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.97 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 39 LKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAIV 118
Cdd:COG2814 234 LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLL 313
|
90 100
....*....|....*....|....*.
gi 240254471 119 YPVLQSIIADSFKESSRGFGFGLWNL 144
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNS 339
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
39-192 |
3.33e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.65 E-value: 3.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 39 LKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAIV 118
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 240254471 119 YPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHdffgiSGWRCAFILSATLSTIVGILVFFF 192
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA-----LGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
31-201 |
4.53e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.76 E-value: 4.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 31 LIPSTAKELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAF 110
Cdd:cd17329 18 VWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 111 NGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHDFfgisgwRCAFILSATLSTIVGILVF 190
Cdd:cd17329 98 TGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF------RLLFLAAAVLFLLAALVLL 171
|
170
....*....|.
gi 240254471 191 FFVSDPREKKT 201
Cdd:cd17329 172 FLLPETRPKRR 182
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
59-193 |
5.67e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 45.72 E-value: 5.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 59 IVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAIVYPVLQSIIADSFKESSRGFG 138
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVA 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 240254471 139 FGLWNLIGTVGGIGGTVVPTVMAghdffGISGWRCAFILSATLSTIVGILVFFFV 193
Cdd:TIGR00880 89 LGLMSAGIALGPLLGPPLGGVLA-----QFLGWRAPFLFLAILALAAFILLAFLL 138
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
110-361 |
7.52e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 48.01 E-value: 7.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 110 FNGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPT-VMAGHDFFGISGWRCAFILSATLSTIVGIL 188
Cdd:cd17327 103 FLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYgVFKILGVGGLAGWRWLFIIEGLITIIIGLV 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 189 VFFFVSD---------PREKKTSSvivhhddqhER-DENNGGtmMESPSSSvWKESWVAIKDV-----TKLRTFQIIVLQ 253
Cdd:cd17327 183 IFFWLPDnpskawfltEEEKELAV---------ERlRANQTG--KGDQKFK-WKQIKEAFKDPrtwllFLFFFCSQITNN 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 254 GIVGSVPwnamLFWTMWfeliGFDHNQAALLNGIFATGQAIGSLVGGIIADKMsrvfpnSGRLICAQFSVFMGAMFSIVL 333
Cdd:cd17327 251 GISNFLP----LILKSL----GFYSLQTNLLSVPIGALGAVSLLIAALLSDRF------KKRGLFAIFACVLALVGSIIL 316
|
250 260 270
....*....|....*....|....*....|.
gi 240254471 334 LRMIPQSVNSFYIFLVTLFL---MGLTITWC 361
Cdd:cd17327 317 LAAPNPPGAYFAAYILGGGSyagFPILLSWI 347
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
32-378 |
7.66e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.00 E-value: 7.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 32 IPSTAKELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISY-DRPTVFAFGSFFWVSSTVATGVSRYFIqVTLGVAF 110
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFgERRVLAVGLLLMGAAALLMALVGSYPV-LLVLLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 111 NGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHdffgiSGWRCAFILSATLSTIVGILVF 190
Cdd:cd17475 94 VGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALH-----YGWRAAFVVAGLVSILAAVLFW 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 191 FFVSDPREKKTssvivhhddqherdennggtmmESPSSSVwkeSWVAIKDVTKLRTFQIIVLQGIVGSVPWNAMLFWTMW 270
Cdd:cd17475 169 LFYREPPAASA----------------------ATESAST---LLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 271 F--ELIGFDHNQAALLNGIFATGQAIGSLVGGIIADkmsRVFPNSgRLICAQFSVFMGAMFSIVLLrMIPQSVNSFYIFL 348
Cdd:cd17475 224 FlhDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSD---RVFGGR-RRPVLVITAAIAAAALLVLS-LLSPGTPLWLLVL 298
|
330 340 350
....*....|....*....|....*....|.
gi 240254471 349 VtLFLMGLT-ITWCGPAINspILAEIVPAKH 378
Cdd:cd17475 299 L-LILLGLFaIGWNGLYLT--LVAESAGPEQ 326
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
39-407 |
1.00e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 1.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 39 LKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAIV 118
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 119 YPvLQSIIADSFKESSRGFGFGLWNLigtVGGIGGTVVPTVMAGhdFFGISGWRCAFILSATLSTIVGILVFFFVSDPRE 198
Cdd:cd17478 102 HP-EGARLASQAAGGRRGLAMSIFSV---GGNLGFALGPLIAAA--LVALFGGLGLLILLIIPGLAVALLLLRLRPLKKP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 199 KKTSSVIVHHDDqherdennggtmmespssSVWKESWVAIkdvtkLRTFQIIVLQGIVGSVPWNAMLFwtmWFELIGFDH 278
Cdd:cd17478 176 EAKKAAAKSSAR------------------STLKGVWRAL-----LLLLIIVFLRSWVLSSLTTFLPF---YLVQRGYSL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 279 NQAALLNGIFATGQAIGSLVGGIIADKMSRVFpnsgrlicaqfsVFMGAMFSIVLLrMIPQSVNSFYIFLVTLFLMGLTI 358
Cdd:cd17478 230 VFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRR------------VIIASLLLAAPF-LLLFLLTPGIWSYILLVLAGFLL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 240254471 359 TWCGPAInsPILA-EIVPaKHRTMVYAFDRALEVTFSSFGAPLVGIMSEK 407
Cdd:cd17478 297 FASFPVT--VVLAqELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADA 343
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
41-190 |
1.68e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.77 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 41 EAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAIVYP 120
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 240254471 121 VLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGtvvpTVMAG--HDFFGISGwrcAFILSATLSTIVGILVF 190
Cdd:cd17370 307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLA----SLIAGylWDLISPSA---AFLFSAVLALIALLLLL 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
63-382 |
1.91e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 63 LASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAIVYPVLQSIIADSFKESSRGFGFGLW 142
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 143 NLIgtvggiggtvvpTVMAGHDFFGISG------WRCAFILSAtLSTIVGILVFFFVSDPREKKTSSVIVHhddqherde 216
Cdd:cd17473 130 SAA------------MSLGGVVFLLLGGalaeigWRAPFLVYL-LALPVLILVLLFLPEPARKSKSAASPG--------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 217 nnggtmmespsssvwkeswVAIKDVTKLRTFQIIVLQGIVGSvpwnaMLFWTMWFEL---IGFDHNQAALLNGIFATGQA 293
Cdd:cd17473 188 -------------------AATAAALPWKRVLPIYFLAFLAM-----LLFYVIPIQLpflLQERGGGSAALIGLALAIAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 294 IGSLVGGIIADKMSRVFPNsGRLICAQFSVFMGAMFSIVLlrmipqsVNSFYIFLVTLFLMGLTITWCGPAINSPILaEI 373
Cdd:cd17473 244 LAGAIGALLFGRLKRRLGK-RRLLAIGFALMALGFLLLAL-------ASGLWVVLLGAILAGLGFGLLLPTLNSWAM-SL 314
|
....*....
gi 240254471 374 VPAKHRTMV 382
Cdd:cd17473 315 VPPELRGRA 323
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
39-406 |
6.44e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 45.23 E-value: 6.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 39 LKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAIV 118
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 119 YPVLQSIIADSFKESSR---GFGFGLWNLigtvggiGGTVVPTVMAGHDFFGIS-GWRCAFILSATLSTIVGILVFFFVS 194
Cdd:COG0738 114 DVAANPYVAALGPETAAsrlNLLHAFFSL-------GALLGPLLGGLLILLGLSlSWHLPYLILAVLLLLLALLFLRSKL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 195 DPREKKTSSVivhhddqherdennggtmmespsssvwKESWVAIKDVTKLRTFQIIVLQGIVGSVPWNAMLFWTMWF--E 272
Cdd:COG0738 187 PEIEEEEEEA---------------------------AGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYlkD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 273 LIGFDHNQAALLNGIFATGQAIGSLVGGIIADKMSRVfpnsgRLICAqFSVFMGAMFSIVLLrmipqsVNSFYIFLVTLF 352
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPV-----RLLRL-SALLAAVGLLLALL------APGPWLALIGLA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 240254471 353 LMGLTITWCGPAINSpILAEIVPAKHRTMVyafdrALEVTFSSFGA----PLVGIMSE 406
Cdd:COG0738 308 LVGLGLSLMFPTIFS-LALDGLGKRTAAAV-----SAVLIMGIVGGaigpPLIGFLAD 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
43-460 |
8.24e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 8.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 43 FHAKLSDIGLLSFIRNIVQGLASPLAGLFAisyDR-----------------PTVFAFGSFFWVSSTVATGvsrYFIQVT 105
Cdd:COG2211 41 LGLSAALVGLILLVARLWDAITDPLIGALS---DRtrtrwgrrrpwiligaiPLALSFVLLFTAPDLSPTG---KLIYAL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 106 LGVAFNGVGHAIVYPVLQSIIADSFKESS-RGFGFGLWNLIGTVGGIGGTVVPTVMAghDFFG---ISGWRCAFILSATL 181
Cdd:COG2211 115 VTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLV--AAFGgdaALGYRLTALIFAVL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 182 STIVGILVFFFVSDPREKKTSSVivhhddqherdennggtmmespsssvwkESWVAIKDVTKLRTFQIIVLQGIVGSVPW 261
Cdd:COG2211 193 GLLAFLLTFFGTKERPVPEEEKV----------------------------SLKESLKALLKNRPFLLLLLAYLLFFLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 262 NAMLFWTMWF--ELIGFDHNQAALLNGIFATGQAIGSLVGGIIADKMsrvfpnsGRLICAQFSVFMGAMFSIVLLRMIPQ 339
Cdd:COG2211 245 ALVAALLLYYfkYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF-------GKKKAFIIGLLLAALGLLLLFFLGPG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 340 SVNSFYIFLVtLFLMGLTITWcgpAINSPILAEIVPAKHRT-------MVYAFDRALEVTFSSFGAPLVGIMSEkLFGFD 412
Cdd:COG2211 318 NLWLLLVLAA-LAGIGLGAIL---VLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLLLA-LFGYV 392
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 240254471 413 AkgidhvnDSGREAEALGKGIMWMMALPFGLCCLCYTPLHFLFRKDRK 460
Cdd:COG2211 393 A-------GAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRER 433
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
41-413 |
8.78e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.57 E-value: 8.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 41 EAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAF-NGVGHAIVY 119
Cdd:cd17355 31 AEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLlGGGGAGTLA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 120 PVLQSIIADSFKESSRGFGFGLwnLIGTVGGIGGTVVPTVMAGHDFFGisgWRCAFILSATLSTIVGILVFFFVSDPREK 199
Cdd:cd17355 111 AVAFATVAAWWFERRRGLALGI--LTAGGGLGSLVFLPLGAALIEAFG---WRTALLVLALLALLVLVPVLLLLRRRPAD 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 200 KTSSVIVHHDDQHerdennggtmmespSSSVWKESWvaikdvtKLRTFQIIVLQGIVGSVPWNAMLFWTMWF-ELIGFDH 278
Cdd:cd17355 186 LALRAYDDASPAS--------------PGSTLKEAL-------RSASFWLLALAFFLCGFAVVGLIVHLVPYlADRGISP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 279 NQAALLNGIFATGQAIGSLVGGIIADKMSRvfpnsgRLICAqfSVFMGAMFSIVLLRMIPQSVNSFYIFLVtlfLMGLTI 358
Cdd:cd17355 245 AAAAVALALIGLFNIVGRLLSGWLGDRYSP------RRLLA--ASYALRALGLALLLLLPFPPLALLLFAA---LFGLGW 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 240254471 359 TWCGPaINSPILAEIVPAKHRTMVYAFDRALEVTFSSFGAPLVGIMSEKLFGFDA 413
Cdd:cd17355 314 GATVP-LTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTA 367
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
275-413 |
9.32e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 9.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 275 GFDHNQAALLNGIFATGQAIGSLVGGIIADKMSRVfpnsgRLICAQFSVFMGAMFSIVLlrmipqsVNSFYIFLVTLFLM 354
Cdd:COG2814 41 GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRR-----RVLLLGLLLFALGSLLCAL-------APSLWLLLAARFLQ 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 240254471 355 GLTITWCGPAINSpILAEIVPAKHRTMVYAFDRALeVTFSSFGAPLVGIMSEKLFGFDA 413
Cdd:COG2814 109 GLGAGALFPAALA-LIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRW 165
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
43-411 |
1.72e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.74 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 43 FHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAIVYPVL 122
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 123 QSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHdFFGISGWRCAFILSAtlstiVGILVFFFVsdprekkts 202
Cdd:cd17316 111 STYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPL-LSGDWGWRILFLIGA-----LPALLALLL--------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 203 svivhhddqherdennggtmmespsssvwkeswvaikdvtkLRTFQIIVLQGIVGSVPWNAMLFW--TMWFELIGFDHNQ 280
Cdd:cd17316 176 -----------------------------------------RRRTLLLILLWFFISFGYYGLTTFlpTYLQTVLGLSPAT 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 281 AALLNGIFATGQAIGSLVGGIIADKMSRvfpnsgRLICAQFSVFMGAMFSIVLLrmipQSVNSFYIFLVTLFLMGLTITW 360
Cdd:cd17316 215 SSLYLLLISLGALVGALIAGLLSDRIGR------KKTLVIGLILSGILALPLFY----LLSGSPTLLLLLLFILSFFVGG 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 240254471 361 CGPAINSpILAEIVPAKHRTMVYAFDRALEVTFSSFGAPLVGIMSEKLFGF 411
Cdd:cd17316 285 VWGALYA-YLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
62-334 |
2.49e-04 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 43.34 E-value: 2.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 62 GLASPLAGLFAISYD------------------RPTVFAFGSFFwvsstVATGV----SRYFIQVTLGVAFNGVGHAIVY 119
Cdd:pfam03137 32 GLPSSLSGLISSSYDignlllivfvsyfggkghRPRWIGVGALL-----MGLGSllfaLPHFLSFFLGQLLLGIGGTPIY 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 120 PVLQSIIADSFKESSRG---------------FGFGL----WNLIGTVGGIGGTVVPTvmaghDFFGISGWRCAFILSAT 180
Cdd:pfam03137 107 TLGISYIDDNVKKKNSPlylgilyavrvlgpaLGFLLgslcLRIYVDIGKVSITLTPK-----DPRWVGAWWLGFLIAGL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 181 LSTIVGILVFFF-VSDPREKKTSSVIVHHDDQHERDENNGGTMMESPSSSVwKESWVAIKDVTKLRTFQIIVLQGIVGSv 259
Cdd:pfam03137 182 LLLLTAIPFFFFpKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGPSL-KDFPKALKRLLKNPVYMLLTLASVFEF- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 260 pwnaMLFWTMWFELIGFDHNQ-------AALLNGIFAT-GQAIGSLVGGIIADKMSRVFPNSGRLICaqFSVFMGAMFSI 331
Cdd:pfam03137 260 ----LLIAGYATFLPKYIETQfglsastANLLTGVVAIpGAALGILLGGLIIKKFKLSAKGLAKFNV--ITSLVSLLLSL 333
|
...
gi 240254471 332 VLL 334
Cdd:pfam03137 334 LLF 336
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
130-358 |
2.65e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.03 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 130 FKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHdffgiSGWRCAFILSATLSTIVGILVFFFVSDprekktssvivhhd 209
Cdd:cd17312 120 FSKKERGTVYGIWSTSHNFGGILAPILAASLASY-----YGWRAAFLVPGIVGLVVAIILFFFLRD-------------- 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 210 dqherdennggtmmeSPsSSVWKESWVaikdvtklrtfqiIVLQGIVGSvpwnAMLFWTMWF--ELIGFDHNQAALLNGI 287
Cdd:cd17312 181 ---------------SP-PYVWVLSLA-------------YAFVYIVRY----ACLDWGPLYlyEVKGYSLIDAGWFSSL 227
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240254471 288 FATGQAIGSLVGGIIADKmsrVFPNSGRLICAQFSVFMgaMFSIVLLRMIPqsvNSFYIFLVTLFLMGLTI 358
Cdd:cd17312 228 YEVGGIAGTILAGLLSDK---LFGGRRAPIAVIYMLLM--TLSLALFWFFP---HNKLLSIVLLFLIGFFV 290
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
170-356 |
8.45e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 8.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 170 GWRCAFILSATLSTIVGILVFFFVSDP------REKKTSSVIVHHDDQHERDENNGGTMMESPSSSVWKESWVAIKDVTK 243
Cdd:TIGR00895 169 GWRSLFYVGGIAPLLLLLLLMRFLPESidflvsKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKT 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 244 LRTFQIIVLQGIVGSVPWNAMLFWTMWFEL-IGFDHNQAALLNGIFATGQAIGSLVGGIIADKMSRVfpnsgrlicaqfS 322
Cdd:TIGR00895 249 ARITVLLWLLYFMLLVGVYFLTNWLPKLMVeLGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR------------V 316
|
170 180 190
....*....|....*....|....*....|....
gi 240254471 323 VFMGAMFSIVLLRMIPQSVNSFYIFLVTLFLMGL 356
Cdd:TIGR00895 317 TALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGF 350
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
267-382 |
1.36e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.64 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 267 WTMWFELIGFDHNQAALLNGIFATGQAIGSLVGGIIADKMSR--VFpnsgrLICAQFSVFMGamfsiVLLRMIPqsvnSF 344
Cdd:cd17317 13 IVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRrpVL-----LLGLVLQIVCG-----VLSAFSP----SY 78
|
90 100 110
....*....|....*....|....*....|....*...
gi 240254471 345 YIFLVTLFLMGLTITWCGPAINSpILAEIVPAKHRTMV 382
Cdd:cd17317 79 ELFLVLRFLVGVTSAGIFTVGFV-LGMEIVGPKYRSFV 115
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
39-144 |
1.97e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.66 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 39 LKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRY--FIQVTLGVAFNGVGHA 116
Cdd:COG2211 255 FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnLWLLLVLAALAGIGLG 334
|
90 100 110
....*....|....*....|....*....|....*
gi 240254471 117 IVYPVLQSIIADS-------FKESSRGFGFGLWNL 144
Cdd:COG2211 335 AILVLPWAMLADVvdydewkTGRRREGLYFGIFTF 369
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
287-382 |
2.13e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 40.35 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 287 IFATGQAIGSLVGGIIADKMSRVFpnSGRLICAQFSVF-MGAMFSivllrmipqsvNSFYIFLVTLFLMGLTITwcGPAI 365
Cdd:cd17374 43 IFMAGLLVGALIFGHLSDRFGRKF--ILLLSLLQLAIFgTCAAFA-----------PTFPVYCVLRFLAGFAVS--GISI 107
|
90
....*....|....*...
gi 240254471 366 NSPILA-EIVPAKHRTMV 382
Cdd:cd17374 108 NTLILGtEWTTPRHRALA 125
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
20-144 |
2.29e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.25 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 20 LATMMQRADEkLIPSTA-KELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVS 98
Cdd:cd17503 3 LGAFMAILDT-TIVNVAlPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 240254471 99 RYFIQVTLGVAFNGVGHAIVYPVLQSIIADSFKESSRGFGFGLWNL 144
Cdd:cd17503 82 PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGL 127
|
|
| COX6C |
pfam02937 |
Cytochrome c oxidase subunit VIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ... |
176-226 |
2.75e-03 |
|
Cytochrome c oxidase subunit VIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIc.
Pssm-ID: 460756 Cd Length: 69 Bit Score: 36.42 E-value: 2.75e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 240254471 176 ILSATLSTIVGILVFFFVSDPREKKTSSVIVHHDDQHERDENNGGTMMESP 226
Cdd:pfam02937 19 VVALALSLGVGLAFKFFVAEPRKKAYADFYKNYDPMKEFERMREAGLFQSV 69
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-198 |
3.42e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.47 E-value: 3.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 39 LKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFA---ISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFnGVGH 115
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSdrlGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLA-GFGL 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 116 AIVYPVLQSIIADSFKESSRGFGFGLWNLIgtvGGIGGTVVPTVMAGhdFFGISGWRCAFILSATLSTIVGILVFFFVSD 195
Cdd:COG2271 286 GGAFGLLWALAAELFPKKARGTASGLVNTF---GFLGGALGPLLVGY--LLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
...
gi 240254471 196 PRE 198
Cdd:COG2271 361 TRK 363
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
245-413 |
4.13e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 4.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 245 RTFQIIVLQGIVGSVPWNAMLFWTMWF-ELIGFDHNQAALLNGIFATGQAIGSLVGGIIADKmsrvfPNSGRLICAQFSV 323
Cdd:cd17352 183 PTFVLLALGVSFAMLGFFVPFVYLPSYaKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK-----PRIGRLYLYIFTL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 324 FMGAMFSIVLLRMipqsvNSFYIFLVTLFLMGLTITWCGpAINSPILAEIVPAKHRTMVYAFDRALEVTFSSFGAPLVGI 403
Cdd:cd17352 258 LILGLSLLAFPLA-----TTYVGLIVFSVLFGFCSGSYS-SLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGL 331
|
170
....*....|
gi 240254471 404 MSEKLFGFDA 413
Cdd:cd17352 332 LRDYTGDYDA 341
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
43-413 |
6.34e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 6.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 43 FHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGHAIVYPVL 122
Cdd:cd17489 26 LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 123 QSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHdffgiSGWRCAFILSATLStIVGILVFFFVSDPREKKTS 202
Cdd:cd17489 106 ATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH-----LGFAVLFIVAAVLA-LLALLLVFLVKDPPPVAAE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 203 svivhhddqherdENNGGTMmeSPSSSVWKESWVAikdvtklrTFQIIVLQGIVGSVpwnaMLFWTMWFELIGFDHnqaa 282
Cdd:cd17489 180 -------------EAEAGTR--AFRRLVEKKVLPP--------ALILFLASIAYGAI----STFLPLYAAERGISN---- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 283 llNGIFATGQAIGSLVGGIIADKMSRVFpnsGRLICAQFSVFMGAmFSIVLLRMIpqsvNSFYIFLVTLFLMGLTITWCG 362
Cdd:cd17489 229 --AGLFFTVYAIALLLSRPFSGKLSDRK---GPKTVIIPGLLLLA-LGLLLLSFA----GSPWMLLLAAVLYGLGFGLLF 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 240254471 363 PAINSPILAEIVPAKHRTMVYAFDRALEVTFsSFGAPLVGIMSEkLFGFDA 413
Cdd:cd17489 299 PALQALAVDLVPPHRRGAANGTFFIFFDLGI-GLGGLLLGLVAE-LFGYRA 347
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
36-334 |
9.09e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.32 E-value: 9.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 36 AKELKEAFHAKLSDIGLLSFIRNIVQGLASPLAGLFAISYDRPTVFAFGSFFWVSSTVATGVSRYFIQVTLGVAFNGVGH 115
Cdd:cd17319 26 APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 116 AIVYPVLQSIIADSFKESSRGFGFGLWNLIGTVGGIGGTVVPTVMAGHdffgiSGWRCAFILSATLSTIVGILVFFFVsd 195
Cdd:cd17319 106 AGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL-----FGWRWAFIIEGLLGLLLAVLWWFYL-- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254471 196 prekktssvivhhddqherdennggtmmespsssvwkeswvaikdvtklRTFQIIVLQGIVGSVPWNAMLFW--TMWFEL 273
Cdd:cd17319 179 -------------------------------------------------RQVWGLALGYFGINYALYGLLTWlpTYLKQA 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240254471 274 IGFDHNQAALLNGIFATGQAIGSLVGGIIADKMSRVfpNSGRLICAQFSVFMGAMFSIVLL 334
Cdd:cd17319 210 RGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG--ARRLVIIIGLLLAAVGLLLAYLT 268
|
|
| |
