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Conserved domains on  [gi|30678181|ref|NP_178601|]
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beta-1,2-N-acetylglucosaminyltransferase II [Arabidopsis thaliana]

Protein Classification

MGAT2 domain-containing protein( domain architecture ID 10523720)

MGAT2 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MGAT2 pfam05060
N-acetylglucosaminyltransferase II (MGAT2); UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside ...
80-414 1.78e-154

N-acetylglucosaminyltransferase II (MGAT2); UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors.


:

Pssm-ID: 461539  Cd Length: 349  Bit Score: 440.95  E-value: 1.78e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181    80 RNHFSPRN-------TDLFPDLAKDRVVIVLYVHNRAQYFRVTVESLSKVKGISETLLIVSHDGYFEEMNRIVESIKFCQ 152
Cdd:pfam05060   1 RNSIYQLNfrqtilnLDKFPSLAPDSLVIVVQVHNRPEYLRLLIESLRKARGIENALLIFSHDFYSEEINRLVQSIDFCR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181   153 VKQIFSPYSPHIYRTSFPGVTLNDCK---NKGDEAKGHCEG--NPDQYGNHRSPKIVSLKHHWWWMMNTVWDGLEETKGH 227
Cdd:pfam05060  81 VLQIFFPYSLQLYPNEFPGQDPNDCPrdiSKEDALKKGCNNaeYPDSYGHYREAKFTQTKHHWWWKLNFVFDRLRVTKGY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181   228 EGHILFIEEDHFLFPNAYRNIQTLTRLKPAKCPDCFAANLAPSDVKSRGEGLESLV-----AERMGNVGYSFNRSVWENI 302
Cdd:pfam05060 161 NGLVLFLEEDHYVAPDFYHVLKLMVKLKPSECPDCDILSLGNYDKLSNYYSLSDKVevkgwISTKHNMGMAFNRDTWYKI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181   303 HQKAREFCFFDDYNWDITMWATV---FPSFgSPVYTLRGPRtsAVHFGKCGLHQgrgDEGDCIDNGVVNiEVKET----- 374
Cdd:pfam05060 241 KSCAEEFCTYDDYNWDWSLQHLSakcLPSP-LKVLVLRGPR--VFHIGDCGLHH---KGKDCRPEQAIN-KLEELlrsnk 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 30678181   375 ----DKVVNIKEGWGVrvykhqaGYKAGFEGwGGWGDDRDRHLC 414
Cdd:pfam05060 314 nylfPKSLTITKKTGV-------AVKPPKKN-GGWGDIRDHELC 349
 
Name Accession Description Interval E-value
MGAT2 pfam05060
N-acetylglucosaminyltransferase II (MGAT2); UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside ...
80-414 1.78e-154

N-acetylglucosaminyltransferase II (MGAT2); UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors.


Pssm-ID: 461539  Cd Length: 349  Bit Score: 440.95  E-value: 1.78e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181    80 RNHFSPRN-------TDLFPDLAKDRVVIVLYVHNRAQYFRVTVESLSKVKGISETLLIVSHDGYFEEMNRIVESIKFCQ 152
Cdd:pfam05060   1 RNSIYQLNfrqtilnLDKFPSLAPDSLVIVVQVHNRPEYLRLLIESLRKARGIENALLIFSHDFYSEEINRLVQSIDFCR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181   153 VKQIFSPYSPHIYRTSFPGVTLNDCK---NKGDEAKGHCEG--NPDQYGNHRSPKIVSLKHHWWWMMNTVWDGLEETKGH 227
Cdd:pfam05060  81 VLQIFFPYSLQLYPNEFPGQDPNDCPrdiSKEDALKKGCNNaeYPDSYGHYREAKFTQTKHHWWWKLNFVFDRLRVTKGY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181   228 EGHILFIEEDHFLFPNAYRNIQTLTRLKPAKCPDCFAANLAPSDVKSRGEGLESLV-----AERMGNVGYSFNRSVWENI 302
Cdd:pfam05060 161 NGLVLFLEEDHYVAPDFYHVLKLMVKLKPSECPDCDILSLGNYDKLSNYYSLSDKVevkgwISTKHNMGMAFNRDTWYKI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181   303 HQKAREFCFFDDYNWDITMWATV---FPSFgSPVYTLRGPRtsAVHFGKCGLHQgrgDEGDCIDNGVVNiEVKET----- 374
Cdd:pfam05060 241 KSCAEEFCTYDDYNWDWSLQHLSakcLPSP-LKVLVLRGPR--VFHIGDCGLHH---KGKDCRPEQAIN-KLEELlrsnk 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 30678181   375 ----DKVVNIKEGWGVrvykhqaGYKAGFEGwGGWGDDRDRHLC 414
Cdd:pfam05060 314 nylfPKSLTITKKTGV-------AVKPPKKN-GGWGDIRDHELC 349
 
Name Accession Description Interval E-value
MGAT2 pfam05060
N-acetylglucosaminyltransferase II (MGAT2); UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside ...
80-414 1.78e-154

N-acetylglucosaminyltransferase II (MGAT2); UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors.


Pssm-ID: 461539  Cd Length: 349  Bit Score: 440.95  E-value: 1.78e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181    80 RNHFSPRN-------TDLFPDLAKDRVVIVLYVHNRAQYFRVTVESLSKVKGISETLLIVSHDGYFEEMNRIVESIKFCQ 152
Cdd:pfam05060   1 RNSIYQLNfrqtilnLDKFPSLAPDSLVIVVQVHNRPEYLRLLIESLRKARGIENALLIFSHDFYSEEINRLVQSIDFCR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181   153 VKQIFSPYSPHIYRTSFPGVTLNDCK---NKGDEAKGHCEG--NPDQYGNHRSPKIVSLKHHWWWMMNTVWDGLEETKGH 227
Cdd:pfam05060  81 VLQIFFPYSLQLYPNEFPGQDPNDCPrdiSKEDALKKGCNNaeYPDSYGHYREAKFTQTKHHWWWKLNFVFDRLRVTKGY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181   228 EGHILFIEEDHFLFPNAYRNIQTLTRLKPAKCPDCFAANLAPSDVKSRGEGLESLV-----AERMGNVGYSFNRSVWENI 302
Cdd:pfam05060 161 NGLVLFLEEDHYVAPDFYHVLKLMVKLKPSECPDCDILSLGNYDKLSNYYSLSDKVevkgwISTKHNMGMAFNRDTWYKI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30678181   303 HQKAREFCFFDDYNWDITMWATV---FPSFgSPVYTLRGPRtsAVHFGKCGLHQgrgDEGDCIDNGVVNiEVKET----- 374
Cdd:pfam05060 241 KSCAEEFCTYDDYNWDWSLQHLSakcLPSP-LKVLVLRGPR--VFHIGDCGLHH---KGKDCRPEQAIN-KLEELlrsnk 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 30678181   375 ----DKVVNIKEGWGVrvykhqaGYKAGFEGwGGWGDDRDRHLC 414
Cdd:pfam05060 314 nylfPKSLTITKKTGV-------AVKPPKKN-GGWGDIRDHELC 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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