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Conserved domains on  [gi|15227294|ref|NP_179269|]
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Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

WD repeat RBAP46/RBAP48/MSI1 family protein( domain architecture ID 13780222)

WD repeat RBAP46/RBAP48/MSI1 family protein binds histones; contains an N-terminal alpha helical domain and WD40 repeats that fold into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042393
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4005630|4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-393 4.85e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 4.85e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 155 TSECDPDLRLVGHDKEGYGLSWSPFKEgYLLSGSQDQKICLWDVSatpQDKVLNamfVYEGHESAIADVSWHmKNENLFG 234
Cdd:cd00200  38 LETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLE---TGECVR---TLTGHTSYVSSVAFS-PDGRILS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 235 SAGEDGRLVIWDTRTNQMQHQVKVHEREVNYLSFNPFNeWVLATASSDSTVALFDLRKLNaPLHVMSSHEGEVFQVEWDP 314
Cdd:cd00200 110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSP 187

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15227294 315 NHETVLASSGeDRRLMVWDLNrvgeeqleieldaedgPPELLFSHGGHKAKISDFAWNKNEPWVIASvAEDNSLQVWQM 393
Cdd:cd00200 188 DGEKLLSSSS-DGTIKLWDLS----------------TGKCLGTLRGHENGVNSVAFSPDGYLLASG-SEDGTIRVWDL 248
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 16-88 8.14e-27

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


:

Pssm-ID: 463513  Cd Length: 69  Bit Score: 101.89  E-value: 8.14e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227294    16 EDFSVWKKNTPFLYDLLISHPLEWPSLTVHWVPSTPNpyvaDSYFGVHKLILGTHTSGSAQDFLMVADVVTPT 88
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPDTSE----GKNYTVQRLLLGTQTSGAEQNYLYVAKVSLPS 69
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-393 4.85e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 4.85e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 155 TSECDPDLRLVGHDKEGYGLSWSPFKEgYLLSGSQDQKICLWDVSatpQDKVLNamfVYEGHESAIADVSWHmKNENLFG 234
Cdd:cd00200  38 LETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLE---TGECVR---TLTGHTSYVSSVAFS-PDGRILS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 235 SAGEDGRLVIWDTRTNQMQHQVKVHEREVNYLSFNPFNeWVLATASSDSTVALFDLRKLNaPLHVMSSHEGEVFQVEWDP 314
Cdd:cd00200 110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSP 187

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15227294 315 NHETVLASSGeDRRLMVWDLNrvgeeqleieldaedgPPELLFSHGGHKAKISDFAWNKNEPWVIASvAEDNSLQVWQM 393
Cdd:cd00200 188 DGEKLLSSSS-DGTIKLWDLS----------------TGKCLGTLRGHENGVNSVAFSPDGYLLASG-SEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
163-394 1.66e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 1.66e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 163 RLVGHDKEGYGLSWSPfkEG-YLLSGSQDQKICLWDVSATPQDKVLnamfvyEGHESAIADVSWHmKNENLFGSAGEDGR 241
Cdd:COG2319 115 TLTGHTGAVRSVAFSP--DGkTLASGSADGTVRLWDLATGKLLRTL------TGHSGAVTSVAFS-PDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 242 LVIWDTRTNQMQHQVKVHEREVNYLSFNPFNEWvLATASSDSTVALFDLRKlNAPLHVMSSHEGEVFQVEWDPNHETvLA 321
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRL-LA 262

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227294 322 SSGEDRRLMVWDLNrvgeeqleieldaedgPPELLFSHGGHKAKISDFAWNKNEPWvIASVAEDNSLQVWQMA 394
Cdd:COG2319 263 SGSADGTVRLWDLA----------------TGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLA 318
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 16-88 8.14e-27

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 101.89  E-value: 8.14e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227294    16 EDFSVWKKNTPFLYDLLISHPLEWPSLTVHWVPSTPNpyvaDSYFGVHKLILGTHTSGSAQDFLMVADVVTPT 88
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPDTSE----GKNYTVQRLLLGTQTSGAEQNYLYVAKVSLPS 69
PTZ00421 PTZ00421
coronin; Provisional
 164-347 3.57e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 55.28  E-value: 3.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294  164 LVGHDKEGYGLSWSPFKEGYLLSGSQDQKICLWDVSATP-QDKVLNAMFVYEGHESAIADVSWHMKNENLFGSAGEDGRL 242
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294  243 VIWDTRTNQMQHQVKVHEREVNYLSFNpFNEWVLATASSDSTVALFDLRKLNAPLHVMSSHEGEVFQVEWDPNHETVLA- 321
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKRKDLIITl 229

                        170       180
                 ....*....|....*....|....*...
gi 15227294  322 --SSGEDRRLMVWDLNRVGEEQLEIELD 347
Cdd:PTZ00421 230 gcSKSQQRQIMLWDTRKMASPYSTVDLD 257
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 296-333 2.98e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.98e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 15227294    296 PLHVMSSHEGEVFQVEWDPNHeTVLASSGEDRRLMVWD 333
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
296-333 1.52e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.52e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 15227294   296 PLHVMSSHEGEVFQVEWDPNHeTVLASSGEDRRLMVWD 333
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-393 4.85e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 4.85e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 155 TSECDPDLRLVGHDKEGYGLSWSPFKEgYLLSGSQDQKICLWDVSatpQDKVLNamfVYEGHESAIADVSWHmKNENLFG 234
Cdd:cd00200  38 LETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLE---TGECVR---TLTGHTSYVSSVAFS-PDGRILS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 235 SAGEDGRLVIWDTRTNQMQHQVKVHEREVNYLSFNPFNeWVLATASSDSTVALFDLRKLNaPLHVMSSHEGEVFQVEWDP 314
Cdd:cd00200 110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSP 187

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15227294 315 NHETVLASSGeDRRLMVWDLNrvgeeqleieldaedgPPELLFSHGGHKAKISDFAWNKNEPWVIASvAEDNSLQVWQM 393
Cdd:cd00200 188 DGEKLLSSSS-DGTIKLWDLS----------------TGKCLGTLRGHENGVNSVAFSPDGYLLASG-SEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
163-394 1.66e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 1.66e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 163 RLVGHDKEGYGLSWSPfkEG-YLLSGSQDQKICLWDVSATPQDKVLnamfvyEGHESAIADVSWHmKNENLFGSAGEDGR 241
Cdd:COG2319 115 TLTGHTGAVRSVAFSP--DGkTLASGSADGTVRLWDLATGKLLRTL------TGHSGAVTSVAFS-PDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 242 LVIWDTRTNQMQHQVKVHEREVNYLSFNPFNEWvLATASSDSTVALFDLRKlNAPLHVMSSHEGEVFQVEWDPNHETvLA 321
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRL-LA 262

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227294 322 SSGEDRRLMVWDLNrvgeeqleieldaedgPPELLFSHGGHKAKISDFAWNKNEPWvIASVAEDNSLQVWQMA 394
Cdd:COG2319 263 SGSADGTVRLWDLA----------------TGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 163-392 3.41e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 3.41e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 163 RLVGHDKEGYGLSWSPfKEGYLLSGSQDQKICLWDVSATPQDKVLNamfvyeGHESAIADVSWHmKNENLFGSAGEDGRL 242
Cdd:cd00200  88 TLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLR------GHTDWVNSVAFS-PDGTFVASSSQDGTI 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 243 VIWDTRTNQMQHQVKVHEREVNYLSFNPfNEWVLATASSDSTVALFDLRKLnAPLHVMSSHEGEVFQVEWDPNHEtVLAS 322
Cdd:cd00200 160 KLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPDGY-LLAS 236

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 323 SGEDRRLMVWDLnRVGEEQLEIEldaedgppellfshgGHKAKISDFAWNKNEPWVIaSVAEDNSLQVWQ 392
Cdd:cd00200 237 GSEDGTIRVWDL-RTGECVQTLS---------------GHTNSVTSLAWSPDGKRLA-SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
163-394 3.44e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 3.44e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 163 RLVGHDKEGYGLSWSPfkEG-YLLSGSQDQKICLWDVsATPQdkvlnAMFVYEGHESAIADVSWHMKNENLFgSAGEDGR 241
Cdd:COG2319 199 TLTGHTGAVRSVAFSP--DGkLLASGSADGTVRLWDL-ATGK-----LLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 242 LVIWDTRTNQMQHQVKVHEREVNYLSFNPFNEWvLATASSDSTVALFDLrKLNAPLHVMSSHEGEVFQVEWDPNHETvLA 321
Cdd:COG2319 270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKT-LA 346

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227294 322 SSGEDRRLMVWDLNRvgeeqleieldaedgpPELLFSHGGHKAKISDFAWNKNEPWvIASVAEDNSLQVWQMA 394
Cdd:COG2319 347 SGSDDGTVRLWDLAT----------------GELLRTLTGHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-395 1.56e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.50  E-value: 1.56e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 164 LVGHDKEGYGLSWSPfKEGYLLSGSQDQKICLWDVSATPQDKVLnamfvyEGHESAIADVSWHMKNENLFgSAGEDGRLV 243
Cdd:cd00200   5 LKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTL------KGHTGPVRDVAASADGTYLA-SGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 244 IWDTRTNQMQHQVKVHEREVNYLSFNPFNEWvLATASSDSTVALFDLRKlNAPLHVMSSHEGEVFQVEWDPNHeTVLASS 323
Cdd:cd00200  77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDG-TFVASS 153

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15227294 324 GEDRRLMVWDLNrvgeeqleieldaedgPPELLFSHGGHKAKISDFAWNKNEPWVIASvAEDNSLQVWQMAE 395
Cdd:cd00200 154 SQDGTIKLWDLR----------------TGKCVATLTGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLST 208
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 16-88 8.14e-27

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 101.89  E-value: 8.14e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227294    16 EDFSVWKKNTPFLYDLLISHPLEWPSLTVHWVPSTPNpyvaDSYFGVHKLILGTHTSGSAQDFLMVADVVTPT 88
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPDTSE----GKNYTVQRLLLGTQTSGAEQNYLYVAKVSLPS 69
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 211-394 3.68e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.95  E-value: 3.68e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 211 FVYEGHESAIADVSWHMKNENLFgSAGEDGRLVIWDTRTNQMQHQVKVHEREVNYLSFNPFNEWvLATASSDSTVALFDL 290
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 291 RKlNAPLHVMSSHEGEVFQVEWDPNHeTVLASSGEDRRLMVWDLNrvgeeqleieldaedgPPELLFSHGGHKAKISDFA 370
Cdd:cd00200  81 ET-GECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVE----------------TGKCLTTLRGHTDWVNSVA 142

                       170       180
                ....*....|....*....|....
gi 15227294 371 WNKNePWVIASVAEDNSLQVWQMA 394
Cdd:cd00200 143 FSPD-GTFVASSSQDGTIKLWDLR 165
WD40 COG2319
WD40 repeat [General function prediction only];
162-394 1.02e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 1.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 162 LRLVGHDKEGYGLSWSPFkEGYLLSGSQDQKICLWDVSATPQDKVLnamfvyEGHESAIADVSWhMKNENLFGSAGEDGR 241
Cdd:COG2319  30 LLLLGLAAAVASLAASPD-GARLAAGAGDLTLLLLDAAAGALLATL------LGHTAAVLSVAF-SPDGRLLASASADGT 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 242 LVIWDTRTNQMQHQVKVHEREVNYLSFNPfNEWVLATASSDSTVALFDLRKlNAPLHVMSSHEGEVFQVEWDPNHETvLA 321
Cdd:COG2319 102 VRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKL-LA 178

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227294 322 SSGEDRRLMVWDLNRvGEEQLEIEldaedgppellfshgGHKAKISDFAWNKNEPWvIASVAEDNSLQVWQMA 394
Cdd:COG2319 179 SGSDDGTVRLWDLAT-GKLLRTLT---------------GHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
164-249 2.57e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 2.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 164 LVGHDKEGYGLSWSPfKEGYLLSGSQDQKICLWDVSATPQDKVLnamfvyEGHESAIADVSWHmKNENLFGSAGEDGRLV 243
Cdd:COG2319 326 LTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTL------TGHTGAVTSVAFS-PDGRTLASGSADGTVR 397


                ....*.
gi 15227294 244 IWDTRT 249
Cdd:COG2319 398 LWDLAT 403
PTZ00421 PTZ00421
coronin; Provisional
 164-347 3.57e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 55.28  E-value: 3.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294  164 LVGHDKEGYGLSWSPFKEGYLLSGSQDQKICLWDVSATP-QDKVLNAMFVYEGHESAIADVSWHMKNENLFGSAGEDGRL 242
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294  243 VIWDTRTNQMQHQVKVHEREVNYLSFNpFNEWVLATASSDSTVALFDLRKLNAPLHVMSSHEGEVFQVEWDPNHETVLA- 321
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKRKDLIITl 229

                        170       180
                 ....*....|....*....|....*...
gi 15227294  322 --SSGEDRRLMVWDLNRVGEEQLEIELD 347
Cdd:PTZ00421 230 gcSKSQQRQIMLWDTRKMASPYSTVDLD 257
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 296-391 8.78e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 8.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294 296 PLHVMSSHEGEVFQVEWDPNHETvLASSGEDRRLMVWDLNrvgeeqleieldaedgPPELLFSHGGHKAKISDFAWNKNE 375
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLE----------------TGELLRTLKGHTGPVRDVAASADG 63

                        90
                ....*....|....*.
gi 15227294 376 PWvIASVAEDNSLQVW 391
Cdd:cd00200  64 TY-LASGSSDKTIRLW 78
PTZ00420 PTZ00420
coronin; Provisional
 250-334 2.32e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.56  E-value: 2.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294  250 NQMQH----QVKVHEREVNYLSFNPFNEWVLATASSDSTVALFDLR-------KLNAPLHVMSSHEGEVFQVEWDPNHET 318
Cdd:PTZ00420  60 NQMRKppviKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhndesvkEIKDPQCILKGHKKKISIIDWNPMNYY 139

                         90
                 ....*....|....*.
gi 15227294  319 VLASSGEDRRLMVWDL 334
Cdd:PTZ00420 140 IMCSSGFDSFVNIWDI 155
PTZ00420 PTZ00420
coronin; Provisional
 294-393 5.18e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 5.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294  294 NAPLHVMSSHEGEVFQVEWDPNHETVLASSGEDRRLMVWDLNRVGEEQLEIEldaedgPPELLFShgGHKAKISDFAWNK 373
Cdd:PTZ00420  64 KPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKEIK------DPQCILK--GHKKKISIIDWNP 135

                         90       100
                 ....*....|....*....|
gi 15227294  374 NEPWVIASVAEDNSLQVWQM 393
Cdd:PTZ00420 136 MNYYIMCSSGFDSFVNIWDI 155
PTZ00420 PTZ00420
coronin; Provisional
 214-290 1.99e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.87  E-value: 1.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294  214 EGHESAIADVSWHMKNENLFGSAGEDGRLVIWDTRTNQM--------QHQVKVHEREVNYLSFNPFNEWVLATASSDSTV 285
Cdd:PTZ00420  71 KGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFV 150


                 ....*
gi 15227294  286 ALFDL 290
Cdd:PTZ00420 151 NIWDI 155
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 296-333 2.98e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.98e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 15227294    296 PLHVMSSHEGEVFQVEWDPNHeTVLASSGEDRRLMVWD 333
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 218-335 4.49e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 4.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294  218 SAIADVSWHMKNENLFGSAGEDGRLVIWDTRTNQMQHQVKVHEREVNYLSFNPFNEWVLATASSDSTVAL---------- 287
Cdd:PLN00181 533 SKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLwsinqgvsig 612

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294  288 --------------------------------FDLRKLNAPLHVMSSHEGEVFQVEWDPNheTVLASSGEDRRLMVWDLN 335
Cdd:PLN00181 613 tiktkaniccvqfpsesgrslafgsadhkvyyYDLRNPKLPLCTMIGHSKTVSYVRFVDS--STLVSSSTDNTLKLWDLS 690
PTZ00420 PTZ00420
coronin; Provisional
 160-256 1.44e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227294  160 PDLRLVGHDKEGYGLSWSPFKEGYLLSGSQDQKICLWDVSATPQD--KVLNAMFVYEGHESAIADVSWHMKNENLFGSAG 237
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSG 145

                         90
                 ....*....|....*....
gi 15227294  238 EDGRLVIWDTRTNQMQHQV 256
Cdd:PTZ00420 146 FDSFVNIWDIENEKRAFQI 164
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 211-246 1.51e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.51e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15227294    211 FVYEGHESAIADVSWHmKNENLFGSAGEDGRLVIWD 246
Cdd:smart00320   6 KTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
296-333 1.52e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.52e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 15227294   296 PLHVMSSHEGEVFQVEWDPNHeTVLASSGEDRRLMVWD 333
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 164-197 9.70e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 9.70e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 15227294    164 LVGHDKEGYGLSWSPFKEgYLLSGSQDQKICLWD 197
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
212-246 1.06e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15227294   212 VYEGHESAIADVSWHmKNENLFGSAGEDGRLVIWD 246
Cdd:pfam00400   6 TLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
164-197 3.44e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 15227294   164 LVGHDKEGYGLSWSPFKEgYLLSGSQDQKICLWD 197
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 249-289 5.23e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.23e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15227294    249 TNQMQHQVKVHEREVNYLSFNPFNEWvLATASSDSTVALFD 289
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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